Determination of vigabatrin in plasma by reversed-phase high-performance liquid chromatography.

abstract：:This study explored the association of 14 single nucleotide polymorphisms in three genes coding for influx transporters (SLC22A1, SLCO1B1, and SLCO1B3), two genes coding for efflux transporters (ABCB1 and ABCG2), and four genes coding for enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A5) with the pharmacokinetics of imati...

journal_title：Therapeutic drug monitoring

authors： Yamakawa Y,Hamada A,Nakashima R,Yuki M,Hirayama C,Kawaguchi T,Saito H

更新日期：2011-04-01 00:00:00

abstract：:This laboratory has developed a simple and efficient solid-phase extraction method that is combined with a high-performance liquid chromatographic method for rapid and precise therapeutic monitoring of haloperidol (Haldol) blood levels. The solid-phase extraction utilizes a mixed bed column. Sensitivity of the chromat...

journal_title：Therapeutic drug monitoring

authors： Hoffman DW,Edkins RD

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) time courses in serum and physiological and behavioral effects associated with smoking 1 or 4 "light cannabis" cigarettes were studied. Biomarkers to differentiate light cannabis versus illegal and medical cannabis use were also investigated. METHODS:Sera ...

journal_title：Therapeutic drug monitoring

authors： Pichini S,Mannocchi G,Berretta P,Zaami S,Pirani F,Pacifici R,Busardò FP

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:The aim of the study is to characterize the pharmacokinetics and the gastrointestinal side effect profiles of enteric-coated mycophenolate sodium (EC-MPS) in de novo kidney transplant patients of Hispanic ethnicity. MATERIALS AND METHODS:The pharmacokinetic study of EC-MPS was conducted in 11 de novo kidney ...

journal_title：Therapeutic drug monitoring

authors： Shah T,Tellez-Corrales E,Yang JW,Qazi Y,Wang J,Wilson J,Hutchinson I,Min DI

更新日期：2011-02-01 00:00:00

abstract：:The authors describe a rapid, useful, specific, and very sensitive high-performance liquid chromatographic assay for the determination of fluvastatin (FV) level using atorvastatin as the internal standard (IS). After a simple deproteinization of 1.0 mL of plasma with acetonitrile, the drug and IS were extracted with t...

journal_title：Therapeutic drug monitoring

authors： Al-Rawithi S,Hussein RF,Alzahrani A

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Hair analysis of ethyl glucuronide (EtG) has become, beside fatty acid ethyl ester, a valuable marker for the detection of moderate and chronic excessive alcohol consumption. So far, only few studies exist about the influence of cosmetic treatment on EtG content in hair. The aim of this study was to evaluate...

journal_title：Therapeutic drug monitoring

authors： Kerekes I,Yegles M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Stiripentol (STP) was approved as an orphan drug in 2007 in Europe as adjunctive therapy with valproic acid (VPA) and clobazam (CLB) for Dravet syndrome. Dravet syndrome is a highly pharmacoresistant form of epilepsy, which starts in early childhood. Data about STP pharmacokinetics and interactions are still...

journal_title：Therapeutic drug monitoring

authors： May TW,Boor R,Mayer T,Jürgens U,Rambeck B,Holert N,Korn-Merker E,Brandt C

更新日期：2012-08-01 00:00:00

abstract：:To evaluate the reliability and practical use of saliva for therapeutic drug monitoring of the antifungal agent voriconazole in immunocompromised patients, a paired-sample study was conducted. Plasma and saliva trough levels were measured in seven children and nine adults who required treatment for the prevention or t...

journal_title：Therapeutic drug monitoring

authors： Michael C,Bierbach U,Frenzel K,Lange T,Basara N,Niederwieser D,Mauz-Körholz C,Preiss R

更新日期：2010-04-01 00:00:00

abstract：:The CYP2D6*10(*10) allele that causes decreased CYP2D6 activity is present in Asians with a high frequency of approximately 50%. We studied the effects of the *10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole. The subjects were 63 Japanese patients with...

journal_title：Therapeutic drug monitoring

authors： Suzuki T,Mihara K,Nakamura A,Nagai G,Kagawa S,Nemoto K,Ohta I,Arakaki H,Uno T,Kondo T

更新日期：2011-02-01 00:00:00

abstract：:The analysis of quinine in whole blood, plasma, urine, and samples dried on filter paper is described. Extraction was made with toluene followed by back-extraction into phosphate buffer. A reversed-phase liquid chromatography system with fluorescence detection was used. The within-day coefficient of variation of the m...

journal_title：Therapeutic drug monitoring

authors： Ericsson O,Fridén M,Hellgren U,Gustafsson LL

更新日期：1993-08-01 00:00:00

abstract：:Metabolism of thiopurine drugs--azathioprine, 6-mercaptopurine, and 6-thioguanine--has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine nucleotide (TGN). However, a sense of uncertainty about the useful...

journal_title：Therapeutic drug monitoring

authors： Duley JA,Florin TH

更新日期：2005-10-01 00:00:00

abstract：:The enantioselectivity of hydroxylation of nortriptyline (NT) to E-10-hydroxynortriptyline (E-10-OH-NT) was studied in human liver microsomes, intestinal homogenate, and patients treated with NT. The rate of formation of (-)-E-10-OH-NT was higher than that of (+)-E-10-OH-NT both in the liver microsomes and in the inte...

journal_title：Therapeutic drug monitoring

authors： Dahl ML,Nordin C,Bertilsson L

更新日期：1991-05-01 00:00:00

abstract：:The pharmacokinetics of rifampicin (RMP) and its principal active metabolite desacetylrifampicin (DA-RMP) were studied in six subjects, ranging in age from 78 to 95 years, after single oral doses of 10 mg/kg RMP. The maximal plasma concentrations (Cmax) and the elimination half-lives (t 1/2 beta) of RMP are 8.83 +/- 1...

journal_title：Therapeutic drug monitoring

authors： Advenier C,Gobert C,Houin G,Bidet D,Richelet S,Tillement JP

更新日期：1983-01-01 00:00:00

abstract：:The TDx digoxin II immunoassay was used in controls and in patients not taking digoxin or any other cardiac glycoside. We report the frequency of interference thought to be caused by digoxin-like factors (DLFs). We found a high incidence of false-positive results in 15 patients with severe hepatic disease (60% false-p...

journal_title：Therapeutic drug monitoring

authors： Avendaño C,Alvarez JS,Sacristan JA,Adin J,Alsar MJ

更新日期：1991-11-01 00:00:00

abstract：:Studies of the antidepressant effect and pharmacokinetics of citalopram have been performed in adults, but the effects on children and adolescents have only been studied to a minor extent despite its increasing use in these age groups. The aim of this study was to investigate a group of adolescents treated for depress...

journal_title：Therapeutic drug monitoring

authors： Carlsson B,Olsson G,Reis M,Walinder J,Nordin C,Lundmark J,Scordo MG,Dahl ML,Bengtsson F,Ahlner J

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Several factors such as low therapeutic index, large interindividual variability in systemic exposure, and the relationships between exposure and toxicity for sorafenib could justify its therapeutic drug monitoring (TDM). To support TDM, a selective and precise high-performance liquid chromatography with ult...

journal_title：Therapeutic drug monitoring

authors： Escudero-Ortiz V,Pérez-Ruixo JJ,Valenzuela B

更新日期：2014-06-01 00:00:00

abstract：:The role of drug assays for screening, diagnosis, and guiding treatment decisions in overdose patients remains unclear. The use of drug concentration data in clinical toxicology research is more problematic, with studies using drug concentrations to simply confirm ingestion in observational studies or others report dr...

journal_title：Therapeutic drug monitoring

authors： Isbister GK

更新日期：2010-06-01 00:00:00

abstract：:The possible occurrence of a kinetic interaction between cyclosporine A and glibenclamide was assessed by reviewing data of six posttransplant diabetic patients who received the two drugs concurrently. Coadministration of the two drugs resulted in a 57% increase in the steady-state plasma cyclosporine levels despite n...

journal_title：Therapeutic drug monitoring

authors： Islam SI,Masuda QN,Bolaji OO,Shaheen FM,Sheikh IA

更新日期：1996-10-01 00:00:00

abstract：:A simple high-performance liquid chromatography (HPLC) method for the determination of methotrexate (MTX) in biological fluids is described. The assay is rapid, the time required for analysis is less than 30 min, and it is sensitive, up to 0.01 microgram/ml, which is three times below the toxic MTX concentration. Fift...

journal_title：Therapeutic drug monitoring

authors： Najjar TA,Matar KM,Alfawaz IM

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Drug of abuse consumption throughout pregnancy is a serious public health problem and an important economic cost to the health system. The aim of this work was to compare maternal interview and hair analysis to determine drug consumption throughout pregnancy and to study relations among maternal i...

journal_title：Therapeutic drug monitoring

authors： Lendoiro E,González-Colmenero E,Concheiro-Guisán A,de Castro A,Cruz A,López-Rivadulla M,Concheiro M

更新日期：2013-06-01 00:00:00

abstract：:Determination of plasma methadone is essential in connection with dose adjustments for patients participating in methadone maintenance programs. We successfully adapted the existing fluorescence polarization immunoassay (FPIA) kit intended for urinary methadone to plasma assays. A concentration interval of 50-900 ng/m...

journal_title：Therapeutic drug monitoring

authors： Beck O,Boreus LO,Borg S,Jacobsson G,Lafolie P,Stensiö M

更新日期：1990-09-01 00:00:00

abstract：:A sensitive method for monitoring serum piroxicam (Feldene) is described. The assay requires 1.0 ml of specimen and involves chloroform extraction from an acidified mixture followed by concentration and injection into a liquid chromatograph. Column effluent is monitored at 330 nm. Retention times of piroxicam and the ...

journal_title：Therapeutic drug monitoring

authors： Fraser AD,Woodbury JF

更新日期：1983-06-01 00:00:00

abstract：:The clinical use of digoxin and phenytoin analyses (in 405 and 152 patients, respectively) furnished by our clinical pharmacological laboratory during a five-month period was evaluated prospectively from request forms. Of first-time analyses of digoxin, 12, 38, and 50% fell above, within, and below our recommended ran...

journal_title：Therapeutic drug monitoring

authors： Bergman U,Rane A,Sjöqvist F,Wiholm BE

更新日期：1981-01-01 00:00:00

abstract：INTRODUCTION:Proton pump inhibitors (PPIs) are often prescribed posttransplantation to prevent gastrointestinal complications. A series of recent studies have reported a relationship between PPI comedication and decreased mycophenolic acid (MPA) exposure. The objective of this subanalysis of the CLEAR data set was to d...

journal_title：Therapeutic drug monitoring

authors： Kiberd BA,Wrobel M,Dandavino R,Keown P,Gourishankar S

更新日期：2011-02-01 00:00:00

abstract：:Several studies have reported that the cytochrome P450 (CYP) 2D6 plays an important role in the fluvoxamine metabolism. However, some other studies have reported that the CYP2D6 genotype has no major impact on the fluvoxamine concentration. This study investigated the dose-dependent effect of CYP2D6-variant alleles on...

journal_title：Therapeutic drug monitoring

authors： Watanabe J,Suzuki Y,Fukui N,Sugai T,Ono S,Inoue Y,Someya T

更新日期：2008-12-01 00:00:00

abstract：:Steady state serum concentrations of risperidone and 9-hydroxyrisperidone (9-OH-risperidone), the active moiety, were measured in 42 patients. The concentration-to-dose ratios (C/D) varied by a factor of 20, from 1.8 to 36.8 (nmol/l)/(mg/24 hours), and 90% of the active moiety was constituted of 9-OH-risperidone. No c...

journal_title：Therapeutic drug monitoring

authors： Olesen OV,Licht RW,Thomsen E,Bruun T,Viftrup JE,Linnet K

更新日期：1998-08-01 00:00:00

abstract：:C(2) Cyclosporine (CsA) level, as a surrogate of area under the time-concentration curve (AUC) 0-4 hours, is a good predictor of drug absorption and clinical outcome after kidney transplantation. It has been difficult to define the optimal C(2) level in the individual case and given the broad range of C(2) due to inte...

journal_title：Therapeutic drug monitoring

authors： Morales J,Buckel E,Fierro A,Zehnder C,Herzog C,Mañalich J

更新日期：2003-06-01 00:00:00

abstract：:To investigate the pharmacokinetics of naloxone in healthy volunteers, we undertook an open-label crossover study in which six male volunteers received naloxone on five occasions: intravenous (0.8 mg), intramuscular (0.8 mg), intranasal (0.8 mg), intravenous (2 mg), and intranasal (2 mg). Samples were collected for 4 ...

journal_title：Therapeutic drug monitoring

authors： Dowling J,Isbister GK,Kirkpatrick CM,Naidoo D,Graudins A

更新日期：2008-08-01 00:00:00

abstract：:The authors report a case that offers insight into the diagnostic challenges of "Munchausen Syndrome by Proxy." Initial presentation with history of fever and later with intractable vomiting led to invasive and expensive diagnostic evaluation before confirming the diagnosis. Certain toxic effects of emetine were clini...

journal_title：Therapeutic drug monitoring

authors： Bader AA,Kerzner B

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:This naturalistic therapeutic drug monitoring (TDM) study aimed to evaluate the relationship between dosage, serum concentration, and clinical outcome in children and adolescents treated with the serotonin reuptake inhibitor sertraline for different indications. METHODS:Steady-state trough serum concentratio...

journal_title：Therapeutic drug monitoring

authors： Taurines R,Burger R,Wewetzer C,Pfuhlmann B,Mehler-Wex C,Gerlach M,Egberts K

更新日期：2013-02-01 00:00:00