Current Practice for Therapeutic Drug Monitoring of Biopharmaceuticals in Inflammatory Bowel Disease.

Abstract:

:Since the late 90s, biopharmaceuticals targeting tumor necrosis factor alpha have revolutionized the treatment of moderately to severely active inflammatory bowel disease. The robust efficacy witnessed in many patients stands in stark contrast with the observation of a proportion of patients who fail to respond or who lose response over time. Therapeutic drug monitoring has been proposed as a means to understand and respond to the variability in clinical response and remission. Various treatment algorithms have been proposed, but optimal use of these measurements in daily practice awaits additional prospective validation trials. This review provides an updated overview on the subject of therapeutic drug monitoring of biopharmaceuticals for the management of inflammatory bowel disease and how we could implement its concepts in a changing landscape.

journal_name

Ther Drug Monit

authors

Detrez I,Van Stappen T,Martín Arranz MD,Papamichael K,Gils A

doi

10.1097/FTD.0000000000000394

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

344-349

issue

4

eissn

0163-4356

issn

1536-3694

journal_volume

39

pub_type

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