6-mercaptopurine plasma levels in children with acute lymphoblastic leukemia: relation to relapse risk and myelotoxicity.

abstract：:Plasma concentration-antidepressant response relationships for dothiepin, nordothiepin, dothiepin-S-oxide, and nordothiepin-S-oxide were investigated in 50 patients (33 women and 17 men), who had had a major depressive episode. Depression and anxiety were assessed at the start of therapy and after 2 and 4 weeks by mea...

journal_title：Therapeutic drug monitoring

authors： Ilett KF,Blythe TH,Hackett LP,Ong RT,Tannenbaum DA,Clarke TM

更新日期：1993-10-01 00:00:00

abstract：:The interlaboratory variability in the assay of theophylline and various anticonvulsant drugs was evaluated in a 16-month prospective study by using two independent experimental approaches: (a) a conventional method based on the distribution of quality control (QC) lyophilized human sera spiked with the test drugs (ph...

journal_title：Therapeutic drug monitoring

authors：

更新日期：1991-03-01 00:00:00

abstract：:Pediatric patients with leukemia, other malignancies, and rheumatological disease receive methotrexate chronically. Because of the documented correlation between methotrexate levels of compliance and clinical outcome, it is conceivable to verify appropriate systemic exposure to the drug. Saliva sampling may be of pote...

journal_title：Therapeutic drug monitoring

authors： Press J,Berkovitch M,Laxer R,Giesbrecht E,Verjee Z,Silverman E,Klein J,Koren G

更新日期：1995-06-01 00:00:00

abstract：:Eight commercial digoxin immunoassay methods were tested in 17 subjects taking spironolactone (but not digoxin) to evaluate cross-reactivity from parent drug and/or metabolites. Four of these methods showed significant (up to 1.9 nmol/L) and variable "apparent digoxin" concentrations, despite the absence of digoxin in...

journal_title：Therapeutic drug monitoring

authors： Morris RG,Lagnado PY,Lehmann DR,Frewin DB,Glistak ML,Burnet RB

更新日期：1987-06-01 00:00:00

abstract：:The performance of the ROCHE FP NAPA reagent, a newly reformulated monoclonal antibody-based fluorescence polarization immunoassay (FPIA) for N-acetylprocainamide, was compared with two commercially available polyclonal antibody-based immunoassays, the Abbott TDx and Syva EMIT. Although excellent correlation was obser...

journal_title：Therapeutic drug monitoring

authors： Laurino JP,McKay J,Fischberg E,Schwenzer K,Kaufman R

更新日期：1994-06-01 00:00:00

abstract：:Most recent cyclosporine (CsA) pharmacokinetic (PK) studies have focused on noncompartmental analysis. Because CsA undergoes significant first-pass elimination after oral dosing, the most appropriate compartment model may need to take this process into account for the construction of a valid population PK model for Sa...

journal_title：Therapeutic drug monitoring

authors： Ducharme MP,Verret L,Brouillette D,Sirois G

更新日期：1998-04-01 00:00:00

abstract：:Differences in product formulations have been shown to affect the therapeutic response by altering the relative bioavailability and pharmacokinetics of a drug. The relative bioavailability and pharmacokinetics of carbamazepine tablets (CBZ) and a chewable tablet formulation were evaluated in 10 normal healthy subjects...

journal_title：Therapeutic drug monitoring

authors： Maas B,Garnett WR,Pellock JM,Comstock TJ

更新日期：1987-01-01 00:00:00

abstract：:A highly sensitive, specific method for determining chloramphenicol levels in human blood plasma and cerebrospinal fluid is described. The method uses high performance liquid chromatography for the analysis, requires minimal quantities of patient specimen, and thus is suitable for use in newborn and pediatric patients...

journal_title：Therapeutic drug monitoring

authors： Sood SP,Green VI,Bailey CL

更新日期：1987-09-01 00:00:00

abstract：:A variety of medications are used in treating patients infected with the human immunodeficiency virus (HIV). These medications are used to control viremia and to prevent and treat opportunistic infections. An individual is often required to take numerous drugs at the same time and thus clinicians are confronted with p...

journal_title：Therapeutic drug monitoring

authors： Dasgupta A,Okhuysen PC

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Current gentamicin dosing algorithms in adult populations target a high peak concentration (Cmax) assuring efficacy and a drug-free period (concentration <0.5 mg/L) preventing toxicity. In contrast, gentamicin-based regimens in neonatal sepsis often aim for lower peak levels and trough concentrations of 0.5-...

journal_title：Therapeutic drug monitoring

authors： van Maarseveen EM,Sprij A,Touw DJ

更新日期：2016-06-01 00:00:00

abstract：:An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the oral antidiabetic tolbutamide and two of its metabolites, 4-hydroxytolbutamide and carboxytolbutamide, in human plasma and urine. The method was based on simple one-step liquid-liquid extraction with te...

journal_title：Therapeutic drug monitoring

authors： Hansen LL,Brøsen K

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Quality management and accreditation in the analytical laboratory setting are developing rapidly and becoming the standard worldwide. Quality management refers to all the activities used by organizations to ensure product or service consistency. Accreditation is a formal recognition by an authoritative regul...

journal_title：Therapeutic drug monitoring

authors： Fulga N

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The pharmacokinetics of long-acting intramuscular paliperidone in a naturalistic setting is not well documented. The objective of this study was to investigate the relationship between dose and serum concentrations of paliperidone using data from a routine therapeutic drug monitoring service. METHODS:Serum ...

journal_title：Therapeutic drug monitoring

authors： Helland A,Spigset O

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 3A (CYP3A) isoenzyme metabolic activity varies between individuals and is therefore a possible candidate of influence on the therapeutic outcome of the tyrosine kinase inhibitor imatinib in patients with chronic myeloid leukemia (CML). The aim of this study was to investigate the influence of...

journal_title：Therapeutic drug monitoring

authors： Skoglund K,Richter J,Olsson-Strömberg U,Bergquist J,Aluthgedara W,Ubhayasekera SJ,Vikingsson S,Svedberg A,Söderlund S,Sandstedt A,Johnsson A,Aagesen J,Alsenhed J,Hägg S,Peterson C,Lotfi K,Gréen H

更新日期：2016-04-01 00:00:00

abstract：:Metabolism of thiopurine drugs--azathioprine, 6-mercaptopurine, and 6-thioguanine--has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine nucleotide (TGN). However, a sense of uncertainty about the useful...

journal_title：Therapeutic drug monitoring

authors： Duley JA,Florin TH

更新日期：2005-10-01 00:00:00

abstract：:The emerging nation of South Africa, in common with some other countries, notably Eastern Europe, is heir to decades of neglect with regards to the exposure of the majority of its population to toxic materials. In this short review, the major toxic health hazards are described. For most of these risks there are now pr...

journal_title：Therapeutic drug monitoring

authors： Stewart MJ

更新日期：2002-02-01 00:00:00

abstract：:Hydroxylation of midazolam (MDZ) is mediated almost exclusively by CYP3A isoforms. The authors describe a high-performance liquid chromatography assay involving MDZ, 1'-hydroxymidazolam, and 4-hydroxymidazolam in plasma. The compounds were eluted on an Ultrasphere ODS, 3-microm particle size, 7.5 cm x 4.6 mm reversed-...

journal_title：Therapeutic drug monitoring

authors： Carrillo JA,Ramos SI,Agundez JA,Martinez C,Benitez J

更新日期：1998-06-01 00:00:00

abstract：:An isocratic high-performance liquid chromatography method with amperometric detection for the assay of plasma salbutamol is described. The plasma extract is injected into the chromatographic system via a loop column. This insures the purification of the injected extracts and allows a simple and rapid liquid-solid ext...

journal_title：Therapeutic drug monitoring

authors： Tamisier-Karolak L,Delhotal-Landes B,Jolliet-Riant P,Milliez J,Jannet D,Barre J,Flouvat B

更新日期：1992-06-01 00:00:00

abstract：:The effect of plasma exchange (PE) on the pharmacokinetics of flumequine (Apurone) was studied in eight patients receiving a single oral dose of 800 mg. The maximum concentration (38 micrograms/ml) and time to maximum concentration (2.6 h) values were not significantly altered by PE beginning 3 h after administration ...

journal_title：Therapeutic drug monitoring

authors： Royer-Morrot MJ,Gérard A,Zhiri A,Schooneman F,Dureux JB,Royer RJ

更新日期：1991-07-01 00:00:00

abstract：:The correlation between single plasma concentration (CP) values of 5-fluorouracil (FU) after a 10-minute i.v. infusion and the total area under the plasma concentration-time curve (AUC) has been studied in 26 cancer patients. FU dose was either 320-550 mg/m2 (seven patients, 13 treatments) or 610-960 mg/m2 (19 patient...

journal_title：Therapeutic drug monitoring

authors： Port RE,Edler L,Herrmann R,Feldmann U

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Hair analysis of ethyl glucuronide (EtG) has become, beside fatty acid ethyl ester, a valuable marker for the detection of moderate and chronic excessive alcohol consumption. So far, only few studies exist about the influence of cosmetic treatment on EtG content in hair. The aim of this study was to evaluate...

journal_title：Therapeutic drug monitoring

authors： Kerekes I,Yegles M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The once-daily formulation of tacrolimus has been reported to exhibit the same efficacy and safety profile as compared with the immediate-release form administered twice daily. However, as a result of differences in their pharmacokinetic (PK) profile, the PK models or Bayesian estimators (MAP-BE) previously ...

journal_title：Therapeutic drug monitoring

authors： Saint-Marcoux F,Debord J,Undre N,Rousseau A,Marquet P

更新日期：2010-04-01 00:00:00

abstract：:This laboratory has developed a simple and efficient solid-phase extraction method that is combined with a high-performance liquid chromatographic method for rapid and precise therapeutic monitoring of haloperidol (Haldol) blood levels. The solid-phase extraction utilizes a mixed bed column. Sensitivity of the chromat...

journal_title：Therapeutic drug monitoring

authors： Hoffman DW,Edkins RD

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Hydroxychloroquine (HCQ) is an effective treatment for patients with cutaneous lupus erythematosus (CLE) or systemic lupus erythematosus (SLE) and has been used for these patients in more than 70 nations. However, in Japan, HCQ has not been approved for CLE or SLE. To establish an appropriate therapeutic reg...

journal_title：Therapeutic drug monitoring

authors： Morita S,Takahashi T,Yoshida Y,Yokota N

更新日期：2016-04-01 00:00:00

abstract：:Pharmacokinetics of intravenous and oral pulsed high-dose dexamethasone were studied in four patients with pemphigus vulgaris. Doses for dexamethasone were varied from 100 to 300 mg. Serum concentrations were measured by high-performance liquid chromatographic procedure with diode assay detection. Bioavailability was ...

journal_title：Therapeutic drug monitoring

authors： Tóth GG,Kloosterman C,Uges DR,Jonkman MF

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Ribavirin exposure after the first dose (D0AUC0-4h) >1755 mcg·h·L is predictive of sustained virological response (SVR) in patients with hepatitis C treated with peginterferon and ribavirin. The aim of this study was to test the benefit of ribavirin early dose adjustment based on this target in naïve patient...

journal_title：Therapeutic drug monitoring

authors： Loustaud-Ratti V,Maynard M,Thevenon S,Pradat P,Rousseau A,Alain S,Deny P,Gagnieu MC,Tran A,Dao T,Silvain C,Lunel-Fabiani F,Picard N,Zublena I,Marquet P,Trepo C,RIBAJUSTE Group.

更新日期：2016-12-01 00:00:00

abstract：:A method is described for the determination of vigabatrin in 50 microliters of plasma by isocratic high-performance liquid chromatography using fluorescence detection. The procedure involves protein precipitation with methanol followed by precolumn derivatisation with o-phthaldialdehyde reagent. Separation of the deri...

journal_title：Therapeutic drug monitoring

authors： Tsanaclis LM,Wicks J,Williams J,Richens A

更新日期：1991-05-01 00:00:00

abstract：:Calculated creatinine clearance (CrCL) estimates are frequently used as estimates of aminoglycoside clearance (AGCL), despite being inadequately studied. Thirty surgical intensive care unit (SICU) patients with stable serum creatinines (0.6-6.3 mg/dl) and steady-state aminoglycoside levels were studied. A one-compartm...

journal_title：Therapeutic drug monitoring

authors： Deeter RG,Krauss EA,Penn F,Nahaczewski AE

更新日期：1989-01-01 00:00:00

abstract：:The greater and more consistent absorption of cyclosporine from the microemulsion formulation (Neoral; Novartis Pharmaceuticals Ltd., Frimley, UK) when compared with that from the original form (Sandimmune; Novartis Pharmaceuticals Ltd., Frimley, UK) results in greater systemic exposure. Lung transplant recipients cou...

journal_title：Therapeutic drug monitoring

authors： Trull A,Steel L,Sharples L,Stewart S,Parameshwar J,McNeil K,Wallwork J

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:SB2, an infliximab (IFX) biosimilar to the reference infliximab (R.I.) product (Remicade), received approval in the European Union for all IFX indications. Many decision algorithms based on the measurement of IFX trough levels and antibodies to infliximab are being increasingly used to optimize IFX treatment...

journal_title：Therapeutic drug monitoring

authors： Jentzer A,Berger AE,Labetoulle R,Haccourt A,Roblin X,Paul S

更新日期：2018-12-01 00:00:00