Procainamide-induced myasthenia-like weakness and dysphagia.

abstract：:A neurophysiologic test battery (consisting of a 24-hour, seven-channel electroencephalogram [EEG], EEG spectral analysis, multiple sleep latency test, visual evoked potentials, critical flicker fusion, and visual contrast sensitivity) was administered twice to 16 patients with juvenile myoclonic epilepsy (JME) in a d...

journal_title：Therapeutic drug monitoring

authors： Sundqvist A,Nilsson BY,Tomson T

更新日期：1999-02-01 00:00:00

abstract：:A computer-based approach for estimating pharmacokinetic data and predicting plasma drug concentrations based on two measurements of plasma drug concentrations was compared with a standard two-point method for estimating aminoglycoside (AG) pharmacokinetic parameters. The computer-based technique was also used to pred...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Pongsin V,Forney R Jr,Gronau G

更新日期：1985-01-01 00:00:00

abstract：:The authors report a case that offers insight into the diagnostic challenges of "Munchausen Syndrome by Proxy." Initial presentation with history of fever and later with intractable vomiting led to invasive and expensive diagnostic evaluation before confirming the diagnosis. Certain toxic effects of emetine were clini...

journal_title：Therapeutic drug monitoring

authors： Bader AA,Kerzner B

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Thiopurine S-methyltransferase (TPMT) is an excellent example of an enzyme whose pharmacogenetic polymorphisms affect efficacy and toxicity of a drug. The association between TPMT activity and thiopurine-related myelosuppression is well recognized. To study the significance of TPMT deficiency in thiopurine m...

journal_title：Therapeutic drug monitoring

authors： Misdaq M,Andag R,Oellerich M,Asif AR,von Ahsen N

更新日期：2012-10-01 00:00:00

abstract：:An original, sensitive, and specific high-performance liquid chromatographic (HPLC) assay was developed for the quantitation of morphine and its two major metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), in human plasma and cerebrospinal fluid (CSF) and in rat plasma, using hydromorphone as ...

journal_title：Therapeutic drug monitoring

authors： Wright AW,Watt JA,Kennedy M,Cramond T,Smith MT

更新日期：1994-04-01 00:00:00

abstract：:The diurnal fluctuations in free and total plasma levels of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-E) and their relationship with intermittent side effects were examined in 10 epileptic patients stabilized on chronic CBZ therapy alone or in combination with phenobarbital (PB). With a t.i.d. or q.i.d....

journal_title：Therapeutic drug monitoring

authors： Riva R,Contin M,Albani F,Perucca E,Ambrosetto G,Gobbi G,Cortelli P,Procaccianti G,Baruzzi A

更新日期：1984-01-01 00:00:00

abstract：:The major goal of immunosuppressive development is improved selectivity of the drug's inhibitory action against T and B cell-mediated as opposed to nonspecific granulocyte-, monocyte-, and macrophage-mediated resistance. This enterprise demands increased knowledge of alloantigen-induced stimulation, signal transductio...

journal_title：Therapeutic drug monitoring

authors： Kahan BD

更新日期：1995-12-01 00:00:00

abstract：:The authors describe a rapid, useful, specific, and very sensitive high-performance liquid chromatographic assay for the determination of fluvastatin (FV) level using atorvastatin as the internal standard (IS). After a simple deproteinization of 1.0 mL of plasma with acetonitrile, the drug and IS were extracted with t...

journal_title：Therapeutic drug monitoring

authors： Al-Rawithi S,Hussein RF,Alzahrani A

更新日期：2003-02-01 00:00:00

abstract：:Based on the principle that vancomycin therapy requires sustained therapeutic concentrations while avoiding high peaks, some authors reported that optimal vancomycin levels could be ensured by measuring trough levels alone (Cmin). The aim of this work was to assess the performance of a one-compartment Bayesian forecas...

journal_title：Therapeutic drug monitoring

authors： Andrés I,López R,Pou L,Piñol F,Pascual C

更新日期：1997-12-01 00:00:00

abstract：:Pharmacokinetics of intravenous and oral pulsed high-dose dexamethasone were studied in four patients with pemphigus vulgaris. Doses for dexamethasone were varied from 100 to 300 mg. Serum concentrations were measured by high-performance liquid chromatographic procedure with diode assay detection. Bioavailability was ...

journal_title：Therapeutic drug monitoring

authors： Tóth GG,Kloosterman C,Uges DR,Jonkman MF

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Chronic opioid use and polypharmacy are commonly seen in chronic pain patients presenting for spine procedures. Substance abuse and misuse have also been reported in this patient population. Negative perioperative effects have been found in patients exposed to chronic opioid, alcohol, and recreational substa...

journal_title：Therapeutic drug monitoring

authors： Clavijo CF,Oliva AM,Dingmann C,Kaizer A,Christians U,Burger E,Patel V,Kleck CJ,Vogel SA,Scott BK,Janik DJ,Jameson LC,Ginde AA

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:The Clinical Pharmacology Quality Assurance (CPQA) program provides semiannual proficiency testing (PT) of antiretroviral analytes for 11 US and international clinical pharmacology laboratories (CPLs) to ensure interlaboratory comparability. In this article, we provide estimates of the main sources of variab...

journal_title：Therapeutic drug monitoring

authors： Browne RW,Rosenkranz SL,Wang Y,Taylor CR,DiFrancesco R,Morse GD

更新日期：2019-08-01 00:00:00

abstract：:This case report highlights a very rare adverse drug reaction of oral roxithromycin causing toxic epidermal necrolysis (TEN). A 54-year-old male patient diagnosed with upper respiratory tract infection was prescribed oral roxithromycin 150 mg twice daily for 7 days. On the 10th day, the patient was admitted to the eme...

journal_title：Therapeutic drug monitoring

authors： Das S,Mondal S,Dey JK

更新日期：2012-08-01 00:00:00

abstract：:There are data suggesting an association between mycophenolic acid (MPA) levels and acute rejection and toxicity in renal transplant recipients treated with mycophenolate mofetil (MMF), and therefore, knowledge of factors determining MPA levels may aid in accurate adjustment of MMF dosage. A total of 4970 samples take...

journal_title：Therapeutic drug monitoring

authors： Borrows R,Chusney G,James A,Stichbury J,Van Tromp J,Cairns T,Griffith M,Hakim N,McLean A,Palmer A,Papalois V,Taube D

更新日期：2005-08-01 00:00:00

abstract：:The effect of plasma exchange on the concentrations of total and unbound phenytoin (DPH) was determined in one normal subject and four patients undergoing therapeutic plasma exchange (PE). The average percentage of plasma exchanged ranged from 57 to 70% among the five patients studied. The reduction in DPH concentrati...

journal_title：Therapeutic drug monitoring

authors： Silberstein LE,Shaw LM

更新日期：1986-01-01 00:00:00

abstract：:Fifteen patients were studied during short-term (5 days at 10-15 mg/m2/day) or long-term (5-104 days at 3 mg/m2/day) doxorubicin infusion. Levels of doxorubicin and metabolites in serum and 24-h timed urine collections were determined by high-performance liquid chromatography. Quantifiable anthracycline levels were id...

journal_title：Therapeutic drug monitoring

authors： Sweatman TW,Lokich JJ,Israel M

更新日期：1989-01-01 00:00:00

abstract：:A stabilized therapeutic drug monitoring procedure incorporating the novel Empore solid-phase extraction membrane (SPEM) for isolation of the antiarrhythmic drugs mexiletine (MEX) and flecainide (FLEC) from serum is described. Routinely, serum (0.5 ml), adjusted to pH 4.5, is passed through an octyl (C8) SPEM to extra...

journal_title：Therapeutic drug monitoring

authors： Lensmeyer GL,Wiebe DA,Doran TC

更新日期：1992-10-01 00:00:00

abstract：:In the last few years, significant developments have occurred on the key issues involved in oral fluid drug testing. New pharmacokinetic studies have been conducted, optimal cutoffs have been proposed, and new studies have examined the correlation between oral fluid drug concentrations and impairment. Recent studies (...

journal_title：Therapeutic drug monitoring

authors： Pil K,Verstraete A

更新日期：2008-04-01 00:00:00

abstract：:The interlaboratory variability in the assay of theophylline and various anticonvulsant drugs was evaluated in a 16-month prospective study by using two independent experimental approaches: (a) a conventional method based on the distribution of quality control (QC) lyophilized human sera spiked with the test drugs (ph...

journal_title：Therapeutic drug monitoring

authors：

更新日期：1991-03-01 00:00:00

abstract：:A serious challenge in diagnosing fetal alcohol spectrum disorder (FASD) is the need to document alcohol use during pregnancy. Maternal/paternal alcohol abuse affects the likelihood of fetal alcohol exposure, and hence the occurrence of FASD. The objective of the current study was to document the use of the fatty acid...

journal_title：Therapeutic drug monitoring

authors： Kulaga V,Pragst F,Fulga N,Koren G

更新日期：2009-04-01 00:00:00

abstract：:To investigate the pharmacokinetics of naloxone in healthy volunteers, we undertook an open-label crossover study in which six male volunteers received naloxone on five occasions: intravenous (0.8 mg), intramuscular (0.8 mg), intranasal (0.8 mg), intravenous (2 mg), and intranasal (2 mg). Samples were collected for 4 ...

journal_title：Therapeutic drug monitoring

authors： Dowling J,Isbister GK,Kirkpatrick CM,Naidoo D,Graudins A

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:In psychopharmacology, treatment with psychotropic drugs is often suboptimal, mainly because of the high interindividual variability in pharmacokinetic properties. Therapeutic drug monitoring (TDM) can be a valuable tool for monitoring the individual effects of a prescribed dosage in a patient, and it facili...

journal_title：Therapeutic drug monitoring

authors： Wang J,Huang H,Yao Q,Lu Y,Zheng Q,Cheng Y,Xu X,Zhou Q,Wu D,Zhang M,Li X,Zhang J

更新日期：2015-10-01 00:00:00

abstract：:PROTEASE INHIBITOR TDM: This study examines the importance of therapeutic drug monitoring (TDM) of protease inhibitors (PI) in adults and children infected with the human immunodeficiency virus (HIV). Pediatric patients were included because information in this population is limited. A high performance liquid chromato...

journal_title：Therapeutic drug monitoring

authors： Walson PD,Cox S,Utkin I,Gerber N,Crim L,Brady M,Koranyi K

更新日期：2003-12-01 00:00:00

abstract：:Recent literature has urged caution in the interpretation of vancomycin serum concentrations in patients with end-stage renal disease (ESRD), because falsely elevated levels in excess of 70% have been reported with the most commonly used fluorescence polarization immunoassay (FPIA). The purpose of this study was to ev...

journal_title：Therapeutic drug monitoring

authors： Smith PF,Petros WP,Soucie MP,Copeland KR

更新日期：1998-04-01 00:00:00

abstract：:A rapid and sensitive method for the quantitation of valproic acid in tears has been developed using gas chromatography/electron capture negative chemical ionization/mass spectrometry. Valproic acid was converted directly into its pentafluorobenzyl ester derivative without the need to perform any extraction from the b...

journal_title：Therapeutic drug monitoring

authors： Nakajima M,Yamato S,Shimada K,Sato S,Kitagawa S,Honda A,Miyamoto J,Shoda J,Ohya M,Miyazaki H

更新日期：2000-12-01 00:00:00

abstract：:For many drugs, therapeutic drug monitoring (TDM) has become widely available and accepted as an important component of clinical decision-making in the intensive care nursery setting. This review analyzes the potential factors that can either expand or restrict neonatal TDM. A case is made for the development of pharm...

journal_title：Therapeutic drug monitoring

authors： Giacoia GP

更新日期：1990-07-01 00:00:00

abstract：:We presented a case of subtherapeutic linezolid concentration in a patient with bullous pemphigoid characterized by large area skin anabrosis complicated by methicillin-resistant Staphylococcus aureus infections. ...

journal_title：Therapeutic drug monitoring

authors： Chen C,Zhang M,Chen H,Fang J

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Stiripentol (STP) was approved as an orphan drug in 2007 in Europe as adjunctive therapy with valproic acid (VPA) and clobazam (CLB) for Dravet syndrome. Dravet syndrome is a highly pharmacoresistant form of epilepsy, which starts in early childhood. Data about STP pharmacokinetics and interactions are still...

journal_title：Therapeutic drug monitoring

authors： May TW,Boor R,Mayer T,Jürgens U,Rambeck B,Holert N,Korn-Merker E,Brandt C

更新日期：2012-08-01 00:00:00

abstract：:The immunosuppressants cyclosporine, tacrolimus, sirolimus, everolimus, and probably also mycophenolic acid require therapeutic drug monitoring (TDM)-guided dosing to ensure that blood concentrations are kept within the target range in transplant patients. Reliable, accurate, and precise test methods are therefore ess...

journal_title：Therapeutic drug monitoring

authors： Christians U,Vinks AA,Langman LJ,Clarke W,Wallemacq P,van Gelder T,Renjen V,Marquet P,Meyer EJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Hydroxychloroquine (HCQ) is an effective treatment for patients with cutaneous lupus erythematosus (CLE) or systemic lupus erythematosus (SLE) and has been used for these patients in more than 70 nations. However, in Japan, HCQ has not been approved for CLE or SLE. To establish an appropriate therapeutic reg...

journal_title：Therapeutic drug monitoring

authors： Morita S,Takahashi T,Yoshida Y,Yokota N

更新日期：2016-04-01 00:00:00