Thyroid medications during pregnancy.

abstract：:Assessment of renal function and relating this parameter to amino-glycoside clearance is important for an appropriate individualization of dosage regimens in patients with impaired renal function. However, it has been suggested that in cystic fibrosis (CF), creatinine clearance (CrCl) is not a good predictor of tobram...

journal_title：Therapeutic drug monitoring

authors： Town DJ,Vinks AA,Jacobs F,Heijerman HG,Bakker W

更新日期：1996-10-01 00:00:00

abstract：:This laboratory has developed a simple and efficient solid-phase extraction method that is combined with a high-performance liquid chromatographic method for rapid and precise therapeutic monitoring of haloperidol (Haldol) blood levels. The solid-phase extraction utilizes a mixed bed column. Sensitivity of the chromat...

journal_title：Therapeutic drug monitoring

authors： Hoffman DW,Edkins RD

更新日期：1994-10-01 00:00:00

abstract：:The use of therapeutic drug monitoring strategies for cyclosporin (CsA) has evolved markedly in recent years since previous consensus guidelines were presented. Apart from the introduction of some new methods, the major change has been the shift away from the traditional predose/trough (C0) sample. The most popular al...

journal_title：Therapeutic drug monitoring

authors： Morris RG,Holt DW,Armstrong VW,Griesmacher A,Napoli KL,Shaw LM,IFCC\/IATDMCT Joint Working Group.

更新日期：2004-04-01 00:00:00

abstract：:The analysis of quinine in whole blood, plasma, urine, and samples dried on filter paper is described. Extraction was made with toluene followed by back-extraction into phosphate buffer. A reversed-phase liquid chromatography system with fluorescence detection was used. The within-day coefficient of variation of the m...

journal_title：Therapeutic drug monitoring

authors： Ericsson O,Fridén M,Hellgren U,Gustafsson LL

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Analysis of residual gene expression of the nuclear factor of activated T cell (NFAT)-regulated genes has been developed as a pharmacodynamic biomarker to monitor therapy with calcineurin inhibitors. The availability of commercial primer sets (Search-LC) and the well-established assay protocol makes this bio...

journal_title：Therapeutic drug monitoring

authors： Abdel-Kahaar E,Giese T,Sommerer C,Rieger H,Shipkova M,Wieland E

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Paclitaxel (PTX; Taxol, Abraxane) is used in many regimens for breast cancer, non-small cell lung cancer (NSCLC), and ovarian cancer. Multiple studies have demonstrated that PTX exhibits a greater than 10-fold interpatient variability of clearance rates when patients are dosed according to body surface area ...

journal_title：Therapeutic drug monitoring

authors： Cline DJ,Zhang H,Lundell GD,Harney RL,Riaz HK,Jarrah J,Li Y,Miyazaki M,Courtney JB,Baburina I,Salamone SJ

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 3A (CYP3A) isoenzyme metabolic activity varies between individuals and is therefore a possible candidate of influence on the therapeutic outcome of the tyrosine kinase inhibitor imatinib in patients with chronic myeloid leukemia (CML). The aim of this study was to investigate the influence of...

journal_title：Therapeutic drug monitoring

authors： Skoglund K,Richter J,Olsson-Strömberg U,Bergquist J,Aluthgedara W,Ubhayasekera SJ,Vikingsson S,Svedberg A,Söderlund S,Sandstedt A,Johnsson A,Aagesen J,Alsenhed J,Hägg S,Peterson C,Lotfi K,Gréen H

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) time courses in serum and physiological and behavioral effects associated with smoking 1 or 4 "light cannabis" cigarettes were studied. Biomarkers to differentiate light cannabis versus illegal and medical cannabis use were also investigated. METHODS:Sera ...

journal_title：Therapeutic drug monitoring

authors： Pichini S,Mannocchi G,Berretta P,Zaami S,Pirani F,Pacifici R,Busardò FP

更新日期：2020-02-01 00:00:00

abstract：:Pediatric patients with leukemia, other malignancies, and rheumatological disease receive methotrexate chronically. Because of the documented correlation between methotrexate levels of compliance and clinical outcome, it is conceivable to verify appropriate systemic exposure to the drug. Saliva sampling may be of pote...

journal_title：Therapeutic drug monitoring

authors： Press J,Berkovitch M,Laxer R,Giesbrecht E,Verjee Z,Silverman E,Klein J,Koren G

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring (TDM) involves the measurement of serum drug concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used to evaluate the antihypertensive drug response. However, approximately 50% of hypertensive patients treated with l...

journal_title：Therapeutic drug monitoring

authors： Rognstad S,Søraas CL,Bergland OU,Høieggen A,Strømmen M,Helland A,Opdal MS

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Tacrolimus, a critical dose drug, is widely used in transplantation. Knowing the contribution of genetic factors, which significantly influence tacrolimus variability, is beneficial in the personalization of its starting dose. The significant impact of CYP3A5*3 polymorphisms on tacrolimus exposure has been r...

journal_title：Therapeutic drug monitoring

authors： Phupradit A,Vadcharavivad S,Ingsathit A,Kantachuvesiri S,Areepium N,Sra-Ium S,Auamnoy T,Sukasem C,Sumethkul V,Kitiyakara C

更新日期：2018-10-01 00:00:00

abstract：:The stability of two new immunosuppressants, tacrolimus and cyclosporin G (CsG), was evaluated in whole blood following incubation of patient specimens at ambient temperature or 4 degrees C for time periods of 2 (48 h) and 7 days (168 h) after collection. No decrease in CsG concentrations was noted over a 7-day period...

journal_title：Therapeutic drug monitoring

authors： Annesley TM,Hunter BC,Fidler DR,Giacherio DA

更新日期：1995-08-01 00:00:00

abstract：:Plasma levels of haloperidol were monitored in children and teenagers suffering from psychotic episodes and/or abnormal movements (tics and Gilles de la Tourette's syndrome). Steady-state concentrations of haloperidol ranged from 0.7 to 19 ng/ml without any apparent relationship with the administered dose (15--285 mic...

journal_title：Therapeutic drug monitoring

authors： Morselli PL,Bianchetti G,Durand G,Le Heuzey MF,Zarifian E,Dugas M

更新日期：1979-01-01 00:00:00

abstract：:Drug discovery programs are actively exploring for therapeutic agents targeting enzymes and receptors regulating sphingolipid metabolism and biologic functions. FTY720 is a close structural analogue of sphingosine with immunomodulatory properties. After oral administration, FTY720 is phosphorylated by sphingosine kina...

journal_title：Therapeutic drug monitoring

authors： Kovarik JM,Schmouder RL,Slade AJ

更新日期：2004-12-01 00:00:00

abstract：:Effect of diabetes mellitus on mycophenolic acid (MPA) pharmacokinetics and catalytic activity of inosine monophosphate dehydrogenase (IMPDH) was investigated in maintenance kidney transplant recipients. Demographically matched diabetic (n=9) and nondiabetic (n=9) patients were included in a 12-hour open-label, steady...

journal_title：Therapeutic drug monitoring

authors： Patel CG,Richman K,Yang D,Yan B,Gohh RY,Akhlaghi F

更新日期：2007-12-01 00:00:00

abstract：:Amprenavir is an HIV-1 protease inhibitor with high protein binding (90%) in human plasma. This study was designed to develop an assay to measure the concentration of unbound amprenavir, to study variation with time in patients, and to investigate whether ritonavir and lopinavir, other protease inhibitors that could b...

journal_title：Therapeutic drug monitoring

authors： Barrail A,Le Tiec C,Paci-Bonaventure S,Furlan V,Vincent I,Taburet AM

更新日期：2006-02-01 00:00:00

abstract：:The emerging nation of South Africa, in common with some other countries, notably Eastern Europe, is heir to decades of neglect with regards to the exposure of the majority of its population to toxic materials. In this short review, the major toxic health hazards are described. For most of these risks there are now pr...

journal_title：Therapeutic drug monitoring

authors： Stewart MJ

更新日期：2002-02-01 00:00:00

abstract：:A gas chromatography-mass spectrometry (GC-MS)-based screening procedure was developed for the detection of diuretics, uricosurics, and/or their metabolites in human urine after extractive methylation. Phase-transfer catalyst remaining in the organic phase was removed by solid-phase extraction on a diol phase. The com...

journal_title：Therapeutic drug monitoring

authors： Beyer J,Bierl A,Peters FT,Maurer HH

更新日期：2005-08-01 00:00:00

abstract：:This investigation was designed to compare three assay techniques, the traditional bioassay (agar diffusion), and two more recent techniques, high-performance liquid chromatography (HPLC) and fluorescence polarization immunoassay (FPIA), for the determination of vancomycin concentrations in serum. One hundred clinical...

journal_title：Therapeutic drug monitoring

authors： Ristuccia PA,Ristuccia AM,Bidanset JH,Cunha BA

更新日期：1984-01-01 00:00:00

abstract：:It is generally accepted that chemical testing of biologic fluids is the most objective means of diagnosis of drug use. The presence of a drug analyte in a biologic specimen can be used to document exposure. The standard for drug testing in toxicology is an immunoassay screen conducted on a urine sample, followed by c...

journal_title：Therapeutic drug monitoring

authors： Kintz P,Samyn N

更新日期：2002-04-01 00:00:00

abstract：:The effect of heparin sodium on the assay of gentamicin using the fluorescence polarization immunoassay system was investigated with varying heparin and gentamicin concentrations. Heparin had no significant effect on gentamicin concentrations as measured by this system. ...

journal_title：Therapeutic drug monitoring

authors： Jackson DS,Bertino JS Jr

更新日期：1984-01-01 00:00:00

abstract：:A minority of athletes continues to use prohibited drugs in sports to enhance performance. Athletes discovered using these drugs can be subject to severe penalties, often resulting in media and public scrutiny, especially at major events such as the Olympic Games. The International Olympic Committee (IOC) has set out ...

journal_title：Therapeutic drug monitoring

authors： Kazlauskas R,Trout G

更新日期：2000-02-01 00:00:00

abstract：:The binding characteristics of the antiepileptic agent and teratogen valproic acid for human serum and human placenta were investigated utilizing equilibrium dialysis of the drugs in serum and in homogenates of whole placenta so that the transplacental transfer of the drug could be better defined. A low-capacity, high...

journal_title：Therapeutic drug monitoring

authors： Bailey DN,Briggs JR

更新日期：2005-06-01 00:00:00

abstract：:Despite its known teratogenic effects, thalidomide has been used to treat a variety of diseases ranging from alleviation of autoimmune disorders to prevention of metastasis of cancers. The exact method of action of thalidomide and its derivatives is still under investigation. Thalidomide undergoes very little metaboli...

journal_title：Therapeutic drug monitoring

authors： Price DK,Ando Y,Kruger EA,Weiss M,Figg WD

更新日期：2002-02-01 00:00:00

abstract：:Lidocaine is widely used in antiarrhythmic therapy, and the need to monitor the drug concentration in the blood of patients receiving lidocaine is well established. We have developed a new assay for lidocaine designed for the routine clinical therapeutic drug monitoring laboratory. A 100-microliter aliquot of blood pl...

journal_title：Therapeutic drug monitoring

authors： Gal J,Freedman MD,Kumar E,Freed CR

更新日期：1981-01-01 00:00:00

abstract：:Epilepsy is characterized by seizures recurring at interindividually differing time intervals. It may be difficult to assess drug response if time intervals between seizures are long. Thus, the existence of surrogate parameters that could be used to reliably identify drug efficacy and tolerability at an early stage an...

journal_title：Therapeutic drug monitoring

authors： Brandt C

更新日期：2019-04-01 00:00:00

abstract：:The objective of this study was to evaluate the analytical performance of the Abbott ARCHITECT Cyclosporine (CsA) immunoassay in 7 clinical laboratories in comparison to liquid chromatography/tandem mass spectrometry (LC/MS/MS), Abbott TDx, Cobas Integra 800, and the Dade Dimension Xpand immunoassay. The ARCHITECT ass...

journal_title：Therapeutic drug monitoring

authors： Wallemacq P,Maine GT,Berg K,Rosiere T,Marquet P,Aimo G,Mengozzi G,Young J,Wonigeit K,Kretschmer R,Wermuth B,Schmid RW

更新日期：2010-04-01 00:00:00

abstract：:A sensitive method is described for the simultaneous determination of mebendazole and hydroxymebendazole using flubendazole as an internal standard. The analytes were isolated with a single chloroform extraction from 1.0 ml of alkalinized plasma or cyst liquid samples. Separation and quantitation were performed with h...

journal_title：Therapeutic drug monitoring

authors： Oosterhuis B,Wetsteyn JC,van Boxtel CJ

更新日期：1984-01-01 00:00:00

abstract：:The major goal of immunosuppressive development is improved selectivity of the drug's inhibitory action against T and B cell-mediated as opposed to nonspecific granulocyte-, monocyte-, and macrophage-mediated resistance. This enterprise demands increased knowledge of alloantigen-induced stimulation, signal transductio...

journal_title：Therapeutic drug monitoring

authors： Kahan BD

更新日期：1995-12-01 00:00:00

abstract：:Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP) were studied in six depressed patients treated with trazodone. The daily dose of trazodone was 150 mg in three cases and 300 mg in three cases. Carbamazepine, 400 mg/day, was coad...

journal_title：Therapeutic drug monitoring

authors： Otani K,Ishida M,Kaneko S,Mihara K,Ohkubo T,Osanai T,Sugawara K

更新日期：1996-04-01 00:00:00