Analysis of isepamicin in human plasma by radioimmunoassay, microbiologic assay, and high-performance liquid chromatography.

abstract：:The monitoring of plasma olanzapine concentrations has been found to be an important and useful tool for optimizing psychiatric treatment. The present study investigated the effect that clinical factors, such as smoking and age, and functional polymorphisms of UGT1A4, CYP1A2, and CYP2D6 genes have on plasma olanzapine...

journal_title：Therapeutic drug monitoring

authors： Nozawa M,Ohnuma T,Matsubara Y,Sakai Y,Hatano T,Hanzawa R,Shibata N,Arai H

更新日期：2008-02-01 00:00:00

abstract：:Individualized tobramycin therapy was systemically evaluated in 26 patients with gram-negative pneumonias involving Pseudomonas aeruginosa and other multiple antibiotic-resistant pathogens. Patient prognoses were classified by underlying diseases, and response was determined according to previously established criteri...

journal_title：Therapeutic drug monitoring

authors： Cipolle RJ,Seifert RD,Zaske DE,Strate RG

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV)-infected individuals show large interindividual variation in response to antiretroviral therapy. Efavirenz (EFV) and nevirapine (NVP) are nonnucleoside reverse transcriptase inhibitors, which are prescribed in combination with other antiretroviral therapy in so-called highl...

journal_title：Therapeutic drug monitoring

authors： Heil SG,van der Ende ME,Schenk PW,van der Heiden I,Lindemans J,Burger D,van Schaik RH

更新日期：2012-04-01 00:00:00

abstract：:Whole blood steady-state trough concentrations of cyclosporine were measured by radioimmunoassay (RIA) and TDx assays employing monoclonal antibodies in 82 samples from 39 renal transplant patients. Intra- and interassay coefficients of variation for the new TDx technique averaged 3.2 and 5.4%, respectively. In the co...

journal_title：Therapeutic drug monitoring

authors： Klotz U

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Antiepileptic drug therapeutic regimens often need to be adjusted individually on the basis of serum assays. We aimed to develop a quantitative, fast, and sensitive liquid chromatography-tandem mass spectrometry method to simultaneously analyze carbamazepine, oxcarbazepine, and the 10-11 epoxide carbamazepin...

journal_title：Therapeutic drug monitoring

authors： Lionetto L,Casolla B,Cavallari M,Tisei P,Buttinelli C,Simmaco M

更新日期：2012-02-01 00:00:00

abstract：:The objective of this study was to evaluate the analytical performance of the Abbott ARCHITECT Cyclosporine (CsA) immunoassay in 7 clinical laboratories in comparison to liquid chromatography/tandem mass spectrometry (LC/MS/MS), Abbott TDx, Cobas Integra 800, and the Dade Dimension Xpand immunoassay. The ARCHITECT ass...

journal_title：Therapeutic drug monitoring

authors： Wallemacq P,Maine GT,Berg K,Rosiere T,Marquet P,Aimo G,Mengozzi G,Young J,Wonigeit K,Kretschmer R,Wermuth B,Schmid RW

更新日期：2010-04-01 00:00:00

abstract：:Drug discovery programs are actively exploring for therapeutic agents targeting enzymes and receptors regulating sphingolipid metabolism and biologic functions. FTY720 is a close structural analogue of sphingosine with immunomodulatory properties. After oral administration, FTY720 is phosphorylated by sphingosine kina...

journal_title：Therapeutic drug monitoring

authors： Kovarik JM,Schmouder RL,Slade AJ

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Quality management and accreditation in the analytical laboratory setting are developing rapidly and becoming the standard worldwide. Quality management refers to all the activities used by organizations to ensure product or service consistency. Accreditation is a formal recognition by an authoritative regul...

journal_title：Therapeutic drug monitoring

authors： Fulga N

更新日期：2013-06-01 00:00:00

abstract：:The aim of this review is to provide information for interpreting outcome results from monitoring of antipsychotics in biological samples. A brief overview of the working mechanisms, pharmacological effects, drug interactions, and analytical methods of classical and atypical antipsychotics is given. Nineteen antipsych...

journal_title：Therapeutic drug monitoring

authors： Patteet L,Morrens M,Maudens KE,Niemegeers P,Sabbe B,Neels H

更新日期：2012-12-01 00:00:00

abstract：:An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the oral antidiabetic tolbutamide and two of its metabolites, 4-hydroxytolbutamide and carboxytolbutamide, in human plasma and urine. The method was based on simple one-step liquid-liquid extraction with te...

journal_title：Therapeutic drug monitoring

authors： Hansen LL,Brøsen K

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Body weight may affect pharmacokinetic parameters in various ways and may therefore have a significant impact on the serum concentration of a drug at a given dose. Although patients with major depressive disorder frequently show an elevated body mass index, studies investigating the relation between body wei...

journal_title：Therapeutic drug monitoring

authors： Unterecker S,Deckert J,Pfuhlmann B

更新日期：2011-12-01 00:00:00

abstract：:A computer-based approach for estimating pharmacokinetic data and predicting plasma drug concentrations based on two measurements of plasma drug concentrations was compared with a standard two-point method for estimating aminoglycoside (AG) pharmacokinetic parameters. The computer-based technique was also used to pred...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Pongsin V,Forney R Jr,Gronau G

更新日期：1985-01-01 00:00:00

abstract：:For many drugs, therapeutic drug monitoring (TDM) has become widely available and accepted as an important component of clinical decision-making in the intensive care nursery setting. This review analyzes the potential factors that can either expand or restrict neonatal TDM. A case is made for the development of pharm...

journal_title：Therapeutic drug monitoring

authors： Giacoia GP

更新日期：1990-07-01 00:00:00

abstract：:Lamotrigine (LG), phenytoin (PY), carbamazepine (CM), and carbamazepine epoxide (CE) are measured with an optimized procedure that uses thin sorbent extraction disks and a highly selective, sterically protected bonded silica high-performance liquid chromatography (HPLC) column. Routinely, serum (200 microliters at pH ...

journal_title：Therapeutic drug monitoring

authors： Lensmeyer GL,Gidal BE,Wiebe DA

更新日期：1997-06-01 00:00:00

abstract：:Several studies have reported that the cytochrome P450 (CYP) 2D6 plays an important role in the fluvoxamine metabolism. However, some other studies have reported that the CYP2D6 genotype has no major impact on the fluvoxamine concentration. This study investigated the dose-dependent effect of CYP2D6-variant alleles on...

journal_title：Therapeutic drug monitoring

authors： Watanabe J,Suzuki Y,Fukui N,Sugai T,Ono S,Inoue Y,Someya T

更新日期：2008-12-01 00:00:00

abstract：:Three automated immunoassays for digoxin in serum were evaluated--Abbott TDxII, Baxter Stratus, and Behring OPUS. The accuracy and precision of the assays were assessed by weighed-in controls and an external quality control program. Coefficients of variation of all methods in serum were < or = 10% at weighed-in concen...

journal_title：Therapeutic drug monitoring

authors： Dodds HM,Norris RL,Johnson AG,Pond SM

更新日期：1995-02-01 00:00:00

abstract：:Six groups of six male Wistar rats were administered methadone in their drinking water over the concentration range 0-0.25 mg/ml. Hair and trunk blood samples were collected after a 6-week period of drug administration. Immunoreactive methadone was measured by radioimmunoassay and methadone and its major metabolite, 2...

journal_title：Therapeutic drug monitoring

authors： Green SJ,Wilson JF

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:The efficacy of drugs for the treatment of substance-related disorders is moderate at best. Therapeutic drug monitoring (TDM) could be an instrument to improve outcomes. Because TDM for most of those drugs is not established, the authors reviewed the literature and built a rating scale to detect the potentia...

journal_title：Therapeutic drug monitoring

authors： Brünen S,Vincent PD,Baumann P,Hiemke C,Havemann-Reinecke U

更新日期：2011-10-01 00:00:00

abstract：:A sensitive method for monitoring serum piroxicam (Feldene) is described. The assay requires 1.0 ml of specimen and involves chloroform extraction from an acidified mixture followed by concentration and injection into a liquid chromatograph. Column effluent is monitored at 330 nm. Retention times of piroxicam and the ...

journal_title：Therapeutic drug monitoring

authors： Fraser AD,Woodbury JF

更新日期：1983-06-01 00:00:00

abstract：:An isocratic high-performance liquid chromatography method with amperometric detection for the assay of plasma salbutamol is described. The plasma extract is injected into the chromatographic system via a loop column. This insures the purification of the injected extracts and allows a simple and rapid liquid-solid ext...

journal_title：Therapeutic drug monitoring

authors： Tamisier-Karolak L,Delhotal-Landes B,Jolliet-Riant P,Milliez J,Jannet D,Barre J,Flouvat B

更新日期：1992-06-01 00:00:00

abstract：:The solubility and stability of amphotericin B in human serum in vitro was assessed using a sensitive high performance liquid chromatographic technique. The solubility of amphotericin B at concentrations ranging from 0.5 micrograms/ml to 10 micrograms/ml in human serum at pH 7.4, at 37 degrees C, and in 5% CO2 (simula...

journal_title：Therapeutic drug monitoring

authors： Edmonds LC,Davidson L,Bertino JS Jr

更新日期：1989-01-01 00:00:00

abstract：:The present study aims to determine the population pharmacokinetic parameters of cyclosporine (CsA) after multiple oral administration of the microemulsion formulation, Neoral, in kidney transplant patients and to propose a limited sampling strategy to predict AUC(0-4h) using them and the Bayesian method. The AUC(0-4h...

journal_title：Therapeutic drug monitoring

authors： Tokui K,Kimata T,Uchida K,Yuasa H,Hayashi Y,Itatsu T,Nabeshima T

更新日期：2004-06-01 00:00:00

abstract：:Recent literature has urged caution in the interpretation of vancomycin serum concentrations in patients with end-stage renal disease (ESRD), because falsely elevated levels in excess of 70% have been reported with the most commonly used fluorescence polarization immunoassay (FPIA). The purpose of this study was to ev...

journal_title：Therapeutic drug monitoring

authors： Smith PF,Petros WP,Soucie MP,Copeland KR

更新日期：1998-04-01 00:00:00

abstract：:The diurnal fluctuations in free and total plasma levels of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-E) and their relationship with intermittent side effects were examined in 10 epileptic patients stabilized on chronic CBZ therapy alone or in combination with phenobarbital (PB). With a t.i.d. or q.i.d....

journal_title：Therapeutic drug monitoring

authors： Riva R,Contin M,Albani F,Perucca E,Ambrosetto G,Gobbi G,Cortelli P,Procaccianti G,Baruzzi A

更新日期：1984-01-01 00:00:00

abstract：:Oral posaconazole (PSZ), an azole antifungal drug, was recently introduced for the treatment of invasive fungal infections. The prescription of PSZ together with the immunosuppressant tacrolimus (TRL) was evaluated in 14 lung transplant patients with cystic fibrosis. PSZ inhibited CYP3A4 TRL metabolism, resulting in a...

journal_title：Therapeutic drug monitoring

authors： Berge M,Chevalier P,Benammar M,Guillemain R,Amrein C,Lefeuvre S,Boussaud V,Billaud EM

更新日期：2009-06-01 00:00:00

abstract：:When first approved, the dosing regimens for zidovudine were 1,200-1,500 mg/day; however, because toxicity developed, the daily dose had to be reduced to 500-600 mg/day. At these lower doses, plasma concentrations for a considerable segment of the dosing interval are often below the assay sensitivity for the high-perf...

journal_title：Therapeutic drug monitoring

authors： DeRemer M,D'Ambrosio R,Bartos L,Cousins S,Morse GD

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Theophylline, a xanthine derivative drug, is used for the treatment of respiratory diseases, such as asthma, and is primarily eliminated by hepatic metabolism. There is marked interindividual variability in theophylline clearance. Therefore, the aim of this study was to evaluate the influence of chronic hepa...

journal_title：Therapeutic drug monitoring

authors： Kurata Y,Muraki S,Kashihara Y,Hirota T,Araki H,Ieiri I

更新日期：2020-12-01 00:00:00

abstract：:The time course of appearance of cotinine in saliva and in daily collections of beard clippings was monitored by gas chromatography with mass spectrometry in six volunteers who were nonsmokers following a single 30-min buccal administration of nicotine as a chewing gum. Salivary cotinine concentrations reached a plate...

journal_title：Therapeutic drug monitoring

authors： Gwent SH,Wilson JF,Tsanaclis LM,Wicks JF

更新日期：1995-04-01 00:00:00

abstract：:Mycophenolate mofetil, the oral prodrug of mycophenolic acid, is indicated as immunosuppressive therapy after renal transplantation. To aid in the investigation of pharmacokinetic-pharmacodynamic relationships of mycophenolic acid in the clinical setting, limited blood sampling strategies have been proposed, and model...

journal_title：Therapeutic drug monitoring

authors： Willis C,Taylor PJ,Salm P,Tett SE,Pillans PI

更新日期：2000-10-01 00:00:00

abstract：:Sotrastaurin (AEB071) is an investigational immunosuppressant that blocks T-lymphocyte activation through protein kinase C inhibition. It is currently in Phase II of clinical development for the prevention of acute rejection after solid organ transplantation. In renal transplant clinical trials, sotrastaurin has been ...

journal_title：Therapeutic drug monitoring

authors： Kovarik JM,Slade A

更新日期：2010-10-01 00:00:00