The relation between dosage, serum concentrations, and clinical outcome in children and adolescents treated with sertraline: a naturalistic study.

abstract：:The current standard of monitoring transplant patients by drug levels is not optimal because it does not take into account the different and individual effects of immunosuppressive drugs on each patient. In this study, the authors tested immune function assays for monitoring transplant patients. Blood was collected fr...

journal_title：Therapeutic drug monitoring

authors： Stalder M,Bîrsan T,Holm B,Haririfar M,Scandling J,Morris RE

更新日期：2003-02-01 00:00:00

abstract：:The prevalence of gestational ethanol exposure and subsequent fetal exposure has been assessed in a cohort of mother-infant dyads in a Mediterranean city (Barcelona, Spain) by meconium analysis of fatty acid ethyl esters (FAEEs) after showing in this population a high prevalence of meconium opiates (8.7%), cocaine (4....

journal_title：Therapeutic drug monitoring

authors： Garcia-Algar O,Kulaga V,Gareri J,Koren G,Vall O,Zuccaro P,Pacifici R,Pichini S

更新日期：2008-04-01 00:00:00

abstract：:Three automated immunoassays for digoxin in serum were evaluated--Abbott TDxII, Baxter Stratus, and Behring OPUS. The accuracy and precision of the assays were assessed by weighed-in controls and an external quality control program. Coefficients of variation of all methods in serum were < or = 10% at weighed-in concen...

journal_title：Therapeutic drug monitoring

authors： Dodds HM,Norris RL,Johnson AG,Pond SM

更新日期：1995-02-01 00:00:00

abstract：:Plasma clonazepam (CZP) and its metabolite [7-aminoclonazepam (7ACZP) and 7-acetamidoclonazepam (7AACZP)] concentrations were measured during a single dosing interval in 10 pediatric epilepsy patients (2-18 years, 11-102 kg) who had been receiving CZP therapeutically from 2 weeks to 4 years. These concentrations were ...

journal_title：Therapeutic drug monitoring

authors： Walson PD,Edge JH

更新日期：1996-02-01 00:00:00

abstract：:The clinical usefulness of cyclosporine is hampered by dose-limiting toxicities to the kidney that are not predicted by drug levels in serum or whole blood. Because of its lipophilic nature, circulating plasma lipoproteins may play a role in drug disposition. This study characterized the pharmacokinetic parameters of ...

journal_title：Therapeutic drug monitoring

authors： Brunner LJ,Luke DR,Lautersztain J,Williams LA,LeMaistre CF,Yau JC

更新日期：1990-03-01 00:00:00

abstract：:The pharmacokinetics of senkyunolide A, one of the major bioactive ingredients in the traditional Chinese medicinal herb Rhizoma Chuanxiong, which is commonly used for the treatment of cardiovascular diseases, was studied in rats. After intravenous (IV) administration, senkyunolide A was extensively distributed (Vd/F:...

journal_title：Therapeutic drug monitoring

authors： Yan R,Lin G,Ko NL,Tam YK

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Chronic opioid use and polypharmacy are commonly seen in chronic pain patients presenting for spine procedures. Substance abuse and misuse have also been reported in this patient population. Negative perioperative effects have been found in patients exposed to chronic opioid, alcohol, and recreational substa...

journal_title：Therapeutic drug monitoring

authors： Clavijo CF,Oliva AM,Dingmann C,Kaizer A,Christians U,Burger E,Patel V,Kleck CJ,Vogel SA,Scott BK,Janik DJ,Jameson LC,Ginde AA

更新日期：2021-02-01 00:00:00

abstract：:A population pharmacokinetic model was developed after administration of orogastric and/or intravenous indomethacin for the treatment of patent ductus arteriosus in preterm infants. Plasma indomethacin concentrations (n=227) were obtained from 90 preterm infants of median gestational age 27 weeks, mean postnatal age o...

journal_title：Therapeutic drug monitoring

authors： Al Za'abi M,Donovan T,Tudehope D,Woodgate P,Collie LA,Charles B

更新日期：2007-12-01 00:00:00

abstract：:Plasma concentrations of isepamicin, a new aminoglycoside antibiotic, were determined by radioimmunoassay (RIA), microbiological assay (MA), and high-performance liquid chromatography (HPLC) in healthy volunteers after administration of 7.5 mg/kg intramuscular dosages once daily for 10 days. Plasma samples were collec...

journal_title：Therapeutic drug monitoring

authors： Lin CC,Veals J,Korduba C,Hilbert MJ,Nomeir A

更新日期：1997-12-01 00:00:00

abstract：:The effect of plasma exchange on the concentrations of total and unbound phenytoin (DPH) was determined in one normal subject and four patients undergoing therapeutic plasma exchange (PE). The average percentage of plasma exchanged ranged from 57 to 70% among the five patients studied. The reduction in DPH concentrati...

journal_title：Therapeutic drug monitoring

authors： Silberstein LE,Shaw LM

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that 5-fluorouracil (5-FU) dosing by use of pharmacokinetic (PK) parameters is superior to the traditional body surface area (BSA) method in colorectal cancer therapy. The purpose of this study was to compare the estimated efficacy and toxicity of the use of PK-guided versus BSA-based ...

journal_title：Therapeutic drug monitoring

authors： Yang R,Zhang Y,Zhou H,Zhang P,Yang P,Tong Q,Lyu Y,Han Y

更新日期：2016-02-01 00:00:00

abstract：:The diurnal fluctuations in free and total plasma levels of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-E) and their relationship with intermittent side effects were examined in 10 epileptic patients stabilized on chronic CBZ therapy alone or in combination with phenobarbital (PB). With a t.i.d. or q.i.d....

journal_title：Therapeutic drug monitoring

authors： Riva R,Contin M,Albani F,Perucca E,Ambrosetto G,Gobbi G,Cortelli P,Procaccianti G,Baruzzi A

更新日期：1984-01-01 00:00:00

abstract：:Mixed-effect modeling has been suggested as a possible tool to detect and describe drug interactions in patient populations receiving drug combinations for the treatment of disease states. The mixed-effect modeling program, NONMEM, was used to measure the effects of the well-known digoxin-quinidine and digoxin-verapam...

journal_title：Therapeutic drug monitoring

authors： Bauer LA,Horn JR,Pettit H

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Stiripentol (STP) was approved as an orphan drug in 2007 in Europe as adjunctive therapy with valproic acid (VPA) and clobazam (CLB) for Dravet syndrome. Dravet syndrome is a highly pharmacoresistant form of epilepsy, which starts in early childhood. Data about STP pharmacokinetics and interactions are still...

journal_title：Therapeutic drug monitoring

authors： May TW,Boor R,Mayer T,Jürgens U,Rambeck B,Holert N,Korn-Merker E,Brandt C

更新日期：2012-08-01 00:00:00

abstract：:The objective of this study was to conduct an assessment of patient and parental preferences and an economic analysis of hospital costs in sampling blood and saliva for therapeutic drug monitoring (TDM). Costs and preferences were evaluated in the course of a study, which compared anticonvulsant concentrations in bloo...

journal_title：Therapeutic drug monitoring

authors： Gorodischer R,Burtin P,Hwang P,Levine M,Koren G

更新日期：1994-10-01 00:00:00

abstract：:A simple and rapid liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for the analysis of voriconazole has been developed. For comparison, serum voriconazole was measured using HPLC and bioassay. For the HPLC-MS/MS assay, samples were prepared in a deep-well block by adding 10 microL of serum to 40 mic...

journal_title：Therapeutic drug monitoring

authors： Keevil BG,Newman S,Lockhart S,Howard SJ,Moore CB,Denning DW

更新日期：2004-12-01 00:00:00

abstract：:The authors have developed a simple isocratic high-pressure liquid chromatographic (HPLC) assay for the simultaneous determination of lamotrigine and other frequently coadministered antiepileptic drugs in serum samples. Lamotrigine extraction was performed on a reversed-phase Oasis HBL preparation column. The eluates ...

journal_title：Therapeutic drug monitoring

authors： Torra M,Rodamilans M,Arroyo S,Corbella J

更新日期：2000-10-01 00:00:00

abstract：:The effect of mycophenolic acid (MPA) in combination with either cyclosporine (CsA) or tacrolimus (TRL) on whole-blood lymphocyte function was assessed in vitro as well as in vivo. For the in vitro studies, rat whole blood was incubated with different concentrations of MPA together with CsA or TRL. In vivo, rats (n = ...

journal_title：Therapeutic drug monitoring

authors： Barten MJ,Shipkova M,Bartsch P,Dhein S,Streit F,Tarnok A,Armstrong VW,Mohr FW,Oellerich M,Gummert JF

更新日期：2005-04-01 00:00:00

abstract：:Plasma levels of haloperidol were monitored in children and teenagers suffering from psychotic episodes and/or abnormal movements (tics and Gilles de la Tourette's syndrome). Steady-state concentrations of haloperidol ranged from 0.7 to 19 ng/ml without any apparent relationship with the administered dose (15--285 mic...

journal_title：Therapeutic drug monitoring

authors： Morselli PL,Bianchetti G,Durand G,Le Heuzey MF,Zarifian E,Dugas M

更新日期：1979-01-01 00:00:00

abstract：:Determination of serum concentrations of certain drugs is becoming increasingly important for optimal patient care. These drugs include many antibiotics, several antiarrhythmics, cardiac glycosides, lithium, phenytoin, some other anticonvulsants, salicylates, and theophylline. Serum level determinations can also be us...

journal_title：Therapeutic drug monitoring

authors： Koch-Weser J

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:SB2, an infliximab (IFX) biosimilar to the reference infliximab (R.I.) product (Remicade), received approval in the European Union for all IFX indications. Many decision algorithms based on the measurement of IFX trough levels and antibodies to infliximab are being increasingly used to optimize IFX treatment...

journal_title：Therapeutic drug monitoring

authors： Jentzer A,Berger AE,Labetoulle R,Haccourt A,Roblin X,Paul S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Perampanel is a new antiepileptic drug (AED) that acts as a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist and is mainly metabolized by cytochrome P450 (CYP) 3A4. This study evaluated the influence of concomitant AEDs on the serum concentration profile of pera...

journal_title：Therapeutic drug monitoring

authors： Yamamoto Y,Usui N,Nishida T,Takahashi Y,Imai K,Kagawa Y,Inoue Y

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Serum trough concentrations as the sole means of monitoring safety and efficacy of vancomycin are insufficient. The daily area under the curve (AUC24) of serum concentration versus time to minimum inhibitory concentration (MIC) ratio of greater than 400 mg × h/L has emerged as a more robust dosing target. A ...

journal_title：Therapeutic drug monitoring

authors： Lewis P

更新日期：2018-06-01 00:00:00

abstract：:The effect of ofloxacin taken for 8 days (200 mg twice daily) on the pharmacokinetics of a single intravenous dose of theophylline (4.3 mg/kg over 15 min) was studied in a crossover procedure among seven healthy male volunteers. Theophylline concentrations were measured serially for 10 h by the immunofluorescence pola...

journal_title：Therapeutic drug monitoring

authors： Al-Turk WA,Shaheen OM,Othman S,Khalaf RM,Awidi AS

更新日期：1988-01-01 00:00:00

abstract：:The pharmacokinetic equations of Chiou, Koup, and Kurland are often used in the pediatric setting to predict steady-state theophylline clearance using non-steady serum theophylline concentrations. However, these equations have not been validated or compared in a pediatric population. We evaluated the ability of these ...

journal_title：Therapeutic drug monitoring

authors： Reiter PD,Hogue SL,Phelps SJ

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Despite significant interindividual variability in prednisolone pharmacokinetics and potentially serious consequences with inadequate or excessive exposure, monitoring of prednisolone levels is not employed to guide therapy. As ultrahigh-performance liquid chromatography-tandem mass spectrometry methods can ...

journal_title：Therapeutic drug monitoring

authors： Yates CJ,Barraclough KA,McWhinney BC,Ungerer JP,Fullinfaw RO,Colman PG,Fourlanos S,Cohney SJ

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Buprenorphine is currently under investigation as a pharmacotherapy to treat pregnant women for opioid dependence. This research evaluates buprenorphine (BUP), norbuprenophine (NBUP), buprenorphine-glucuronide (BUP-Gluc), and norbuprenorphine-glucuronide (NBUP-Gluc) pharmacokinetics after high-dose (14-20 mg...

journal_title：Therapeutic drug monitoring

authors： Concheiro M,Jones HE,Johnson RE,Choo R,Huestis MA

更新日期：2011-10-01 00:00:00

abstract：:The time course of appearance of cotinine in saliva and in daily collections of beard clippings was monitored by gas chromatography with mass spectrometry in six volunteers who were nonsmokers following a single 30-min buccal administration of nicotine as a chewing gum. Salivary cotinine concentrations reached a plate...

journal_title：Therapeutic drug monitoring

authors： Gwent SH,Wilson JF,Tsanaclis LM,Wicks JF

更新日期：1995-04-01 00:00:00

abstract：:Pharmacokinetics of intravenous and oral pulsed high-dose dexamethasone were studied in four patients with pemphigus vulgaris. Doses for dexamethasone were varied from 100 to 300 mg. Serum concentrations were measured by high-performance liquid chromatographic procedure with diode assay detection. Bioavailability was ...

journal_title：Therapeutic drug monitoring

authors： Tóth GG,Kloosterman C,Uges DR,Jonkman MF

更新日期：1999-10-01 00:00:00

abstract：:Iron overload resulting from transfusion dependency in some patients with chronic anaemia can be prevented by chelation. Deferasirox is an oral alternative to the well studied but inconvenient deferroxamine therapy. The pharmacokinetic parameters of this new drug suggest potential interindividual variability and patie...

journal_title：Therapeutic drug monitoring

authors： Chauzit E,Bouchet S,Micheau M,Mahon FX,Moore N,Titier K,Molimard M

更新日期：2010-08-01 00:00:00