Diffusion characteristics of placental preparations affect the digoxin passage across the isolated placental lobule.

abstract：:The interaction between valproic acid (VPA) and phenytoin (DPH) was examined during therapeutic monitoring in an epileptic outpatient population. Gas-liquid chromatographic methods were used to measure DPH and VPA concentrations. (1) In 12 patients on stable DPH regimens, the mean DPH level declined from 19.7 to 15.3 ...

journal_title：Therapeutic drug monitoring

authors： Friel PN,Leal KW,Wilensky AJ

更新日期：1979-01-01 00:00:00

abstract：:Australia is blessed with a great diversity of unique species in its fresh waters and in the marine environment around its coast. There is evidence that human and natural events are impacting on these species. Such impacts are associated with various agricultural, industrial, and domestic practices and with natural an...

journal_title：Therapeutic drug monitoring

authors： Moore MR,Shaw G

更新日期：2000-02-01 00:00:00

abstract：:Since the late 90s, biopharmaceuticals targeting tumor necrosis factor alpha have revolutionized the treatment of moderately to severely active inflammatory bowel disease. The robust efficacy witnessed in many patients stands in stark contrast with the observation of a proportion of patients who fail to respond or who...

journal_title：Therapeutic drug monitoring

authors： Detrez I,Van Stappen T,Martín Arranz MD,Papamichael K,Gils A

更新日期：2017-08-01 00:00:00

abstract：:Nineteen acutely disturbed psychotic Asian patients were treated with a single intramuscular injection of 50 mg of zuclopenthixol acetate in Viscoleo. Patients were assessed clinically before and after treatment using the Brief Psychiatric Rating Scale (BPRS). Serum zuclopenthixol and the inactive geometric isomer tra...

journal_title：Therapeutic drug monitoring

authors： Tan CH,Low BL,Ng LL,Khoo YM,Lee HS

更新日期：1993-04-01 00:00:00

abstract：:Phenytoin is an anticonvulsant that requires therapeutic drug monitoring. Recently, Bayer HealthCare, Diagnostics Division released a turbidimetric immunoassay of phenytoin on the ADVIA 1650 analyzer. We evaluated the analytic performance of this assay by comparing values obtained in 52 patients receiving Phenytoin us...

journal_title：Therapeutic drug monitoring

authors： Datta P,Scurlock D,Dasgupta A

更新日期：2005-06-01 00:00:00

abstract：:This study was designed to establish whether plasma lidocaine concentrations changed subsequent to contact with a new formulation of rubber-stopper Vacutainer collection tubes. Plasma lidocaine concentrations from blood samples exposed to rubber stoppers for one hour were compared with concentrations from blood sample...

journal_title：Therapeutic drug monitoring

authors： Lopez LM,Sen A,Robinson JD,Curry RW Jr

更新日期：1987-12-01 00:00:00

abstract：:Monitoring of serum voriconazole concentrations has been proposed to optimize therapeutic effect and minimize toxicity. However, little is known about the clinical use of voriconazole therapeutic drug monitoring (TDM) by treating physicians. Four hundred seventy-eight episodes corresponding with 161 adult patients (me...

journal_title：Therapeutic drug monitoring

authors： Miyakis S,van Hal SJ,Solvag CJ,Ray J,Marriott D

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Tacrolimus (TAC) has a narrow therapeutic index and high interindividual and intraindividual pharmacokinetic variability, necessitating therapeutic drug monitoring to individualize dosage. Recent evidence suggests that intragraft TAC concentrations may better predict transplant outcomes. This study aimed to ...

journal_title：Therapeutic drug monitoring

authors： Noll BD,Coller JK,Somogyi AA,Morris RG,Russ GR,Hesselink DA,Van Gelder T,Sallustio BC

更新日期：2013-10-01 00:00:00

abstract：:One tablet containing 755 mg of lithium tryptophanate (10.8 mEq of lithium) was administered to eight healthy volunteers. The main pharmacokinetic parameters for the group of subjects were estimated. Pharmacokinetic parameters (mean +/- SD) from plasma and saliva were respectively: half life (t1/2) 17 +/- 6 vs. 21.8 +...

journal_title：Therapeutic drug monitoring

authors： Obach R,Borja J,Pruñonosa J,Vallès JM,Torrent J,Izquierdo I,Jané F

更新日期：1988-01-01 00:00:00

abstract：:Theophylline clearance was estimated by a single-sample technique in 19 subjects with acute clinical respiratory infections. Mean (+/- SD) theophylline clearance during acute illness was 0.044 +/- 0.011 L X h-1 X kg-1 compared to 0.043 +/- 0.012 L X h-1 X kg-1 1 month later. In a subset of five subjects, single-sample...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Schwartz J,Martin M,Jauregui L

更新日期：1987-09-01 00:00:00

abstract：:In a prospective study over 6 months, the relationship between serum lipid parameters and CsA whole blood trough concentrations was investigated in 39 renal transplant recipients receiving a triple immunosuppressive therapy with cyclosporin (CsA), azathioprine and prednisone. CsA trough concentrations were measured wi...

journal_title：Therapeutic drug monitoring

authors： von Ahsen N,Helmhold M,Schütz E,Eisenhauer T,Armstrong VW,Oellerich M

更新日期：1997-04-01 00:00:00

abstract：INTRODUCTION:Proton pump inhibitors (PPIs) are often prescribed posttransplantation to prevent gastrointestinal complications. A series of recent studies have reported a relationship between PPI comedication and decreased mycophenolic acid (MPA) exposure. The objective of this subanalysis of the CLEAR data set was to d...

journal_title：Therapeutic drug monitoring

authors： Kiberd BA,Wrobel M,Dandavino R,Keown P,Gourishankar S

更新日期：2011-02-01 00:00:00

abstract：:The analysis of quinine in whole blood, plasma, urine, and samples dried on filter paper is described. Extraction was made with toluene followed by back-extraction into phosphate buffer. A reversed-phase liquid chromatography system with fluorescence detection was used. The within-day coefficient of variation of the m...

journal_title：Therapeutic drug monitoring

authors： Ericsson O,Fridén M,Hellgren U,Gustafsson LL

更新日期：1993-08-01 00:00:00

abstract：:The pharmacokinetics of oxycodone have been determined after single-dose administration by the intravenous (4.6-7.3 mg), oral (tablets, 9.1 mg and syrup, 9.1 mg), and rectal (30 mg) routes, in 48 patients undergoing minor surgery. There were no significant differences in the mean elimination half-lives between the int...

journal_title：Therapeutic drug monitoring

authors： Leow KP,Smith MT,Watt JA,Williams BE,Cramond T

更新日期：1992-12-01 00:00:00

abstract：:Their common clinical use, frequency of adverse effects, serious therapeutic indications, treatment failures, and availability of sensitive assays make corticosteroids such as prednisone and prednisolone candidates for therapeutic drug monitoring. Complicating the interpretation of plasma drug concentrations are the f...

journal_title：Therapeutic drug monitoring

authors： Jusko WJ,Rose JQ

更新日期：1980-01-01 00:00:00

abstract：:The solubility and stability of amphotericin B in human serum in vitro was assessed using a sensitive high performance liquid chromatographic technique. The solubility of amphotericin B at concentrations ranging from 0.5 micrograms/ml to 10 micrograms/ml in human serum at pH 7.4, at 37 degrees C, and in 5% CO2 (simula...

journal_title：Therapeutic drug monitoring

authors： Edmonds LC,Davidson L,Bertino JS Jr

更新日期：1989-01-01 00:00:00

abstract：:The pharmacokinetics of rifampicin (RMP) and its principal active metabolite desacetylrifampicin (DA-RMP) were studied in six subjects, ranging in age from 78 to 95 years, after single oral doses of 10 mg/kg RMP. The maximal plasma concentrations (Cmax) and the elimination half-lives (t 1/2 beta) of RMP are 8.83 +/- 1...

journal_title：Therapeutic drug monitoring

authors： Advenier C,Gobert C,Houin G,Bidet D,Richelet S,Tillement JP

更新日期：1983-01-01 00:00:00

abstract：:An epileptic patient well controlled on valproic acid (VPA) developed a prolonged episode of status epilepticus 12 days after initiation of 75 mg of clomipramine (CMI) to treat depression. Serum level of VPA in the emergency room was unchanged from her previous levels; serum level of CMI was very elevated despite the ...

journal_title：Therapeutic drug monitoring

authors： DeToledo JC,Haddad H,Ramsay RE

更新日期：1997-02-01 00:00:00

abstract：:There are data suggesting an association between mycophenolic acid (MPA) levels and acute rejection and toxicity in renal transplant recipients treated with mycophenolate mofetil (MMF), and therefore, knowledge of factors determining MPA levels may aid in accurate adjustment of MMF dosage. A total of 4970 samples take...

journal_title：Therapeutic drug monitoring

authors： Borrows R,Chusney G,James A,Stichbury J,Van Tromp J,Cairns T,Griffith M,Hakim N,McLean A,Palmer A,Papalois V,Taube D

更新日期：2005-08-01 00:00:00

abstract：:Recent literature has urged caution in the interpretation of vancomycin serum concentrations in patients with end-stage renal disease (ESRD), because falsely elevated levels in excess of 70% have been reported with the most commonly used fluorescence polarization immunoassay (FPIA). The purpose of this study was to ev...

journal_title：Therapeutic drug monitoring

authors： Smith PF,Petros WP,Soucie MP,Copeland KR

更新日期：1998-04-01 00:00:00

abstract：:Plasma concentrations of isepamicin, a new aminoglycoside antibiotic, were determined by radioimmunoassay (RIA), microbiological assay (MA), and high-performance liquid chromatography (HPLC) in healthy volunteers after administration of 7.5 mg/kg intramuscular dosages once daily for 10 days. Plasma samples were collec...

journal_title：Therapeutic drug monitoring

authors： Lin CC,Veals J,Korduba C,Hilbert MJ,Nomeir A

更新日期：1997-12-01 00:00:00

abstract：:It has recently been shown that acute changes of venous blood ammonia (NH3) may predict short-term adverse effects of valproic acid (VPA). In the present study, the time course of NH3 concentration after a single oral dose of VPA (800 mg) was monitored in 68 epileptic patients. Patients were classified into four group...

journal_title：Therapeutic drug monitoring

authors： Zaccara G,Paganini M,Campostrini R,Moroni F,Valenza T,Messori A,Bartelli M,Arnetoli G,Zappoli R

更新日期：1985-01-01 00:00:00

abstract：:The authors evaluated an integrated approach for the screening of drugs in biosamples consisting of gas chromatography/mass spectrometry analysis of serum or whole blood (SB/GC-MS) and of high-performance liquid chromatographic and ultraviolet (HPLC-UV) analysis of urine with the REMEDi HS Biorad system (U/REM) (Bio-r...

journal_title：Therapeutic drug monitoring

authors： Valli A,Polettini A,Papa P,Montagna M

更新日期：2001-06-01 00:00:00

abstract：:Recently, a semiautomated fluorescence polarization immunoassay (FPIA) for determination of parent cyclosporin (CsA) has been developed for the Abbott AxSYM system. The new CsA assay measures the drug from an extracted whole blood specimen. The authors report here the evaluation of this new assay and the comparison wi...

journal_title：Therapeutic drug monitoring

authors： Sabaté I,Ginard M,González JM,Baró E,Acebes G,Cuadros J,Lirón FJ

更新日期：2000-08-01 00:00:00

abstract：:A method is described for the determination of vigabatrin in 50 microliters of plasma by isocratic high-performance liquid chromatography using fluorescence detection. The procedure involves protein precipitation with methanol followed by precolumn derivatisation with o-phthaldialdehyde reagent. Separation of the deri...

journal_title：Therapeutic drug monitoring

authors： Tsanaclis LM,Wicks J,Williams J,Richens A

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 3A (CYP3A) isoenzyme metabolic activity varies between individuals and is therefore a possible candidate of influence on the therapeutic outcome of the tyrosine kinase inhibitor imatinib in patients with chronic myeloid leukemia (CML). The aim of this study was to investigate the influence of...

journal_title：Therapeutic drug monitoring

authors： Skoglund K,Richter J,Olsson-Strömberg U,Bergquist J,Aluthgedara W,Ubhayasekera SJ,Vikingsson S,Svedberg A,Söderlund S,Sandstedt A,Johnsson A,Aagesen J,Alsenhed J,Hägg S,Peterson C,Lotfi K,Gréen H

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The once-daily formulation of tacrolimus has been reported to exhibit the same efficacy and safety profile as compared with the immediate-release form administered twice daily. However, as a result of differences in their pharmacokinetic (PK) profile, the PK models or Bayesian estimators (MAP-BE) previously ...

journal_title：Therapeutic drug monitoring

authors： Saint-Marcoux F,Debord J,Undre N,Rousseau A,Marquet P

更新日期：2010-04-01 00:00:00

abstract：:A simple and sensitive column-switching high-performance liquid chromatographic method for the simultaneous determination of itraconazole (ITZ) and its active metabolite, hydroxyitraconazole (HIT) in human plasma is described. ITZ, HIT, and an internal standard, R051012, were extracted from 1 mL of alkalinized plasma ...

journal_title：Therapeutic drug monitoring

authors： Uno T,Shimizu M,Sugawara K,Tateishi T

更新日期：2006-08-01 00:00:00

abstract：:Two blood-sampling techniques, capillary and venous, were compared using the EMIT method. No difference was found in reproducibility. However, persistent positive bias of 0.628 micrograms/ml (p less than 0.01) was noted with the capillary sampling method. Any hemolysis that occurred in the capillary sampling technique...

journal_title：Therapeutic drug monitoring

authors： Frazer JF 3rd,Stasiowski P,Boyd GK

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Despite significant interindividual variability in prednisolone pharmacokinetics and potentially serious consequences with inadequate or excessive exposure, monitoring of prednisolone levels is not employed to guide therapy. As ultrahigh-performance liquid chromatography-tandem mass spectrometry methods can ...

journal_title：Therapeutic drug monitoring

authors： Yates CJ,Barraclough KA,McWhinney BC,Ungerer JP,Fullinfaw RO,Colman PG,Fourlanos S,Cohney SJ

更新日期：2014-02-01 00:00:00