Facultative heterochromatin: is there a distinctive molecular signature?

abstract：:Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate. Although PLCs play central roles in myriad signaling cascades, the molecular details of ...

journal_title：Molecular cell

authors： Hicks SN,Jezyk MR,Gershburg S,Seifert JP,Harden TK,Sondek J

更新日期：2008-08-08 00:00:00

abstract：:Homeothermic organisms maintain their core body temperature in a narrow, tightly controlled range. Whether and how subtle circadian oscillations or disease-associated changes in core body temperature are sensed and integrated in gene expression programs remain elusive. Furthermore, a thermo-sensor capable of sensing t...

journal_title：Molecular cell

authors： Haltenhof T,Kotte A,De Bortoli F,Schiefer S,Meinke S,Emmerichs AK,Petermann KK,Timmermann B,Imhof P,Franz A,Loll B,Wahl MC,Preußner M,Heyd F

更新日期：2020-04-02 00:00:00

abstract：:In this issue, He et al. (2015) show how herpes virus usurps a cellular metabolic enzyme to induce RIG-I deamidation and RNA-independent activation, likely to better prevent further innate immune responses. ...

journal_title：Molecular cell

authors： Kolakofsky D,Garcin D

更新日期：2015-04-02 00:00:00

abstract：:Hydroxyl radical footprinting and directed probing from Fe(II)-derivatized IF3 have been used to map the interaction of IF3 relative to 16S rRNA and tRNA(Met)(f) in the 30S ribosomal subunit. Our results place the two domains of IF3 on opposite sides of the initiator tRNA, with the C domain at the platform interface a...

journal_title：Molecular cell

authors： Dallas A,Noller HF

更新日期：2001-10-01 00:00:00

abstract：:The abundant chromatin-associated human factor HCF-1 is a heterodimeric complex of HCF-1N and HCF-1C subunits that are essential for two stages of the cell cycle. The HCF-1N subunit promotes G1 phase progression, whereas the HCF-1C subunit ensures proper cytokinesis at completion of M phase. How the HCF-1C subunit fun...

journal_title：Molecular cell

authors： Julien E,Herr W

更新日期：2004-06-18 00:00:00

abstract：:X chromosome inactivation (XCI) depends on a noncoding sense-antisense transcript pair, Xist and Tsix. At the onset of XCI, Xist RNA accumulates on one of two Xs, coating and silencing the chromosome in cis. The molecular basis for monoallelic Xist upregulation is not known, though evidence predominantly supports a po...

journal_title：Molecular cell

authors： Sun BK,Deaton AM,Lee JT

更新日期：2006-03-03 00:00:00

abstract：:Calreticulin and calnexin are homologous lectins that serve as molecular chaperones for glycoproteins in the endoplasmic reticulum of eukaryotic cells. Here we show that calreticulin depletion specifically accelerates the maturation of cellular and viral glycoproteins with a modest decrease in folding efficiency. Caln...

journal_title：Molecular cell

authors： Molinari M,Eriksson KK,Calanca V,Galli C,Cresswell P,Michalak M,Helenius A

更新日期：2004-01-16 00:00:00

abstract：:BRCA1 functions at two distinct steps during homologous recombination (HR). Initially, it promotes DNA end resection, and subsequently it recruits the PALB2 and BRCA2 mediator complex, which stabilizes RAD51-DNA nucleoprotein filaments. Loss of 53BP1 rescues the HR defect in BRCA1-deficient cells by increasing resecti...

journal_title：Molecular cell

authors： Zong D,Adam S,Wang Y,Sasanuma H,Callén E,Murga M,Day A,Kruhlak MJ,Wong N,Munro M,Ray Chaudhuri A,Karim B,Xia B,Takeda S,Johnson N,Durocher D,Nussenzweig A

更新日期：2019-03-21 00:00:00

abstract：:RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying these global interactions remain poorly understood. We elucidated regulatory mechanisms of the RNA-binding protein HuR, by integrating data from diverse high-throughput targeting technologies, specifically PAR-CLIP, RIP-chip, and...

journal_title：Molecular cell

authors： Mukherjee N,Corcoran DL,Nusbaum JD,Reid DW,Georgiev S,Hafner M,Ascano M Jr,Tuschl T,Ohler U,Keene JD

更新日期：2011-08-05 00:00:00

abstract：:Actin-related proteins (Arps) and conventional actin are enigmatic components of many chromatin-remodeling enzyme complexes. The yeast INO80 ATP-dependent chromatin-remodeling complex contains stoichiometric amounts of Arp4, Arp5, Arp8, and actin. Here we have revealed functions of Arp5 and Arp8 by analysis of mutants...

journal_title：Molecular cell

authors： Shen X,Ranallo R,Choi E,Wu C

更新日期：2003-07-01 00:00:00

abstract：:Conjugation of ubiquitin (Ub) to a protein substrate targets the substrate for degradation or functional modification, which is tightly controlled by diverse mechanisms including phosphorylation of the substrate. An emerging mechanism involves regulation of the E3 Ub ligase, for example, the JNK-dependent phosphorylat...

journal_title：Molecular cell

authors： Yang C,Zhou W,Jeon MS,Demydenko D,Harada Y,Zhou H,Liu YC

更新日期：2006-01-06 00:00:00

abstract：:The identification of metazoan origins of DNA replication has so far been hampered by the lack of a suitable genetic screening and by the cumbersomeness of the currently available mapping procedures. Here we describe the construction of a library of nascent DNA, representative of all cellular origin sequences, and its...

journal_title：Molecular cell

authors： Todorovic V,Giadrossi S,Pelizon C,Mendoza-Maldonado R,Masai H,Giacca M

更新日期：2005-08-19 00:00:00

abstract：:S(N)1-type alkylating agents that produce cytotoxic O(6)-methyl-G (O(6)-meG) DNA adducts induce cell cycle arrest and apoptosis in a manner requiring the DNA mismatch repair (MMR) proteins MutSalpha and MutLalpha. Here, we show that checkpoint signaling in response to DNA methylation occurs during S phase and requires...

journal_title：Molecular cell

authors： Yoshioka K,Yoshioka Y,Hsieh P

更新日期：2006-05-19 00:00:00

abstract：:The formation of silenced and condensed heterochromatin foci involves enrichment of heterochromatin protein 1 (HP1). HP1 can bridge chromatin segments and form liquid droplets, but the biophysical principles underlying heterochromatin compartmentalization in the cell nucleus are elusive. Here, we assess mechanisticall...

journal_title：Molecular cell

authors： Erdel F,Rademacher A,Vlijm R,Tünnermann J,Frank L,Weinmann R,Schweigert E,Yserentant K,Hummert J,Bauer C,Schumacher S,Al Alwash A,Normand C,Herten DP,Engelhardt J,Rippe K

更新日期：2020-04-16 00:00:00

abstract：:Deep orange and carnation are two of the classic eye color genes in Drosophila. Here, we demonstrate that Deep orange is part of a protein complex that localizes to endosomal compartments. A second component of this complex is Carnation, a homolog of Sec1p-like regulators of membrane fusion. Because complete loss of d...

journal_title：Molecular cell

authors： Sevrioukov EA,He JP,Moghrabi N,Sunio A,Krämer H

更新日期：1999-10-01 00:00:00

abstract：:In a recent issue of Molecular Cell, Büttner et al. (2007) described dual roles for the conserved mitochondrial protein endonuclease G in budding yeast apoptosis and proliferation that illuminate some of the contradictory and confusing findings regarding this protein in mammalian cells. ...

journal_title：Molecular cell

authors： Burhans WC,Weinberger M

更新日期：2007-02-09 00:00:00

abstract：:Activation of retrograde signaling (RS) by mitochondrial dysfunction or by inhibition of TOR kinases in yeast results in nuclear accumulation of the transcription factors, Rtg1p and Rtg3p. This process requires Rtg2p, a novel cytoplasmic protein with an N-terminal ATP binding domain. We show that Rtg2p controls RS by ...

journal_title：Molecular cell

authors： Liu Z,Sekito T,Spírek M,Thornton J,Butow RA

更新日期：2003-08-01 00:00:00

abstract：:In Saccharomyces cerevisiae, telomere replication occurs in late S phase and is accompanied by dynamic remodeling of its protein components. Here, we show that MRX (Mre11-Rad50-Xrs2), an evolutionarily conserved protein complex involved in DNA double-strand break (DSB) repair, is recruited to the telomeres in late S p...

journal_title：Molecular cell

authors： Takata H,Tanaka Y,Matsuura A

更新日期：2005-02-18 00:00:00

abstract：:Activation of NF-kappaB is regulated via numerous ubiquitin- and proteasome-mediated steps; an important one is processing of the precursor p105 to the p50 active subunit. The mechanisms involved are largely unknown, because this is an exceptional case where the ubiquitin system does not destroy its substrate complete...

journal_title：Molecular cell

authors： Kravtsova-Ivantsiv Y,Cohen S,Ciechanover A

更新日期：2009-02-27 00:00:00

abstract：:Prokaryotes use a mechanism called priming to update their CRISPR immunological memory to rapidly counter revisiting, mutated viruses, and plasmids. Here we have determined how new spacers are produced and selected for integration into the CRISPR array during priming. We show that Cas3 couples CRISPR interference to a...

journal_title：Molecular cell

authors： Künne T,Kieper SN,Bannenberg JW,Vogel AI,Miellet WR,Klein M,Depken M,Suarez-Diez M,Brouns SJ

更新日期：2016-09-01 00:00:00

abstract：:In this issue, Isom et al. (2013) report their exciting discovery that G proteins can sense pH changes to fine-tune signaling in response to metabolic changes. ...

journal_title：Molecular cell

authors： Sprang SR

更新日期：2013-08-22 00:00:00

abstract：:The double Holliday junction (dHJ) is generally regarded to be a key intermediate of meiotic recombination, whose resolution is critical for the formation of crossover recombinants. In fission yeast, the Mus81-Eme1 endonuclease has been implicated in resolving dHJs. Consistent with this role, we show that Mus81-Eme1 i...

journal_title：Molecular cell

authors： Osman F,Dixon J,Doe CL,Whitby MC

更新日期：2003-09-01 00:00:00

abstract：:Both H4K16 acetylation and H3K4 trimethylation are required for gene activation. However, it is still largely unclear how these modifications are orchestrated by transcriptional factors. Here, we analyzed the mechanism of the transcriptional activation by FOXP3, an X-linked suppressor of autoimmune diseases and cancer...

journal_title：Molecular cell

authors： Katoh H,Qin ZS,Liu R,Wang L,Li W,Li X,Wu L,Du Z,Lyons R,Liu CG,Liu X,Dou Y,Zheng P,Liu Y

更新日期：2011-12-09 00:00:00

abstract：:In a recent issue of Molecular Cell, use NMR to identify peptidyl-prolyl cis-trans isomerization as an autoinhibitory switch in the adaptor protein Crk, suggesting a new mechanism for controlling the rate of formation of signaling complexes. ...

journal_title：Molecular cell

authors： Nicholson LK,Lu KP

更新日期：2007-02-23 00:00:00

abstract：:N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m6A-positive and m6A-negative RNA populations. Bo...

journal_title：Molecular cell

authors： Xiang JF,Yang Q,Liu CX,Wu M,Chen LL,Yang L

更新日期：2018-01-04 00:00:00

abstract：:In bacteria, Hfq is a core RNA chaperone that catalyzes the interaction of mRNAs with regulatory small RNAs (sRNAs). To determine in vivo RNA sequence requirements for Hfq interactions, and to study riboregulation in a bacterial pathogen, Hfq was UV crosslinked to RNAs in enterohemorrhagic Escherichia coli (EHEC). Hfq...

journal_title：Molecular cell

authors： Tree JJ,Granneman S,McAteer SP,Tollervey D,Gally DL

更新日期：2014-07-17 00:00:00

abstract：:Trimethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex 2 (PRC2) has been linked to embryonic stem cell (ESC) identity and pluripotency. EZH2, the catalytic subunit of PRC2, has been reported as the sole histone methyltransferase that methylates H3K27 and mediates transcriptional silencing. Analysis...

journal_title：Molecular cell

authors： Shen X,Liu Y,Hsu YJ,Fujiwara Y,Kim J,Mao X,Yuan GC,Orkin SH

更新日期：2008-11-21 00:00:00

abstract：:Among the five KCNQ channels, also known as the Kv7 voltage-gated potassium (Kv) channels, KCNQ2-KCNQ5 control neuronal excitability. Dysfunctions of KCNQ2-KCNQ5 are associated with neurological disorders such as epilepsy, deafness, and neuropathic pain. Here, we report the cryoelectron microscopy (cryo-EM) structures...

journal_title：Molecular cell

authors： Li T,Wu K,Yue Z,Wang Y,Zhang F,Shen H

更新日期：2021-01-07 00:00:00

abstract：:Mammalian lefty and zebrafish antivin form a subgroup of the TGF beta superfamily. We report that mouse mutants for lefty2 have an expanded primitive streak and form excess mesoderm, a phenotype opposite to that of mutants for the TGF beta gene nodal. Analogously, overexpression of Antivin or Lefty2 in zebrafish embry...

journal_title：Molecular cell

authors： Meno C,Gritsman K,Ohishi S,Ohfuji Y,Heckscher E,Mochida K,Shimono A,Kondoh H,Talbot WS,Robertson EJ,Schier AF,Hamada H

更新日期：1999-09-01 00:00:00

abstract：:Checkpoint proteins respond to DNA damage by halting the cell cycle until the damage is repaired. In this issue of Molecular Cell, Furuya et al. (2010) provide evidence that checkpoint proteins need to be removed from sites of damage in order to properly repair it. ...

journal_title：Molecular cell

authors： Paek AL,Weinert T

更新日期：2010-11-24 00:00:00