A practical limited sampling strategy to predict free prednisolone exposure and glycemia in kidney transplant recipients.

abstract：BACKGROUND:Previous reports have suggested that polymorphism of the opioid receptor A118G affects the efficacy of opioid analgesia. The aim of this study was to investigate whether such polymorphism contributed to variability in epidural mixture (sufentanil plus ropivacaine) requirements through patient-controlled epid...

journal_title：Therapeutic drug monitoring

authors： Xu GH,Gao M,Sheng QY,Liu XS,Gu EW

更新日期：2015-02-01 00:00:00

abstract：:Lopinavir is one of the most-widely used protease inhibitors in the treatment of HIV-1 infected patients. Concentration-effect relationships have been described for both antiviral activity and toxicity. Less is known about patient characteristics that may determine interpatient variability in lopinavir plasma concentr...

journal_title：Therapeutic drug monitoring

authors： van der Leur MR,Burger DM,la Porte CJ,Koopmans PP

更新日期：2006-10-01 00:00:00

abstract：:The remarkably strong formation of the mycophenolic acid molecular ion from mycophenolic acid glucuronide during electrospray atmospheric pressure ionization in patients' serum samples is described. It is concluded that because of this effect appropriate chromatographic separation prior to tandem-mass spectrometric an...

journal_title：Therapeutic drug monitoring

authors： Vogeser M,Zachoval R,Spöhrer U,Jacob K

更新日期：2001-12-01 00:00:00

abstract：:Two published case reports showed that addition of risperidone (1 and 2 mg/d) to a clozapine treatment resulted in a strong increase of clozapine plasma levels. As clozapine is metabolized by cytochrome P450 isozymes, a study was initiated to assess the in vivo interaction potential of risperidone on various cytochrom...

journal_title：Therapeutic drug monitoring

authors： Eap CB,Bondolfi G,Zullino D,Bryois C,Fuciec M,Savary L,Jonzier-Perey M,Baumann P

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:The aim of this study was to conduct a population pharmacokinetic (PK) analysis of meropenem and to explore the optimal dosing strategy for meropenem in critically ill patients with acute kidney injury receiving treatment with continuous hemodiafiltration (CHDF). METHODS:Blood samples were obtained on days ...

journal_title：Therapeutic drug monitoring

authors： Niibe Y,Suzuki T,Yamazaki S,Suzuki T,Takahashi N,Hattori N,Nakada TA,Oda S,Ishii I

更新日期：2020-08-01 00:00:00

abstract：:The immunosuppressive potential of mycophenolic acid (MPA) correlates well with MPA exposure [area under the concentration-time curve (AUC)]. Monitoring MPA AUC is important and helpful for maintaining the efficacy of mycophenolate mofetil while minimizing its side effects, but full MPA AUC monitoring is laborious, co...

journal_title：Therapeutic drug monitoring

authors： Zicheng Y,Xianghui W,Peijun Z,Da X,Weixia Z,Hongzhuan C

更新日期：2007-10-01 00:00:00

abstract：:A 64-year-old man on chronic hemodialysis for end-stage renal disease developed peritoneal carcinomatosis, and palliative chemotherapy with fluorouracil was started. The drug was administered (325 mg/m as IV bolus, at 2 PM) on 2 separate occasions, ie, 1 hour after dialysis and 2 days later, 49 hours after dialysis. T...

journal_title：Therapeutic drug monitoring

authors： Gusella M,Rebeschini M,Cartei G,Ferrazzi E,Ferrari M,Padrini R

更新日期：2005-12-01 00:00:00

abstract：:Levels of the anticonvulsant drugs phenobarbitone, phenytoin, carbamazepine, and primidone were measured in the plasma and saliva of 202 epileptic children (5 months-18 years old). Gas-liquid chromatography (GLC) and EMIT immunoassay were used to analyse the samples. Saliva to plasma ratios were as follows (means +/- ...

journal_title：Therapeutic drug monitoring

authors： Goldsmith RF,Ouvrier RA

更新日期：1981-01-01 00:00:00

abstract：:Oral posaconazole (PSZ), an azole antifungal drug, was recently introduced for the treatment of invasive fungal infections. The prescription of PSZ together with the immunosuppressant tacrolimus (TRL) was evaluated in 14 lung transplant patients with cystic fibrosis. PSZ inhibited CYP3A4 TRL metabolism, resulting in a...

journal_title：Therapeutic drug monitoring

authors： Berge M,Chevalier P,Benammar M,Guillemain R,Amrein C,Lefeuvre S,Boussaud V,Billaud EM

更新日期：2009-06-01 00:00:00

abstract：:Theophylline clearance was estimated by a single-sample technique in 19 subjects with acute clinical respiratory infections. Mean (+/- SD) theophylline clearance during acute illness was 0.044 +/- 0.011 L X h-1 X kg-1 compared to 0.043 +/- 0.012 L X h-1 X kg-1 1 month later. In a subset of five subjects, single-sample...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Schwartz J,Martin M,Jauregui L

更新日期：1987-09-01 00:00:00

abstract：:An epileptic patient well controlled on valproic acid (VPA) developed a prolonged episode of status epilepticus 12 days after initiation of 75 mg of clomipramine (CMI) to treat depression. Serum level of VPA in the emergency room was unchanged from her previous levels; serum level of CMI was very elevated despite the ...

journal_title：Therapeutic drug monitoring

authors： DeToledo JC,Haddad H,Ramsay RE

更新日期：1997-02-01 00:00:00

abstract：:The aminoglycoside antibiotics gentamicin and tobramycin have been monitored traditionally by measuring peak and trough drug levels in serum. We found interpretation of these data to be hazardous, due to variations in the drug administration-specimen collection process and routine medical events and practices. We desc...

journal_title：Therapeutic drug monitoring

authors： Gorsky JE,Latts JR

更新日期：1983-06-01 00:00:00

abstract：:Infection with drug-resistant HIV-1 may result from the acquisition of mutant strains or from their selection within the individual; either can compromise the efficacy of antiretroviral therapy (ART). Drug-resistance testing is recommended to assist in the choice of ART. Herein, factors that contribute to the selectio...

journal_title：Therapeutic drug monitoring

authors： Frenkel LM,Tobin NH

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Tacrolimus, a critical dose drug, is widely used in transplantation. Knowing the contribution of genetic factors, which significantly influence tacrolimus variability, is beneficial in the personalization of its starting dose. The significant impact of CYP3A5*3 polymorphisms on tacrolimus exposure has been r...

journal_title：Therapeutic drug monitoring

authors： Phupradit A,Vadcharavivad S,Ingsathit A,Kantachuvesiri S,Areepium N,Sra-Ium S,Auamnoy T,Sukasem C,Sumethkul V,Kitiyakara C

更新日期：2018-10-01 00:00:00

abstract：:Whole blood steady-state trough concentrations of cyclosporine were measured by radioimmunoassay (RIA) and TDx assays employing monoclonal antibodies in 82 samples from 39 renal transplant patients. Intra- and interassay coefficients of variation for the new TDx technique averaged 3.2 and 5.4%, respectively. In the co...

journal_title：Therapeutic drug monitoring

authors： Klotz U

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Infliximab is a chimeric monoclonal antibody that binds to human tumor necrosis factor alpha and which is approved for refractory spondyloarthritis (SpA). Individual adjustment of infliximab dosage may help to improve the therapeutic response in SpA. We investigated whether a knowledge of infliximab serum co...

journal_title：Therapeutic drug monitoring

authors： Méric JC,Mulleman D,Ducourau E,Lauféron F,Miow Lin DC,Watier H,Goupille P,Paintaud G

更新日期：2011-08-01 00:00:00

abstract：:The effects of the cytochrome P450 (CYP) 2D6 genotype and cigarette smoking on the steady-state plasma concentrations (C(ss)) of fluvoxamine (FLV) and its demethylated metabolite fluvoxamino acid (FLA) were studied in 49 Japanese depressed patients receiving FLV 200 mg/d. The C(ss) of FLV and FLA were measured by HPLC...

journal_title：Therapeutic drug monitoring

authors： Gerstenberg G,Aoshima T,Fukasawa T,Yoshida K,Takahashi H,Higuchi H,Murata Y,Shimoyama R,Ohkubo T,Shimizu T,Otani K

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Solithromycin is a fourth-generation macrolide antibiotic with potential efficacy in pediatric community-acquired bacterial pneumonia. Pharmacokinetic (PK) studies of solithromycin in pediatric subjects are limited, therefore application of minimally invasive drug sampling techniques, such as dried blood spo...

journal_title：Therapeutic drug monitoring

authors： Beechinor RJ,Cohen-Wolkowiez M,Jasion T,Hornik CP,Lang JE,Hernandez R,Gonzalez D

更新日期：2019-12-01 00:00:00

abstract：:The relationship between changes in cyclosporin (CyA) dose or CyA blood concentration and the reciprocal creatinine concentration was investigated by cross-correlation analysis over the first 3 postoperative months in 32 consecutive heart and heart-lung recipients. Exploratory analysis suggested that early changes in ...

journal_title：Therapeutic drug monitoring

authors： Trull AK,Best NG,Tan KK,Hue KL,Higenbottam TW,Large S,Wallwork J

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:To increase target attainment rates, switching the mode of administration from intermittent (InI) to continuous infusion (CoI) has been proposed. In this study, target attainment rates and interpatient variation in exposure were compared between vancomycin InI- and CoI-treated critically ill patients. METHO...

journal_title：Therapeutic drug monitoring

authors： van Maarseveen EM,Gipmans S,Vasbinder E,Petjak M,van Zanten AR

更新日期：2016-06-01 00:00:00

abstract：:Nineteen acutely disturbed psychotic Asian patients were treated with a single intramuscular injection of 50 mg of zuclopenthixol acetate in Viscoleo. Patients were assessed clinically before and after treatment using the Brief Psychiatric Rating Scale (BPRS). Serum zuclopenthixol and the inactive geometric isomer tra...

journal_title：Therapeutic drug monitoring

authors： Tan CH,Low BL,Ng LL,Khoo YM,Lee HS

更新日期：1993-04-01 00:00:00

abstract：:The authors have developed a simple isocratic high-pressure liquid chromatographic (HPLC) assay for the simultaneous determination of lamotrigine and other frequently coadministered antiepileptic drugs in serum samples. Lamotrigine extraction was performed on a reversed-phase Oasis HBL preparation column. The eluates ...

journal_title：Therapeutic drug monitoring

authors： Torra M,Rodamilans M,Arroyo S,Corbella J

更新日期：2000-10-01 00:00:00

abstract：:Mycophenolic acid, the active metabolite of the immunosuppressant and antiproliferative agent, mycophenolate mofetil, is primarily metabolized by glucuronidation to the inactive 7-O-glucuronide. Although the uridine diphosphate (UDP) 7-O-glucuronide is the principal excretion product of this drug, carboxyl-linked gluc...

journal_title：Therapeutic drug monitoring

authors： Mackenzie PI

更新日期：2000-02-01 00:00:00

abstract：:Tyrosine kinase inhibitors are the standard of care for the treatment of chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. Dasatinib is a second-generation tyrosine kinase inhibitor that has been shown to be efficacious in treatment of patients with chronic myeloid leukemia or ...

journal_title：Therapeutic drug monitoring

authors： Shayani S

更新日期：2010-12-01 00:00:00

abstract：:A highly sensitive, specific method for determining chloramphenicol levels in human blood plasma and cerebrospinal fluid is described. The method uses high performance liquid chromatography for the analysis, requires minimal quantities of patient specimen, and thus is suitable for use in newborn and pediatric patients...

journal_title：Therapeutic drug monitoring

authors： Sood SP,Green VI,Bailey CL

更新日期：1987-09-01 00:00:00

abstract：:5-Methoxy-N,N-dialkyltryptamines are tryptamine derivatives that possess strong hallucinogenic effects. Because of their escalating popularity and potent physiological effects, an increasing number of acute poisoning cases have been reported in various countries. For their metabolism in humans, only a few studies have...

journal_title：Therapeutic drug monitoring

authors： Katagi M,Kamata T,Zaitsu K,Shima N,Kamata H,Nakanishi K,Nishioka H,Miki A,Tsuchihashi H

更新日期：2010-06-01 00:00:00

abstract：:Results of phenobarbital analyses are presented for 14 patients with chronic renal failure, and compared using gas-liquid chromatography (GLC), enzyme immunoassay (EIA), and fluorescence polarization immunoassay (FPIA). Correlation of FPIA with GLC and EIA was poor. ...

journal_title：Therapeutic drug monitoring

authors： Bridges RR,Jennison TA

更新日期：1984-01-01 00:00:00

abstract：:In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27.0 mg/kg (SD +/- 11.9), phenytoin, 6.33 mg/kg (SD +/- 1.36), and co-anticonvulsants, the mean percentage of daily free valproic acid was 11.72 (SD +/- 2.10) and of phenytoin 20.39 (SD +/- 3.32). By serial within-d...

journal_title：Therapeutic drug monitoring

authors： Haidukewych D,Rodin EA

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Nivolumab is a fully humanized IgG4 monoclonal antibody that targets the programmed death-1 (PD-1) receptor, disrupting PD-1-mediated signaling and restoring antitumor immunity. The objective of this study was to develop a nivolumab quantification method using liquid chromatography-tandem mass spectrometry (...

journal_title：Therapeutic drug monitoring

authors： Irie K,Okada A,Yamasaki Y,Kokan C,Hata A,Kaji R,Fukushima K,Sugioka N,Okada Y,Katakami N,Fukushima S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:In humans, donepezil (D) is metabolized to 5-O-desmethyl-donepezil (5DD), 6-O-desmethyl-donepezil (6DD), and donepezil-N-oxide (DNox). Although 6DD and DNox are pharmacologically active, the activity of 5DD is unknown. At present, no routine methods are available to detect D and its 3 metabolites simultaneou...

journal_title：Therapeutic drug monitoring

authors： Groppa F,Coin A,De Rosa G,Granziera S,Alexopoulos C,Pamio MV,Padrini R

更新日期：2016-02-01 00:00:00