Multicenter quality control study of amikacin assay for monitoring once-daily dosing regimens. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer.

abstract：:A method for the quantitative determination of the tricyclic antidepressant drug amitriptyline (AT) and its active major metabolite, nortriptyline (NT), in plasma is described. The method involves a three-step extraction procedure, no derivatization, and a rapid run on a gas--liquid chromatograph equipped with a nitro...

journal_title：Therapeutic drug monitoring

authors： Hals PA,Lundgren TI,Aarbakke J

更新日期：1982-01-01 00:00:00

abstract：:Previous studies have categorized duloxetine as a moderate inhibitor of CYP2D6. The aim of the present study was to investigate the potential interactions between duloxetine and the two CYP2D6 substrates risperidone and aripiprazole in psychiatric patients. Serum concentration data from patients treated with risperido...

journal_title：Therapeutic drug monitoring

authors： Hendset M,Molden E,Enoksen TB,Refsum H,Hermann M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Busulfan (Bu) and cyclophosphamide (Cy) are frequently included in conditioning regimens before hematopoietic stem cell transplantation (HSCT). Both drugs are detoxified by glutathione transferases (GST), and GST gene variants may explain some of the interindividual variability in pharmacokinetics and drug t...

journal_title：Therapeutic drug monitoring

authors： Bremer S,Fløisand Y,Brinch L,Gedde-Dahl T,Bergan S

更新日期：2015-08-01 00:00:00

abstract：:The greater and more consistent absorption of cyclosporine from the microemulsion formulation (Neoral; Novartis Pharmaceuticals Ltd., Frimley, UK) when compared with that from the original form (Sandimmune; Novartis Pharmaceuticals Ltd., Frimley, UK) results in greater systemic exposure. Lung transplant recipients cou...

journal_title：Therapeutic drug monitoring

authors： Trull A,Steel L,Sharples L,Stewart S,Parameshwar J,McNeil K,Wallwork J

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring (TDM) involves the measurement of serum drug concentrations to optimize pharmacotherapy. Traditionally, blood pressure measurements alone, and not TDM, have been used to evaluate the antihypertensive drug response. However, approximately 50% of hypertensive patients treated with l...

journal_title：Therapeutic drug monitoring

authors： Rognstad S,Søraas CL,Bergland OU,Høieggen A,Strømmen M,Helland A,Opdal MS

更新日期：2021-02-01 00:00:00

abstract：:It is generally accepted that chemical testing of biologic fluids is the most objective means of diagnosis of drug use. The presence of a drug analyte in a biologic specimen can be used to document exposure. The standard for drug testing in toxicology is an immunoassay screen conducted on a urine sample, followed by c...

journal_title：Therapeutic drug monitoring

authors： Kintz P,Samyn N

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:The objective of the present study was to perform an external evaluation of published linezolid population pharmacokinetic and pharmacodynamic models, in order to evaluate the predictive performance using an independent dataset. Another aim was to offer an elegant environment for display and simulation of bo...

journal_title：Therapeutic drug monitoring

authors： Ogami C,Tsuji Y,Nishi Y,Kawasuji H,To H,Yamamoto Y

更新日期：2020-09-28 00:00:00

abstract：:An analytical technique using liquid chromatography (LC) coupled with electrospray-mass spectrometry (ESI--MS) has been developed for the simultaneous determination of five protease inhibitors (PIs): saquinavir, indinavir, ritonavir, nelfinavir, and amprenavir; and three non-nucleoside reverse transcriptase inhibitors...

journal_title：Therapeutic drug monitoring

authors： Villani P,Feroggio M,Gianelli L,Bartoli A,Montagna M,Maserati R,Regazzi MB

更新日期：2001-08-01 00:00:00

abstract：:5alpha-Reductase inhibitors such as finasteride are prohibited in sports according to the World Anti-Doping Agency. This class of drugs is used therapeutically to treat benign prostatic hyperplasia, as well as male baldness, by decreasing 5alpha-reductase activity. Accordingly, metabolic pathways of endogenous as well...

journal_title：Therapeutic drug monitoring

authors： Thevis M,Geyer H,Mareck U,Flenker U,Schänzer W

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:The Clinical Pharmacology Quality Assurance (CPQA) program provides semiannual proficiency testing (PT) of antiretroviral analytes for 11 US and international clinical pharmacology laboratories (CPLs) to ensure interlaboratory comparability. In this article, we provide estimates of the main sources of variab...

journal_title：Therapeutic drug monitoring

authors： Browne RW,Rosenkranz SL,Wang Y,Taylor CR,DiFrancesco R,Morse GD

更新日期：2019-08-01 00:00:00

abstract：:Hyperlipidemia interferes with spectrophotometric assays of a number of analytes. No interference was found in the assay of gentamicin, phenytoin, or phenobarbital due to turbidity in levels of triglyceride less than or equal to 2,000 mg/dl with the Abbott TDx or Syva enzyme multiplied immunoassay (EMIT) methods. Ther...

journal_title：Therapeutic drug monitoring

authors： Baer DM,Paulson RA

更新日期：1987-01-01 00:00:00

abstract：:Eight commercial digoxin immunoassay methods were tested in 17 subjects taking spironolactone (but not digoxin) to evaluate cross-reactivity from parent drug and/or metabolites. Four of these methods showed significant (up to 1.9 nmol/L) and variable "apparent digoxin" concentrations, despite the absence of digoxin in...

journal_title：Therapeutic drug monitoring

authors： Morris RG,Lagnado PY,Lehmann DR,Frewin DB,Glistak ML,Burnet RB

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the serum concentrations of olanzapine in relation to age, sex, and other factors in Chinese patients aged between 10 and 90 years. METHODS:Data for 884 olanzapine patients, deposited between 2016 and 2017, were retrieved from the therapeutic drug monitoring da...

journal_title：Therapeutic drug monitoring

authors： Deng SH,Wang ZZ,Lu HY,Li L,Hu JQ,Zhu XQ,Xie HS,Chen HZ,Zhang M,Ni XJ,Qiu C,Shang DW,Wen YG

更新日期：2020-08-01 00:00:00

abstract：:Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP) were studied in six depressed patients treated with trazodone. The daily dose of trazodone was 150 mg in three cases and 300 mg in three cases. Carbamazepine, 400 mg/day, was coad...

journal_title：Therapeutic drug monitoring

authors： Otani K,Ishida M,Kaneko S,Mihara K,Ohkubo T,Osanai T,Sugawara K

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Tacrolimus pharmacokinetics in obese patients have been poorly studied. Herein, the authors explored the impact of obesity on tacrolimus exposure in kidney transplant recipients (KTRs) and estimated a more suitable initial dosage in this population. METHODS:A retrospective, observational, monocentric case-c...

journal_title：Therapeutic drug monitoring

authors： Robert V,Manos-Sampol E,Manson T,Robert T,Decourchelle N,Anne-Sophie G,Quaranta S,Moal V,Legris T

更新日期：2020-10-05 00:00:00

abstract：:A study was conducted to determine whether assay-specific quantitative differences exist in the determination of vancomycin serum concentrations obtained from patients with renal dysfunction. Vancomycin serum concentrations were obtained during the first week of therapy for each of three time intervals: 48-96 h, 96-14...

journal_title：Therapeutic drug monitoring

authors： Peckman HJ,Dupuis RE,Sawyer WT,Brouwer KL,Cross RE

更新日期：1996-12-01 00:00:00

abstract：:Metabolism of thiopurine drugs--azathioprine, 6-mercaptopurine, and 6-thioguanine--has provided a powerful pharmacogenetic model incorporating polymorphism of the enzyme thiopurine methyltransferase (TPMT) and the primary active metabolite, thioguanine nucleotide (TGN). However, a sense of uncertainty about the useful...

journal_title：Therapeutic drug monitoring

authors： Duley JA,Florin TH

更新日期：2005-10-01 00:00:00

abstract：:The study was designed to determine the steady-state pharmacokinetic profile of diazepam and desmethyldiazepam following a 15-mg controlled-release capsule dosed once daily at either 7 a.m. or 11 p.m. compared with the respective profiles of the conventional 5-mg tablet dosed three times a day at 7 a.m., 12 p.m., and ...

journal_title：Therapeutic drug monitoring

authors： Wills RJ,Colburn WA

更新日期：1983-01-01 00:00:00

abstract：:Currently no pharmacogenomics-based criteria exist to guide clinicians in identifying individuals who are at risk of hearing loss from cisplatin-based chemotherapy. This review summarizes findings from pharmacogenomic studies that report genetic polymorphisms associated with cisplatin-induced hearing loss and aims to ...

journal_title：Therapeutic drug monitoring

authors： Lee JW,Pussegoda K,Rassekh SR,Monzon JG,Liu G,Hwang S,Bhavsar AP,Pritchard S,Ross CJ,Amstutz U,Carleton BC,CPNDS Clinical Recommendations Group.

更新日期：2016-08-01 00:00:00

abstract：:Our aim was to evaluate the isolated placental lobule to study maternofetal transplacental digoxin transfer and accumulation in placental tissue in vitro. Digoxin passage across the isolated lobule of 10 human placentas was calculated from repeated fetal and maternal perfusate samples, and placental tissue digoxin con...

journal_title：Therapeutic drug monitoring

authors： Schmolling J,Jung S,Reinsberg J,Schlebusch H

更新日期：1997-02-01 00:00:00

abstract：:Gabapentin is used in analgesic treatment of neuropathic pain, and large interindividual variation has been observed in the pharmacokinetics (PK) of the drug. The aim of this study was to develop a population PK model for gabapentin appropriate for monitoring patients with neuropathic pain and for individualizing thei...

journal_title：Therapeutic drug monitoring

authors： Carlsson KC,van de Schootbrugge M,Eriksen HO,Moberg ER,Karlsson MO,Hoem NO

更新日期：2009-02-01 00:00:00

abstract：:Nineteen acutely disturbed psychotic Asian patients were treated with a single intramuscular injection of 50 mg of zuclopenthixol acetate in Viscoleo. Patients were assessed clinically before and after treatment using the Brief Psychiatric Rating Scale (BPRS). Serum zuclopenthixol and the inactive geometric isomer tra...

journal_title：Therapeutic drug monitoring

authors： Tan CH,Low BL,Ng LL,Khoo YM,Lee HS

更新日期：1993-04-01 00:00:00

abstract：:The solubility and stability of amphotericin B in human serum in vitro was assessed using a sensitive high performance liquid chromatographic technique. The solubility of amphotericin B at concentrations ranging from 0.5 micrograms/ml to 10 micrograms/ml in human serum at pH 7.4, at 37 degrees C, and in 5% CO2 (simula...

journal_title：Therapeutic drug monitoring

authors： Edmonds LC,Davidson L,Bertino JS Jr

更新日期：1989-01-01 00:00:00

abstract：:The authors report preliminary findings on the potential contribution of CYP2C19 isoenzyme to the human metabolism of N-desmethylclobazam (N-CLB), the main active metabolite of clobazam (CLB), a benzodiazepine frequently used as add-on therapy in patients with refractory epilepsy. Two children on CLB treatment showing...

journal_title：Therapeutic drug monitoring

authors： Contin M,Sangiorgi S,Riva R,Parmeggiani A,Albani F,Baruzzi A

更新日期：2002-12-01 00:00:00

abstract：:A simple and rapid liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for the analysis of voriconazole has been developed. For comparison, serum voriconazole was measured using HPLC and bioassay. For the HPLC-MS/MS assay, samples were prepared in a deep-well block by adding 10 microL of serum to 40 mic...

journal_title：Therapeutic drug monitoring

authors： Keevil BG,Newman S,Lockhart S,Howard SJ,Moore CB,Denning DW

更新日期：2004-12-01 00:00:00

abstract：:Rapamycin (RAPA) is a new immunosuppressive drug with a potency similar to that of FK506 and up to a 100-fold greater than that of cyclosporine (CsA). RAPA has shown to be efficacious in the prolongation of allograft survival in a number of animal models. In early studies, RAPA was administered on a dose/weight basis,...

journal_title：Therapeutic drug monitoring

authors： Yatscoff RW,LeGatt DF,Kneteman NM

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:In children with cystic fibrosis (CF), the currently recommended amikacin dose ranges between 30-35 mg/kg/day; however, data supporting this dosing efficacy is lacking. Herein, the objectives were to develop a non-parametric pharmacokinetic population model (POPPK) for amikacin in children with CF and invest...

journal_title：Therapeutic drug monitoring

authors： Woillard JB,Bouchet S,Fayon M,Marquet P,Monchaud C,Bui S

更新日期：2020-12-17 00:00:00

abstract：:The effect of plasma exchange on the concentrations of total and unbound phenytoin (DPH) was determined in one normal subject and four patients undergoing therapeutic plasma exchange (PE). The average percentage of plasma exchanged ranged from 57 to 70% among the five patients studied. The reduction in DPH concentrati...

journal_title：Therapeutic drug monitoring

authors： Silberstein LE,Shaw LM

更新日期：1986-01-01 00:00:00

abstract：:This case report highlights a very rare adverse drug reaction of oral roxithromycin causing toxic epidermal necrolysis (TEN). A 54-year-old male patient diagnosed with upper respiratory tract infection was prescribed oral roxithromycin 150 mg twice daily for 7 days. On the 10th day, the patient was admitted to the eme...

journal_title：Therapeutic drug monitoring

authors： Das S,Mondal S,Dey JK

更新日期：2012-08-01 00:00:00

abstract：UNLABELLED:Oral fluid is an attractive alternative matrix for drug testing with a noninvasive and directly observed collection, but there are few controlled cocaine administration studies to guide interpretation. MATERIALS AND METHODS:While residing on a closed research unit for up to 10 weeks under constant medical s...

journal_title：Therapeutic drug monitoring

authors： Scheidweiler KB,Spargo EA,Kelly TL,Cone EJ,Barnes AJ,Huestis MA

更新日期：2010-10-01 00:00:00