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Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese.

Abstract：

:In this study, we tested the interleukin-6 (IL-6) gene as an important candidate gene for its linkage and association with the variation of bone phenotypes (bone mineral density [BMD] and bone size) in young Chinese female subjects. We genotyped the IL-6 gene at the -634C/G restriction fragment length polymorphism (RFLP) site (ID, RS1800796) in 1263 individuals from 402 Chinese nuclear families, composed of both parents and at least one healthy daughter (mean age +/- SD, 31.4 +/- 5.8 years). Using the daughters' bone phenotypes, we tested total-family association, within-family association (via transmission disequilibrium test, [TDT]), and linkage, between the -634C/G marker and bone phenotypes at the spine and the hip. No significant association or linkage was found for bone size and BMD, although a trend was observed for linkage between the IL-6 gene -634C/G marker and L1-4 spinal BMD (adjusted for age, weight, and height). Our results, together with the findings from other studies, indicate that the IL-6 gene, although important for postmenopausal bone loss, may have a limited impact on peak bone mass variation in a Chinese population.

journal_name

J Bone Miner Metab

journal_title

Journal of bone and mineral metabolism

authors

Lei SF,Liu YZ,Deng FY,Li YM,Li MX,Deng HW

doi

10.1007/s00774-004-0607-y

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

323-8

issue

4

eissn

0914-8779

issn

1435-5604

journal_volume

23

pub_type

杂志文章

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