Lack of pharmacokinetic interaction between chloroquine and imipramine.

abstract：:This investigation was designed to compare three assay techniques, the traditional bioassay (agar diffusion), and two more recent techniques, high-performance liquid chromatography (HPLC) and fluorescence polarization immunoassay (FPIA), for the determination of vancomycin concentrations in serum. One hundred clinical...

journal_title：Therapeutic drug monitoring

authors： Ristuccia PA,Ristuccia AM,Bidanset JH,Cunha BA

更新日期：1984-01-01 00:00:00

abstract：:The analysis of quinine in whole blood, plasma, urine, and samples dried on filter paper is described. Extraction was made with toluene followed by back-extraction into phosphate buffer. A reversed-phase liquid chromatography system with fluorescence detection was used. The within-day coefficient of variation of the m...

journal_title：Therapeutic drug monitoring

authors： Ericsson O,Fridén M,Hellgren U,Gustafsson LL

更新日期：1993-08-01 00:00:00

abstract：:Theophylline clearance was estimated by a single-sample technique in 19 subjects with acute clinical respiratory infections. Mean (+/- SD) theophylline clearance during acute illness was 0.044 +/- 0.011 L X h-1 X kg-1 compared to 0.043 +/- 0.012 L X h-1 X kg-1 1 month later. In a subset of five subjects, single-sample...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Schwartz J,Martin M,Jauregui L

更新日期：1987-09-01 00:00:00

abstract：:The effect of mycophenolic acid (MPA) in combination with either cyclosporine (CsA) or tacrolimus (TRL) on whole-blood lymphocyte function was assessed in vitro as well as in vivo. For the in vitro studies, rat whole blood was incubated with different concentrations of MPA together with CsA or TRL. In vivo, rats (n = ...

journal_title：Therapeutic drug monitoring

authors： Barten MJ,Shipkova M,Bartsch P,Dhein S,Streit F,Tarnok A,Armstrong VW,Mohr FW,Oellerich M,Gummert JF

更新日期：2005-04-01 00:00:00

abstract：:It has been suggested that lamotrigine (LTG) may enhance the toxicity of carbamazepine (CBZ) by increasing the concentration of the active metabolite carbamazepine-10,11-epoxide (CBZ-E) in adult patients. The authors investigated this hypothesis in an add-on study in 11 children and 3 adolescents, aged 6-22 years, who...

journal_title：Therapeutic drug monitoring

authors： Eriksson AS,Boreus LO

更新日期：1997-10-01 00:00:00

abstract：:Mixed-effect modeling has been suggested as a possible tool to detect and describe drug interactions in patient populations receiving drug combinations for the treatment of disease states. The mixed-effect modeling program, NONMEM, was used to measure the effects of the well-known digoxin-quinidine and digoxin-verapam...

journal_title：Therapeutic drug monitoring

authors： Bauer LA,Horn JR,Pettit H

更新日期：1996-02-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is increasingly used for the treatment of autoimmune diseases (AID). In renal transplant recipients, it has been demonstrated that adjustment of the MMF dose according to the area under the plasma concentration versus time curve (AUC) of mycophenolic acid (MPA), the active moiety of MMF, im...

journal_title：Therapeutic drug monitoring

authors： de Winter BC,Neumann I,van Hest RM,van Gelder T,Mathot RA

更新日期：2009-06-01 00:00:00

abstract：:Designer drugs of the methylenedioxyphenylalkylamine type are increasingly abused. Studies on their metabolism in humans are necessary to develop a reliable gas chromatography--mass spectrometry (GC-MS) screening procedure. Such a method must allow their detection in urine for drug testing in clinical and forensic tox...

journal_title：Therapeutic drug monitoring

authors： Maurer HH

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Drug blood levels can only serve as a surrogate because of the lack of information on the drug's direct pharmacological effects in the individual patient. Measurement of the mammalian target of rapamycin (mTOR) activity dependent on the phosphorylation status of p70 S6 kinase (p70 S6K) offers a practical way...

journal_title：Therapeutic drug monitoring

authors： Hartmann B,He X,Keller F,Fischereder M,Guba M,Schmid H

更新日期：2013-04-01 00:00:00

abstract：:Monitoring of serum voriconazole concentrations has been proposed to optimize therapeutic effect and minimize toxicity. However, little is known about the clinical use of voriconazole therapeutic drug monitoring (TDM) by treating physicians. Four hundred seventy-eight episodes corresponding with 161 adult patients (me...

journal_title：Therapeutic drug monitoring

authors： Miyakis S,van Hal SJ,Solvag CJ,Ray J,Marriott D

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Tacrolimus pharmacokinetics in obese patients have been poorly studied. Herein, the authors explored the impact of obesity on tacrolimus exposure in kidney transplant recipients (KTRs) and estimated a more suitable initial dosage in this population. METHODS:A retrospective, observational, monocentric case-c...

journal_title：Therapeutic drug monitoring

authors： Robert V,Manos-Sampol E,Manson T,Robert T,Decourchelle N,Anne-Sophie G,Quaranta S,Moal V,Legris T

更新日期：2020-10-05 00:00:00

abstract：INTRODUCTION:Proton pump inhibitors (PPIs) are often prescribed posttransplantation to prevent gastrointestinal complications. A series of recent studies have reported a relationship between PPI comedication and decreased mycophenolic acid (MPA) exposure. The objective of this subanalysis of the CLEAR data set was to d...

journal_title：Therapeutic drug monitoring

authors： Kiberd BA,Wrobel M,Dandavino R,Keown P,Gourishankar S

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:In children with cystic fibrosis (CF), the currently recommended amikacin dose ranges between 30-35 mg/kg/day; however, data supporting this dosing efficacy is lacking. Herein, the objectives were to develop a non-parametric pharmacokinetic population model (POPPK) for amikacin in children with CF and invest...

journal_title：Therapeutic drug monitoring

authors： Woillard JB,Bouchet S,Fayon M,Marquet P,Monchaud C,Bui S

更新日期：2020-12-17 00:00:00

abstract：:A simple and rapid reversed-phase C-18 high-performance liquid chromatography (HPLC) assay without a prior extraction step for dihydroquinidine (HQD) in serum is described. The method is selective and useful for monitoring HQD and its presumed metabolites, quinidine (QD), N-oxide QD, 3-hydroxy QD (3-OHQD), and 10-11-d...

journal_title：Therapeutic drug monitoring

authors： Camsonne R,Moulin MA,Albessard F,Perault M

更新日期：1984-01-01 00:00:00

abstract：:Several studies suggest that therapeutic drug monitoring of protease inhibitors and nonnucleoside reverse transcriptase inhibitors may contribute to the clinical outcome of HIV-infected patients. Because of the growing number of antiretroviral drugs and of drug combinations than can be administered to these patients, ...

journal_title：Therapeutic drug monitoring

authors： Poirier JM,Robidou P,Jaillon P

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Fosphenytoin, the diphosphate ester salt of phenytoin, is widely used to treat status epilepticus. The aim of this study was to develop a population pharmacokinetic (PPK) model to describe serum phenytoin concentrations after the intravenous administration of fosphenytoin in adult and elderly epileptic patie...

journal_title：Therapeutic drug monitoring

authors： Higuchi K,Yamashita D,Kashihara Y,Kakara M,Hirota T,Hirakawa M,Ieiri I

更新日期：2019-10-01 00:00:00

abstract：:The authors report a case that offers insight into the diagnostic challenges of "Munchausen Syndrome by Proxy." Initial presentation with history of fever and later with intractable vomiting led to invasive and expensive diagnostic evaluation before confirming the diagnosis. Certain toxic effects of emetine were clini...

journal_title：Therapeutic drug monitoring

authors： Bader AA,Kerzner B

更新日期：1999-04-01 00:00:00

abstract：:This case report highlights a very rare adverse drug reaction of oral roxithromycin causing toxic epidermal necrolysis (TEN). A 54-year-old male patient diagnosed with upper respiratory tract infection was prescribed oral roxithromycin 150 mg twice daily for 7 days. On the 10th day, the patient was admitted to the eme...

journal_title：Therapeutic drug monitoring

authors： Das S,Mondal S,Dey JK

更新日期：2012-08-01 00:00:00

abstract：:A model for predicting unbound concentrations of mycophenolic acid (MPA) was developed in 84 subjects and then tested in an independent group of 19 hematopoietic cell transplant recipients. Total and unbound MPA concentrations and total mycophenolic glucuronide concentrations were measured between weeks 1 and 4 posttr...

journal_title：Therapeutic drug monitoring

authors： Huang J,Jacobson P,Brundage R

更新日期：2007-08-01 00:00:00

abstract：:A computer-based approach for estimating pharmacokinetic data and predicting plasma drug concentrations based on two measurements of plasma drug concentrations was compared with a standard two-point method for estimating aminoglycoside (AG) pharmacokinetic parameters. The computer-based technique was also used to pred...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Pongsin V,Forney R Jr,Gronau G

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:The indication for the antiepileptic drug lacosamide (LCM) was recently extended to include children from the age of 4 years. Real-life data on the use and serum concentrations of LCM in children and adolescents are limited. The purpose of this study was to investigate the use of LCM in this patient group in...

journal_title：Therapeutic drug monitoring

authors： Larsen Burns M,Nikanorova M,Baftiu A,Borg Rasmussen J,Johannessen SI,Johannessen Landmark C

更新日期：2019-06-01 00:00:00

abstract：:The aim of this study was to investigate the use of psychotropic medication and therapeutic drug monitoring in a high-security psychiatric unit and to compare the doses and serum concentrations both with the recommended intervals and with the doses and serum concentrations in a control group. One hundred thirty-two pa...

journal_title：Therapeutic drug monitoring

authors： Castberg I,Spigset O

更新日期：2008-10-01 00:00:00

abstract：:Individualized tobramycin therapy was systemically evaluated in 26 patients with gram-negative pneumonias involving Pseudomonas aeruginosa and other multiple antibiotic-resistant pathogens. Patient prognoses were classified by underlying diseases, and response was determined according to previously established criteri...

journal_title：Therapeutic drug monitoring

authors： Cipolle RJ,Seifert RD,Zaske DE,Strate RG

更新日期：1980-01-01 00:00:00

abstract：:Mycophenolate mofetil, the oral prodrug of mycophenolic acid, is indicated as immunosuppressive therapy after renal transplantation. To aid in the investigation of pharmacokinetic-pharmacodynamic relationships of mycophenolic acid in the clinical setting, limited blood sampling strategies have been proposed, and model...

journal_title：Therapeutic drug monitoring

authors： Willis C,Taylor PJ,Salm P,Tett SE,Pillans PI

更新日期：2000-10-01 00:00:00

abstract：:The authors have developed a simple isocratic high-pressure liquid chromatographic (HPLC) assay for the simultaneous determination of lamotrigine and other frequently coadministered antiepileptic drugs in serum samples. Lamotrigine extraction was performed on a reversed-phase Oasis HBL preparation column. The eluates ...

journal_title：Therapeutic drug monitoring

authors： Torra M,Rodamilans M,Arroyo S,Corbella J

更新日期：2000-10-01 00:00:00

abstract：:The effect of ofloxacin taken for 8 days (200 mg twice daily) on the pharmacokinetics of a single intravenous dose of theophylline (4.3 mg/kg over 15 min) was studied in a crossover procedure among seven healthy male volunteers. Theophylline concentrations were measured serially for 10 h by the immunofluorescence pola...

journal_title：Therapeutic drug monitoring

authors： Al-Turk WA,Shaheen OM,Othman S,Khalaf RM,Awidi AS

更新日期：1988-01-01 00:00:00

abstract：:The evaluation of a radioimmunoassay (RIA) for the monitoring of cyclosporine (CSA) that utilizes a monoclonal antibody specific for the parent compound is described. The assay exhibited good analytical recovery (greater than 95%), precision (coefficient of variation less than 10%), and linearity in plasma and whole b...

journal_title：Therapeutic drug monitoring

authors： Copeland KR,Yatscoff RW

更新日期：1988-01-01 00:00:00

abstract：:The in vitro stability of cocaine (COC) was monitored in fresh whole blood and plasma stabilized with potassium fluoride (0.25%) for as long as 15 days. The samples were stored at 4 degreesC, 20 degreesC and 40 degreesC. Additionally, fresh plasma samples containing either benzoylecgonine (BZE), ecgonine methyl ester ...

journal_title：Therapeutic drug monitoring

authors： Skopp G,Klingmann A,Pötsch L,Mattern R

更新日期：2001-04-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) in combination with cyclosporine (CsA) or Tacrolimus (TAC) has been show to be a potent immunosuppressive agent. The authors assessed the mycophenolic acid (MPA) plasma levels achieved in clinical practice and evaluated the effect of concomitant administration of CsA and TAC . One hundred f...

journal_title：Therapeutic drug monitoring

authors： Pou L,Brunet M,Cantarell C,Vidal E,Oppenheimer F,Monforte V,Vilardell J,Roman A,Martorell J,Capdevila L

更新日期：2001-02-01 00:00:00

abstract：:A simple and sensitive method is presented for the determination of gold in various biological matrices by flameless atomic absorption spectrometry (FAAS). The effects of the biological media on the atomic absorption of gold and the application of some of the important fundamental principles in relation to the measure...

journal_title：Therapeutic drug monitoring

authors： Sharma RP

更新日期：1982-01-01 00:00:00