Reversed-phase high-performance liquid chromatography determination of quinine in plasma, whole blood, urine, and samples dried on filter paper.

abstract：:Six groups of six male Wistar rats were administered methadone in their drinking water over the concentration range 0-0.25 mg/ml. Hair and trunk blood samples were collected after a 6-week period of drug administration. Immunoreactive methadone was measured by radioimmunoassay and methadone and its major metabolite, 2...

journal_title：Therapeutic drug monitoring

authors： Green SJ,Wilson JF

更新日期：1996-12-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) in combination with cyclosporine (CsA) or Tacrolimus (TAC) has been show to be a potent immunosuppressive agent. The authors assessed the mycophenolic acid (MPA) plasma levels achieved in clinical practice and evaluated the effect of concomitant administration of CsA and TAC . One hundred f...

journal_title：Therapeutic drug monitoring

authors： Pou L,Brunet M,Cantarell C,Vidal E,Oppenheimer F,Monforte V,Vilardell J,Roman A,Martorell J,Capdevila L

更新日期：2001-02-01 00:00:00

abstract：:Phenytoin is an effective anticonvulsant, but high serum phenytoin concentrations may be associated with serious toxicity. The upper limit for the therapeutic serum concentration of phenytoin is considered to be 80 micromol/L. However, in some situations higher serum concentrations are needed to control seizures. The ...

journal_title：Therapeutic drug monitoring

authors： Kozer E,Parvez S,Minassian BA,Kobayashi J,Verjee Z,Koren G

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Dried blood spot (DBS) sampling is a blood collection tool that uses a finger prick to obtain a blood drop on a DBS card. It can be used for therapeutic drug monitoring, a method that uses blood drug concentrations to optimize individual treatment. DBS sampling is believed to be a simpler way of blood collec...

journal_title：Therapeutic drug monitoring

authors： Zuur MA,Veenhof H,Aleksa A,Vanʼt Boveneind-Vrubleuskaya N,Darmawan E,Hasnain MG,Heysell SK,Jongedijk EM,Koster RA,Magis-Escurra C,Martinez N,Molinas G,Mondal D,Mulyani UA,Perwitasari DA,Tsivunchyk A,Touw DJ,Alffenaar JC

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Tacrolimus (TAC) has a narrow therapeutic index and high interindividual and intraindividual pharmacokinetic variability, necessitating therapeutic drug monitoring to individualize dosage. Recent evidence suggests that intragraft TAC concentrations may better predict transplant outcomes. This study aimed to ...

journal_title：Therapeutic drug monitoring

authors： Noll BD,Coller JK,Somogyi AA,Morris RG,Russ GR,Hesselink DA,Van Gelder T,Sallustio BC

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Despite significant interindividual variability in prednisolone pharmacokinetics and potentially serious consequences with inadequate or excessive exposure, monitoring of prednisolone levels is not employed to guide therapy. As ultrahigh-performance liquid chromatography-tandem mass spectrometry methods can ...

journal_title：Therapeutic drug monitoring

authors： Yates CJ,Barraclough KA,McWhinney BC,Ungerer JP,Fullinfaw RO,Colman PG,Fourlanos S,Cohney SJ

更新日期：2014-02-01 00:00:00

abstract：:Results of phenobarbital analyses are presented for 14 patients with chronic renal failure, and compared using gas-liquid chromatography (GLC), enzyme immunoassay (EIA), and fluorescence polarization immunoassay (FPIA). Correlation of FPIA with GLC and EIA was poor. ...

journal_title：Therapeutic drug monitoring

authors： Bridges RR,Jennison TA

更新日期：1984-01-01 00:00:00

abstract：:The possible occurrence of a kinetic interaction between cyclosporine A and glibenclamide was assessed by reviewing data of six posttransplant diabetic patients who received the two drugs concurrently. Coadministration of the two drugs resulted in a 57% increase in the steady-state plasma cyclosporine levels despite n...

journal_title：Therapeutic drug monitoring

authors： Islam SI,Masuda QN,Bolaji OO,Shaheen FM,Sheikh IA

更新日期：1996-10-01 00:00:00

abstract：:Bayesian estimation (BE) of pharmacokinetic parameters enables the clinician to adjust the dosage of high-dose methotrexate (HDMTX) to correct the inter- and intraindividual variation of concentrations that are responsible for severe toxicity. In this study of 672 HDMTX infusions, we validated an approach that consist...

journal_title：Therapeutic drug monitoring

authors： Pignon T,Lacarelle B,Duffaud F,Guillet P,Catalin J,Durand A,Favre R

更新日期：1995-10-01 00:00:00

abstract：:The purpose of this study was to construct a population pharmacokinetic (PK) metabolism (MB) model to describe ciprofloxacin (C) concentrations in plasma and vitreous and aqueous humors in 26 patients. Ciprofloxacin was given as a 3-day oral prophylactic treatment to 26 patients before vitrectomy. Plasma, vitreous, an...

journal_title：Therapeutic drug monitoring

authors： Di Marco MP,Chen J,Wainer IW,Ducharme MP

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a narrow therapeutic index medication, which requires therapeutic drug monitoring to optimize dosing based on systemic exposure. MITRA microsampling offers a convenient, minimally invasive approach for the collection of capillary blood samples from a fingerprick versus conventional venous blood...

journal_title：Therapeutic drug monitoring

authors： Undre N,Dawson I,Aluvihare V,Kamar N,Saliba F,Torpey N,Anaokar S,Kazeem G,Hussain I

更新日期：2020-12-03 00:00:00

abstract：:A model for predicting unbound concentrations of mycophenolic acid (MPA) was developed in 84 subjects and then tested in an independent group of 19 hematopoietic cell transplant recipients. Total and unbound MPA concentrations and total mycophenolic glucuronide concentrations were measured between weeks 1 and 4 posttr...

journal_title：Therapeutic drug monitoring

authors： Huang J,Jacobson P,Brundage R

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Solithromycin is a fourth-generation macrolide antibiotic with potential efficacy in pediatric community-acquired bacterial pneumonia. Pharmacokinetic (PK) studies of solithromycin in pediatric subjects are limited, therefore application of minimally invasive drug sampling techniques, such as dried blood spo...

journal_title：Therapeutic drug monitoring

authors： Beechinor RJ,Cohen-Wolkowiez M,Jasion T,Hornik CP,Lang JE,Hernandez R,Gonzalez D

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The efficacy of drugs for the treatment of substance-related disorders is moderate at best. Therapeutic drug monitoring (TDM) could be an instrument to improve outcomes. Because TDM for most of those drugs is not established, the authors reviewed the literature and built a rating scale to detect the potentia...

journal_title：Therapeutic drug monitoring

authors： Brünen S,Vincent PD,Baumann P,Hiemke C,Havemann-Reinecke U

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Chronic opioid use and polypharmacy are commonly seen in chronic pain patients presenting for spine procedures. Substance abuse and misuse have also been reported in this patient population. Negative perioperative effects have been found in patients exposed to chronic opioid, alcohol, and recreational substa...

journal_title：Therapeutic drug monitoring

authors： Clavijo CF,Oliva AM,Dingmann C,Kaizer A,Christians U,Burger E,Patel V,Kleck CJ,Vogel SA,Scott BK,Janik DJ,Jameson LC,Ginde AA

更新日期：2021-02-01 00:00:00

abstract：:The postulated therapeutic activity of nortriptyline metabolites has prompted investigation of dosage adjustments based on plasma levels of nortriptyline (NT) and its metabolites. The method assumes that metabolite concentrations vary independently of nortriptyline concentrations among patients. This study tests that ...

journal_title：Therapeutic drug monitoring

authors： Lukey BJ,Jones DR,Wright JH,Hurst HE

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study is to characterize the pharmacokinetics and the gastrointestinal side effect profiles of enteric-coated mycophenolate sodium (EC-MPS) in de novo kidney transplant patients of Hispanic ethnicity. MATERIALS AND METHODS:The pharmacokinetic study of EC-MPS was conducted in 11 de novo kidney ...

journal_title：Therapeutic drug monitoring

authors： Shah T,Tellez-Corrales E,Yang JW,Qazi Y,Wang J,Wilson J,Hutchinson I,Min DI

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Raltegravir is the first human immunodeficiency virus-1 (HIV-1) integrase inhibitor used in treatment-experienced patients who have evidence of viral replication and HIV-1 strains resistance to multiple antiretroviral regimens. Etravirine is a novel NNRTI, active against HIV-1 strains harboring multiple NNRT...

journal_title：Therapeutic drug monitoring

authors： Quaranta S,Woloch C,Paccou A,Giocanti M,Solas C,Lacarelle B

更新日期：2009-12-01 00:00:00

abstract：:An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the tricyclic antidepressant clomipramine and six metabolites: desmethylclomipramine, 2- and 8-hydroxy-clomipramine, 2- and 8-hydroxydesmethylclomipramine and didesmethyl-clomipramine in plasma and urine. I...

journal_title：Therapeutic drug monitoring

authors： Nielsen KK,Brøsen K

更新日期：1993-04-01 00:00:00

abstract：:A simple and rapid liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for the analysis of voriconazole has been developed. For comparison, serum voriconazole was measured using HPLC and bioassay. For the HPLC-MS/MS assay, samples were prepared in a deep-well block by adding 10 microL of serum to 40 mic...

journal_title：Therapeutic drug monitoring

authors： Keevil BG,Newman S,Lockhart S,Howard SJ,Moore CB,Denning DW

更新日期：2004-12-01 00:00:00

abstract：:Two separate studies were carried out to assess the effect of valproic acid on the steady-state plasma concentrations of clozapine and its major metabolites norclozapine and clozapine N-oxide in psychotic patients. In the first study, concentrations of clozapine and metabolites were compared between patients treated w...

journal_title：Therapeutic drug monitoring

authors： Facciolà G,Avenoso A,Scordo MG,Madia AG,Ventimiglia A,Perucca E,Spina E

更新日期：1999-06-01 00:00:00

abstract：:A neurophysiologic test battery (consisting of a 24-hour, seven-channel electroencephalogram [EEG], EEG spectral analysis, multiple sleep latency test, visual evoked potentials, critical flicker fusion, and visual contrast sensitivity) was administered twice to 16 patients with juvenile myoclonic epilepsy (JME) in a d...

journal_title：Therapeutic drug monitoring

authors： Sundqvist A,Nilsson BY,Tomson T

更新日期：1999-02-01 00:00:00

abstract：:The aims of this study were to determine the relationship between saliva and plasma methadone concentrations and the influence of variability in saliva pH. Saliva and plasma samples were taken before the daily dose of methadone in 60 patients undergoing methadone maintenance treatment (MMT). Saliva pH was measured imm...

journal_title：Therapeutic drug monitoring

authors： Shiran MR,Hassanzadeh-Khayyat M,Iqbal MZ,Lagundoye O,Seivewright N,Lennard MS,Tucker GT,Rostami-Hodjegan A

更新日期：2005-10-01 00:00:00

abstract：:An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the oral antidiabetic tolbutamide and two of its metabolites, 4-hydroxytolbutamide and carboxytolbutamide, in human plasma and urine. The method was based on simple one-step liquid-liquid extraction with te...

journal_title：Therapeutic drug monitoring

authors： Hansen LL,Brøsen K

更新日期：1999-12-01 00:00:00

abstract：:Digoxin and gentamicin are widely used in pediatric medicine, and therapeutic monitoring is mandatory because of their narrow margin of safety and wide interpatient and intrapatient pharmacokinetic variabilities. Saliva sampling may be of potential interest, especially in children, in whom blood sampling is often diff...

journal_title：Therapeutic drug monitoring

authors： Berkovitch M,Bistritzer T,Aladjem M,Burtin P,Dagan T,Chen-Levi Z,Freedom R,Koren G

更新日期：1998-06-01 00:00:00

abstract：:Despite its known teratogenic effects, thalidomide has been used to treat a variety of diseases ranging from alleviation of autoimmune disorders to prevention of metastasis of cancers. The exact method of action of thalidomide and its derivatives is still under investigation. Thalidomide undergoes very little metaboli...

journal_title：Therapeutic drug monitoring

authors： Price DK,Ando Y,Kruger EA,Weiss M,Figg WD

更新日期：2002-02-01 00:00:00

abstract：:Based on the principle that vancomycin therapy requires sustained therapeutic concentrations while avoiding high peaks, some authors reported that optimal vancomycin levels could be ensured by measuring trough levels alone (Cmin). The aim of this work was to assess the performance of a one-compartment Bayesian forecas...

journal_title：Therapeutic drug monitoring

authors： Andrés I,López R,Pou L,Piñol F,Pascual C

更新日期：1997-12-01 00:00:00

abstract：:Cefsulodin is a third-generation cephalosporin with a unique specificity for Pseudomonas aeruginosa. To study the pharmacokinetics of this agent in children, a rapid and sensitive high-performance liquid chromatographic micromethod was developed for plasma and urine. Protein was precipitated from plasma with one volum...

journal_title：Therapeutic drug monitoring

authors： Ackers IM,Myers CM,Blumer JL

更新日期：1984-01-01 00:00:00

abstract：:A noninstrumented enzyme immunochromatography (EIC) method for monitoring carbamazepine using whole blood was compared to the enzyme-multiplied immunoassay technique (EMIT), fluorescence polarization immunoassay (FPIA), and high-performance liquid chromatography (HPLC). Samples from 74 patients were evaluated in the c...

journal_title：Therapeutic drug monitoring

authors： Oles KS,Penry JK,Dyer RD

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that 5-fluorouracil (5-FU) dosing by use of pharmacokinetic (PK) parameters is superior to the traditional body surface area (BSA) method in colorectal cancer therapy. The purpose of this study was to compare the estimated efficacy and toxicity of the use of PK-guided versus BSA-based ...

journal_title：Therapeutic drug monitoring

authors： Yang R,Zhang Y,Zhou H,Zhang P,Yang P,Tong Q,Lyu Y,Han Y

更新日期：2016-02-01 00:00:00