Comparison of three immunoassays for the determination of N-acetylprocainamide. Determination of false elevations by a polyclonal antibody-based method.

abstract：:The DuPont theophylline assay reagent kit, a particle-enhanced turbidimetric inhibition immunoassay (PETINIA) method adapted for use on a centrifugal fast analyzer, was evaluated. It was compared with fluorescence polarization immunoassay (FPIA). Day-to-day precision was 4.7% at 6.8 micrograms/ml, and 3.3% at 26.6 mic...

journal_title：Therapeutic drug monitoring

authors： Lawrence JL,Elser RC

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Oral fluid (OF) is being developed as a specimen for the determination of drug intake as an alternative to serum and plasma. It is generally considered as an attractive specimen due to the noninvasive nature of the sampling procedure and the relation to the free fraction of drug in the blood. These features ...

journal_title：Therapeutic drug monitoring

authors： Neumann J,Beck O,Dahmen N,Böttcher M

更新日期：2018-04-01 00:00:00

abstract：:Given the high prevalence of the use of medications in daily practice and the large number of people taking antirheumatic agents, the risk of drug-drug interactions and of hepatotoxicity is of concern. Both old and new compounds show such a risk. Nonsteroidal antinflammatory drugs are widely used drugs with potential ...

journal_title：Therapeutic drug monitoring

authors： Anelli MG,Scioscia C,Grattagliano I,Lapadula G

更新日期：2012-12-01 00:00:00

abstract：:Previous studies have categorized duloxetine as a moderate inhibitor of CYP2D6. The aim of the present study was to investigate the potential interactions between duloxetine and the two CYP2D6 substrates risperidone and aripiprazole in psychiatric patients. Serum concentration data from patients treated with risperido...

journal_title：Therapeutic drug monitoring

authors： Hendset M,Molden E,Enoksen TB,Refsum H,Hermann M

更新日期：2010-12-01 00:00:00

abstract：:This case report highlights a very rare adverse drug reaction caused by oral aripiprazole resulting in severe hypoglycemia. A 72-year-old-male patient suffering from Parkinson disease on prolonged carbidopa plus levodopa combination therapy (carbidopa 25 mg plus levodopa 100 mg, thrice daily) for 1.3 years was recentl...

journal_title：Therapeutic drug monitoring

authors： Mondal S,Saha I,Das S,Ganguly A,Ghosh A,Kumar Das A

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:This naturalistic therapeutic drug monitoring (TDM) study aimed to evaluate the relationship between dosage, serum concentration, and clinical outcome in children and adolescents treated with the serotonin reuptake inhibitor sertraline for different indications. METHODS:Steady-state trough serum concentratio...

journal_title：Therapeutic drug monitoring

authors： Taurines R,Burger R,Wewetzer C,Pfuhlmann B,Mehler-Wex C,Gerlach M,Egberts K

更新日期：2013-02-01 00:00:00

abstract：:Effect of diabetes mellitus on mycophenolic acid (MPA) pharmacokinetics and catalytic activity of inosine monophosphate dehydrogenase (IMPDH) was investigated in maintenance kidney transplant recipients. Demographically matched diabetic (n=9) and nondiabetic (n=9) patients were included in a 12-hour open-label, steady...

journal_title：Therapeutic drug monitoring

authors： Patel CG,Richman K,Yang D,Yan B,Gohh RY,Akhlaghi F

更新日期：2007-12-01 00:00:00

abstract：:A rapid and simple procedure based on gas chromatography-mass spectrometry (GC-MS) is described for determination of Delta-tetrahydrocannabinol (THC), 11-hydroxy-Delta-tetrahydrocannabinol (THC-OH) and 11-nor-Delta-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in meconium using Delta-tetrahydrocannabinol (Delta-TH...

journal_title：Therapeutic drug monitoring

authors： Marchei E,Pellegrini M,Pacifici R,Palmi I,Lozano J,García-Algar O,Pichini S

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:There is a high coincidence between obesity and psychiatric disorders including depression. Depressive disorders are commonly treated with antidepressants, including the selective serotonin reuptake inhibitor Lexapro (escitalopram). Although candidates for elective Roux-en-Y gastric bypass (RYGB) surgery may...

journal_title：Therapeutic drug monitoring

authors： Marzinke MA,Petrides AK,Steele K,Schweitzer MA,Magnuson TH,Reinblatt SP,Coughlin JW,Clarke W

更新日期：2015-06-01 00:00:00

abstract：:Vancomycin is widely used in the prophylaxis and treatment of infections in neutropenic patients with cancer. The objective of this study was to analyze liver damage effects on vancomycin pharmacokinetics and determine the necessity for liver function evaluation when selecting vancomycin dosing schedules in these pati...

journal_title：Therapeutic drug monitoring

authors： Aldaz A,Ortega A,Idoate A,Giráldez J,Brugarolas A

更新日期：2000-06-01 00:00:00

abstract：:Two separate studies were carried out to assess the effect of valproic acid on the steady-state plasma concentrations of clozapine and its major metabolites norclozapine and clozapine N-oxide in psychotic patients. In the first study, concentrations of clozapine and metabolites were compared between patients treated w...

journal_title：Therapeutic drug monitoring

authors： Facciolà G,Avenoso A,Scordo MG,Madia AG,Ventimiglia A,Perucca E,Spina E

更新日期：1999-06-01 00:00:00

abstract：:An epileptic patient well controlled on valproic acid (VPA) developed a prolonged episode of status epilepticus 12 days after initiation of 75 mg of clomipramine (CMI) to treat depression. Serum level of VPA in the emergency room was unchanged from her previous levels; serum level of CMI was very elevated despite the ...

journal_title：Therapeutic drug monitoring

authors： DeToledo JC,Haddad H,Ramsay RE

更新日期：1997-02-01 00:00:00

abstract：:A 64-year-old man with chronic renal insufficiency was hospitalized with dysphagia and inability to keep his head erect 11 months after beginning procainamide hydrochloride (PA) for control of atrial flutter. Evaluation revealed esophageal dysmotility, worsening renal function, and elevated serum PA and N-acetylprocai...

journal_title：Therapeutic drug monitoring

authors： Miller CD,Oleshansky MA,Gibson KF,Cantilena LR

更新日期：1993-06-01 00:00:00

abstract：:The immunosuppressant mycophenolic acid (MPA) used for solid organ transplantation is predominantly metabolized to a pharmacologically inactive phenolic glucuronide (MPAG) and, to a lesser extent, to the pharmacologically active acyl glucuronide (AcMPAG). The recently introduced CEDIA Mycophenolic Acid Assay from Micr...

journal_title：Therapeutic drug monitoring

authors： Shipkova M,Schütz E,Besenthal I,Fraunberger P,Wieland E

更新日期：2010-02-01 00:00:00

abstract：:The effect of ofloxacin taken for 8 days (200 mg twice daily) on the pharmacokinetics of a single intravenous dose of theophylline (4.3 mg/kg over 15 min) was studied in a crossover procedure among seven healthy male volunteers. Theophylline concentrations were measured serially for 10 h by the immunofluorescence pola...

journal_title：Therapeutic drug monitoring

authors： Al-Turk WA,Shaheen OM,Othman S,Khalaf RM,Awidi AS

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the serum concentrations of olanzapine in relation to age, sex, and other factors in Chinese patients aged between 10 and 90 years. METHODS:Data for 884 olanzapine patients, deposited between 2016 and 2017, were retrieved from the therapeutic drug monitoring da...

journal_title：Therapeutic drug monitoring

authors： Deng SH,Wang ZZ,Lu HY,Li L,Hu JQ,Zhu XQ,Xie HS,Chen HZ,Zhang M,Ni XJ,Qiu C,Shang DW,Wen YG

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:In this study, the authors studied the effect of thioridazine (TDZ) on the pharmacokinetic profile of quetiapine (QTP) in Taiwanese patients with schizophrenia. METHODS:Sixteen subjects with schizophrenia were recruited for this study. The authors pretreated 8 patients with TDZ 50 mg daily continuously give...

journal_title：Therapeutic drug monitoring

authors： Chang SC,Lu ML,Wang YC,Lin FW,Huang SH,Kuo PH,Ho HO,Wu TH

更新日期：2012-06-01 00:00:00

abstract：:The clinical usefulness of cyclosporine is hampered by dose-limiting toxicities to the kidney that are not predicted by drug levels in serum or whole blood. Because of its lipophilic nature, circulating plasma lipoproteins may play a role in drug disposition. This study characterized the pharmacokinetic parameters of ...

journal_title：Therapeutic drug monitoring

authors： Brunner LJ,Luke DR,Lautersztain J,Williams LA,LeMaistre CF,Yau JC

更新日期：1990-03-01 00:00:00

abstract：:Euthyroid women experience dramatic changes in their thyroid physiology in order to accommodate the presence of placental and fetal tissues. These adaptations to the pregnant state make it crucial to develop reliable trimester-specific intervals for thyroid parameters. Use of non-pregnant reference intervals could lea...

journal_title：Therapeutic drug monitoring

authors： Bach-Huynh TG,Jonklaas J

更新日期：2006-06-01 00:00:00

abstract：:A study was conducted to determine whether assay-specific quantitative differences exist in the determination of vancomycin serum concentrations obtained from patients with renal dysfunction. Vancomycin serum concentrations were obtained during the first week of therapy for each of three time intervals: 48-96 h, 96-14...

journal_title：Therapeutic drug monitoring

authors： Peckman HJ,Dupuis RE,Sawyer WT,Brouwer KL,Cross RE

更新日期：1996-12-01 00:00:00

abstract：:The effect of plasma exchange (PE) on the pharmacokinetics of flumequine (Apurone) was studied in eight patients receiving a single oral dose of 800 mg. The maximum concentration (38 micrograms/ml) and time to maximum concentration (2.6 h) values were not significantly altered by PE beginning 3 h after administration ...

journal_title：Therapeutic drug monitoring

authors： Royer-Morrot MJ,Gérard A,Zhiri A,Schooneman F,Dureux JB,Royer RJ

更新日期：1991-07-01 00:00:00

abstract：:Metabolism of thiopurine drugs--azathioprine, 6-mercaptopurine, and 6-thioguanine--has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine nucleotide (TGN). However, a sense of uncertainty about the useful...

journal_title：Therapeutic drug monitoring

authors： Duley JA,Florin TH

更新日期：2005-10-01 00:00:00

abstract：:Itraconazole is a new triazole antifungal agent. Active orally, this drug is effective against a wide range of fungal pathogens that includes Aspergillus species, and its use in leukemic and AIDS patients is currently on the increase. Oral itraconazole absorption presents up to threefold interindividual variation in m...

journal_title：Therapeutic drug monitoring

authors： Poirier JM,Lebot M,Descamps P,Levy M,Cheymol G

更新日期：1994-12-01 00:00:00

abstract：:Plasma concentration-antidepressant response relationships for dothiepin, nordothiepin, dothiepin-S-oxide, and nordothiepin-S-oxide were investigated in 50 patients (33 women and 17 men), who had had a major depressive episode. Depression and anxiety were assessed at the start of therapy and after 2 and 4 weeks by mea...

journal_title：Therapeutic drug monitoring

authors： Ilett KF,Blythe TH,Hackett LP,Ong RT,Tannenbaum DA,Clarke TM

更新日期：1993-10-01 00:00:00

abstract：:One tablet containing 755 mg of lithium tryptophanate (10.8 mEq of lithium) was administered to eight healthy volunteers. The main pharmacokinetic parameters for the group of subjects were estimated. Pharmacokinetic parameters (mean +/- SD) from plasma and saliva were respectively: half life (t1/2) 17 +/- 6 vs. 21.8 +...

journal_title：Therapeutic drug monitoring

authors： Obach R,Borja J,Pruñonosa J,Vallès JM,Torrent J,Izquierdo I,Jané F

更新日期：1988-01-01 00:00:00

abstract：:A method for the quantitative determination of the tricyclic antidepressant drug amitriptyline (AT) and its active major metabolite, nortriptyline (NT), in plasma is described. The method involves a three-step extraction procedure, no derivatization, and a rapid run on a gas--liquid chromatograph equipped with a nitro...

journal_title：Therapeutic drug monitoring

authors： Hals PA,Lundgren TI,Aarbakke J

更新日期：1982-01-01 00:00:00

abstract：:Three automated immunoassays for digoxin in serum were evaluated--Abbott TDxII, Baxter Stratus, and Behring OPUS. The accuracy and precision of the assays were assessed by weighed-in controls and an external quality control program. Coefficients of variation of all methods in serum were < or = 10% at weighed-in concen...

journal_title：Therapeutic drug monitoring

authors： Dodds HM,Norris RL,Johnson AG,Pond SM

更新日期：1995-02-01 00:00:00

abstract：:The authors describe a rapid, useful, specific, and very sensitive high-performance liquid chromatographic assay for the determination of fluvastatin (FV) level using atorvastatin as the internal standard (IS). After a simple deproteinization of 1.0 mL of plasma with acetonitrile, the drug and IS were extracted with t...

journal_title：Therapeutic drug monitoring

authors： Al-Rawithi S,Hussein RF,Alzahrani A

更新日期：2003-02-01 00:00:00

abstract：:Most recent cyclosporine (CsA) pharmacokinetic (PK) studies have focused on noncompartmental analysis. Because CsA undergoes significant first-pass elimination after oral dosing, the most appropriate compartment model may need to take this process into account for the construction of a valid population PK model for Sa...

journal_title：Therapeutic drug monitoring

authors： Ducharme MP,Verret L,Brouillette D,Sirois G

更新日期：1998-04-01 00:00:00

abstract：:Our aim was to evaluate the isolated placental lobule to study maternofetal transplacental digoxin transfer and accumulation in placental tissue in vitro. Digoxin passage across the isolated lobule of 10 human placentas was calculated from repeated fetal and maternal perfusate samples, and placental tissue digoxin con...

journal_title：Therapeutic drug monitoring

authors： Schmolling J,Jung S,Reinsberg J,Schlebusch H

更新日期：1997-02-01 00:00:00