Effect of flavones and their metabolites on induction of SOS repair in the strain PQ37--E. coli K-12.

abstract：:The increase in the lipid peroxide level in the serum and liver of female mice after bilateral ovariectomy evidenced antioxidant activities of female hormones. This increase was abolished upon administration of female hormones. Similar increase in the level of lipid peroxide was observed in the serum of women who had ...

journal_title：Acta biochimica Polonica

authors： Yagi K

更新日期：1997-01-01 00:00:00

abstract：:So far, azide has been consistently reported to act as an inhibitor of metal enzymes, especially copper proteins. The present work shows that azide can also act as an activator of polyphenol oxidase II (PPO II) from tobacco leaves. From the square-wave voltammetry of native PPO II, peroxide-PPO II complex and azide-PP...

journal_title：Acta biochimica Polonica

authors： Shi C,Liu Q,Dai Y,Xie Y,Xu X

更新日期：2002-01-01 00:00:00

abstract：:Standard ocular tumor treatment includes brachytherapy, as well as proton therapy, particularly for large melanoma tumors. However, the effects of different radiation types on the metastatic spread is not clear. We aimed at comparing ruthenium ((106)Ru, emitting β electrons) and iodine ((125)I, γ-radiation) brachyther...

journal_title：Acta biochimica Polonica

authors： Romanowska-Dixon B,Elas M,Swakoń J,Sowa U,Ptaszkiewicz M,Szczygieł M,Krzykawska M,Olko P,Urbańska K

更新日期：2013-01-01 00:00:00

abstract：:Small nucleolar RNAs (snoRNAs) are molecules located in the cell nucleolus and in Cajal bodies. Many scientific reports show that snoRNAs are not only responsible for modifications of other RNAs but also fulfill multiple other functions such as metabolic stress regulation or modulation of alternative splicing. Full-le...

journal_title：Acta biochimica Polonica

authors： Mleczko AM,Bąkowska-Żywicka K

更新日期：2016-01-01 00:00:00

abstract：:The properties of red blood cell membranes in patients with chronic renal failure were investigated using electron paramagnetic resonance spectroscopy. Using spin traps, 5,5-dimethylpirroline-1 oxide and N-tert-butyl-alpha-phenylnitrone, we found generation of hydroxyl radicals in the blood of patients with chronic re...

journal_title：Acta biochimica Polonica

authors： Gwoździński K,Janicka M,Brzeszczyńska J,Luciak M

更新日期：1997-01-01 00:00:00

abstract：:1. The lupin cotyledons contain two cytoplasm-specific lysine tRNAs, one chloroplast-specific, one mitochondria-specific species, and three species common to all the cell compartments investigated; the lysine tRNAs were separated by reversed-phase chromatography (RPC-5). 2. The two cytoplasmic lysine tRNAs are predomi...

journal_title：Acta biochimica Polonica

authors： Augustyniak H,Pawełkiewicz J

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Recent studies showed that sushi repeat containing protein X linked 2 (SRPX2) could participate in the development of various malignant tumors. However, its role in non-small cell lung cancer (NSCLC) was unknown. The aim of the study was to prospectively investigate the role of SRPX2 in NSCLC cell proliferat...

journal_title：Acta biochimica Polonica

authors： Li X,Liu J,Sun H,Zou Y,Chen J,Chen Y,Chen C,Wu X

更新日期：2020-06-18 00:00:00

abstract：:Pathogen-specific acquired immunity in bacteria is mediated by the CRISPR (clustered regularly interspaced short palindromic repeats)-Cas systems. Thermus thermophilus strain HB8 contains CRISPR systems of several major subtypes (type I, IIIA and IIIB), and has become a widely studied model for CRISPR biology. We have...

journal_title：Acta biochimica Polonica

authors： Szychowska M,Siwek W,Pawolski D,Kazrani AA,Pyrc K,Bochtler M

更新日期：2016-01-01 00:00:00

abstract：:The G protein-coupled histamine H4 receptor (H4R) is the last member of histamine receptors family discovered so far. Its expression pattern, together with postulated involvement in a wide variety of immunological and inflammatory processes make histamine H4 receptor an interesting target for drug development. Potenti...

journal_title：Acta biochimica Polonica

authors： Karcz T,Kieć-Kononowicz K

更新日期：2013-01-01 00:00:00

abstract：:The capabilities of porcine adrenal cortex mitochondria to oxidize glycerol-3-phosphate (GP) were studied. In comparison with bovine adrenal cortex mitochondria, porcine mitochondria oxidized GP about three times more actively (18.9 vs 6.1 nmol O(2)/min per mg protein in the presence of ADP) and the activity of mitoch...

journal_title：Acta biochimica Polonica

authors： Popinigis J,Antosiewicz J,Kaczor JJ,Rauchová H,Lenaz G

更新日期：2004-01-01 00:00:00

abstract：:The study aimed to check the effectiveness of anticancer therapy combining a vascular-disruptive drug (combretastatin phosphate, CA4P) and a liposomal formulation of a chemotherapeutic (doxorubicin). CA4P was synthesized in our laboratory according to a previously described procedure. The antivascular drug and long-ci...

journal_title：Acta biochimica Polonica

authors： Mitrus I,Sochanik A,Cichoń T,Szala S

更新日期：2009-01-01 00:00:00

abstract：:Geranylgeranyl diphosphate (GGPP) synthase was purified to homogeneity from bovine brain in a one-step affinity column procedure. For the construction of the affinity column, a farnesyl diphosphate (FPP) analog, O-(6-amino-1-hexyl)-P-farnesylmethyl phosphonophosphate, was synthesized and linked to the spacer of the ma...

journal_title：Acta biochimica Polonica

authors： Sagami H,Morita Y,Korenaga T,Ogura K

更新日期：1994-01-01 00:00:00

abstract：:Growth arrest and DNA damage-inducible (GADD) 45 proteins are regulators of cell death and survival. The proinflammatory cytokine IL-1β strongly increases the level of the transcript encoding GADD45α in rat insulin-producing INS-1E cells. The activation of Gadd45α gene is clearly dependent on JNK and NF-κB activation ...

journal_title：Acta biochimica Polonica

authors： Skalniak L,Gurgul-Convey E,Okreglicka K,Skalniak A,Jura J

更新日期：2013-01-01 00:00:00

abstract：:1. Gluconeogenesis from glutamine, fumarate, pyruvate, glutamine plus fumarate, and glutamine plus pyruvate, was generally higher at pH 7.1 than at pH 7.4 and 7.7, whereas ammoniagenesis did not depend on the pH of the medium. 2. The intermediates of the Krebs cycle decreased ammonia formation from glutamine, raising ...

journal_title：Acta biochimica Polonica

authors： Strzelecki T,Rogulski J

更新日期：1977-01-01 00:00:00

abstract：:Influenza A virus infections are the major public health concern and cause significant morbidity and mortality each year worldwide. Vaccination is the main strategy of influenza epidemic prevention. However, seasonal vaccines induce strain-specific immunity and must be reformulated annually based on prediction of the ...

journal_title：Acta biochimica Polonica

authors： Uranowska K,Tyborowska J,Jurek A,Szewczyk B,Gromadzka B

更新日期：2014-01-01 00:00:00

abstract：:The purpose of this study was to examine the effects of oxidative stress caused by hydroperoxide (H(2)O(2)) in the presence of iron ions (Fe(2+)) on mitochondria of the amoeba Acanthamoeba castellanii. We used isolated mitochondria of A. castellanii and exposed them to four levels of H(2)O(2) concentration: 0.5, 5, 15...

journal_title：Acta biochimica Polonica

authors： Trocha LK,Stobienia O

更新日期：2007-01-01 00:00:00

abstract：:The reaction of nitrite (NO2-) with horseradish peroxidase and lactoperoxidase was studied. Sequential mixing stopped-flow measurements gave the following values for the rate constants of the reaction of nitrite with compounds II (oxoferryl heme intermediates) of horseradish peroxidase and lactoperoxidase at pH 7.0, 1...

journal_title：Acta biochimica Polonica

authors： Gebicka L

更新日期：1999-01-01 00:00:00

abstract：:Analysis of 664 known structures of protein kinase complexes with halogenated ligands revealed 424 short contacts between a halogen atom and a potential protein X-bond acceptor, the topology and geometry of which were analyzed according to the type of a halogen atom (X = Cl, Br, I) and a putative protein X-bond accept...

journal_title：Acta biochimica Polonica

authors： Poznański J,Winiewska M,Czapinska H,Poznańska A,Shugar D

更新日期：2016-01-01 00:00:00

abstract：:The immunodiffusion cross-reactivity and competitive inhibition ELISA assays were used for immunological differentiation of latent form, cleaved form and guanidinium hydrochloride (GuHCl) induced polymer of human alpha 1-proteinase inhibitor (alpha 1-PI). Under the conditions studied, the differences between latent fo...

journal_title：Acta biochimica Polonica

authors： Wawrzos I,Kitagawa Y,Kołoczek H

更新日期：1996-01-01 00:00:00

abstract：:(E)-2'-deoxy-2'-(fluoromethylene)-cytidine (FMdC), a deoxycytidine analog displaying a very high toxicity toward a variety of solid tumor cell lines and xenografts, is activated intracellularly by deoxycytidine kinase (dCK). We have compared cytotoxicity of FMdC towards a human promyeolocytic leukemia line HL-60 and a...

journal_title：Acta biochimica Polonica

authors： Grie P,Koronkiewicz M,Skierski JS

更新日期：2000-01-01 00:00:00

abstract：:This study aimed to evaluate the antidotal potency of tenocyclidine (TCP) that probably might protect acetylcholinesterase (AChE) in the case of organophosphate poisoning. TCP was tested alone as a pretreatment or in combination with atropine as a therapy in rats poisoned with (1/4) and (1/2) of LD(50) of soman. Possi...

journal_title：Acta biochimica Polonica

authors： Petek MJ,Berend S,Kopjar N,Zeljezić D,Mladinić M,Radić B,Vrdoljak AL

更新日期：2008-01-01 00:00:00

abstract：:Dansylated analogues of the potent and selective micro opioid peptide agonist [Dmt(1)]DALDA (H-Dmt-D-Arg-Phe-Lys-NH(2); Dmt = 2',6'-dimethyltyrosine) were prepared either by substitution of N(beta)-dansyl-alpha,beta-diaminopropionic acid or N(epsilon)-dansyllysine for Lys(4), or by attachment of a dansyl group to the ...

journal_title：Acta biochimica Polonica

authors： Berezowska I,Lemieux C,Chung NN,Zelent B,Schiller PW

更新日期：2004-01-01 00:00:00

abstract：:The photochemical characteristics of mesophyll and bundle sheath chloroplasts isolated from the leaves of C4 species were investigated in Zea mays (NADP-ME type), Panicum miliaceum (NAD-ME type) and Panicum maximum (PEP-CK type) plants. The aim of this work was to gain information about selected photochemical properti...

journal_title：Acta biochimica Polonica

authors： Romanowska E,Drozak A

更新日期：2006-01-01 00:00:00

abstract：:Ledakrin, 1-nitro-9-[3'-(N,N'-dimethyl)aminopropyl]aminoacridine administered intraperitoneally at a dose up to 20 mg/kg into sham operated and partially hepatectomized rats inhibited RNA polymerase B activity in the isolated liver nuclei. The average chain length of the in vitro transcript was reduced while the numbe...

journal_title：Acta biochimica Polonica

authors： Krawczyk Z

更新日期：1982-01-01 00:00:00

abstract：:Little is known about the molecular background of clinical variability of Charcot-Marie-Tooth type 1A (CMT1A) disease and hereditary neuropathy with liability to pressure palsies (HNPP). The CMT1A and HNPP disorders result from duplication and deletion of the PMP22 gene respectively. In a series of studies performed o...

journal_title：Acta biochimica Polonica

authors： Sinkiewicz-Darol E,Kabzińska D,Moszyńska I,Kochański A

更新日期：2010-01-01 00:00:00

abstract：:X-ray crystallography provides important insights into structure-function relationship in biomolecules. However, protein crystals are usually hard to obtain which hinders our understanding of multiple important processes. Crystallization requires large amount of protein sample, whereas recombinant proteins are often u...

journal_title：Acta biochimica Polonica

authors： Janczak M,Bukowski M,Górecki A,Dubin G,Dubin A,Wladyka B

更新日期：2015-01-01 00:00:00

abstract：:Influenza virus infection is a major source of morbidity and mortality worldwide. Due to the variable effectiveness of existing vaccines, especially in the early stages of an epidemic, antiviral drugs represent the first line of defense against the virus. Currently, there are two major classes of anti-influenza drugs ...

journal_title：Acta biochimica Polonica

authors： Król E,Rychłowska M,Szewczyk B

更新日期：2014-01-01 00:00:00

abstract：:Sirtuins (type III histone deacetylases) are an important member of a group of enzymes that modify chromatin conformation. We investigated the role of sirtuin inhibitor, GPI 19015, in double strand break (DSB) repair in CHO-K1 wt and xrs-6 mutant cells. The latter is defective in DNA-dependent protein kinase (DNA-PK)-...

journal_title：Acta biochimica Polonica

authors： Wojewódzka M,Kruszewski M,Buraczewska I,Xu W,Massuda E,Zhang J,Szumiel I

更新日期：2007-01-01 00:00:00

abstract：:This review describes the recently developed GeneChip technology that provides efficient access to genetic information using miniaturised, high-density arrays of DNA or oligonucleotide probes. Such microarrays are powerful tools to study the molecular basis of interactions on a scale that would be impossible using con...

journal_title：Acta biochimica Polonica

authors： Gabig M,Wegrzyn G

更新日期：2001-01-01 00:00:00

abstract：:Previous reports indicated that long noncoding RNA 662 (LINC00662) plays a crucial role in several human cancers. Here, we studied the expression pattern of LINC00662 and explored its function in human breast cancer. The expression level of LINC00662 was determined in human breast cancer cell lines and tissues by real...

journal_title：Acta biochimica Polonica

authors： Cheng L,Xing Z,Zhang P,Xu W

更新日期：2020-06-19 00:00:00