Abstract:
INTRODUCTION:Low lean mass (LM) is a risk factor for chronic disease, a major cause of disability and diminished quality of life, and is a heritable trait. However, relatively few specific genetic factors have been identified as potentially influencing this trait. METHODS:In this study, we selected 1493 single-nucleotide polymorphisms (SNP) in 155 candidate genes involved in anabolic, catabolic, growth hormone, and other related pathways and examined their association with LM, assessed by dual-energy x-ray absorptiometry, in a sample of 2760 non-Hispanic and Hispanic white postmenopausal women from the Women's Health Initiative (WHI) Observational Study. We assessed the replication of our top findings in a meta-analysis of 20 genome-wide association studies (n = 38,292) conducted by the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium Musculoskeletal Working Group. RESULTS:We identified 32 SNPs that had nominally significant associations with LM in the WHI cohort. In the replication stage, we find that SNP rs2276541 in the activin A receptor, type IIB (ACVR2B), was significantly associated with LM (β = 0.15, P = 2.17 × 10). ACVR2B codes for a receptor for a negative regulator of skeletal muscle, myostatin, and has previously been identified in a candidate gene study as a determinant of skeletal muscle mass. CONCLUSIONS:Our findings support a previously proposed role of ACVR2B allelic variation as a determinant of muscle mass and extend prior findings in men and women. Additional large-scale studies will be needed to confirm our findings in different populations.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Klimentidis YC,Bea JW,Thompson P,Klimecki WT,Hu C,Wu G,Nicholas JS,Ryckman KK,Chen Zdoi
10.1249/MSS.0000000000000889subject
Has Abstractpub_date
2016-07-01 00:00:00pages
1270-5issue
7eissn
0195-9131issn
1530-0315journal_volume
48pub_type
杂志文章abstract:PURPOSE:This study examined the validity of the assumption of lower-extremity kinematic parameter reproducibility and symmetry during running with different velocities and stride frequencies. METHODS:Each of 12 female long-distance runners ran on a treadmill in combinations of three different velocities (2.5, 3.0, and...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000069337.49567.F0
更新日期:2003-06-01 00:00:00
abstract::The purposes of this study were to evaluate (a) the effects of step rate and upper body support on the VO2 and HR responses to fixed work rates on the StairMaster 4000 (SM), (b) the accuracy of the SM settings, and (c) how HR compared with that measured during grade-walking on a treadmill. Six subjects worked at a slo...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract:PURPOSE:This study was conducted to test the hypothesis of autonomic imbalance in overtrained athletes during sleep and after awakening with analyses of heart rate variability (HRV) and nocturnal urine stress hormones. METHODS:We examined 12 athletes diagnosed to be severely overtrained (OA, 6 men and 6 women, mean ag...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000184631.27641.b5
更新日期:2006-02-01 00:00:00
abstract:INTRODUCTION/PURPOSE:Aging modifies neuromuscular activation of agonist and antagonist muscles during walking. Power training can evoke adaptations in neuromuscular activation that underlie gains in muscle strength and power but it is unknown if these adaptations transfer to dynamic tasks such as walking. We examined t...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001345
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:This study tested the hypothesis that the magnitude of cardiovascular (CV) drift and decrease in maximal oxygen uptake (V[spacing dot above]O2max) would be greater at 35 degrees C than at 22 degrees C. METHODS:The increase in HR and decrease in stroke volume (SV) between 15 and 45 min of cycling at 59.2 +/- 1....
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181666ed7
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:To investigate the effects of blood flow restriction (BFR) combined with electrical muscle stimulation (EMS) on skeletal muscle mass and strength during a period of limb disuse. METHODS:Thirty healthy participants (22 ± 3 years; 23 ± 3 kg·m) were randomly assigned to either: control (CON; n=10), BFR alone (BFR...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002544
更新日期:2020-10-22 00:00:00
abstract:PURPOSE:To determine the effects of age, gender, and ethnicity on the predicted aerobic power of youth as they age from 8 to 16 yr. METHODS:The sample was a multicohort group of 2540 African Americans (N = 543) and Caucasians (N = 1997), 1279 (50.4%) girls and 1261 (49.6%) boys. Heights, weights, and sum of skin folds...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200201000-00022
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:To examine longitudinal change in cardiorespiratory fitness and odds of incident sleep problems. METHODS:A cohort of 7368 men and 1155 women, age 20-85 yr, was recruited from the Aerobics Center Longitudinal Study. The cohort did not complain of sleep problems, depression, or anxiety at their first clinic visi...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000506
更新日期:2015-05-01 00:00:00
abstract:INTRODUCTION:Cardiac magnetic resonance (CMR) late gadolinium enhancement (LGE) and T1 mapping techniques enable the quantification of focal and diffuse myocardial LGE, respectively. Studies have shown evidence of fibrosis in middle-age athletes, but not relative to physically active (PA) adults who perform recommended...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002411
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:The GENEA shows high accuracy for classification of sedentary, household, walking, and running activities when sampling at 80 Hz on three axes. It is not known whether it is possible to decrease this sampling frequency and/or the number of axes without detriment to classification accuracy. The purpose of t...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31825e19fd
更新日期:2012-11-01 00:00:00
abstract:INTRODUCTION:Oral beta2-agonist administration improves muscle function in persons without asthma. We performed a double-blind, randomized, controlled crossover study to assess whether acute inhaled salbutamol administration improves muscle strength and fatigability in healthy moderately trained subjects. METHODS:Quad...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0b013e31816b87aa
更新日期:2008-07-01 00:00:00
abstract::A generalized knowledge of opiates has been available for centuries, but it was not until 1975, following the isolation of the first endogenous opioids, that it was appreciated that their analgesic properties were mediated via specific receptors. Three general classes of opioids are now recognized: the endorphins, the...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1985-02-01 00:00:00
abstract:PURPOSE:The prevalences of diabetes, hypertension, and high cholesterol all decrease with increased levels of physical activity and cardiorespiratory fitness. Whether these reductions extend beyond contemporary guideline activity levels and whether fitness affects medication use independent of activity, remains unclear...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/mss.0b013e318145b337
更新日期:2007-11-01 00:00:00
abstract::The present investigation tested the hypotheses that there would be greater prevalence of expiratory flow limitation (EFL) in endurance-trained (ET) youth cyclists compared with a recreationally active control (CON) group. METHODS:Twelve ET youth male cyclists (16.3 ± 1.0 yr (13-18 yr), 176.5 ± 6.2 cm, 64.2 ± 5.9 kg)...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002325
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To investigate the use of Tritrac accelerometers to measure energy expenditure (EE) of various activities for women in the field setting, as compared with portable indirect calorimetry. METHODS:Twenty women (age 20-29) performed a choreographed routine of six activities (walking, jogging, stair climbing, walki...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200210000-00020
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:High-throughput profiling of metabolic status (metabolomics) allows for the assessment of small-molecule metabolites that may participate in exercise-induced biochemical pathways and corresponding cardiometabolic risk modification. We sought to describe the changes in a diverse set of plasma metabolite profiles...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000001594
更新日期:2018-07-01 00:00:00
abstract::Twelve 9- to 12-year-old children (6 boys, 6 girls) performed four exercise-in-heat (35 degrees C, 45% RH) trials which differed in the composition of the fluids they drank. In each trial, subjects cycled for one 20-min and two 15-min bouts at 50% peak VO2 with 10-min rest periods in between. In a fourth bout, they cy...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::Eight older (52 to 62 yr old) post-menopausal and 8 younger (20 to 30 yr old) women were matched with respect to body size, fatness, and maximal oxygen consumption, heat-acclimated, and then exercised at 35 to 40% maximal oxygen consumption in a warm-humid (37 degrees C, 60% relative humidity) environment. Results wer...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198820020-00009
更新日期:1988-04-01 00:00:00
abstract:PURPOSE:This study investigated the kinetic and the kinematic differences in female athletes in single-leg static jumps in an aquatic environment compared with those performed on dry land. METHODS:Twelve healthy, junior national team handball players participated. Subjects completed a familiarization and a testing ses...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181a252b7
更新日期:2009-09-01 00:00:00
abstract:INTRODUCTION/PURPOSE:Regular aerobic exercise reduces aortic stiffness. However, the mechanisms by which chronic exercise lowers arterial stiffness are not known. To determine the molecular mechanisms of these changes, the alteration of gene expression in the aorta by aerobic exercise training was measured with the mic...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000175052.37087.f8
更新日期:2005-10-01 00:00:00
abstract:INTRODUCTION:Although both humans and quadrupeds frequently coordinate breathing and limb movement during running, early studies in humans focused on how increased breathing flexibility in humans allowed for relaxed or even transient coordination during locomotion. This difference was used to explain why quadrupeds had...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318248d907
更新日期:2012-07-01 00:00:00
abstract::Since the first reported use of knee braces for prophylactic purposes in 1979, these braces have gone through a period of widespread popularity and use, followed by increasing skepticism as to their effectiveness. Early use was unsupported by significant clinical or laboratory data. Multiple studies regarding prophyla...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1991-07-01 00:00:00
abstract:PURPOSE:Cardiac aldosterone might be involved in the deleterious effects of nandrolone decanoate (ND) on the heart. Therefore, we investigated the involvement of cardiac aldosterone, by the pharmacological block of AT1 or mineralocorticoid receptors, on cardiac hypertrophy and fibrosis. METHODS:Male Wistar rats were r...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318217e8b6
更新日期:2011-10-01 00:00:00
abstract::Relatively few studies have assessed the prospective relationship of sedentary lifestyle and coronary heart disease (CHD) in women. We performed a nested case-control study, identifying 50 cases of acute CHD in women and 150 age-matched controls. Risk factors including sedentary lifestyle, cigarette smoking, hypertens...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract:PURPOSE:For most people, the benefits of physical activity far outweigh the risks. Research has suggested that exercise preparticipation questionnaires might refer an unwarranted number of adults for medical evaluation before exercise initiation, creating a potential barrier to adoption. The new American College of Spo...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001331
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:The effect of exercise on body mass is likely to be partially mediated through changes in appetite control. However, no studies have examined the effect of chronic exercise on obestatin and cholecystokinin (CCK) plasma concentrations or the sensitivity to detect differences in preload energy in obese individual...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0b013e31827d1618
更新日期:2013-05-01 00:00:00
abstract::Two healthy females and twelve healthy males, aged 19-24 yr, underwent strength training for periods of 9-21 wk. The muscles trained included extensor digitorum brevis (N = 3), soleus (N = 7), brachioradialis (N = 4), and the hypothenar muscles (N = 3). The effect of training on motoneuron excitability was measured as...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:This study established the published prediction equations for the energy expenditure of walking and running compared with the measured values. To make this comparison we first determined whether differences exist in energy expenditure for 1600 m of walking versus running, and whether energy expenditure differen...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000147584.87788.0e
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:Tibial stress fracture is a common overuse running injury that results from the interplay of repetitive mechanical loading and bone strength. This research project aimed to determine whether female runners with a history of tibial stress fracture (TSF) differ in ground reaction force (GRF) parameters during run...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000117116.90297.e1
更新日期:2004-03-01 00:00:00
abstract:PURPOSE:We asked whether submaximal exercise with chest wall restriction (CWR), as a model of restrictive pulmonary disease, would result in fatigue of the diaphragm in healthy humans. METHODS:To address this question, we used cervical magnetic stimulation of the phrenic nerves along with measures of transdiaphragmati...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181ef5e67
更新日期:2011-03-01 00:00:00