Spurious phenobarbital levels by fluorescence polarization immunoassay using TDx analyzer in patients with renal disease.

abstract：BACKGROUND:Recently, high-dose oral synthetic delta-9-tetrahydrocannabinol (THC) was shown to alleviate cannabis withdrawal symptoms. The present data describe cannabinoid pharmacokinetics in chronic, daily cannabis smokers who received high-dose oral THC pharmacotherapy and later a smoked cannabis challenge. METHODS:...

journal_title：Therapeutic drug monitoring

authors： Milman G,Bergamaschi MM,Lee D,Mendu DR,Barnes AJ,Vandrey R,Huestis MA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Posaconazole is an azole antifungal agent with a broad spectrum of activity and a manageable side-effect profile. Although the pharmacokinetics of posaconazole have been described in healthy volunteers who received the drug by means of a nasogastric tube or with nutritional supplements, the pharmacokinetics ...

journal_title：Therapeutic drug monitoring

authors： Ray J,Campbell L,Rudham S,Nguyen Q,Marriott D

更新日期：2011-08-01 00:00:00

abstract：:A simple and rapid reversed-phase C-18 high-performance liquid chromatography (HPLC) assay without a prior extraction step for dihydroquinidine (HQD) in serum is described. The method is selective and useful for monitoring HQD and its presumed metabolites, quinidine (QD), N-oxide QD, 3-hydroxy QD (3-OHQD), and 10-11-d...

journal_title：Therapeutic drug monitoring

authors： Camsonne R,Moulin MA,Albessard F,Perault M

更新日期：1984-01-01 00:00:00

abstract：INTRODUCTION:Proton pump inhibitors (PPIs) are often prescribed posttransplantation to prevent gastrointestinal complications. A series of recent studies have reported a relationship between PPI comedication and decreased mycophenolic acid (MPA) exposure. The objective of this subanalysis of the CLEAR data set was to d...

journal_title：Therapeutic drug monitoring

authors： Kiberd BA,Wrobel M,Dandavino R,Keown P,Gourishankar S

更新日期：2011-02-01 00:00:00

abstract：:Therapeutic drug monitoring in antituberculosis chemotherapy may play a strategic role in improving outcomes in selected patients. The most important use is in assisting clinicians to optimize therapy to achieve success and minimize toxicity. The other principal indication lies in the management of interaction of anti...

journal_title：Therapeutic drug monitoring

authors： Yew WW

更新日期：1998-10-01 00:00:00

abstract：:An index of desipramine (DMI) hydroxylation, calculated as the ratio between the amounts of DMI and 2-hydroxydesipramine (2-OH-DMI) excreted in urine after 25 mg orally, was determined in 16 depressed patients. The index varied almost 100-fold between the patients and correlated significantly to the steady-state plasm...

journal_title：Therapeutic drug monitoring

authors： Spina E,Arena A,Pisani F

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Because of its superior sensitivity and specificity, multianalyte high-performance liquid chromatography coupled with tandem mass spectrometry has become the gold standard in clinical toxicology. Although several qualitative and quantitative liquid chromatography coupled with tandem mass spectrometry assays ...

journal_title：Therapeutic drug monitoring

authors： Klepacki J,Davari B,Boulet M,Lizarraga R,Christians U

更新日期：2017-10-01 00:00:00

abstract：:In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27.0 mg/kg (SD +/- 11.9), phenytoin, 6.33 mg/kg (SD +/- 1.36), and co-anticonvulsants, the mean percentage of daily free valproic acid was 11.72 (SD +/- 2.10) and of phenytoin 20.39 (SD +/- 3.32). By serial within-d...

journal_title：Therapeutic drug monitoring

authors： Haidukewych D,Rodin EA

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Oral fluid (OF) is being developed as a specimen for the determination of drug intake as an alternative to serum and plasma. It is generally considered as an attractive specimen due to the noninvasive nature of the sampling procedure and the relation to the free fraction of drug in the blood. These features ...

journal_title：Therapeutic drug monitoring

authors： Neumann J,Beck O,Dahmen N,Böttcher M

更新日期：2018-04-01 00:00:00

abstract：:The prevalence of gestational ethanol exposure and subsequent fetal exposure has been assessed in a cohort of mother-infant dyads in a Mediterranean city (Barcelona, Spain) by meconium analysis of fatty acid ethyl esters (FAEEs) after showing in this population a high prevalence of meconium opiates (8.7%), cocaine (4....

journal_title：Therapeutic drug monitoring

authors： Garcia-Algar O,Kulaga V,Gareri J,Koren G,Vall O,Zuccaro P,Pacifici R,Pichini S

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Raltegravir is the first human immunodeficiency virus-1 (HIV-1) integrase inhibitor used in treatment-experienced patients who have evidence of viral replication and HIV-1 strains resistance to multiple antiretroviral regimens. Etravirine is a novel NNRTI, active against HIV-1 strains harboring multiple NNRT...

journal_title：Therapeutic drug monitoring

authors： Quaranta S,Woloch C,Paccou A,Giocanti M,Solas C,Lacarelle B

更新日期：2009-12-01 00:00:00

abstract：:The current standard of monitoring transplant patients by drug levels is not optimal because it does not take into account the different and individual effects of immunosuppressive drugs on each patient. In this study, the authors tested immune function assays for monitoring transplant patients. Blood was collected fr...

journal_title：Therapeutic drug monitoring

authors： Stalder M,Bîrsan T,Holm B,Haririfar M,Scandling J,Morris RE

更新日期：2003-02-01 00:00:00

abstract：:The plasma binding of phenytoin and the relationship between phenytoin concentrations in salivary and plasma ultrafiltrates were evaluated in pediatric epileptic patients aged 2-15 years. Paired samples of plasma and saliva were ultrafiltered through an Amicon YMT membrane. Phenytoin concentrations were measured by a ...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Forney RB Jr,Voeller K

更新日期：1983-01-01 00:00:00

abstract：:A simple high-performance liquid chromatography (HPLC) method for the determination of methotrexate (MTX) in biological fluids is described. The assay is rapid, the time required for analysis is less than 30 min, and it is sensitive, up to 0.01 microgram/ml, which is three times below the toxic MTX concentration. Fift...

journal_title：Therapeutic drug monitoring

authors： Najjar TA,Matar KM,Alfawaz IM

更新日期：1992-04-01 00:00:00

abstract：:In a crossover study balanced for sex, treatments, and treatment order, we have investigated the pharmacokinetics of diltiazem after single oral doses in 10 healthy middle-aged volunteers. The diltiazem doses employed were 60 mg and 120 mg and contained 1.85 MBq [14C] diltiazem. The absorption was rapid and did not di...

journal_title：Therapeutic drug monitoring

authors： Höglund P,Nilsson LG

更新日期：1989-09-01 00:00:00

abstract：:Theophylline clearance was estimated by a single-sample technique in 19 subjects with acute clinical respiratory infections. Mean (+/- SD) theophylline clearance during acute illness was 0.044 +/- 0.011 L X h-1 X kg-1 compared to 0.043 +/- 0.012 L X h-1 X kg-1 1 month later. In a subset of five subjects, single-sample...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Schwartz J,Martin M,Jauregui L

更新日期：1987-09-01 00:00:00

abstract：:The selection of an appropriate therapy and dosing regimen is a significant challenge in the treatment of cancer. Although there are recommended standardized chemotherapy protocols for some types of cancer, protocol changes that usually only occur after large clinical trials demonstrate improvements and individual pat...

journal_title：Therapeutic drug monitoring

authors： Knezevic CE,Clarke W

更新日期：2020-02-01 00:00:00

abstract：:Ultrafiltration techniques for the separation of bound and free ligand are dependent on minimal amounts of protein-bound drug leakage through the membrane devices. A dye-impregnated test strip protein assay (Chemstrip-9) provides a rapid, visual assessment of membrane protein leakage. The test strips are sensitive to ...

journal_title：Therapeutic drug monitoring

authors： Turley CP,Milligan T

更新日期：1985-01-01 00:00:00

abstract：:Immunization of New Zealand white rabbits with a bovine serum albumin conjugate of 7-hydroxy-N-carboxyethyl-N-deshydroxyethylfluphenazine produced highly specific antisera for 7-hydroxyfluphenazine (7-OHFLU). A radioimmunoassay (RIA) was developed using antisera from one of the rabbits that enabled for the first time ...

journal_title：Therapeutic drug monitoring

authors： Aravagiri M,Marder SR,Van Putten T,Hawes EM,McKay G,Midha KK

更新日期：1994-02-01 00:00:00

abstract：:The immunosuppressants cyclosporine, tacrolimus, sirolimus, everolimus, and probably also mycophenolic acid require therapeutic drug monitoring (TDM)-guided dosing to ensure that blood concentrations are kept within the target range in transplant patients. Reliable, accurate, and precise test methods are therefore ess...

journal_title：Therapeutic drug monitoring

authors： Christians U,Vinks AA,Langman LJ,Clarke W,Wallemacq P,van Gelder T,Renjen V,Marquet P,Meyer EJ

更新日期：2015-12-01 00:00:00

abstract：:Vancomycin is widely used in the prophylaxis and treatment of infections in neutropenic patients with cancer. The objective of this study was to analyze liver damage effects on vancomycin pharmacokinetics and determine the necessity for liver function evaluation when selecting vancomycin dosing schedules in these pati...

journal_title：Therapeutic drug monitoring

authors： Aldaz A,Ortega A,Idoate A,Giráldez J,Brugarolas A

更新日期：2000-06-01 00:00:00

abstract：:Effect of diabetes mellitus on mycophenolic acid (MPA) pharmacokinetics and catalytic activity of inosine monophosphate dehydrogenase (IMPDH) was investigated in maintenance kidney transplant recipients. Demographically matched diabetic (n=9) and nondiabetic (n=9) patients were included in a 12-hour open-label, steady...

journal_title：Therapeutic drug monitoring

authors： Patel CG,Richman K,Yang D,Yan B,Gohh RY,Akhlaghi F

更新日期：2007-12-01 00:00:00

abstract：:C(2) Cyclosporine (CsA) level, as a surrogate of area under the time-concentration curve (AUC) 0-4 hours, is a good predictor of drug absorption and clinical outcome after kidney transplantation. It has been difficult to define the optimal C(2) level in the individual case and given the broad range of C(2) due to inte...

journal_title：Therapeutic drug monitoring

authors： Morales J,Buckel E,Fierro A,Zehnder C,Herzog C,Mañalich J

更新日期：2003-06-01 00:00:00

abstract：:An analysis of pH-induced changes of drug binding may contribute to the understanding of the mechanisms involved and the clinical relevance. A literature search was performed, and acceptance criteria set up, to select reported data for quantitative evaluation. The relationship between percentage of unbound drug, fu, a...

journal_title：Therapeutic drug monitoring

authors： Hinderling PH,Hartmann D

更新日期：2005-02-01 00:00:00

abstract：:To evaluate the reliability and practical use of saliva for therapeutic drug monitoring of the antifungal agent voriconazole in immunocompromised patients, a paired-sample study was conducted. Plasma and saliva trough levels were measured in seven children and nine adults who required treatment for the prevention or t...

journal_title：Therapeutic drug monitoring

authors： Michael C,Bierbach U,Frenzel K,Lange T,Basara N,Niederwieser D,Mauz-Körholz C,Preiss R

更新日期：2010-04-01 00:00:00

abstract：:The clinical use of digoxin and phenytoin analyses (in 405 and 152 patients, respectively) furnished by our clinical pharmacological laboratory during a five-month period was evaluated prospectively from request forms. Of first-time analyses of digoxin, 12, 38, and 50% fell above, within, and below our recommended ran...

journal_title：Therapeutic drug monitoring

authors： Bergman U,Rane A,Sjöqvist F,Wiholm BE

更新日期：1981-01-01 00:00:00

abstract：:The in vitro stability of cocaine (COC) was monitored in fresh whole blood and plasma stabilized with potassium fluoride (0.25%) for as long as 15 days. The samples were stored at 4 degreesC, 20 degreesC and 40 degreesC. Additionally, fresh plasma samples containing either benzoylecgonine (BZE), ecgonine methyl ester ...

journal_title：Therapeutic drug monitoring

authors： Skopp G,Klingmann A,Pötsch L,Mattern R

更新日期：2001-04-01 00:00:00

abstract：:A high-performance liquid chromatography (HPLC) method was developed for the simultaneous analysis of trimethoprim (TMP), sulphamethoxazole (SMX), and acetylsulphamethoxazole (AcSMX) in small amounts of blood. The method involved precipitation with 50 microL trichloracetic acid (1M) to 125 microL plasma or serum sampl...

journal_title：Therapeutic drug monitoring

authors： Rønn AM,Mutabingwa TK,Kreisby S,Angelo HR,Fuursted K,Bygbjerg IC

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Perampanel is a new antiepileptic drug (AED) that acts as a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist and is mainly metabolized by cytochrome P450 (CYP) 3A4. This study evaluated the influence of concomitant AEDs on the serum concentration profile of pera...

journal_title：Therapeutic drug monitoring

authors： Yamamoto Y,Usui N,Nishida T,Takahashi Y,Imai K,Kagawa Y,Inoue Y

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Paclitaxel (PTX; Taxol, Abraxane) is used in many regimens for breast cancer, non-small cell lung cancer (NSCLC), and ovarian cancer. Multiple studies have demonstrated that PTX exhibits a greater than 10-fold interpatient variability of clearance rates when patients are dosed according to body surface area ...

journal_title：Therapeutic drug monitoring

authors： Cline DJ,Zhang H,Lundell GD,Harney RL,Riaz HK,Jarrah J,Li Y,Miyazaki M,Courtney JB,Baburina I,Salamone SJ

更新日期：2013-12-01 00:00:00