Abstract:
:A model for predicting unbound concentrations of mycophenolic acid (MPA) was developed in 84 subjects and then tested in an independent group of 19 hematopoietic cell transplant recipients. Total and unbound MPA concentrations and total mycophenolic glucuronide concentrations were measured between weeks 1 and 4 posttransplant. The relationships between MPA unbound concentrations and common clinical biochemical markers were investigated. Mean prediction error and root mean square error of the model were calculated to assess prediction bias and precision, respectively. The best model for estimation of unbound concentrations included serum creatinine (SCr) and total bilirubin. The model for predicting unbound MPA fraction percentage was [0.928 + (serum creatinine mg/dL) x 0.392] (x1.48 if total bilirubin > or =3 mg/dL). Unbound MPA concentration (ng/mL) then can be estimated by total MPA concentration (ng/mL) x predicted MPA unbound percentage. Serum albumin was not significant in the regression model. There was no significant correlation between mycophenolic acid glucuronide and unbound MPA. This model demonstrated low bias (mean prediction error, 0.81 ng/mL) but poor precision (root mean square error, 19.49 ng/mL). In the validation population, this model showed poor bias and precision (mean prediction error, -5.42 ng/mL; root mean square error, 35.71 ng/mL). The models overestimated the measured unbound concentrations in the study population but underestimated in the validation population and did not provide satisfactory predictions for clinical assessments. Direct measurements of unbound MPA concentrations are necessary in patients requiring unbound concentration monitoring.
journal_name
Ther Drug Monitjournal_title
Therapeutic drug monitoringauthors
Huang J,Jacobson P,Brundage Rdoi
10.1097/FTD.0b013e318074d979subject
Has Abstractpub_date
2007-08-01 00:00:00pages
385-90issue
4eissn
0163-4356issn
1536-3694pii
00007691-200708000-00001journal_volume
29pub_type
临床试验,杂志文章abstract::The in vitro stability of cocaine (COC) was monitored in fresh whole blood and plasma stabilized with potassium fluoride (0.25%) for as long as 15 days. The samples were stored at 4 degreesC, 20 degreesC and 40 degreesC. Additionally, fresh plasma samples containing either benzoylecgonine (BZE), ecgonine methyl ester ...
journal_title:Therapeutic drug monitoring
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doi:10.1097/00007691-200104000-00014
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journal_title:Therapeutic drug monitoring
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journal_title:Therapeutic drug monitoring
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journal_title:Therapeutic drug monitoring
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journal_title:Therapeutic drug monitoring
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journal_title:Therapeutic drug monitoring
pub_type: 杂志文章
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journal_title:Therapeutic drug monitoring
pub_type: 杂志文章,meta分析
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journal_title:Therapeutic drug monitoring
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journal_title:Therapeutic drug monitoring
pub_type: 杂志文章
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journal_title:Therapeutic drug monitoring
pub_type: 杂志文章
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journal_title:Therapeutic drug monitoring
pub_type: 杂志文章,评审
doi:10.1097/01.ftd.0000194504.62892.b2
更新日期:2006-02-01 00:00:00
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journal_title:Therapeutic drug monitoring
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journal_title:Therapeutic drug monitoring
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journal_title:Therapeutic drug monitoring
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更新日期:1996-04-01 00:00:00
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journal_title:Therapeutic drug monitoring
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journal_title:Therapeutic drug monitoring
pub_type: 杂志文章,多中心研究
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