A rational basis for the measurement of free phenytoin concentration in critically ill trauma patients.

Abstract:

:Phenytoin binding to serum proteins and factors influencing protein binding were investigated in 38 critically ill trauma patients. In 24% of these patients, the free fraction of phenytoin was < or = 10%, whereas in 76%, the free phenytoin fraction was increased > 10%--up to 24%. Nonantiepileptic comedication, sex, or age had no influence on phenytoin binding in any of the 38 patients. Elevated free phenytoin fraction was found in those with hypoalbuminemia and hepatic and renal impairments. In these patients, the free phenytoin fraction should be measured routinely.

journal_name

Ther Drug Monit

authors

Zielmann S,Mielck F,Kahl R,Kazmaier S,Sydow M,Kolk J,Burchardi H

doi

10.1097/00007691-199404000-00005

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

139-44

issue

2

eissn

0163-4356

issn

1536-3694

journal_volume

16

pub_type

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