Quantitation of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in plasma and cerebrospinal fluid using solid-phase extraction and high-performance liquid chromatography with electrochemical detection.

abstract：:The immunosuppressant mycophenolic acid (MPA) used for solid organ transplantation is predominantly metabolized to a pharmacologically inactive phenolic glucuronide (MPAG) and, to a lesser extent, to the pharmacologically active acyl glucuronide (AcMPAG). The recently introduced CEDIA Mycophenolic Acid Assay from Micr...

journal_title：Therapeutic drug monitoring

authors： Shipkova M,Schütz E,Besenthal I,Fraunberger P,Wieland E

更新日期：2010-02-01 00:00:00

abstract：:Phenytoin is an anticonvulsant that requires therapeutic drug monitoring. Recently, Bayer HealthCare, Diagnostics Division released a turbidimetric immunoassay of phenytoin on the ADVIA 1650 analyzer. We evaluated the analytic performance of this assay by comparing values obtained in 52 patients receiving Phenytoin us...

journal_title：Therapeutic drug monitoring

authors： Datta P,Scurlock D,Dasgupta A

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Hair analysis of ethyl glucuronide (EtG) has become, beside fatty acid ethyl ester, a valuable marker for the detection of moderate and chronic excessive alcohol consumption. So far, only few studies exist about the influence of cosmetic treatment on EtG content in hair. The aim of this study was to evaluate...

journal_title：Therapeutic drug monitoring

authors： Kerekes I,Yegles M

更新日期：2013-08-01 00:00:00

abstract：UNLABELLED:Oral fluid is an attractive alternative matrix for drug testing with a noninvasive and directly observed collection, but there are few controlled cocaine administration studies to guide interpretation. MATERIALS AND METHODS:While residing on a closed research unit for up to 10 weeks under constant medical s...

journal_title：Therapeutic drug monitoring

authors： Scheidweiler KB,Spargo EA,Kelly TL,Cone EJ,Barnes AJ,Huestis MA

更新日期：2010-10-01 00:00:00

abstract：:We describe the case of a pediatric patient on azathioprine therapy with previously undiagnosed homozygote thiopurine S-methyltransferase (TPMT) deficiency, resulting in myelotoxic thiopurine metabolite levels. The patient was successfully treated with a very low azathioprine dose of 50 mg once a week (4% of standard ...

journal_title：Therapeutic drug monitoring

authors： van Moorsel SA,Bevers N,Meurs M,van Rossum LK,Hooymans PM,Wong DR

更新日期：2017-02-01 00:00:00

abstract：:A sensitive method is described for the simultaneous determination of mebendazole and hydroxymebendazole using flubendazole as an internal standard. The analytes were isolated with a single chloroform extraction from 1.0 ml of alkalinized plasma or cyst liquid samples. Separation and quantitation were performed with h...

journal_title：Therapeutic drug monitoring

authors： Oosterhuis B,Wetsteyn JC,van Boxtel CJ

更新日期：1984-01-01 00:00:00

abstract：:Gabapentin is used in analgesic treatment of neuropathic pain, and large interindividual variation has been observed in the pharmacokinetics (PK) of the drug. The aim of this study was to develop a population PK model for gabapentin appropriate for monitoring patients with neuropathic pain and for individualizing thei...

journal_title：Therapeutic drug monitoring

authors： Carlsson KC,van de Schootbrugge M,Eriksen HO,Moberg ER,Karlsson MO,Hoem NO

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:The association of CYP3A5, CYP3A4, and ABCB1 single nucleotide polymorphisms (SNPs) with cyclosporine (CsA) pharmacokinetics is controversial. The authors studied the influence of these SNPs on CsA pharmacokinetics as well as on the incidence of biopsy-proven acute rejection (BPAR) and renal function after k...

journal_title：Therapeutic drug monitoring

authors： Bouamar R,Hesselink DA,van Schaik RH,Weimar W,Macphee IA,de Fijter JW,van Gelder T

更新日期：2011-04-01 00:00:00

abstract：:A simple high-performance liquid chromatography (HPLC) method for the determination of methotrexate (MTX) in biological fluids is described. The assay is rapid, the time required for analysis is less than 30 min, and it is sensitive, up to 0.01 microgram/ml, which is three times below the toxic MTX concentration. Fift...

journal_title：Therapeutic drug monitoring

authors： Najjar TA,Matar KM,Alfawaz IM

更新日期：1992-04-01 00:00:00

abstract：:The role of drug assays for screening, diagnosis, and guiding treatment decisions in overdose patients remains unclear. The use of drug concentration data in clinical toxicology research is more problematic, with studies using drug concentrations to simply confirm ingestion in observational studies or others report dr...

journal_title：Therapeutic drug monitoring

authors： Isbister GK

更新日期：2010-06-01 00:00:00

abstract：:A rapid and simultaneous determination of several analgesic antiinflammatory agents--ibuprofen, acetaminophen, indomethacin, and salicylic acid--in human serum was developed by using capillary zone electrophoresis (CZE) coupled with diode-array ultraviolet detection. After precipitation of serum protein with acetonitr...

journal_title：Therapeutic drug monitoring

authors： Makino K,Yano T,Maiguma T,Teshima D,Sendo T,Itoh Y,Oishi R

更新日期：2003-10-01 00:00:00

abstract：:The effect of nonlinear kinetics on the steady-state ratio of serum phenytoin (PHT) to total 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) was studied in epileptic patients. In each patient, the ratio increased in a nonlinear fashion in relation to both the PHT dose and the PHT serum level. Patients with longer appar...

journal_title：Therapeutic drug monitoring

authors： Bourgeois BF,Wad N

更新日期：1985-01-01 00:00:00

abstract：:A sensitive method for monitoring serum piroxicam (Feldene) is described. The assay requires 1.0 ml of specimen and involves chloroform extraction from an acidified mixture followed by concentration and injection into a liquid chromatograph. Column effluent is monitored at 330 nm. Retention times of piroxicam and the ...

journal_title：Therapeutic drug monitoring

authors： Fraser AD,Woodbury JF

更新日期：1983-06-01 00:00:00

abstract：:During once-daily dosing regimens of aminoglycosides, administration of large single doses results in high peak levels and low 24-h trough levels. However, commercial assays for monitoring aminoglycoside levels are designed to cover the smaller range of serum concentrations usually observed during multiple daily dosin...

journal_title：Therapeutic drug monitoring

authors： Blaser J,König C,Fatio R,Follath F,Cometta A,Glauser M

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Analysis of residual gene expression of the nuclear factor of activated T cell (NFAT)-regulated genes has been developed as a pharmacodynamic biomarker to monitor therapy with calcineurin inhibitors. The availability of commercial primer sets (Search-LC) and the well-established assay protocol makes this bio...

journal_title：Therapeutic drug monitoring

authors： Abdel-Kahaar E,Giese T,Sommerer C,Rieger H,Shipkova M,Wieland E

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Theophylline, a xanthine derivative drug, is used for the treatment of respiratory diseases, such as asthma, and is primarily eliminated by hepatic metabolism. There is marked interindividual variability in theophylline clearance. Therefore, the aim of this study was to evaluate the influence of chronic hepa...

journal_title：Therapeutic drug monitoring

authors： Kurata Y,Muraki S,Kashihara Y,Hirota T,Araki H,Ieiri I

更新日期：2020-12-01 00:00:00

abstract：:Several studies suggest that therapeutic drug monitoring of protease inhibitors and nonnucleoside reverse transcriptase inhibitors may contribute to the clinical outcome of HIV-infected patients. Because of the growing number of antiretroviral drugs and of drug combinations than can be administered to these patients, ...

journal_title：Therapeutic drug monitoring

authors： Poirier JM,Robidou P,Jaillon P

更新日期：2005-04-01 00:00:00

abstract：:One tablet containing 755 mg of lithium tryptophanate (10.8 mEq of lithium) was administered to eight healthy volunteers. The main pharmacokinetic parameters for the group of subjects were estimated. Pharmacokinetic parameters (mean +/- SD) from plasma and saliva were respectively: half life (t1/2) 17 +/- 6 vs. 21.8 +...

journal_title：Therapeutic drug monitoring

authors： Obach R,Borja J,Pruñonosa J,Vallès JM,Torrent J,Izquierdo I,Jané F

更新日期：1988-01-01 00:00:00

abstract：:The authors report a case that offers insight into the diagnostic challenges of "Munchausen Syndrome by Proxy." Initial presentation with history of fever and later with intractable vomiting led to invasive and expensive diagnostic evaluation before confirming the diagnosis. Certain toxic effects of emetine were clini...

journal_title：Therapeutic drug monitoring

authors： Bader AA,Kerzner B

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:The efficacy of drugs for the treatment of substance-related disorders is moderate at best. Therapeutic drug monitoring (TDM) could be an instrument to improve outcomes. Because TDM for most of those drugs is not established, the authors reviewed the literature and built a rating scale to detect the potentia...

journal_title：Therapeutic drug monitoring

authors： Brünen S,Vincent PD,Baumann P,Hiemke C,Havemann-Reinecke U

更新日期：2011-10-01 00:00:00

abstract：:The effect of mycophenolic acid (MPA) in combination with either cyclosporine (CsA) or tacrolimus (TRL) on whole-blood lymphocyte function was assessed in vitro as well as in vivo. For the in vitro studies, rat whole blood was incubated with different concentrations of MPA together with CsA or TRL. In vivo, rats (n = ...

journal_title：Therapeutic drug monitoring

authors： Barten MJ,Shipkova M,Bartsch P,Dhein S,Streit F,Tarnok A,Armstrong VW,Mohr FW,Oellerich M,Gummert JF

更新日期：2005-04-01 00:00:00

abstract：:The effect of heparin sodium on the assay of gentamicin using the fluorescence polarization immunoassay system was investigated with varying heparin and gentamicin concentrations. Heparin had no significant effect on gentamicin concentrations as measured by this system. ...

journal_title：Therapeutic drug monitoring

authors： Jackson DS,Bertino JS Jr

更新日期：1984-01-01 00:00:00

abstract：:The clinical correlates of methylphenidate blood levels in hyper-active children and normal adults were examined in five studies. Although occasional correlations between blood levels and neuroendocrine response were noted within subjects along the pharmacokinetic time profile of the drug, no significant associations ...

journal_title：Therapeutic drug monitoring

authors： Gualtieri CT,Hicks RE,Patrick K,Schroeder SR,Breese GR

更新日期：1984-01-01 00:00:00

abstract：:A stabilized therapeutic drug monitoring procedure incorporating the novel Empore solid-phase extraction membrane (SPEM) for isolation of the antiarrhythmic drugs mexiletine (MEX) and flecainide (FLEC) from serum is described. Routinely, serum (0.5 ml), adjusted to pH 4.5, is passed through an octyl (C8) SPEM to extra...

journal_title：Therapeutic drug monitoring

authors： Lensmeyer GL,Wiebe DA,Doran TC

更新日期：1992-10-01 00:00:00

abstract：:The evaluation of a radioimmunoassay (RIA) for the monitoring of cyclosporine (CSA) that utilizes a monoclonal antibody specific for the parent compound is described. The assay exhibited good analytical recovery (greater than 95%), precision (coefficient of variation less than 10%), and linearity in plasma and whole b...

journal_title：Therapeutic drug monitoring

authors： Copeland KR,Yatscoff RW

更新日期：1988-01-01 00:00:00

abstract：:Plasma levels of haloperidol were monitored in children and teenagers suffering from psychotic episodes and/or abnormal movements (tics and Gilles de la Tourette's syndrome). Steady-state concentrations of haloperidol ranged from 0.7 to 19 ng/ml without any apparent relationship with the administered dose (15--285 mic...

journal_title：Therapeutic drug monitoring

authors： Morselli PL,Bianchetti G,Durand G,Le Heuzey MF,Zarifian E,Dugas M

更新日期：1979-01-01 00:00:00

abstract：:An accurate and specific liquid chromatographic method for the separation and analysis of the R(+) and S(-) enantiomers of both aminoglutethimide (AG) and its acetylated metabolite (AcAG) in plasma, saliva, and urine is described. The separation was achieved by use of two serial Chiralcel OD columns [cellulose tris(3,...

journal_title：Therapeutic drug monitoring

authors： Alshowaier IA,el-Yazigi A,Ezzat A,el-Warith AA,Nicholls PJ

更新日期：1995-10-01 00:00:00

abstract：:An epileptic patient well controlled on valproic acid (VPA) developed a prolonged episode of status epilepticus 12 days after initiation of 75 mg of clomipramine (CMI) to treat depression. Serum level of VPA in the emergency room was unchanged from her previous levels; serum level of CMI was very elevated despite the ...

journal_title：Therapeutic drug monitoring

authors： DeToledo JC,Haddad H,Ramsay RE

更新日期：1997-02-01 00:00:00

abstract：:The development of inexpensive in-house reagents for the assay of carbamazepine in serum, using a commercially available derivative and antiserum is described. They were adapted for use on the Abbott TDx as direct replacements for commercial reagents. Comparison with a high-performance liquid chromatography method is ...

journal_title：Therapeutic drug monitoring

authors： Colbert DL,Turner GJ

更新日期：1993-06-01 00:00:00

abstract：:An analysis of pH-induced changes of drug binding may contribute to the understanding of the mechanisms involved and the clinical relevance. A literature search was performed, and acceptance criteria set up, to select reported data for quantitative evaluation. The relationship between percentage of unbound drug, fu, a...

journal_title：Therapeutic drug monitoring

authors： Hinderling PH,Hartmann D

更新日期：2005-02-01 00:00:00