Overview of FTY720 clinical pharmacokinetics and pharmacology.

abstract：:Fentanyl, sufentanil, and morphine are commonly used in the conduct of anesthesia. Medical staff working with these drugs are at high risk of addiction. To detect and prevent diversion, a method was developed to quantify these drugs in discard syringes using the BioRad REMEDi HS Drug Profiling System. For fentanyl, th...

journal_title：Therapeutic drug monitoring

authors： Holth LS,Friesen R,Green C,Krahn J

更新日期：2002-10-01 00:00:00

abstract：:Plasma concentrations of isepamicin, a new aminoglycoside antibiotic, were determined by radioimmunoassay (RIA), microbiological assay (MA), and high-performance liquid chromatography (HPLC) in healthy volunteers after administration of 7.5 mg/kg intramuscular dosages once daily for 10 days. Plasma samples were collec...

journal_title：Therapeutic drug monitoring

authors： Lin CC,Veals J,Korduba C,Hilbert MJ,Nomeir A

更新日期：1997-12-01 00:00:00

abstract：:The pharmacokinetics of oxycodone have been determined after single-dose administration by the intravenous (4.6-7.3 mg), oral (tablets, 9.1 mg and syrup, 9.1 mg), and rectal (30 mg) routes, in 48 patients undergoing minor surgery. There were no significant differences in the mean elimination half-lives between the int...

journal_title：Therapeutic drug monitoring

authors： Leow KP,Smith MT,Watt JA,Williams BE,Cramond T

更新日期：1992-12-01 00:00:00

abstract：:Sirolimus is a new immunosuppressive drug that has been evaluated in animal experiments. The current study was conducted on humans with reformulated sirolimus in doses from 3 mg/m2 to 15 mg/m2. Sixteen renal transplant recipients were included in this phase I study to determine the safety, tolerance, and preliminary p...

journal_title：Therapeutic drug monitoring

authors： Brattström C,Säwe J,Tydén G,Herlenius G,Claesson K,Zimmerman J,Groth CG

更新日期：1997-08-01 00:00:00

abstract：:The immunosuppressive potential of mycophenolic acid (MPA) correlates well with MPA exposure [area under the concentration-time curve (AUC)]. Monitoring MPA AUC is important and helpful for maintaining the efficacy of mycophenolate mofetil while minimizing its side effects, but full MPA AUC monitoring is laborious, co...

journal_title：Therapeutic drug monitoring

authors： Zicheng Y,Xianghui W,Peijun Z,Da X,Weixia Z,Hongzhuan C

更新日期：2007-10-01 00:00:00

abstract：:A reverse-phase high-performance liquid chromatographic (HPLC) method for the measurement of lamotrigine (LTG) simultaneously with phenobarbitone (PB), phenytoin (PHT), and carbamazepine (CBZ) is described using hexobarbital as the internal standard. The method uses the chromophore at 307 nm to detect LTG in the prese...

journal_title：Therapeutic drug monitoring

authors： Ramachandran S,Underhill S,Jones SR

更新日期：1994-02-01 00:00:00

abstract：:A noninstrumented enzyme immunochromatography (EIC) method for monitoring carbamazepine using whole blood was compared to the enzyme-multiplied immunoassay technique (EMIT), fluorescence polarization immunoassay (FPIA), and high-performance liquid chromatography (HPLC). Samples from 74 patients were evaluated in the c...

journal_title：Therapeutic drug monitoring

authors： Oles KS,Penry JK,Dyer RD

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Raltegravir is the first human immunodeficiency virus-1 (HIV-1) integrase inhibitor used in treatment-experienced patients who have evidence of viral replication and HIV-1 strains resistance to multiple antiretroviral regimens. Etravirine is a novel NNRTI, active against HIV-1 strains harboring multiple NNRT...

journal_title：Therapeutic drug monitoring

authors： Quaranta S,Woloch C,Paccou A,Giocanti M,Solas C,Lacarelle B

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that 5-fluorouracil (5-FU) dosing by use of pharmacokinetic (PK) parameters is superior to the traditional body surface area (BSA) method in colorectal cancer therapy. The purpose of this study was to compare the estimated efficacy and toxicity of the use of PK-guided versus BSA-based ...

journal_title：Therapeutic drug monitoring

authors： Yang R,Zhang Y,Zhou H,Zhang P,Yang P,Tong Q,Lyu Y,Han Y

更新日期：2016-02-01 00:00:00

abstract：:We report a clinically relevant suspected interaction between acyclovir and the antiepileptic drugs phenytoin (PHT) and valproic acid (VPA). In a child receiving PHT and VPA therapy, a 6-day acyclovir treatment reduced PHT and VPA plasma concentrations to subtherapeutic values. This probably worsened both clinical sta...

journal_title：Therapeutic drug monitoring

authors： Parmeggiani A,Riva R,Posar A,Rossi PG

更新日期：1995-06-01 00:00:00

abstract：:The aims of this study were to determine the relationship between saliva and plasma methadone concentrations and the influence of variability in saliva pH. Saliva and plasma samples were taken before the daily dose of methadone in 60 patients undergoing methadone maintenance treatment (MMT). Saliva pH was measured imm...

journal_title：Therapeutic drug monitoring

authors： Shiran MR,Hassanzadeh-Khayyat M,Iqbal MZ,Lagundoye O,Seivewright N,Lennard MS,Tucker GT,Rostami-Hodjegan A

更新日期：2005-10-01 00:00:00

abstract：:The effect of ofloxacin taken for 8 days (200 mg twice daily) on the pharmacokinetics of a single intravenous dose of theophylline (4.3 mg/kg over 15 min) was studied in a crossover procedure among seven healthy male volunteers. Theophylline concentrations were measured serially for 10 h by the immunofluorescence pola...

journal_title：Therapeutic drug monitoring

authors： Al-Turk WA,Shaheen OM,Othman S,Khalaf RM,Awidi AS

更新日期：1988-01-01 00:00:00

abstract：:A case of desmethylimipramine (DMI) overdose is described. The analysis of DMI and its main metabolite, 2-hydroxydesmethylimipramine (2-OH-DMI), in plasma was performed by high performance liquid chromatography with fluorescence detection. Characterization of the elimination kinetics of DMI by using the SAAM 25 comput...

journal_title：Therapeutic drug monitoring

authors： Spina E,Henthorn TK,Eleborg L,Nordin C,Säwe J

更新日期：1985-01-01 00:00:00

abstract：:The TDx digoxin II immunoassay was used in controls and in patients not taking digoxin or any other cardiac glycoside. We report the frequency of interference thought to be caused by digoxin-like factors (DLFs). We found a high incidence of false-positive results in 15 patients with severe hepatic disease (60% false-p...

journal_title：Therapeutic drug monitoring

authors： Avendaño C,Alvarez JS,Sacristan JA,Adin J,Alsar MJ

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:SB2, an infliximab (IFX) biosimilar to the reference infliximab (R.I.) product (Remicade), received approval in the European Union for all IFX indications. Many decision algorithms based on the measurement of IFX trough levels and antibodies to infliximab are being increasingly used to optimize IFX treatment...

journal_title：Therapeutic drug monitoring

authors： Jentzer A,Berger AE,Labetoulle R,Haccourt A,Roblin X,Paul S

更新日期：2018-12-01 00:00:00

abstract：:Lopinavir is one of the most-widely used protease inhibitors in the treatment of HIV-1 infected patients. Concentration-effect relationships have been described for both antiviral activity and toxicity. Less is known about patient characteristics that may determine interpatient variability in lopinavir plasma concentr...

journal_title：Therapeutic drug monitoring

authors： van der Leur MR,Burger DM,la Porte CJ,Koopmans PP

更新日期：2006-10-01 00:00:00

abstract：:The aim of this review is to provide information for interpreting outcome results from monitoring of antipsychotics in biological samples. A brief overview of the working mechanisms, pharmacological effects, drug interactions, and analytical methods of classical and atypical antipsychotics is given. Nineteen antipsych...

journal_title：Therapeutic drug monitoring

authors： Patteet L,Morrens M,Maudens KE,Niemegeers P,Sabbe B,Neels H

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:The aim of the study is to characterize the pharmacokinetics and the gastrointestinal side effect profiles of enteric-coated mycophenolate sodium (EC-MPS) in de novo kidney transplant patients of Hispanic ethnicity. MATERIALS AND METHODS:The pharmacokinetic study of EC-MPS was conducted in 11 de novo kidney ...

journal_title：Therapeutic drug monitoring

authors： Shah T,Tellez-Corrales E,Yang JW,Qazi Y,Wang J,Wilson J,Hutchinson I,Min DI

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Lacosamide (LCM) is one of the newer antiepileptic drugs (AEDs) licensed as add-on treatment for partial epilepsy. Data on LCM pharmacokinetics and interactions are limited and partly contradictory. The purpose of this study was to assess the effect of concomitant AED therapy on steady state plasma concentra...

journal_title：Therapeutic drug monitoring

authors： Contin M,Albani F,Riva R,Candela C,Mohamed S,Baruzzi A

更新日期：2013-12-01 00:00:00

abstract：:Phenytoin binding to serum proteins and factors influencing protein binding were investigated in 38 critically ill trauma patients. In 24% of these patients, the free fraction of phenytoin was < or = 10%, whereas in 76%, the free phenytoin fraction was increased > 10%--up to 24%. Nonantiepileptic comedication, sex, or...

journal_title：Therapeutic drug monitoring

authors： Zielmann S,Mielck F,Kahl R,Kazmaier S,Sydow M,Kolk J,Burchardi H

更新日期：1994-04-01 00:00:00

abstract：:It has been suggested that lamotrigine (LTG) may enhance the toxicity of carbamazepine (CBZ) by increasing the concentration of the active metabolite carbamazepine-10,11-epoxide (CBZ-E) in adult patients. The authors investigated this hypothesis in an add-on study in 11 children and 3 adolescents, aged 6-22 years, who...

journal_title：Therapeutic drug monitoring

authors： Eriksson AS,Boreus LO

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been one of the most widely used antiepileptic drugs. It is slowly absorbed, extensively plasma protein-bound, exhibits a nonlinear, concentration-dependent pharmacokinetic profile, and has a narrow therapeutic range...

journal_title：Therapeutic drug monitoring

authors： Aliwarga T,Cloyd JC,Goel V,Brundage RC,Marino SE,Leppik IE,Remmel RP

更新日期：2011-02-01 00:00:00

abstract：:We have suggested previously that acute tolerance to the chronotropic effect of cocaine develops and that tolerance is incomplete, such that the heart-rate decline in the presence of stable plasma cocaine concentrations approaches a plateau that exceeds the baseline heart rate. One possible mechanism for heart-rate de...

journal_title：Therapeutic drug monitoring

authors： Ambre JJ

更新日期：1993-12-01 00:00:00

abstract：:We describe a patient with invasive pulmonary aspergillosis on extracorporeal membrane oxygenation therapy in which therapeutic drug monitoring and individualization of therapy by measuring voriconazole plasma concentrations were performed. ...

journal_title：Therapeutic drug monitoring

authors： Brüggemann RJ,Antonius T,Heijst Av,Hoogerbrugge PM,Burger DM,Warris A

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a narrow therapeutic index medication, which requires therapeutic drug monitoring to optimize dosing based on systemic exposure. MITRA microsampling offers a convenient, minimally invasive approach for the collection of capillary blood samples from a fingerprick versus conventional venous blood...

journal_title：Therapeutic drug monitoring

authors： Undre N,Dawson I,Aluvihare V,Kamar N,Saliba F,Torpey N,Anaokar S,Kazeem G,Hussain I

更新日期：2020-12-03 00:00:00

abstract：:The relationship between changes in cyclosporin (CyA) dose or CyA blood concentration and the reciprocal creatinine concentration was investigated by cross-correlation analysis over the first 3 postoperative months in 32 consecutive heart and heart-lung recipients. Exploratory analysis suggested that early changes in ...

journal_title：Therapeutic drug monitoring

authors： Trull AK,Best NG,Tan KK,Hue KL,Higenbottam TW,Large S,Wallwork J

更新日期：1992-08-01 00:00:00

abstract：:Pentobarbital serum concentrations associated with a high-dose therapeutic regimen were determined using EMIT immunoassay reagents. Replicate analyses of serum controls resulted in a within-assay coefficient of variation of 5.0% and a between-assay coefficient of variation of 10%. Regression analysis of 44 serum sampl...

journal_title：Therapeutic drug monitoring

authors： Pape BE,Cary PL,Clay LC,Godolphin W

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Beta-lactams are first-line antibiotics for the management of superficial infections due to burn injury. There is sparse data available on therapeutic drug monitoring (TDM) in patients with burns in a ward setting. This study was conducted to evaluate the utility of a beta-lactam TDM program in a cohort of b...

journal_title：Therapeutic drug monitoring

authors： Patel BM,Paratz J,See NC,Muller MJ,Rudd M,Paterson D,Briscoe SE,Ungerer J,McWhinney BC,Lipman J,Roberts JA

更新日期：2012-04-01 00:00:00

abstract：:In the last few years, significant developments have occurred on the key issues involved in oral fluid drug testing. New pharmacokinetic studies have been conducted, optimal cutoffs have been proposed, and new studies have examined the correlation between oral fluid drug concentrations and impairment. Recent studies (...

journal_title：Therapeutic drug monitoring

authors： Pil K,Verstraete A

更新日期：2008-04-01 00:00:00

abstract：:An isocratic high-performance liquid chromatography method with amperometric detection for the assay of plasma salbutamol is described. The plasma extract is injected into the chromatographic system via a loop column. This insures the purification of the injected extracts and allows a simple and rapid liquid-solid ext...

journal_title：Therapeutic drug monitoring

authors： Tamisier-Karolak L,Delhotal-Landes B,Jolliet-Riant P,Milliez J,Jannet D,Barre J,Flouvat B

更新日期：1992-06-01 00:00:00