Clonazepam disposition in pediatric patients.

abstract：:During the past two decades, in association with the commencement of chronic dialysis therapy and prolongation of the uremic state, aluminum toxicity has represented a major cause of morbidity and mortality in uremic patients. The uremic patient has been found to be at higher risk of aluminum loading and toxicity from...

journal_title：Therapeutic drug monitoring

authors： Alfrey AC

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Colistin is increasingly used as the last therapeutic option for the treatment of multidrug-resistant, Gram-negative bacterial infections. To ensure safe and efficacious use of colistin, therapeutic drug monitoring (TDM) is needed due to its narrow therapeutic window. This study aimed to evaluate the pharmac...

journal_title：Therapeutic drug monitoring

authors： Kim EJ,Oh J,Lee K,Yu KS,Chung JY,Hwang JH,Nam EY,Kim HS,Kim M,Park JS,Song KH,Kim ES,Song J,Kim HB

更新日期：2019-02-01 00:00:00

abstract：:Digoxin and gentamicin are widely used in pediatric medicine, and therapeutic monitoring is mandatory because of their narrow margin of safety and wide interpatient and intrapatient pharmacokinetic variabilities. Saliva sampling may be of potential interest, especially in children, in whom blood sampling is often diff...

journal_title：Therapeutic drug monitoring

authors： Berkovitch M,Bistritzer T,Aladjem M,Burtin P,Dagan T,Chen-Levi Z,Freedom R,Koren G

更新日期：1998-06-01 00:00:00

abstract：:A gas chromatography-mass spectrometry (GC-MS)-based screening procedure was developed for the detection of diuretics, uricosurics, and/or their metabolites in human urine after extractive methylation. Phase-transfer catalyst remaining in the organic phase was removed by solid-phase extraction on a diol phase. The com...

journal_title：Therapeutic drug monitoring

authors： Beyer J,Bierl A,Peters FT,Maurer HH

更新日期：2005-08-01 00:00:00

abstract：:A method is described for the determination of vigabatrin in 50 microliters of plasma by isocratic high-performance liquid chromatography using fluorescence detection. The procedure involves protein precipitation with methanol followed by precolumn derivatisation with o-phthaldialdehyde reagent. Separation of the deri...

journal_title：Therapeutic drug monitoring

authors： Tsanaclis LM,Wicks J,Williams J,Richens A

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Desmopressin (D-amino D-arginine vasopressin: dDAVP) is used for the treatment of patients with hemophilia A and Von Willebrand disease. Studies on the rationale of dosing are scarce and mainly focus on the underlying causes of the vast differences in desmopressin response among individuals. The aim of this ...

journal_title：Therapeutic drug monitoring

authors： de Jager NCB,Heijdra JM,Pistorius M,Kruip MJHA,Leebeek FWG,Cnossen MH,Mathôt RAA

更新日期：2020-12-01 00:00:00

abstract：:5-Methoxy-N,N-dialkyltryptamines are tryptamine derivatives that possess strong hallucinogenic effects. Because of their escalating popularity and potent physiological effects, an increasing number of acute poisoning cases have been reported in various countries. For their metabolism in humans, only a few studies have...

journal_title：Therapeutic drug monitoring

authors： Katagi M,Kamata T,Zaitsu K,Shima N,Kamata H,Nakanishi K,Nishioka H,Miki A,Tsuchihashi H

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:There is a high coincidence between obesity and psychiatric disorders including depression. Depressive disorders are commonly treated with antidepressants, including the selective serotonin reuptake inhibitor Lexapro (escitalopram). Although candidates for elective Roux-en-Y gastric bypass (RYGB) surgery may...

journal_title：Therapeutic drug monitoring

authors： Marzinke MA,Petrides AK,Steele K,Schweitzer MA,Magnuson TH,Reinblatt SP,Coughlin JW,Clarke W

更新日期：2015-06-01 00:00:00

abstract：:The objective of this study was to evaluate the analytical performance of the Abbott ARCHITECT Cyclosporine (CsA) immunoassay in 7 clinical laboratories in comparison to liquid chromatography/tandem mass spectrometry (LC/MS/MS), Abbott TDx, Cobas Integra 800, and the Dade Dimension Xpand immunoassay. The ARCHITECT ass...

journal_title：Therapeutic drug monitoring

authors： Wallemacq P,Maine GT,Berg K,Rosiere T,Marquet P,Aimo G,Mengozzi G,Young J,Wonigeit K,Kretschmer R,Wermuth B,Schmid RW

更新日期：2010-04-01 00:00:00

abstract：:A population analysis of the kinetics of lithium was performed from experimental and observational data in 113 subjects in order to propose a new approach for lithium dosage individualization. The kinetics of lithium is described by a two-compartment model. Age, body weight, height, and serum creatinine are included a...

journal_title：Therapeutic drug monitoring

authors： Taright N,Mentré F,Mallet A,Jouvent R

更新日期：1994-06-01 00:00:00

abstract：:Racemic methadone is increasingly used to manage cancer pain. The authors studied 13 terminally ill patients with cancer pain, who underwent switching (rotation) from morphine to methadone. The relationship between initial morphine dose and final methadone dose, the pharmacokinetics of R- and S- methadone, and the deg...

journal_title：Therapeutic drug monitoring

authors： Auret K,Roger Goucke C,Ilett KF,Page-Sharp M,Boyd F,Oh TE

更新日期：2006-06-01 00:00:00

abstract：:A comparative bioavailability study of carbamazepine (CBZ) in tablets and a syrup preparation was carried out in six volunteers, using a crossover design. Plasma and saliva samples were collected at appropriate times, and the plasma specimens were analyzed by high performance liquid chromatography for concentrations o...

journal_title：Therapeutic drug monitoring

authors： Hooper WD,King AR,Patterson M,Dickinson RG,Eadie MJ

更新日期：1985-01-01 00:00:00

abstract：:An accurate and specific liquid chromatographic method for the separation and analysis of the R(+) and S(-) enantiomers of both aminoglutethimide (AG) and its acetylated metabolite (AcAG) in plasma, saliva, and urine is described. The separation was achieved by use of two serial Chiralcel OD columns [cellulose tris(3,...

journal_title：Therapeutic drug monitoring

authors： Alshowaier IA,el-Yazigi A,Ezzat A,el-Warith AA,Nicholls PJ

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:To increase target attainment rates, switching the mode of administration from intermittent (InI) to continuous infusion (CoI) has been proposed. In this study, target attainment rates and interpatient variation in exposure were compared between vancomycin InI- and CoI-treated critically ill patients. METHO...

journal_title：Therapeutic drug monitoring

authors： van Maarseveen EM,Gipmans S,Vasbinder E,Petjak M,van Zanten AR

更新日期：2016-06-01 00:00:00

abstract：:The effect of plasma exchange on the concentrations of total and unbound phenytoin (DPH) was determined in one normal subject and four patients undergoing therapeutic plasma exchange (PE). The average percentage of plasma exchanged ranged from 57 to 70% among the five patients studied. The reduction in DPH concentrati...

journal_title：Therapeutic drug monitoring

authors： Silberstein LE,Shaw LM

更新日期：1986-01-01 00:00:00

abstract：:Effect of diabetes mellitus on mycophenolic acid (MPA) pharmacokinetics and catalytic activity of inosine monophosphate dehydrogenase (IMPDH) was investigated in maintenance kidney transplant recipients. Demographically matched diabetic (n=9) and nondiabetic (n=9) patients were included in a 12-hour open-label, steady...

journal_title：Therapeutic drug monitoring

authors： Patel CG,Richman K,Yang D,Yan B,Gohh RY,Akhlaghi F

更新日期：2007-12-01 00:00:00

abstract：:A model for predicting unbound concentrations of mycophenolic acid (MPA) was developed in 84 subjects and then tested in an independent group of 19 hematopoietic cell transplant recipients. Total and unbound MPA concentrations and total mycophenolic glucuronide concentrations were measured between weeks 1 and 4 posttr...

journal_title：Therapeutic drug monitoring

authors： Huang J,Jacobson P,Brundage R

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:The aim of this study was to conduct a population pharmacokinetic (PK) analysis of meropenem and to explore the optimal dosing strategy for meropenem in critically ill patients with acute kidney injury receiving treatment with continuous hemodiafiltration (CHDF). METHODS:Blood samples were obtained on days ...

journal_title：Therapeutic drug monitoring

authors： Niibe Y,Suzuki T,Yamazaki S,Suzuki T,Takahashi N,Hattori N,Nakada TA,Oda S,Ishii I

更新日期：2020-08-01 00:00:00

abstract：:Since the late 90s, biopharmaceuticals targeting tumor necrosis factor alpha have revolutionized the treatment of moderately to severely active inflammatory bowel disease. The robust efficacy witnessed in many patients stands in stark contrast with the observation of a proportion of patients who fail to respond or who...

journal_title：Therapeutic drug monitoring

authors： Detrez I,Van Stappen T,Martín Arranz MD,Papamichael K,Gils A

更新日期：2017-08-01 00:00:00

abstract：:Individualized tobramycin therapy was systemically evaluated in 26 patients with gram-negative pneumonias involving Pseudomonas aeruginosa and other multiple antibiotic-resistant pathogens. Patient prognoses were classified by underlying diseases, and response was determined according to previously established criteri...

journal_title：Therapeutic drug monitoring

authors： Cipolle RJ,Seifert RD,Zaske DE,Strate RG

更新日期：1980-01-01 00:00:00

abstract：:Simplified pharmacokinetic methods have been used to estimate caffeine clearance in subjects with liver disease. There is a need to have a reliable, easy to implement method for research and possible clinical use. This study evaluates the use of Bayesian pharmacokinetic forecasting techniques to estimate caffeine clea...

journal_title：Therapeutic drug monitoring

authors： Denaro CP,Jacob P 3rd,Benowitz NL

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Previous reports have suggested that polymorphism of the opioid receptor A118G affects the efficacy of opioid analgesia. The aim of this study was to investigate whether such polymorphism contributed to variability in epidural mixture (sufentanil plus ropivacaine) requirements through patient-controlled epid...

journal_title：Therapeutic drug monitoring

authors： Xu GH,Gao M,Sheng QY,Liu XS,Gu EW

更新日期：2015-02-01 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic interactions between the gastrokinetic drug cisapride and the antipsychotic drugs bromperidol and haloperidol were studied in 29 schizophrenic inpatients. Fourteen patients were taking bromperidol (12-24 mg/d), and 15 were taking haloperidol (12-36 mg/d). Cisapride 10 mg/d was coadm...

journal_title：Therapeutic drug monitoring

authors： Mihara K,Otani K,Yasui N,Ishida M,Kondo T,Suzuki A,Furukori H,Nagashima U,Kaneko S,Inoue Y

更新日期：1999-06-01 00:00:00

abstract：:The TDx digoxin II immunoassay was used in controls and in patients not taking digoxin or any other cardiac glycoside. We report the frequency of interference thought to be caused by digoxin-like factors (DLFs). We found a high incidence of false-positive results in 15 patients with severe hepatic disease (60% false-p...

journal_title：Therapeutic drug monitoring

authors： Avendaño C,Alvarez JS,Sacristan JA,Adin J,Alsar MJ

更新日期：1991-11-01 00:00:00

abstract：:Digitalis-like immunoreactive substances (DLIS) obtained from maternal and umbilical cord plasma at delivery were measured by fluorescence polarization immunoassay (FPIA; TDX, Abbott) and microparticle enzyme immunoassay (MEIA; IMX, Abbott). In each sample, concentrations of dehydroepiandrosterone, dehydroepiandroster...

journal_title：Therapeutic drug monitoring

authors： Ijiri Y,Hayashi T,Kamegai H,Ohi K,Suzuki K,Kitaura Y,Takenaka H

更新日期：2003-04-01 00:00:00

abstract：:Rapamycin (RAPA) is a new immunosuppressive drug with a potency similar to that of FK506 and up to a 100-fold greater than that of cyclosporine (CsA). RAPA has shown to be efficacious in the prolongation of allograft survival in a number of animal models. In early studies, RAPA was administered on a dose/weight basis,...

journal_title：Therapeutic drug monitoring

authors： Yatscoff RW,LeGatt DF,Kneteman NM

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the serum concentrations of olanzapine in relation to age, sex, and other factors in Chinese patients aged between 10 and 90 years. METHODS:Data for 884 olanzapine patients, deposited between 2016 and 2017, were retrieved from the therapeutic drug monitoring da...

journal_title：Therapeutic drug monitoring

authors： Deng SH,Wang ZZ,Lu HY,Li L,Hu JQ,Zhu XQ,Xie HS,Chen HZ,Zhang M,Ni XJ,Qiu C,Shang DW,Wen YG

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Lacosamide (LCM) is one of the newer antiepileptic drugs (AEDs) licensed as add-on treatment for partial epilepsy. Data on LCM pharmacokinetics and interactions are limited and partly contradictory. The purpose of this study was to assess the effect of concomitant AED therapy on steady state plasma concentra...

journal_title：Therapeutic drug monitoring

authors： Contin M,Albani F,Riva R,Candela C,Mohamed S,Baruzzi A

更新日期：2013-12-01 00:00:00

abstract：:A case of desmethylimipramine (DMI) overdose is described. The analysis of DMI and its main metabolite, 2-hydroxydesmethylimipramine (2-OH-DMI), in plasma was performed by high performance liquid chromatography with fluorescence detection. Characterization of the elimination kinetics of DMI by using the SAAM 25 comput...

journal_title：Therapeutic drug monitoring

authors： Spina E,Henthorn TK,Eleborg L,Nordin C,Säwe J

更新日期：1985-01-01 00:00:00

abstract：:Hydroxylation of midazolam (MDZ) is mediated almost exclusively by CYP3A isoforms. The authors describe a high-performance liquid chromatography assay involving MDZ, 1'-hydroxymidazolam, and 4-hydroxymidazolam in plasma. The compounds were eluted on an Ultrasphere ODS, 3-microm particle size, 7.5 cm x 4.6 mm reversed-...

journal_title：Therapeutic drug monitoring

authors： Carrillo JA,Ramos SI,Agundez JA,Martinez C,Benitez J

更新日期：1998-06-01 00:00:00