Possible interaction between cyclosporine and glibenclamide in posttransplant diabetic patients.

Abstract:

:The possible occurrence of a kinetic interaction between cyclosporine A and glibenclamide was assessed by reviewing data of six posttransplant diabetic patients who received the two drugs concurrently. Coadministration of the two drugs resulted in a 57% increase in the steady-state plasma cyclosporine levels despite normal hepatic and renal functions in the patients. This elevation in cyclosporine level is possibly due to an interaction between the two drugs resulting from an inhibition of CYP3A4-mediated metabolism of cyclosporine by glibenclamide. This observation calls for a closer monitoring of cyclosporine plasma levels during concomitant administration of these two drugs in this group of patients.

journal_name

Ther Drug Monit

authors

Islam SI,Masuda QN,Bolaji OO,Shaheen FM,Sheikh IA

doi

10.1097/00007691-199610000-00017

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

624-6

issue

5

eissn

0163-4356

issn

1536-3694

journal_volume

18

pub_type

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