Telomere maintenance through spatial control of telomeric proteins.

abstract：:Retinoic acid is known to have profound effects on developmental processes. It has been implicated as a putative morphogen in the developing chick limb bud and regenerating amphibian limb blastema and has been demonstrated to have powerful teratogenic effects in mammals, including humans. Recently, three specific reti...

journal_title：Molecular and cellular biology

authors： Giguère V,Shago M,Zirngibl R,Tate P,Rossant J,Varmuza S

更新日期：1990-05-01 00:00:00

abstract：:Three classes of E3 ubiquitin ligases, members of the Cbl, Hakai, and SOCS-Cul5-RING ligase families, stimulate the ubiquitination of phosphotyrosine-containing proteins, including receptor and nonreceptor tyrosine kinases and their phosphorylated substrates. Because ubiquitination frequently routes proteins for degra...

journal_title：Molecular and cellular biology

authors： Cooper JA,Kaneko T,Li SS

更新日期：2015-06-01 00:00:00

abstract：:A series of simian virus 40 (SV40)-immortalized hepatocyte cell lines were characterized for albumin production, the regulation of albumin production, and the expression of other liver-specific genes. This series of cell lines is particularly useful for studying the regulation of hepatocyte gene expression because the...

journal_title：Molecular and cellular biology

authors： Woodworth CD,Isom HC

更新日期：1987-10-01 00:00:00

abstract：:Inactivation of DNA mismatch repair by mutation or by transcriptional silencing of the MLH1 gene results in genome instability and cancer predisposition. We recently found (P. V. Shcherbakova and T. A. Kunkel, Mol. Cell. Biol. 19:3177-3183, 1999) that an elevated spontaneous mutation rate can also result from increase...

journal_title：Molecular and cellular biology

authors： Shcherbakova PV,Hall MC,Lewis MS,Bennett SE,Martin KJ,Bushel PR,Afshari CA,Kunkel TA

更新日期：2001-02-01 00:00:00

abstract：:Although both osteoblasts and adipocytes have a common origin, i.e., mesenchymal cells, the molecular mechanisms that define the direction of two different lineages are presently unknown. In this study, we investigated the role of a transcription factor, CCAAT/enhancer binding protein beta (C/EBPbeta), and its isoform...

journal_title：Molecular and cellular biology

authors： Hata K,Nishimura R,Ueda M,Ikeda F,Matsubara T,Ichida F,Hisada K,Nokubi T,Yamaguchi A,Yoneda T

更新日期：2005-03-01 00:00:00

abstract：:We have previously characterized a cloned cDNA coding for a developmentally regulated mRNA in Drosophila melanogaster whose expression is selectively regulated at the translational level during oogenesis and embryogenesis. In this report we show that this translationally regulated mRNA (rpA1) codes for an acidic ribos...

journal_title：Molecular and cellular biology

authors： Kay MA,Jacobs-Lorena M

更新日期：1985-12-01 00:00:00

abstract：:We deduced the structure of the mouse profilin II gene. It contains five exons that can generate four different transcripts by alternative splicing. Two transcripts encode different profilin II isoforms (designated IIa and IIb) that have similar affinities for actin but different affinities for polyphosphoinositides a...

journal_title：Molecular and cellular biology

authors： Lambrechts A,Braun A,Jonckheere V,Aszodi A,Lanier LM,Robbens J,Van Colen I,Vandekerckhove J,Fässler R,Ampe C

更新日期：2000-11-01 00:00:00

abstract：:Transforming Harvey (Ha) ras oncogene products accelerated the time course of Xenopus oocyte maturation induced by insulin, insulinlike growth factor 1, or progesterone. The transforming constructs, [Val-12]Ha p21 and [Val-12, Thr-59]Ha p21, displayed equal potency and efficacy in their abilities to accelerate the gro...

journal_title：Molecular and cellular biology

authors： Sadler SE,Maller JL,Gibbs JB

更新日期：1990-04-01 00:00:00

abstract：:Hydroxyurea (HU) is a DNA replication inhibitor that negatively affects both the elongation and initiation phases of replication and triggers the "intra-S phase checkpoint." Previous work with budding yeast has shown that, during a short exposure to HU, MEC1/RAD53 prevent initiation at some late S phase origins. In th...

journal_title：Molecular and cellular biology

authors： Alvino GM,Collingwood D,Murphy JM,Delrow J,Brewer BJ,Raghuraman MK

更新日期：2007-09-01 00:00:00

abstract：:The 5'-flanking DNA sequences involved in the specific and efficient transcription of the polyoma virus early region have been investigated. Sequence requirements for efficient in vivo expression differed from those in vitro. Deletion of DNA located between 200 and 400 base pairs before the principal cap sites severel...

journal_title：Molecular and cellular biology

authors： Jat P,Novak U,Cowie A,Tyndall C,Kamen R

更新日期：1982-07-01 00:00:00

abstract：:Transfection of a hamster cell mutant with human DNA corrected both the low-density lipoprotein receptor-deficient phenotype and the multiple glycosylation defects of the cells. Independently transfected colonies contained a small set of common human DNA fragments. These fragments may correspond to the human analog of...

journal_title：Molecular and cellular biology

authors： Kingsley DM,Sege RD,Kozarsky KF,Krieger M

更新日期：1986-07-01 00:00:00

abstract：:The slow/cardiac troponin C (cTnC) gene is expressed in three distinct striated muscle lineages: cardiac myocytes, embryonic fast skeletal myotubes, and adult slow skeletal myocytes. We have reported previously that cTnC gene expression in cardiac muscle is regulated by a cardiac-specific promoter/enhancer located in ...

journal_title：Molecular and cellular biology

authors： Parmacek MS,Ip HS,Jung F,Shen T,Martin JF,Vora AJ,Olson EN,Leiden JM

更新日期：1994-03-01 00:00:00

abstract：:Normal cells do not divide indefinitely due to a process known as replicative senescence. Human cells arrest growth with a senescent phenotype when they acquire one or more critically short telomeres as a consequence of cell division. Recent evidence suggests that certain types of DNA damage, chromatin remodeling, and...

journal_title：Molecular and cellular biology

authors： Dimri GP,Itahana K,Acosta M,Campisi J

更新日期：2000-01-01 00:00:00

abstract：:To investigate whether the human pro alpha 1(I) collagen chain could form an in vivo functional interspecies heterotrimer with the mouse pro alpha 2(I) collagen chain, we introduced the human COL1A1 gene into Mov13 mice which have a functional deletion of the endogenous COL1A1 gene. Transgenic mouse strains (HucI and ...

journal_title：Molecular and cellular biology

authors： Wu H,Bateman JF,Schnieke A,Sharpe A,Barker D,Mascara T,Eyre D,Bruns R,Krimpenfort P,Berns A

更新日期：1990-04-01 00:00:00

abstract：:We have constructed a recombinant pBR322 plasmid composed of a subgenomic transforming fragment of bovine papillomavirus DNA and the hepatitis B surface antigen gene from cloned hepatitis B virus DNA and used it for transfection of NIH 3T3 mouse fibroblasts. The transformed cells retain the plasmids in extrachromosoma...

journal_title：Molecular and cellular biology

authors： Wang Y,Stratowa C,Schaefer-Ridder M,Doehmer J,Hofschneider PH

更新日期：1983-06-01 00:00:00

abstract：:Recruitment of modifiers and remodelers to specific DNA sites within chromatin plays a critical role in controlling gene expression. The study of globin gene regulation provides a convergence point within which to address these issues in the context of tissue-specific and developmentally regulated expression. In this ...

journal_title：Molecular and cellular biology

authors： Zhang W,Kadam S,Emerson BM,Bieker JJ

更新日期：2001-04-01 00:00:00

abstract：:Initiation of T-lymphocyte-mediated immune responses involves two cellular processes: entry into the cell cycle (G(0)-->G(1)) for clonal proliferation and coordinated changes in surface and secreted molecules that mediate effector functions. However, a point during G(0)-->G(1) beyond which T cells are committed to ent...

journal_title：Molecular and cellular biology

authors： Lea NC,Orr SJ,Stoeber K,Williams GH,Lam EW,Ibrahim MA,Mufti GJ,Thomas NS

更新日期：2003-04-01 00:00:00

abstract：:The 3' poly(A) tail of eukaryotic mRNAs and the poly(A) binding protein (PABP) play important roles in the regulation of translation. Recently, a human PABP-interacting protein, Paip2, which disrupts the PABP-poly(A) interaction and consequently inhibits translation, was described. To gain insight into the biological ...

journal_title：Molecular and cellular biology

authors： Roy G,Miron M,Khaleghpour K,Lasko P,Sonenberg N

更新日期：2004-02-01 00:00:00

abstract：:The calcineurin-nuclear factor of activated T cells (NFAT) signaling pathway has been shown to be of critical importance in regulating the growth response of cardiac myocytes. We have previously demonstrated that calcineurin A(beta) (CnA(beta)) mRNA and protein are increased in response to growth stimulation, although...

journal_title：Molecular and cellular biology

authors： Oka T,Dai YS,Molkentin JD

更新日期：2005-08-01 00:00:00

abstract：:TGF-alpha-PE40 is a hybrid protein composed of transforming growth factor-alpha (TGF-alpha) fused to a 40,000-dalton segment of Pseudomonas exotoxin A (PE40). This hybrid protein possesses the receptor-binding activity of TGF-alpha and the cell-killing properties of PE40. These properties enable TGF-alpha-PE40 to bind...

journal_title：Molecular and cellular biology

authors： Edwards GM,DeFeo-Jones D,Tai JY,Vuocolo GA,Patrick DR,Heimbrook DC,Oliff A

更新日期：1989-07-01 00:00:00

abstract：:A significant challenge to our understanding of eukaryotic transcriptional regulation is to determine how multiple signal transduction pathways converge on a single promoter to regulate transcription in divergent fashions. To study this, we have investigated the transcriptional regulation of the Schizosaccharomyces po...

journal_title：Molecular and cellular biology

authors： Neely LA,Hoffman CS

更新日期：2000-09-01 00:00:00

abstract：:We have cloned and sequenced the CRY1 gene, encoding ribosomal protein S14 in Chlamydomonas reinhardtii, and found that it is highly similar to S14/rp59 proteins from other organisms, including mammals, Drosophila melanogaster, and Saccharomyces cerevisiae. We isolated a mutant strain resistant to the eukaryotic trans...

journal_title：Molecular and cellular biology

authors： Nelson JA,Savereide PB,Lefebvre PA

更新日期：1994-06-01 00:00:00

abstract：:A molecular karyotype of Neurospora crassa was obtained by using an alternating-field gel electrophoresis system which employs contour-clamped homogeneous electric fields. The migration of all seven N. crassa chromosomal DNAs was defined, and five of the seven molecules were separated from one another. The estimated s...

journal_title：Molecular and cellular biology

authors： Orbach MJ,Vollrath D,Davis RW,Yanofsky C

更新日期：1988-04-01 00:00:00

abstract：:Tumor-promoting phorbol esters affect a variety of cellular functions which may underlie tumor promotion. We isolated from human lymphocytes a cDNA clone whose gene is inducible by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate as well as by the T-cell mitogen phytohemagglutinin. Nuclear transcription experim...

journal_title：Molecular and cellular biology

authors： Arya SK,Wong-Staal F,Gallo RC

更新日期：1984-11-01 00:00:00

abstract：:The stem-loop in the 5' untranslated region (UTR) of collagen α1(I) and α2(I) mRNAs (5'SL) is the key element regulating their stability and translation. Stabilization of collagen mRNAs is the predominant mechanism for high collagen expression in fibrosis. LARP6 binds the 5'SL of α1(I) and α2(I) mRNAs with high affini...

journal_title：Molecular and cellular biology

authors： Challa AA,Stefanovic B

更新日期：2011-09-01 00:00:00

abstract：:Members of the Spalt gene family encode putative transcription factors characterized by seven to nine C2H2 zinc finger motifs. Four genes have been identified in mice--Spalt1 to Spalt4 (Sall1 to Sall4). Spalt homologues are widely expressed in neural and mesodermal tissues during early embryogenesis. Sall3 is normally...

journal_title：Molecular and cellular biology

authors： Parrish M,Ott T,Lance-Jones C,Schuetz G,Schwaeger-Nickolenko A,Monaghan AP

更新日期：2004-08-01 00:00:00

abstract：:The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most transgenic strains carrying activated onc...

journal_title：Molecular and cellular biology

authors： Guy CT,Cardiff RD,Muller WJ

更新日期：1992-03-01 00:00:00

abstract：:Gradients of Wnt/beta-catenin signaling coordinate development and physiological homeostasis in metazoan animals. Proper embryonic development of the fruit fly Drosophila melanogaster requires the Naked cuticle (Nkd) protein to attenuate a gradient of Wnt/beta-catenin signaling across each segmental anlage. Nkd inhibi...

journal_title：Molecular and cellular biology

authors： Zhang S,Cagatay T,Amanai M,Zhang M,Kline J,Castrillon DH,Ashfaq R,Oz OK,Wharton KA Jr

更新日期：2007-06-01 00:00:00

abstract：:To investigate the role of insulin receptor substrate 1 (IRS-1) and IRS-2, the two ubiquitously expressed IRS proteins, in adipocyte differentiation, we established embryonic fibroblast cells with four different genotypes, i.e., wild-type, IRS-1 deficient (IRS-1(-/-)), IRS-2 deficient (IRS-2(-/-)), and IRS-1 IRS-2 dou...

journal_title：Molecular and cellular biology

authors： Miki H,Yamauchi T,Suzuki R,Komeda K,Tsuchida A,Kubota N,Terauchi Y,Kamon J,Kaburagi Y,Matsui J,Akanuma Y,Nagai R,Kimura S,Tobe K,Kadowaki T

更新日期：2001-04-01 00:00:00

abstract：:The Ras pathway is critical for the development and function of T lymphocytes. The stimulation of this GTPase in T cells occurs primarily through the Vav1- and phospholipase C-gamma1-dependent activation of RasGRP1, a diacylglycerol-responsive Ras GDP/GTP exchange factor. Here, we show that a second exchange factor, R...

journal_title：Molecular and cellular biology

authors： Ruiz S,Santos E,Bustelo XR

更新日期：2007-12-01 00:00:00