Abstract：
PURPOSE:An augmented pulmonary artery wedge pressure (PAWP) response may explain exercise intolerance in some humans. However, routine use of exercise hemodynamic testing is limited by a lack of data from normal older men and women. Our objective was to evaluate the exercise PAWP response and the potential for sexual dimorphism in healthy, nondyspneic older adults. METHODS:Thirty-six healthy volunteers (18 men [54 ± 7 yr] and 18 women [58 ± 6 yr]) were studied at rest (control) and during two stages of semi-upright cycle ergometry, at heart rates of 100 bpm (light exercise) and 120 bpm (moderate exercise). Right heart catheterization was performed to measure pulmonary pressures. The PAWP response to exercise was assessed in context of exercise work rate and body size. RESULTS:At control, PAWP was similar between men and women. Work rates were significantly smaller in women at comparable HR (P < 0.001). PAWP increased similarly at light exercise, with no further increase at moderate exercise. When indexed to work rate alone or work rate adjusted to body weight and height, the PAWP response at light and moderate exercise was significantly elevated in women compared with men (P < 0.05 condition-sex interaction). The change in PAWP relative to the increase in cardiac output did not exceed 2 mm Hg·L·min in any volunteer at moderate exercise. CONCLUSIONS:The similar rise in the PAWP response to submaximal exercise occurs despite lower work rate in healthy older women compared with men, even when adjusted for smaller body size. It is important to consider sex in the development of normal reference ranges for exercise hemodynamic testing.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Esfandiari S,Wright SP,Goodman JM,Sasson Z,Mak Sdoi
10.1249/MSS.0000000000001227subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1297-1304issue
7eissn
0195-9131issn
1530-0315journal_volume
49pub_type
杂志文章abstract：PURPOSE:Postactivation potentiation (PAP), i.e., the increase in twitch torque following a maximal voluntary conditioning contraction, has been shown to depend on muscle contractile conditions (e.g., muscle length). Few studies, however, have investigated the extent of twitch PAP under dynamic conditions in human subje...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e318160ba54
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:To compare voluntary and electrically evoked knee extensor torque, surface electromyography (EMG), and activation level obtained under seated versus supine position, i.e., with shortened versus lengthened rectus femoris (RF) muscle. METHODS:The knee extensor torque obtained during maximal voluntary contraction...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.MSS.0000084426.03247.93
更新日期：2003-09-01 00:00:00
abstract：PURPOSE:The purpose of the present study was to examine the effect of increased protein intake on short-term decrements in endurance performance during a block of high-intensity training. METHODS:Trained male cyclists (VO(2max) = 64.2 ± 6.5 mL·kg(-1)·min(-1)) completed two 3-wk trials both divided equally into normal ...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1249/MSS.0b013e3181f684c9
更新日期：2011-04-01 00:00:00
abstract：INTRODUCTION:This study examined the effect of endurance exercise on dendritic arborization in the dentate gyrus subregion in rodents exposed to a predator scent stress (PSS). METHODS:Sprague-Dawley rats were randomly assigned to one of four treatment groups. In two of the groups, rats were unexposed to PSS but either...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001038
更新日期：2016-12-01 00:00:00
abstract：INTRODUCTION:The application of an autologous plasma rich in growth factors is beneficial in restoring connective tissues, as shown by clinical evidence in oral surgery and more recently in arthroscopic anterior cruciate ligament reconstruction and two cases of ruptured Achilles tendon in professional athletes. This is...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.MSS.0000089344.44434.50
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:The purpose of this investigation was to examine the effects of differing amounts of beta-hydroxy-beta-methylbutyrate (HMB), 0, 36, and 76 mg x kg(-1) x d(-1), on hematology, hepatic and renal function during 8 wk of resistance training. METHODS:Thirty-seven, untrained collegiate males and were randomly assign...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00005768-200012000-00023
更新日期：2000-12-01 00:00:00
abstract：PURPOSE:The asthmatic airway responds to exercise by bronchodilation (BD) during and bronchoconstriction (BC) after exercise. A refractory period induced by an initial exercise challenge that provides protection against BC during a subsequent exercise bout has also been observed. However, no studies examining during-ex...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200301000-00004
更新日期：2003-01-01 00:00:00
abstract：:In a cross-sectional study using a two-stage probability sample (N = 1,600) of the population of Northern Ireland, there was an inverse association between the highest recorded recent activity and total cholesterol (P < or = 0.01), LDL (P < or = 0.01), triglyceride (P < or = 0.05) and Chol:HDL ratio (P < or = 0.001) i...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199606000-00011
更新日期：1996-06-01 00:00:00
abstract：PURPOSE:The increased physiological demand of pregnancy results in profound adaptation of the maternal cardiovascular system, reflected by greater resting cardiac output and left ventricular (LV) deformation. Whether the increased resting demand alters acute cardiac responses to exercise in healthy pregnant women is no...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002554
更新日期：2020-11-03 00:00:00
abstract：:The case of a table tennis player suffering from intra-articular loose bodies of the elbow is reported. The patient developed the first signs of osteochondritis dissecans of the right lateral humeral condyle at age 16 but underwent surgery only 6 yr later. He has now resumed training and competition, despite some resi...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:The objective of this study was to design and validate a working tool for the objective evaluation of daily energy expenditure (DEE) by means of a simple, noninvasive method: the QAPSE (Saint-Etienne Physical Activity Questionnaire), a questionnaire about physical activity (PA) over a period of 7 d (168 h). This eight...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:To compare the physiological response to a cocaine-exercise challenge in cocaine-conditioned animals with that of acute-cocaine animals, rats were injected i.p. with either cocaine (20 mg.kg-1) or saline, twice daily for 14 consecutive days. On the 15th day (test day) cocaine-conditioned rats received an i.v. injectio...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:The purposes of this study were to assess a) the effectiveness of Masai Barefoot Technology (MBT) shoe in reducing knee pain in persons with knee osteoarthritis (OA) and (b) changes in balance, ankle and knee ROM, and ankle strength compared with a high-end walking shoe for 12 wk. METHODS:The research design w...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/01.mss.0000228364.93703.53
更新日期：2006-10-01 00:00:00
abstract：:Energy expenditure during bicycling on flat terrain depends predominantly on air resistance, which is a function of total frontal area (bicycle and rider), coefficient of drag, and air speed. Body position on the bicycle may affect energy expenditure by altering either frontal area or coefficient of drag. In this stud...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：PURPOSE:The purpose of this study was to determine the effect of thermal stress and hydration status on immune function during exercise. METHODS:Ten trained men completed four cycle ergometer rides at 55% VO2peak under the following conditions: EN (euhydrated neutral; 22 degrees C, 30% RH), DN (dehydrated neutral), EH...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200212000-00013
更新日期：2002-12-01 00:00:00
abstract：:The purpose of this study was to identify anatomical variables associated with plantar-fasciitis sufferers. Selected anatomical variables which were chosen for measurement were leg length, pronation of the subtalar joint, plantar and dorsiflexion ability, and arch height of the foot, as well as the variables height, w...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：PURPOSE:This study examined the relationship between age and gender with physical activity (PA) and how meeting of PA guidelines (PAGL) is related to socioeconomic status (SES) and sedentary behaviors (SB). METHODS:Data were collected from 11-, 13-, and 15-yr-old students in 32 countries participating in the Health Be...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181917722
更新日期：2009-04-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to identify key demographic and health factors associated with physical activity (PA) participation in adults with type 1 or type 2 diabetes. METHODS:Participants were adults > or = 18 yr of age living in the province of Alberta, Canada who were previously diagnosed with type...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000228937.86539.95
更新日期：2006-08-01 00:00:00
abstract：INTRODUCTION:Physical activity may affect health via DNA methylation. The epigenetic influences of sedentary behaviors such as television viewing are unknown. We performed a genomewide study of DNA methylation in peripheral blood in relation to physical activity and television viewing time. METHODS:DNA methylation was...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001827
更新日期：2019-03-01 00:00:00
abstract：INTRODUCTION:This study tested the hypothesis that females rely on thermal behavior to a greater extent during and after exercise, relative to males. METHODS:In a 24°C ± 1°C; (45% ± 10% RH) environment, 10 males (M) and 10 females (F) (22 ± 2 yr) cycled for 60 min (metabolic heat production: M, 117 ± 18 W·m; F, 129 ± ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001756
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:Physical endurance can be limited by muscle glycogen stores, in that glycogen depletion markedly reduces external work. During carbohydrate restriction, the liver synthesizes the ketone bodies, D-β-hydroxybutyrate, and acetoacetate from fatty acids. In animals and in the presence of glucose, D-β-hydroxybut...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0000000000001292
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:The purpose of study was to determine whether quadriceps/patella and Achilles tendon length and flexibility of the knee extensors and plantar flexors are related to walking and running economy. METHODS:Twenty-one male distance runners were subjects. Quadriceps/patella and Achilles tendon length were measured b...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e318210464a
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:To compare different methods of quantifying time in physical activity (PA). METHODS:Twenty-five participants (12 male, 13 female) volunteered to be monitored for seven consecutive days, during which different PA patterns were measured by the simultaneous heart-rate motion sensor technique (HR+M). At the end of...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.MSS.0000099091.38917.76
更新日期：2003-12-01 00:00:00
abstract：PURPOSE:To compare the classic physiological variables linked to endurance performance (VO2max, %VO2max at lactate threshold (LT), and running economy (RE)) with peak treadmill velocity (PTV) as predictors of performance in a 16-km time trial. METHODS:Seventeen healthy, well-trained distance runners (10 males and 7 fe...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181c0669d
更新日期：2010-05-01 00:00:00
abstract：PURPOSES:To compare the claudication distances between men and women patients with peripheral arterial disease (PAD), and to determine whether sex differences in claudication pain persisted after controlling for potential confounders such as demographic, functional, and physiological measures. METHODS:A total of 488 m...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200211000-00001
更新日期：2002-11-01 00:00:00
abstract：PURPOSE:Most studies that use either a single exercise session, exercise training, or a cross-sectional design have failed to find a relationship between exercise and plasma lipoprotein(a) [Lp(a)] concentrations. However, a few studies investigating the effects of longer and/or more strenuous exercise have shown elevat...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200109000-00014
更新日期：2001-09-01 00:00:00
abstract：INTRODUCTION AND PURPOSE:Physical inactivity in postmenopausal women contributes to a rise in atherogenic risk factors associated with the metabolic syndrome. Although regular physical activity positively contributes to health, inactivity progressively increases with age. The Dose Response to Exercise in Women aged 45-...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1249/01.MSS.0000113738.06267.E5
更新日期：2004-02-01 00:00:00
abstract：PURPOSE:To examine relationships between selected sociodemographic, health-related and environmental factors and levels of physical activity in older adults across three age groups. METHODS:Seven hundred sixty-four older adults (mean age = 77.4 +/- 8.6 yr) from a midsize Canadian city completed a self-administered que...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000181303.51937.9c
更新日期：2005-10-01 00:00:00
abstract：PURPOSE:This study was undertaken to determine whether endurance training is associated with changes in myocardial perfusion in humans. METHODS:Myocardial perfusion was measured in eleven trained and nine sedentary men at rest and during adenosine-stimulated hyperemia using positron emission tomography (PET). Left ven...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1097/00005768-200206000-00007
更新日期：2002-06-01 00:00:00
abstract：PURPOSE:In large epidemiologic studies, physical activity (PA) is often assessed using PA questionnaires (PAQ). Because available PAQ may not capture the full range of PA in which urban Chinese adults engage, a PAQ was developed for this purpose. We examined the validity of this PAQ and the 1-yr stability of PA in 545 ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181e1fcd5
更新日期：2010-12-01 00:00:00
