Possible interaction between cyclosporine and glibenclamide in posttransplant diabetic patients.

abstract：BACKGROUND:Despite significant interindividual variability in prednisolone pharmacokinetics and potentially serious consequences with inadequate or excessive exposure, monitoring of prednisolone levels is not employed to guide therapy. As ultrahigh-performance liquid chromatography-tandem mass spectrometry methods can ...

journal_title：Therapeutic drug monitoring

authors： Yates CJ,Barraclough KA,McWhinney BC,Ungerer JP,Fullinfaw RO,Colman PG,Fourlanos S,Cohney SJ

更新日期：2014-02-01 00:00:00

abstract：:We report a clinically relevant suspected interaction between acyclovir and the antiepileptic drugs phenytoin (PHT) and valproic acid (VPA). In a child receiving PHT and VPA therapy, a 6-day acyclovir treatment reduced PHT and VPA plasma concentrations to subtherapeutic values. This probably worsened both clinical sta...

journal_title：Therapeutic drug monitoring

authors： Parmeggiani A,Riva R,Posar A,Rossi PG

更新日期：1995-06-01 00:00:00

abstract：:The pharmacokinetics of rifampicin (RMP) and its principal active metabolite desacetylrifampicin (DA-RMP) were studied in six subjects, ranging in age from 78 to 95 years, after single oral doses of 10 mg/kg RMP. The maximal plasma concentrations (Cmax) and the elimination half-lives (t 1/2 beta) of RMP are 8.83 +/- 1...

journal_title：Therapeutic drug monitoring

authors： Advenier C,Gobert C,Houin G,Bidet D,Richelet S,Tillement JP

更新日期：1983-01-01 00:00:00

abstract：:The performance of the ROCHE FP NAPA reagent, a newly reformulated monoclonal antibody-based fluorescence polarization immunoassay (FPIA) for N-acetylprocainamide, was compared with two commercially available polyclonal antibody-based immunoassays, the Abbott TDx and Syva EMIT. Although excellent correlation was obser...

journal_title：Therapeutic drug monitoring

authors： Laurino JP,McKay J,Fischberg E,Schwenzer K,Kaufman R

更新日期：1994-06-01 00:00:00

abstract：:Studies examining associations between antidepressant response and plasma levels of bupropion and its metabolites have yielded contradictory findings. There have been no such studies in youth. This study explored such associations in 8 boys and 8 girls, age 11 to 17 years, all prescribed bupropion sustained release (S...

journal_title：Therapeutic drug monitoring

authors： Daviss WB,Perel JM,Brent DA,Axelson DA,Rudolph GR,Gilchrist R,Nuss S,Birmaher B

更新日期：2006-04-01 00:00:00

abstract：:Using mobile long-term electroencephalographic (EEG) monitoring in 7 absence epilepsy patients, the course of spike-wave discharge rate before and during valproate monotherapy was measured and compared to the profile of valproic acid serum level. Correlation analysis was done, taking into account an eventual time dela...

journal_title：Therapeutic drug monitoring

authors： Burr W,Froescher W,Hoffmann F,Stefan H

更新日期：1984-01-01 00:00:00

abstract：:Eight subjects were studied in a randomized crossover design to determine the effect of aluminum-magnesium hydroxide (AMH), calcium carbonate (CC), and aluminum hydroxide-magnesium trisilicate (AHMT) on the bioavailability of a single, 600-mg dose of phenytoin administered orally. Each subject received phenytoin alone...

journal_title：Therapeutic drug monitoring

authors： Carter BL,Garnett WR,Pellock JM,Stratton MA,Howell JR

更新日期：1981-01-01 00:00:00

abstract：:The immunosuppressants cyclosporine, tacrolimus, sirolimus, everolimus, and probably also mycophenolic acid require therapeutic drug monitoring (TDM)-guided dosing to ensure that blood concentrations are kept within the target range in transplant patients. Reliable, accurate, and precise test methods are therefore ess...

journal_title：Therapeutic drug monitoring

authors： Christians U,Vinks AA,Langman LJ,Clarke W,Wallemacq P,van Gelder T,Renjen V,Marquet P,Meyer EJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Dried blood spot (DBS) sampling is a blood collection tool that uses a finger prick to obtain a blood drop on a DBS card. It can be used for therapeutic drug monitoring, a method that uses blood drug concentrations to optimize individual treatment. DBS sampling is believed to be a simpler way of blood collec...

journal_title：Therapeutic drug monitoring

authors： Zuur MA,Veenhof H,Aleksa A,Vanʼt Boveneind-Vrubleuskaya N,Darmawan E,Hasnain MG,Heysell SK,Jongedijk EM,Koster RA,Magis-Escurra C,Martinez N,Molinas G,Mondal D,Mulyani UA,Perwitasari DA,Tsivunchyk A,Touw DJ,Alffenaar JC

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:To investigate the predictive value of the risperidone and venlafaxine metabolic ratios and CYP2D6 genotype. METHODS:The determination of risperidone, 9-hydroxyrisperidone, and venlafaxine, O-desmethylvenlafaxine, N-desmethylvenlafaxine and CYP2D6 genotype was performed in 425 and 491 patients, respectively. T...

journal_title：Therapeutic drug monitoring

authors： Mannheimer B,Haslemo T,Lindh JD,Eliasson E,Molden E

更新日期：2016-02-01 00:00:00

abstract：:In a prospective study over 6 months, the relationship between serum lipid parameters and CsA whole blood trough concentrations was investigated in 39 renal transplant recipients receiving a triple immunosuppressive therapy with cyclosporin (CsA), azathioprine and prednisone. CsA trough concentrations were measured wi...

journal_title：Therapeutic drug monitoring

authors： von Ahsen N,Helmhold M,Schütz E,Eisenhauer T,Armstrong VW,Oellerich M

更新日期：1997-04-01 00:00:00

abstract：:A method for the quantitative determination of the tricyclic antidepressant drug amitriptyline (AT) and its active major metabolite, nortriptyline (NT), in plasma is described. The method involves a three-step extraction procedure, no derivatization, and a rapid run on a gas--liquid chromatograph equipped with a nitro...

journal_title：Therapeutic drug monitoring

authors： Hals PA,Lundgren TI,Aarbakke J

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Drug blood levels can only serve as a surrogate because of the lack of information on the drug's direct pharmacological effects in the individual patient. Measurement of the mammalian target of rapamycin (mTOR) activity dependent on the phosphorylation status of p70 S6 kinase (p70 S6K) offers a practical way...

journal_title：Therapeutic drug monitoring

authors： Hartmann B,He X,Keller F,Fischereder M,Guba M,Schmid H

更新日期：2013-04-01 00:00:00

abstract：:Two separate studies were carried out to assess the effect of valproic acid on the steady-state plasma concentrations of clozapine and its major metabolites norclozapine and clozapine N-oxide in psychotic patients. In the first study, concentrations of clozapine and metabolites were compared between patients treated w...

journal_title：Therapeutic drug monitoring

authors： Facciolà G,Avenoso A,Scordo MG,Madia AG,Ventimiglia A,Perucca E,Spina E

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Busulfan dose adjustment is routinely guided by plasma concentration monitoring using 4-9 blood samples per dose adjustment, but a pharmacometric Bayesian approach could reduce this sample burden. METHODS:The authors developed a nonparametric population model with Pmetrics. They used it to simulate optimal ...

journal_title：Therapeutic drug monitoring

authors： Neely M,Philippe M,Rushing T,Fu X,van Guilder M,Bayard D,Schumitzky A,Bleyzac N,Goutelle S

更新日期：2016-06-01 00:00:00

abstract：:During once-daily dosing regimens of aminoglycosides, administration of large single doses results in high peak levels and low 24-h trough levels. However, commercial assays for monitoring aminoglycoside levels are designed to cover the smaller range of serum concentrations usually observed during multiple daily dosin...

journal_title：Therapeutic drug monitoring

authors： Blaser J,König C,Fatio R,Follath F,Cometta A,Glauser M

更新日期：1995-04-01 00:00:00

abstract：:Based on the principle that vancomycin therapy requires sustained therapeutic concentrations while avoiding high peaks, some authors reported that optimal vancomycin levels could be ensured by measuring trough levels alone (Cmin). The aim of this work was to assess the performance of a one-compartment Bayesian forecas...

journal_title：Therapeutic drug monitoring

authors： Andrés I,López R,Pou L,Piñol F,Pascual C

更新日期：1997-12-01 00:00:00

abstract：:To interpret blood levels of tricyclic antidepressants, we studied the distributions of amitriptyline and nortriptyline in human blood and explored their control by plasma factors. Each compound (300 ng/ml) was added to whole adult blood and to cord blood with decreased alpha-1-glycoprotein (AGP). Drugs (250 ng/ml) we...

journal_title：Therapeutic drug monitoring

authors： Amitai Y,Kennedy EJ,DeSandre P,Frischer H

更新日期：1993-08-01 00:00:00

abstract：:The current standard of monitoring transplant patients by drug levels is not optimal because it does not take into account the different and individual effects of immunosuppressive drugs on each patient. In this study, the authors tested immune function assays for monitoring transplant patients. Blood was collected fr...

journal_title：Therapeutic drug monitoring

authors： Stalder M,Bîrsan T,Holm B,Haririfar M,Scandling J,Morris RE

更新日期：2003-02-01 00:00:00

abstract：:Simplified pharmacokinetic methods have been used to estimate caffeine clearance in subjects with liver disease. There is a need to have a reliable, easy to implement method for research and possible clinical use. This study evaluates the use of Bayesian pharmacokinetic forecasting techniques to estimate caffeine clea...

journal_title：Therapeutic drug monitoring

authors： Denaro CP,Jacob P 3rd,Benowitz NL

更新日期：1998-02-01 00:00:00

abstract：:An analytical technique using liquid chromatography (LC) coupled with electrospray-mass spectrometry (ESI--MS) has been developed for the simultaneous determination of five protease inhibitors (PIs): saquinavir, indinavir, ritonavir, nelfinavir, and amprenavir; and three non-nucleoside reverse transcriptase inhibitors...

journal_title：Therapeutic drug monitoring

authors： Villani P,Feroggio M,Gianelli L,Bartoli A,Montagna M,Maserati R,Regazzi MB

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Fosphenytoin, the diphosphate ester salt of phenytoin, is widely used to treat status epilepticus. The aim of this study was to develop a population pharmacokinetic (PPK) model to describe serum phenytoin concentrations after the intravenous administration of fosphenytoin in adult and elderly epileptic patie...

journal_title：Therapeutic drug monitoring

authors： Higuchi K,Yamashita D,Kashihara Y,Kakara M,Hirota T,Hirakawa M,Ieiri I

更新日期：2019-10-01 00:00:00

abstract：:Phenytoin is an anticonvulsant that requires therapeutic drug monitoring. Recently, Bayer HealthCare, Diagnostics Division released a turbidimetric immunoassay of phenytoin on the ADVIA 1650 analyzer. We evaluated the analytic performance of this assay by comparing values obtained in 52 patients receiving Phenytoin us...

journal_title：Therapeutic drug monitoring

authors： Datta P,Scurlock D,Dasgupta A

更新日期：2005-06-01 00:00:00

abstract：:Plasma concentration-antidepressant response relationships for dothiepin, nordothiepin, dothiepin-S-oxide, and nordothiepin-S-oxide were investigated in 50 patients (33 women and 17 men), who had had a major depressive episode. Depression and anxiety were assessed at the start of therapy and after 2 and 4 weeks by mea...

journal_title：Therapeutic drug monitoring

authors： Ilett KF,Blythe TH,Hackett LP,Ong RT,Tannenbaum DA,Clarke TM

更新日期：1993-10-01 00:00:00

abstract：:The CYP2D6*10(*10) allele that causes decreased CYP2D6 activity is present in Asians with a high frequency of approximately 50%. We studied the effects of the *10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole. The subjects were 63 Japanese patients with...

journal_title：Therapeutic drug monitoring

authors： Suzuki T,Mihara K,Nakamura A,Nagai G,Kagawa S,Nemoto K,Ohta I,Arakaki H,Uno T,Kondo T

更新日期：2011-02-01 00:00:00

abstract：:The greater and more consistent absorption of cyclosporine from the microemulsion formulation (Neoral; Novartis Pharmaceuticals Ltd., Frimley, UK) when compared with that from the original form (Sandimmune; Novartis Pharmaceuticals Ltd., Frimley, UK) results in greater systemic exposure. Lung transplant recipients cou...

journal_title：Therapeutic drug monitoring

authors： Trull A,Steel L,Sharples L,Stewart S,Parameshwar J,McNeil K,Wallwork J

更新日期：1999-02-01 00:00:00

abstract：:Hydroxylation of midazolam (MDZ) is mediated almost exclusively by CYP3A isoforms. The authors describe a high-performance liquid chromatography assay involving MDZ, 1'-hydroxymidazolam, and 4-hydroxymidazolam in plasma. The compounds were eluted on an Ultrasphere ODS, 3-microm particle size, 7.5 cm x 4.6 mm reversed-...

journal_title：Therapeutic drug monitoring

authors： Carrillo JA,Ramos SI,Agundez JA,Martinez C,Benitez J

更新日期：1998-06-01 00:00:00

abstract：:The authors describe a rapid, useful, specific, and very sensitive high-performance liquid chromatographic assay for the determination of fluvastatin (FV) level using atorvastatin as the internal standard (IS). After a simple deproteinization of 1.0 mL of plasma with acetonitrile, the drug and IS were extracted with t...

journal_title：Therapeutic drug monitoring

authors： Al-Rawithi S,Hussein RF,Alzahrani A

更新日期：2003-02-01 00:00:00

abstract：:For the evaluation and interpretation of pharmacokinetic data reliable quantitative determinations are a requirement that can only be met by well-characterized and fully validated analytical methods. To cope with these requirements a method is being established that is based on an integrated and automated fiber-optic ...

journal_title：Therapeutic drug monitoring

authors： Gygax D,Botta L,Ehrat M,Graf P,Lefèvre G,Oroszlan P,Pfister C

更新日期：1996-08-01 00:00:00

abstract：:Previous studies have categorized duloxetine as a moderate inhibitor of CYP2D6. The aim of the present study was to investigate the potential interactions between duloxetine and the two CYP2D6 substrates risperidone and aripiprazole in psychiatric patients. Serum concentration data from patients treated with risperido...

journal_title：Therapeutic drug monitoring

authors： Hendset M,Molden E,Enoksen TB,Refsum H,Hermann M

更新日期：2010-12-01 00:00:00