High single dose of mitoxantrone and cytarabine in acute non-lymphocytic leukemia: a pharmacokinetic and clinical study.

abstract：BACKGROUND:Beta-lactams are first-line antibiotics for the management of superficial infections due to burn injury. There is sparse data available on therapeutic drug monitoring (TDM) in patients with burns in a ward setting. This study was conducted to evaluate the utility of a beta-lactam TDM program in a cohort of b...

journal_title：Therapeutic drug monitoring

authors： Patel BM,Paratz J,See NC,Muller MJ,Rudd M,Paterson D,Briscoe SE,Ungerer J,McWhinney BC,Lipman J,Roberts JA

更新日期：2012-04-01 00:00:00

abstract：:A comparative bioavailability study of carbamazepine (CBZ) in tablets and a syrup preparation was carried out in six volunteers, using a crossover design. Plasma and saliva samples were collected at appropriate times, and the plasma specimens were analyzed by high performance liquid chromatography for concentrations o...

journal_title：Therapeutic drug monitoring

authors： Hooper WD,King AR,Patterson M,Dickinson RG,Eadie MJ

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:The combination of trimethoprim (TMP) and sulfamethoxazole (SMX) is used to treat a number of bacterial infections. TMP/SMX concentrations in serum are conventionally monitored using high-performance liquid chromatography (HPLC) or liquid chromatography tandem mass spectrometry. These methods require laborio...

journal_title：Therapeutic drug monitoring

authors： Fatica E,Faber J,Gaffron C,Bjergum M,Langman L,Jannetto P

更新日期：2020-10-01 00:00:00

abstract：:This study was undertaken to model the relationship between clonazepam plasma concentrations and a central nervous system adverse effect (impairment of the psychomotor performance) following the oral administration of immediate-release tablets of clonazepam in healthy volunteers. Such a (P)pharmacokinetic/(P)pharmacod...

journal_title：Therapeutic drug monitoring

authors： dos Santos FM,Gonçalves JC,Caminha R,da Silveira GE,Neves CS,Gram KR,Ferreira CT,Jacqmin P,Noël F

更新日期：2009-10-01 00:00:00

abstract：:The objective of this study was to conduct an assessment of patient and parental preferences and an economic analysis of hospital costs in sampling blood and saliva for therapeutic drug monitoring (TDM). Costs and preferences were evaluated in the course of a study, which compared anticonvulsant concentrations in bloo...

journal_title：Therapeutic drug monitoring

authors： Gorodischer R,Burtin P,Hwang P,Levine M,Koren G

更新日期：1994-10-01 00:00:00

abstract：:The efficacy of low-dose, ritonavir-boosted saquinavir (SQV/rtv) once daily plus 2 nucleoside retrotranscriptase inhibitors (NRTIs) in pregnant human immunodeficiency virus (HIV)-1-infected women was prospectively evaluated, ensuring a SQV minimum concentration (Cmin) >/=100 ng/mL with a therapeutic drug monitoring st...

journal_title：Therapeutic drug monitoring

authors： Lopez-Cortes LF,Ruiz-Valderas R,Rivero A,Camacho A,Marquez-Solero M,Santos J,García-Lazaro M,Viciana P,Rodriguez-Baños J,Ocampo A

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to conduct a population pharmacokinetic (PK) analysis of meropenem and to explore the optimal dosing strategy for meropenem in critically ill patients with acute kidney injury receiving treatment with continuous hemodiafiltration (CHDF). METHODS:Blood samples were obtained on days ...

journal_title：Therapeutic drug monitoring

authors： Niibe Y,Suzuki T,Yamazaki S,Suzuki T,Takahashi N,Hattori N,Nakada TA,Oda S,Ishii I

更新日期：2020-08-01 00:00:00

abstract：:Indomethacin (INDO) pharmacokinetics were examined in 18 neonates on 19 occasions, before and after patent ductus arteriosus (PDA) closure. Patients received INDO as an initial dose of 0.25 mg/kg intravenously, and INDO serum concentrations were measured 2 and 8 h after the dose. Subsequent doses were individualized b...

journal_title：Therapeutic drug monitoring

authors： Gal P,Ransom JL,Weaver RL,Schall S,Wyble LE,Carlos RQ,Brown Y

更新日期：1991-01-01 00:00:00

abstract：:The adsorption of amitriptyline, desipramine, doxepin, imipramine, and nortriptyline onto cholestyramine was demonstrated in vitro with use of 1.2 mol/L HCl at 37 degrees C to simulate gastric fluid. Binding to cholestyramine was approximately 80% for each of the tricyclic antidepressants, and this was about the same ...

journal_title：Therapeutic drug monitoring

authors： Bailey DN,Coffee JJ,Anderson B,Manoguerra AS

更新日期：1992-08-01 00:00:00

abstract：:Despite its known teratogenic effects, thalidomide has been used to treat a variety of diseases ranging from alleviation of autoimmune disorders to prevention of metastasis of cancers. The exact method of action of thalidomide and its derivatives is still under investigation. Thalidomide undergoes very little metaboli...

journal_title：Therapeutic drug monitoring

authors： Price DK,Ando Y,Kruger EA,Weiss M,Figg WD

更新日期：2002-02-01 00:00:00

abstract：:A method is described for the determination of vigabatrin in 50 microliters of plasma by isocratic high-performance liquid chromatography using fluorescence detection. The procedure involves protein precipitation with methanol followed by precolumn derivatisation with o-phthaldialdehyde reagent. Separation of the deri...

journal_title：Therapeutic drug monitoring

authors： Tsanaclis LM,Wicks J,Williams J,Richens A

更新日期：1991-05-01 00:00:00

abstract：:The current article describes a new assay to measure thiopurine methyltransferase (TPMT) activity from red blood cells. This method is based on the measurement of the reaction product 6-methylmercaptopurine (6-MMP) by high-performance liquid chromatography (HPLC). 6-MMP is extracted by ethyl acetate with recoveries of...

journal_title：Therapeutic drug monitoring

authors： Menor C,Fueyo JA,Escribano O,Cara C,Fernández-Moreno MD,Román ID,Guijarro LG

更新日期：2001-10-01 00:00:00

abstract：:Monitoring of serum voriconazole concentrations has been proposed to optimize therapeutic effect and minimize toxicity. However, little is known about the clinical use of voriconazole therapeutic drug monitoring (TDM) by treating physicians. Four hundred seventy-eight episodes corresponding with 161 adult patients (me...

journal_title：Therapeutic drug monitoring

authors： Miyakis S,van Hal SJ,Solvag CJ,Ray J,Marriott D

更新日期：2010-10-01 00:00:00

abstract：:Fluorescence polarization immunoassay (FPIA) (TDx, Abbott Laboratories Diagnostics, Irvin, TX, U.S.A.) is commonly utilized for quantitative determination of gentamicin serum concentrations. Recently, automated homogeneous latex agglutination (LA) (Technicon Immuno-1, Miles Diagnostics Division, Tarrytown, NY, U.S.A.)...

journal_title：Therapeutic drug monitoring

authors： Madaras-Kelly KJ,Mihalovic S,Zittel D,Ehresman D,Lakatua DJ,Rotschafer JC

更新日期：1994-08-01 00:00:00

abstract：:Thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulphydryl compounds, such as the thiopurine drugs azathioprine, mercaptopurine, and thioguanine. These drugs form the same terminal metabolites, the thioguanine nucleotides (TGNs). ...

journal_title：Therapeutic drug monitoring

authors： Lennard L

更新日期：1998-10-01 00:00:00

abstract：:A method for analyzing flecainide in plasma was developed and assessed. Based on the use of C18 extraction columns eight or fewer times, the rapid and simple extraction procedure provided consistent, high-efficiency flecainide extraction (>85%). Using reverse-phase, high-performance liquid chromatography with fluorome...

journal_title：Therapeutic drug monitoring

authors： Wilson KM,Schneider JJ,Ravenscroft PJ

更新日期：1998-08-01 00:00:00

abstract：:Previous studies have categorized duloxetine as a moderate inhibitor of CYP2D6. The aim of the present study was to investigate the potential interactions between duloxetine and the two CYP2D6 substrates risperidone and aripiprazole in psychiatric patients. Serum concentration data from patients treated with risperido...

journal_title：Therapeutic drug monitoring

authors： Hendset M,Molden E,Enoksen TB,Refsum H,Hermann M

更新日期：2010-12-01 00:00:00

abstract：:Twenty-four epileptic women were followed-up during late pregnancy, labor, and early puerperium in order to detect possible alterations in serum protein binding of antiepileptic drugs (AEDs). The total and free concentrations of carbamazepine (CBZ), phenytoin (PHT), and valproate (VPA) in maternal serum were measured....

journal_title：Therapeutic drug monitoring

authors： Bardy AH,Hiilesmaa VK,Teramo K,Neuvonen PJ

更新日期：1990-01-01 00:00:00

abstract：:This investigation was designed to compare three assay techniques, the traditional bioassay (agar diffusion), and two more recent techniques, high-performance liquid chromatography (HPLC) and fluorescence polarization immunoassay (FPIA), for the determination of vancomycin concentrations in serum. One hundred clinical...

journal_title：Therapeutic drug monitoring

authors： Ristuccia PA,Ristuccia AM,Bidanset JH,Cunha BA

更新日期：1984-01-01 00:00:00

abstract：:Since therapeutic drug monitoring is rapidly becoming a widely used tool in clinical medicine, we prospectively assessed 390 serum drug assays over a 4-week period to determine the appropriateness of serum sample collection. The results of appropriately collected samples were used to evaluate the ability of the physic...

journal_title：Therapeutic drug monitoring

authors： Bussey HI,Hoffman EW

更新日期：1983-01-01 00:00:00

abstract：:The authors aimed to evaluate the utility of the history and clinical signs for predicting ingestion of poisons in children. A prospective cohort study was performed of all patients presenting with suspected poisoning to a pediatric emergency department over a 13-month period. Clinical data were collected on a preform...

journal_title：Therapeutic drug monitoring

authors： Hwang CF,Foot CL,Eddie G,Johnson L,Reith DM

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:To investigate the predictive value of the risperidone and venlafaxine metabolic ratios and CYP2D6 genotype. METHODS:The determination of risperidone, 9-hydroxyrisperidone, and venlafaxine, O-desmethylvenlafaxine, N-desmethylvenlafaxine and CYP2D6 genotype was performed in 425 and 491 patients, respectively. T...

journal_title：Therapeutic drug monitoring

authors： Mannheimer B,Haslemo T,Lindh JD,Eliasson E,Molden E

更新日期：2016-02-01 00:00:00

abstract：:Bayesian estimation (BE) of pharmacokinetic parameters enables the clinician to adjust the dosage of high-dose methotrexate (HDMTX) to correct the inter- and intraindividual variation of concentrations that are responsible for severe toxicity. In this study of 672 HDMTX infusions, we validated an approach that consist...

journal_title：Therapeutic drug monitoring

authors： Pignon T,Lacarelle B,Duffaud F,Guillet P,Catalin J,Durand A,Favre R

更新日期：1995-10-01 00:00:00

abstract：:Pharmacokinetics of intravenous and oral pulsed high-dose dexamethasone were studied in four patients with pemphigus vulgaris. Doses for dexamethasone were varied from 100 to 300 mg. Serum concentrations were measured by high-performance liquid chromatographic procedure with diode assay detection. Bioavailability was ...

journal_title：Therapeutic drug monitoring

authors： Tóth GG,Kloosterman C,Uges DR,Jonkman MF

更新日期：1999-10-01 00:00:00

abstract：:The immunosuppressive potential of mycophenolic acid (MPA) correlates well with MPA exposure [area under the concentration-time curve (AUC)]. Monitoring MPA AUC is important and helpful for maintaining the efficacy of mycophenolate mofetil while minimizing its side effects, but full MPA AUC monitoring is laborious, co...

journal_title：Therapeutic drug monitoring

authors： Zicheng Y,Xianghui W,Peijun Z,Da X,Weixia Z,Hongzhuan C

更新日期：2007-10-01 00:00:00

abstract：:Linezolid is an antibiotic used to treat infections caused by drug-resistant gram-positive organisms, including vancomycin-resistant Enterococcus faecium, multi-drug resistant Streptococcus pneumoniae, and methicillin-resistant Staphylococcus aureus. The adverse effects of linezolid can include thrombocytopenia and ne...

journal_title：Therapeutic drug monitoring

authors： Rao GG,Konicki R,Cattaneo D,Alffenaar JW,Marriott DJE,Neely M,IATDMCT Antimicrobial Scientific Committee.

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:This naturalistic therapeutic drug monitoring (TDM) study aimed to evaluate the relationship between dosage, serum concentration, and clinical outcome in children and adolescents treated with the serotonin reuptake inhibitor sertraline for different indications. METHODS:Steady-state trough serum concentratio...

journal_title：Therapeutic drug monitoring

authors： Taurines R,Burger R,Wewetzer C,Pfuhlmann B,Mehler-Wex C,Gerlach M,Egberts K

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:SB2, an infliximab (IFX) biosimilar to the reference infliximab (R.I.) product (Remicade), received approval in the European Union for all IFX indications. Many decision algorithms based on the measurement of IFX trough levels and antibodies to infliximab are being increasingly used to optimize IFX treatment...

journal_title：Therapeutic drug monitoring

authors： Jentzer A,Berger AE,Labetoulle R,Haccourt A,Roblin X,Paul S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Several factors such as low therapeutic index, large interindividual variability in systemic exposure, and the relationships between exposure and toxicity for sorafenib could justify its therapeutic drug monitoring (TDM). To support TDM, a selective and precise high-performance liquid chromatography with ult...

journal_title：Therapeutic drug monitoring

authors： Escudero-Ortiz V,Pérez-Ruixo JJ,Valenzuela B

更新日期：2014-06-01 00:00:00

abstract：:The authors report preliminary findings on the potential contribution of CYP2C19 isoenzyme to the human metabolism of N-desmethylclobazam (N-CLB), the main active metabolite of clobazam (CLB), a benzodiazepine frequently used as add-on therapy in patients with refractory epilepsy. Two children on CLB treatment showing...

journal_title：Therapeutic drug monitoring

authors： Contin M,Sangiorgi S,Riva R,Parmeggiani A,Albani F,Baruzzi A

更新日期：2002-12-01 00:00:00