当前位置： SCI文献检索 > JOURNAL OF BONE AND MINERAL METABOLISM期刊下所有文献 > Nonenzymatic collagen cross-links induced by glycoxidation (pentosidine) predicts vertebral fractures.

Nonenzymatic collagen cross-links induced by glycoxidation (pentosidine) predicts vertebral fractures.

Abstract：

:Advanced glycation end products (AGE) in collagen have been reported to decrease the mechanical property of bone. However, there are no available data on the relation between fracture risk and levels of glycoxidative (nonenzymatic) cross-links of collagen in clinical samples. A total of 432 Japanese elderly women who were not receiving any drug treatment for osteoporosis were selected and followed for 5.2 +/- 3.3 (mean +/- SD) years for this observational study. Vertebral fractures and bone mineral density were assessed at baseline and then at 1- to 2-year intervals or at indication of any symptom. Two types of collagen metabolites were measured at baseline: urinary N-terminal telopeptide of type I collagen (NTX), a marker of pyridinium cross-link, and urinary pentosidine, a nonenzymatic collagen cross-link produced by AGEs. A total of 97 incident vertebral fractures on 72 subjects were observed. Simple regression analysis using Cox's hazards model showed that log-transformed urinary NTX and pentosidine are significant risk factors for time-dependent incidence of vertebral fractures, in addition to the traditional risk factors (age, lumbar bone mineral density, and number of prevalent vertebral fractures). However, urinary excretion of pentosidine (hazard ratio, 1.33; 95% CI, 1.01-1.76, P = 0.04) was a significant predictor of incident vertebral fracture after adjustment for other traditional risk factors. The present data suggest that AGE-related collagen cross-link is a novel risk for vertebral fracture.

journal_name

J Bone Miner Metab

journal_title

Journal of bone and mineral metabolism

authors

Shiraki M,Kuroda T,Tanaka S,Saito M,Fukunaga M,Nakamura T

doi

10.1007/s00774-007-0784-6

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

93-100

issue

1

eissn

0914-8779

issn

1435-5604

journal_volume

26

pub_type

杂志文章

相关文献

JOURNAL OF BONE AND MINERAL METABOLISM文献大全
  • Absolute height reduction and percent height ratio of the vertebral body in incident fracture in Japanese women.

    abstract：:Vertebral fractures are the most common complication associated with osteoporosis. The definition of prevalent or incident vertebral fractures is important in epidemiological evaluation and in clinical trials of osteoporosis treatment. There have been few reports regarding the morphometric cutoff criteria for incident...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-003-0457-z

    authors： Fukunaga M,Nakamura T,Shiraki M,Kuroda T,Ohta H,Hosoi T,Orimo H

    更新日期：2004-01-01 00:00:00

  • Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice.

    abstract：:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-010-0202-3

    authors： Yao GQ,Wu JJ,Troiano N,Insogna K

    更新日期：2011-03-01 00:00:00

  • Fructooligosaccharides prevent disorders of the femoral neck following gastrectomy in growing rats.

    abstract：:Gastrectomy-evoked osteopenia in the femoral metaphysis of rats can be prevented by the consumption of fructooligosaccharides (FOS). We examined the effect of FOS on the femoral neck. Twenty-eight 5-week-old male Sprague-Dawley rats were divided into two groups, sham-operated (SH) and gastrectomized (GX). One week aft...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-003-0423-9

    authors： Hirama Y,Morohashi T,Sano T,Maki K,Ohta A,Sakai N,Yamada S,Sasa R

    更新日期：2003-01-01 00:00:00

  • Bone microstructure is significantly altered in CRPS-affected distal tibiae as detected by HR-pQCT: a retrospective cross-sectional study.

    abstract：:In the course of complex regional pain syndrome (CRPS), local osteopenia in the subchondral/subcortical areas of the affected limb represents a central manifestation. Mechanistic aspects of CRPS-associated pathologies remain unclear, and knowledge about bone morphology in CRPS-affected areas is rare. The aim of this s...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-018-0976-2

    authors： Oehler N,Rolvien T,Schmidt T,Butscheidt S,Oheim R,Barvencik F,Mussawy H

    更新日期：2019-07-01 00:00:00

  • Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese.

    abstract：:In this study, we tested the interleukin-6 (IL-6) gene as an important candidate gene for its linkage and association with the variation of bone phenotypes (bone mineral density [BMD] and bone size) in young Chinese female subjects. We genotyped the IL-6 gene at the -634C/G restriction fragment length polymorphism (RF...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-004-0607-y

    authors： Lei SF,Liu YZ,Deng FY,Li YM,Li MX,Deng HW

    更新日期：2005-01-01 00:00:00

  • Assessment of adherence to treatment of postmenopausal osteoporosis with raloxifene and/or alfacalcidol in postmenopausal Japanese women.

    abstract：:Patients who are diagnosed with osteoporosis and beginning treatment often discontinue their osteoporosis medication relatively early after the start of treatment because of their poor recognition of fracture risk and the asymptomatic nature of osteoporosis. In this study we aimed to assess adherence to treatment with...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-009-0112-4

    authors： Gorai I,Tanaka Y,Hattori S,Iwaoki Y

    更新日期：2010-03-01 00:00:00

  • MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis.

    abstract：:Osteoarthritis is an aging-related degenerative disease that severely influences the elders' life quality. However, there have been few clinical approaches available until now. Currently, more knowledge of the pathology of osteoarthritis has been illustrated. Especially, diabetes can be the only predictor of osteoarth...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,评审

    doi：10.1007/s00774-014-0628-0

    authors： Jingsheng S,Yibing W,Jun X,Siqun W,Jianguo W,Feiyan C,Gangyong H,Jie C

    更新日期：2015-01-01 00:00:00

  • Alfacalcidol treatment increases bone mass from anticatabolic and anabolic effects on cancellous and cortical bone in intact female rats.

    abstract：:It has been reported that alfacalcidol had an anticatabolic and anabolic effect on bone in ovariectomized and aged male rat models, but this has not been tested on intact female rats. The current study was to determine the effects of alfacalcidol on cancellous and cortical bone in intact female rats with or without ex...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-008-0854-4

    authors： Liu XQ,Chen HY,Tian XY,Setterberg RB,Li M,Jee WS

    更新日期：2008-01-01 00:00:00

  • Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice.

    abstract：:Nitrogen-containing bisphosphonates such as zoledronic acid (ZOL) and pamidronate have been widely and successfully used for the treatment of cancer patients with bone metastases and/or hypercalcemia. Accumulating recent reports have shown that cancer patients who have received these bisphosphonates occasionally manif...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-009-0128-9

    authors： Kobayashi Y,Hiraga T,Ueda A,Wang L,Matsumoto-Nakano M,Hata K,Yatani H,Yoneda T

    更新日期：2010-03-01 00:00:00

  • A significant induction of neutrophilic chemoattractants but not RANKL in synoviocytes stimulated with interleukin 17.

    abstract：:Interleukin 17 (IL-17) is a cytokine implicated in the promotion of osteoclastogenesis. Its effect has been believed not to be directly exerted on osteoclast precursors, but rather indirectly carried out via an induction of receptor activator of NF-κB ligand (RANKL), the osteoclast differentiation factor, on osteoclas...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-014-0565-y

    authors： Ota M,Yanagisawa M,Tachibana H,Yokota K,Araki Y,Sato K,Mimura T

    更新日期：2015-01-01 00:00:00

  • Hindlimb-unloading suppresses B cell population in the bone marrow and peripheral circulation associated with OPN expression in circulating blood cells.

    abstract：:Rodent hindlimb unloading (HU) by tail-suspension is a model to investigate disuse-induced bone loss in vivo. Previously, we have shown that osteopontin (OPN, also known as Spp1) is required for unloading-induced bone loss. However, how unloading affects OPN expression in the body is not fully understood. Here, we exa...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-014-0568-8

    authors： Ezura Y,Nagata J,Nagao M,Hemmi H,Hayata T,Rittling S,Denhardt DT,Noda M

    更新日期：2015-01-01 00:00:00

  • Identification of the CLCN7 gene mutations in two Chinese families with autosomal dominant osteopetrosis (type II).

    abstract：:Here we report the identification of two different mutations in chloride channel 7 gene in two unrelated patients with autosomal dominant osteopetrosis type II. We determined that one patient (a 32-year-old woman) carried a heterozygous gene for a R767W mutation in exon 24, and another patient (a 17-year-old boy) carr...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-009-0051-0

    authors： Zhang ZL,He JW,Zhang H,Hu WW,Fu WZ,Gu JM,Yu JB,Gao G,Hu YQ,Li M,Liu YJ

    更新日期：2009-01-01 00:00:00

  • Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis.

    abstract：:The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics of the 194 female patients included in the study were 183 postmenopausal, age 6...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00774-017-0861-4

    authors： Ebina K,Hirao M,Hashimoto J,Hagihara K,Kashii M,Kitaguchi K,Matsuoka H,Iwahashi T,Chijimatsu R,Yoshikawa H

    更新日期：2018-07-01 00:00:00

  • A pilot investigation of load-carrying on the head and bone mineral density in premenopausal, black African women.

    abstract：:Although the influence of weight-bearing activity on bone mass has been widely investigated in white women, few studies have been conducted in black, African populations. We investigated bone mineral density (BMD) in black South African women, with and without a history of load-carrying on the head. We also investigat...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-009-0113-3

    authors： Lloyd R,Hind K,Micklesfield LK,Carroll S,Truscott JG,Parr B,Davies S,Cooke C

    更新日期：2010-03-01 00:00:00

  • Millimeter wave promotes the synthesis of extracellular matrix and the proliferation of chondrocyte by regulating the voltage-gated K+ channel.

    abstract：:Previously, we reported that millimeter wave promoted the chondrocyte proliferation by pushing cell cycle progression. Activation of K(+) channels plays an essential role in the stimulating of extracellular matrix (ECM) synthesis and the cell proliferation in chondrocytes. While it is unclear if millimeter wave enhanc...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0513-2

    authors： Li X,Liu C,Liang W,Ye H,Chen W,Lin R,Li Z,Liu X,Wu M

    更新日期：2014-07-01 00:00:00

  • High prevalence of spine–femur bone mineral density discordance and comparison of vertebral fracture risk assessment using femoral neck and lumbar spine bone density in Korean patients.

    abstract：:The aim of this study was to evaluate the prevalence of spine–femur discordance, and to compare the effectiveness of femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) for estimation of the risk of vertebral fractures. Women who were evaluated with dual energy X-ray absorptiometry between January 2001 ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0512-3

    authors： Seok H,Kim KJ,Kim KM,Rhee Y,Cha BS,Lim SK

    更新日期：2014-07-01 00:00:00

  • Effect of alendronate on bone mineral density and bone turnover in Thai postmenopausal osteoporosis.

    abstract：:Alendronate has recently been approved for the prevention and treatment of postmenopausal osteoporosis, and its efficacy has been demonstrated in many Western countries. Our present study was performed to evaluate the effect of alendronate on bone mineral density (BMD) and its tolerability in Thais. Eighty postmenopau...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00774-003-0438-2

    authors： Chailurkit LO,Jongjaroenprasert W,Rungbunnapun S,Ongphiphadhanakul B,Sae-tung S,Rajatanavin R

    更新日期：2003-01-01 00:00:00

  • Evaluating spine micro-architectural texture (via TBS) discriminates major osteoporotic fractures from controls both as well as and independent of site matched BMD: the Eastern European TBS study.

    abstract：:The aim of the study was to assess the clinical performance of the model combining areal bone mineral density (aBMD) at spine and microarchitecural texture (TBS) for the detection of the osteoporotic fracture. The Eastern European Study is a multicenter study (Serbia, Bulgaria, Romania and Ukraine) evaluating the role...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00774-013-0529-7

    authors： Vasic J,Petranova T,Povoroznyuk V,Barbu CG,Karadzic M,Gojkovic F,Elez J,Winzenrieth R,Hans D,CulaficVojinovic V,Poiana C,Dzerovych N,Rashkov R,Dimic A

    更新日期：2014-09-01 00:00:00

  • Higher response with bone mineral density increase with monthly injectable ibandronate 1 mg compared with oral risedronate in the MOVER study.

    abstract：:We examined response to bone mineral density (BMD) gains in the MOVER study following treatment with intravenous (IV) ibandronate 1 mg/month, and investigated the characteristics of a non-responder group. At 1 year, responder rates for patients with BMD increases >0 % were similar with IV ibandronate 0.5 or 1 mg/month...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-015-0717-8

    authors： Nakano T,Yamamoto M,Hashimoto J,Tobinai M,Yoshida S,Nakamura T

    更新日期：2016-11-01 00:00:00

  • Hypophosphatemic rickets accompanying McCune-Albright syndrome: evidence that a humoral factor causes hypophosphatemia.

    abstract：:McCune-Albright syndrome (MAS) is sometimes complicated by hypophosphatemia. However, it remains unclear whether a humoral factor is associated with the cause of hypophosphatemia. We isolated cells with mutations of the Gsalpha gene from fibrous bone dysplasia tissues of two MAS patients (MAS cells). Severe combined i...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740170012

    authors： Yamamoto T,Miyamoto KI,Ozono K,Taketani Y,Katai K,Miyauchi A,Shima M,Yoshikawa H,Yoh K,Takeda E,Okada S

    更新日期：2001-01-01 00:00:00

  • Bone mineral density and bone microarchitecture after long-term suppressive levothyroxine treatment of differentiated thyroid carcinoma in young adult patients.

    abstract：:Bone mineral density (BMD) seems not to be decreased in young patients given long-term suppressive doses of levothyroxine (LT4), but information regarding the bone microstructure in these patients is lacking. The aim of this study was to determine whether supraphysiologic doses of LT4, initiated during childhood or ad...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00774-015-0680-4

    authors： Mendonça Monteiro de Barros G,Madeira M,Vieira Neto L,de Paula Paranhos Neto F,Carvalho Mendonça LM,Corrêa Barbosa Lima I,Corbo R,Fleiuss Farias ML

    更新日期：2016-07-01 00:00:00

  • Alendronate treatment promotes bone formation with a less anisotropic microstructure during intramembranous ossification in rats.

    abstract：:There are safety concerns regarding administration of bisphosphonates to children. Little is known about the effects of bisphosphonates on bone matrix organization during bone modeling. The present study examined the effects of alendronate (ALN) on bone matrices formed by intramembranous ossification in the appendicul...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-007-0782-8

    authors： Kashii M,Hashimoto J,Nakano T,Umakoshi Y,Yoshikawa H

    更新日期：2008-01-01 00:00:00

  • The influence of the sensory neurotransmitter calcitonin gene-related peptide on bone marrow mesenchymal stem cells from ovariectomized rats.

    abstract：:In order to explore the effects of calcitonin gene-related peptide (CGRP) on bone mesenchymal stem cells (BMSCs) from ovariectomized (OVX) rats, an OVX rat model was used. An ELISA was performed to examine the changes in CGRP level in the plasma and skeleton. The BMSCs from the sham rats were designated group A. The B...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-016-0780-9

    authors： Chen J,Ma G,Liu W,Liu Y,Ding Y

    更新日期：2017-09-01 00:00:00

  • Prospective, mono-institutional study of the impact of a systematic prevention program on incidence and outcome of osteonecrosis of the jaw in patients treated with bisphosphonates for bone metastases.

    abstract：:The aim of our study was to investigate the occurrence of osteonecrosis of the jaw (ONJ) after implementation of dental preventive measures before starting bisphosphonates (BPs) therapy and during treatment. All consecutive patients with bone lesions eligible for BPs treatment were prospectively evaluated. Before star...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-014-0566-x

    authors： Bramati A,Girelli S,Farina G,Dazzani MC,Torri V,Moretti A,Piva S,Dimaiuta M,La Verde N

    更新日期：2015-01-01 00:00:00

  • Low serum 25-hydroxyvitamin D is associated with low grip strength in an older Japanese population.

    abstract：:Positive associations between vitamin D levels and hand grip strength have been reported worldwide, but the results are not consistent and few studies on East Asian populations have been published. The aim of this study was to determine whether such an association is present in a community-dwelling Japanese population...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-019-01040-w

    authors： Kitsu T,Kabasawa K,Ito Y,Kitamura K,Watanabe Y,Tanaka J,Nakamura K,Narita I

    更新日期：2020-03-01 00:00:00

  • Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis.

    abstract：:We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-016-0736-0

    authors： Hoffmann DB,Sehmisch S,Hofmann AM,Eimer C,Komrakova M,Saul D,Wassmann M,Stürmer KM,Tezval M

    更新日期：2017-01-01 00:00:00

  • Vitamin K(2) (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis.

    abstract：:Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK(4) group received calcium with menaquinone 4 (MK(4)) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and under...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s007740300025

    authors： Miki T,Nakatsuka K,Naka H,Kitatani K,Saito S,Masaki H,Tomiyoshi Y,Morii H,Nishizawa Y

    更新日期：2003-01-01 00:00:00

  • Peripheral computed tomography (pQCT) detected short-term effect of AAACa (heated oyster shell with heated algal ingredient HAI): a double-blind comparison with CaCO3 and placebo.

    abstract：:Trabecular bone density at the distal radius and cortical bone density at the midradius were measured in four randomized groups of women before and after 4 months administration of AAACa, oyster shell heated under reduced pressure with addition of heated algal ingredient (HAI) (group A); AACa, the same preparation wit...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s007740070022

    authors： Fujita T,Fujii Y,Goto B,Miyauchi A,Takagi Y

    更新日期：2000-01-01 00:00:00

  • Changes in serum levels of biochemical markers of bone turnover during 10 years among Japanese men and women: associated factors and birth-cohort effect. The Taiji Study.

    abstract：:We aimed to clarify changes in biochemical markers of bone turnover (BTMs) over 10 years, associations with changes in bone mineral density (BMD), and birth-cohort effects in a Japanese community. We randomly selected 400 individuals (age, 40-79 years; 50 of each gender and age stratum) from a list of registered resid...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-011-0266-8

    authors： Yoshimura N,Muraki S,Oka H,Kawaguchi H,Nakamura K,Akune T

    更新日期：2011-11-01 00:00:00

  • Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis.

    abstract：:Syndecans are single-pass integral membrane components that serve as co-receptors for growth factors and cytokines and can elicit signal transduction via their cytoplasmic tails. We review here previous studies from our groups on syndecan-3 biology and function in the growth plates of developing long bones in chick an...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,评审

    doi：10.1007/s00774-004-0584-1

    authors： Pacifici M,Shimo T,Gentili C,Kirsch T,Freeman TA,Enomoto-Iwamoto M,Iwamoto M,Koyama E

    更新日期：2005-01-01 00:00:00