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Hop/STI1 modulates retinal proliferation and cell death independent of PrPC.

Abstract：

:Hop/STI1 is a co-chaperone adaptor protein for Hsp70/Hsp90 complexes. Hop/STI1 is found extracellularly and modulates cell death and differentiation through interaction with the prion protein (PrP(C)). Here, we investigated the expression of hop/STI1 and its role upon cell proliferation and cell death in the developing retina. Hop/STI1 is more expressed in developing rat retina than in the mature tissue. Hop/STI1 blocks retinal cell death in the neuroblastic layer (NBL) in a PrP(C) dependent manner, but failed to protect ganglion cells against axotomy-induced cell death. An antibody raised against hop/STI1 (alpha-STI1) blocked both ganglion cell and NBL cell death independent of PrP(C). cAMP/PKA, ERK, PI3K and PKC signaling pathways were not involved in these effects. Hop/STI1 treatment reduced proliferation, while alpha-STI1 increased proliferation in the developing retina, both independent of PrP(C). We conclude that hop/STI1 can modulate both proliferation and cell death in the developing retina independent of PrP(C).

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Arruda-Carvalho M,Njaine B,Silveira MS,Linden R,Chiarini LB

doi

10.1016/j.bbrc.2007.07.038

subject

Has Abstract

pub_date

2007-09-21 00:00:00

pages

474-80

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01515-X

journal_volume

361

pub_type

杂志文章

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