Abstract:
PURPOSE:This study determined the dose-response effects of inhaled salbutamol (SAL) on time-trial performance and urine concentrations of SAL (cSAL). METHODS:Nonasthmatic, trained male cyclists and triathletes (N = 37) were studied. Day 1 consisted of screening for airway hyperresponsiveness, using a eucapnic voluntary hyperpnea test (EVH), followed by an incremental exercise test to determine V O 2max and peak power (P max). On days 2-5, athletes performed a 20-km time trial 15 min after inhalation (PI) of placebo, 200 microg (D2), 400 microg (D4), or 800 microg (D8) of SAL. At 60 min PI, urine samples were provided. All conditions were randomized and double blinded, with repeated-measures ANOVA used to determine effects of dose. Post hoc analysis was done with Tukey's HSD test. RESULTS:Seven subjects had positive responses to the EVH test, resulting in a 19% incidence within this sample; they were excluded from further participation in this study. The remaining subjects (N = 30) had a V O 2max of 67.1 (4.3) mL x kg(-1) x min(-1) and Pmax of 457 (31) W (W). There was no effect of dose on completion time (P > 0.05), mean power (P > 0.05), or mean heart rate (P > 0.05). Similarly, SAL had no effect on any metabolic or ventilatory parameters (P > 0.05). Urine cSAL increased with dose and was highly variable, with the peak value observed being 831 ng x mL(-1) after a dose of 800 microg. Moderate but significant correlations were noted between cSAL and urine specific gravity at higher doses (D4, r = 0.42; D8, r = 0.37). CONCLUSIONS:These findings suggest that inhaled SAL does not enhance time-trial performance, regardless of dose, and that urine cSAL after exercise is related to dose, demonstrates high variability, and is partially related to hydration status.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Sporer BC,Sheel AW,McKenzie DCdoi
10.1249/mss.0b013e3181591df7subject
Has Abstractpub_date
2008-01-01 00:00:00pages
149-57issue
1eissn
0195-9131issn
1530-0315journal_volume
40pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Because physical activity researchers are increasingly using objective portable devices, this review describes the current state of the technology to assess physical activity, with a focus on specific sensors and sensor properties currently used in monitors and their strengths and weaknesses. Additional sens...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1249/MSS.0b013e3182399bc8
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Low lean mass (LM) is a risk factor for chronic disease, a major cause of disability and diminished quality of life, and is a heritable trait. However, relatively few specific genetic factors have been identified as potentially influencing this trait. METHODS:In this study, we selected 1493 single-nucleot...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000889
更新日期:2016-07-01 00:00:00
abstract::This study examined the association between aerobic, caloric exercise expenditure and life status (living vs deceased) as well as the prevalence rates of hypertension (HBP) and cardiovascular disease (CVD) in former male athletes (ATH) and non-athletes (N-ATH). The initial survey for this study was done in 1952. Follo...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-199012000-00002
更新日期:1990-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to provide baseline data on immune status of exercising and sedentary exclusively lactating women. Dietary intake and body composition were also investigated to determine whether they related to immune function. METHODS:Healthy, exclusively breastfeeding women with a body mass ind...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000128245.39808.36
更新日期:2004-06-01 00:00:00
abstract:UNLABELLED:Considerable evidence suggests regular physical activity can reduce chronic pain symptoms. The dysfunction of endogenous facilitatory and inhibitory systems has been implicated in multiple chronic pain conditions. However, few studies have investigated the relationship between levels of physical activity and...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3182a69cf1
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:This study evaluated the factorial validity of a self-report measure of concussion-related symptom severity among a large sample of male, high-school athletes. METHODS:Participants (N = 1089) were nonconcussed, male, high-school football players. All participants completed a single baseline self-report measure...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000183186.98212.d5
更新日期:2006-01-01 00:00:00
abstract::Anaerobic ATP production in skeletal muscle and the accumulated oxygen deficit (O2D) incurred during an exhaustive cycle bout (duration = 173 +/- 24 s; intensity = 112 +/- 3% VO2peak), were determined in 10 male cyclists (mean +/- SD: VO2peak = 69.8 +/- 4.2 ml.kg-1.min-1). Anaerobic ATP production (mmol.kg-1 d.w.) was...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199603000-00007
更新日期:1996-03-01 00:00:00
abstract::Ten pairs of monozygotic twins of both sexes were submitted to a 20-wk endurance-training program, four and five times per week, 40 min per session, at an average of 80% of the maximal heart rate reserve. Testing and training were performed on cycle ergometers. Maximal aerobic power (MAP in ml O2 X min-1 X kg-1) and v...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198410000-00012
更新日期:1984-10-01 00:00:00
abstract:PURPOSE:Heart rate (HR) is widely used to adjust exercise intensity in aerobic training. Training HR recommendations are calculated often from simple equations. Because at lactate steady state (LASS) may be an intensity of exercise eliciting similar objective measures of intensity and similar subjective measures of met...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200205000-00024
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:The importance of the brain in sports was recently confirmed by the negative effect of mental fatigue (MF) on sport-specific psychomotor skills. Creatine supplementation improves strength but can also improve cognitive functioning. To explore the role of creatine in combating MF, we evaluated whether creatine s...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000002122
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:This study aimed to establish whether time spent in sport-related physical activities and sedentary behaviors (e.g., TV viewing, videogame usage, and homework) was prospectively associated with change in blood pressure (BP) for 5 yr. METHODS:Eight hundred and twenty-one students age 6 yr at baseline (397 girls...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000166
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare architectural characteristics of leg muscles of sprinters and distance runners. METHODS:Skeletal muscle architectural characteristics were studied in 23 elite male 100-m sprinters (SPR, 10.0-10.9 s for 100 m), 24 elite male distance runners (DR, 13.5-14.5 min for 5000 m...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200006000-00014
更新日期:2000-06-01 00:00:00
abstract:PURPOSE:Objective measurement with body worn instrumentation is a preferred and increasingly common way to gather information about young people's physical activity. Measured samples have been typically small and recruited through schools. The purpose of this article was to present the descriptive epidemiology of child...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181d58a92
更新日期:2010-09-01 00:00:00
abstract::We investigated the breath-by-breath pattern of ventilatory response to bicycle exercise in seven elite male cyclists (VO2max = 71.7 ml X min-1 X kg-1) and ten sedentary males (VO2max = 47.3 ml X min-1 X kg-1) to analyze differences in breathing patterns between individuals with normal and high exercise ventilations (...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Relatively few studies have assessed the prospective relationship of sedentary lifestyle and coronary heart disease (CHD) in women. We performed a nested case-control study, identifying 50 cases of acute CHD in women and 150 age-matched controls. Risk factors including sedentary lifestyle, cigarette smoking, hypertens...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract:PURPOSE AND METHODS:It is commonly recognized that there is familial aggregation for physical activity level. However, the genes and sequence variants responsible for the familial clustering have not been investigated. We performed a genome-wide linkage scan based on 432 markers typed in 767 subjects from 207 families ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000078937.22939.7E
更新日期:2003-08-01 00:00:00
abstract::Hydrostatic weighing (HW) was performed at residual volume (RV) and total lung capacity without head submersion (TLCNS). Ninety-five males (25.6 +/- 4.9 yr) and 87 females (22.6 +/- 5.2 yr) were studied at two laboratory sites using identical protocols. Twenty males and 20 females were separated from the original grou...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1249/00005768-198802000-00010
更新日期:1988-02-01 00:00:00
abstract::Acute and chronic positive mood changes have been said to occur with running and jogging. It has been suggested that endogenous substances with opioid activity (endorphins) may serve as modulators of mood. The authors report experiments in which mood changes associated with long-distance running were measured by pre- ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198201000-00002
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:The development of valid measures of built environments relevant for physical activity is an important step toward controlling the global epidemic of physical inactivity-related noncommunicable diseases and deaths. This study assessed the construct validity of a self-report neighborhood environment walkability ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001131
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:An augmented pulmonary artery wedge pressure (PAWP) response may explain exercise intolerance in some humans. However, routine use of exercise hemodynamic testing is limited by a lack of data from normal older men and women. Our objective was to evaluate the exercise PAWP response and the potential for sexual d...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001227
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:The objectives of the present study were to examine gender differences and between-day variability of isometric hamstring muscle peak torque and perceived exertion. METHODS:Subjects included 20 healthy, college-aged male (N = 10) and female (N = 10) volunteers. Each subject completed five maximal voluntary iso...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1249/01.MSS.0000089246.90005.47
更新日期:2003-10-01 00:00:00
abstract:PURPOSE:The main purpose of the present study was to measure the total oxygen consumed, accumulation of blood metabolites, and performance during alternating intensity exercise before and after a period of creatine (Cr) loading in well-trained humans. METHODS:Fourteen males were randomly assigned to two groups of seve...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200002000-00018
更新日期:2000-02-01 00:00:00
abstract::In 1983 a representative sample of Danish adolescents 16-19 yr of age were selected to participate in a study to determine risk profile for coronary heart disease. Eight years later (1991), we performed a follow-up study of the same participants 23-27 yr of age to compare risk factors. In the young adults power was ge...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::The purpose of this study was to determine the feasibility of using a 6" digital caliper and a 20x viewing microscope to measure hematocrit (HCT) from microhematocrit tubes. The reliability and validity of the digital caliper technique (DC) was simultaneously compared with that of the conventional "turntable" style mi...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract:PURPOSE:The aim of this study was to test whether a tidally ventilated homogeneous lung model can correctly describe arterial and end-tidal gas partial pressures and thus the difference in end-tidal and arterial gas partial pressures at rest and during exercise. METHODS:The implemented mathematical modeling described ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200204000-00010
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:Fit individuals with metabolic syndrome (MetS) have lower mortality risk compared with less fit counterparts, despite the presence of obesity as a component of the syndrome. To understand the importance of fitness in treating this condition, we examined the association of fitness and fatness with central hemody...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000916
更新日期:2016-08-01 00:00:00
abstract::Although low back pain (LBP) is a widespread and disabling health problem, there is a lack of evidence based medicine with respect to its treatment and rehabilitation. A major reason for this is the poor understanding of the underlying mechanisms of the LBP syndromes. In an attempt to fill this gap, the present review...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-200111000-00014
更新日期:2001-11-01 00:00:00
abstract::Acute bouts of aerobic exercise have been consistently associated with significant reductions in anxiety, but explanations for this effect remain elusive. The cerebral lateralization hypothesis predicts that anxiety reductions would be caused by a postexercise decrease in anterior right, relative to left, hemisphere a...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract:PURPOSE:The fluctuations in force during a steady contraction can be influenced by age, vision, and level of physiological arousal. The aim of this study was to determine the effects of a stressor on the force fluctuations and information transmission exhibited by young, middle-aged, and older adults when a pinch-grip ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000178103.72988.cd
更新日期:2005-12-01 00:00:00
abstract:PURPOSE:To evaluate the relations between %HRmax, %HRR, %VO2max, and %VO2R in elite cyclists and to check whether the intensity scale recommended by ACSM in its 1998 position stand is also applicable to this specific population. METHODS:Twenty-six male elite road cyclists (25.1 +/- 0.7 yr, 71.0 +/- 1.2 kg, 70.9 +/- 1....
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000246996.63976.5f
更新日期:2007-02-01 00:00:00