Cell regulation by phosphotyrosine-targeted ubiquitin ligases.


:Three classes of E3 ubiquitin ligases, members of the Cbl, Hakai, and SOCS-Cul5-RING ligase families, stimulate the ubiquitination of phosphotyrosine-containing proteins, including receptor and nonreceptor tyrosine kinases and their phosphorylated substrates. Because ubiquitination frequently routes proteins for degradation by the lysosome or proteasome, these E3 ligases are able to potently inhibit tyrosine kinase signaling. Their loss or mutational inactivation can contribute to cancer, autoimmunity, or endocrine disorders, such as diabetes. However, these ligases also have biological functions that are independent of their ubiquitination activity. Here we review relevant literature and then focus on more-recent developments in understanding the structures, substrates, and pathways through which the phosphotyrosine-specific ubiquitin ligases regulate diverse aspects of cell biology.


Mol Cell Biol


Cooper JA,Kaneko T,Li SS




Has Abstract


2015-06-01 00:00:00














  • Ribosomal protein L7a is encoded by a gene (Surf-3) within the tightly clustered mouse surfeit locus.

    abstract::The mouse Surfeit locus, which contains a cluster of at least four genes (Surf-1 to Surf-4), is unusual in that adjacent genes are separated by no more than 73 base pairs (bp). The heterogeneous 5' ends of Surf-1 and Surf-2 are separated by only 15 to 73 bp, the 3' ends of Surf-1 and Surf-3 are only 70 bp apart, and t...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Giallongo A,Yon J,Fried M

    更新日期:1989-01-01 00:00:00

  • Sequence conservation and structural organization of the glycerol-3-phosphate dehydrogenase promoter in mice and humans.

    abstract::Cloned segments of the mouse glycerol-3-phosphate dehydrogenase (GPDH) gene, Gdc-1, were used to screen a human library. Human clones obtained spanned 25 kilobases of genomic DNA containing the human GPDH gene, GPD1. The 4 kb of sequence obtained from the 5'-flanking region and first exon of GPD1 was compared with the...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Gwynn B,Lyford KA,Birkenmeier EH

    更新日期:1990-10-01 00:00:00

  • Cell-specific expression of the human parathyroid hormone gene in rat pituitary cells.

    abstract::The promoter region of the human parathyroid hormone gene was fused to the Escherichia coli neo gene and introduced into GH4C1 rat pituitary and human HeLa cells. Both TATA boxes of the human parathyroid hormone gene accurately directed transcription in GH4C1 cells; the parathyroid hormone promoter was inactive in HeL...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Igarashi T,Okazaki T,Potter H,Gaz R,Kronenberg HM

    更新日期:1986-05-01 00:00:00

  • Pseudouridine modification in the tRNA(Tyr) anticodon is dependent on the presence, but independent of the size and sequence, of the intron in eucaryotic tRNA(Tyr) genes.

    abstract::In Saccharomyces cerevisiae, pseudouridine formation in the middle position of the tRNA(Tyr) anticodon (psi 35) is dependent on the presence of the intron in the tRNA(Tyr) gene (Johnson and Abelson, Nature 302:681-687, 1983). Drosophila melanogaster tRNA(Tyr) genes contain introns of three size classes: 20 or 21 base ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Choffat Y,Suter B,Behra R,Kubli E

    更新日期:1988-08-01 00:00:00

  • Interleukin-7 retroviruses transform pre-B cells by an autocrine mechanism not evident in Abelson murine.

    abstract::In this study, we have constructed retroviral vectors expressing the interleukin-7 (IL-7) cDNA and have used infection with these retroviruses to express this cytokine endogenously in an IL-7-dependent pre-B-cell line. Infection with IL-7 retroviruses, but not with a control retrovirus, resulted in the conversion of t...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Overell RW,Clark L,Lynch D,Jerzy R,Schmierer A,Weisser KE,Namen AE,Goodwin RG

    更新日期:1991-03-01 00:00:00

  • DNA-mediated transfer of human melanoma cell surface glycoprotein gp130: identification of transfectants by erythrocyte rosetting.

    abstract::DNA sequences encoding a human melanoma membrane-bound sialoglycoprotein of 130,000 molecular weight (gp130) were introduced into a clonal derivative of mouse B-16 melanoma cells with the selectable neomycin resistance gene (aminoglycoside phosphotransferase). Mouse transfectants were identified by a rapid and precise...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Albino AP,Graf LH Jr,Kantor RR,McLean W,Silagi S,Old LJ

    更新日期:1985-04-01 00:00:00

  • Transient JMJD2B-mediated reduction of H3K9me3 levels improves reprogramming of embryonic stem cells into cloned embryos.

    abstract::Correct reprogramming of epigenetic marks in the donor nuclei is crucial for successful cloning by nuclear transfer. Specific epigenetic modifications, such as repressive histone lysine methylation marks, are known to be very stable and difficult to reprogram. The discovery of histone lysine demethylases has opened up...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Antony J,Oback F,Chamley LW,Oback B,Laible G

    更新日期:2013-03-01 00:00:00

  • Amino-terminal extension generated from an upstream AUG codon increases the efficiency of mitochondrial import of yeast N2,N2-dimethylguanosine-specific tRNA methyltransferases.

    abstract::Fusions between the TRM1 gene of Saccharomyces cerevisiae and COXIV or DHFR were made to examine the mitochondrial targeting signals of N2,N2-dimethylguanosine-specific tRNA methyltransferase [tRNA (m2(2)G)dimethyltransferase]. This enzyme is responsible for the modification of both mitochondrial and cytoplasmic tRNAs...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Ellis SR,Hopper AK,Martin NC

    更新日期:1989-04-01 00:00:00

  • Characterization of pp85, a target of oncogenes and growth factor receptors.

    abstract::An 85,000-molecular-weight polypeptide (85K polypeptide) has previously been identified as a common substrate for tyrosine phosphorylation upon polyomavirus middle T transformation or upon platelet-derived growth factor stimulation of 3T3 cells. In each case, pp85 has an associated phosphatidylinositol kinase activity...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Cohen B,Liu YX,Druker B,Roberts TM,Schaffhausen BS

    更新日期:1990-06-01 00:00:00

  • A conserved telomerase motif within the catalytic domain of telomerase reverse transcriptase is specifically required for repeat addition processivity.

    abstract::Telomerase is a ribonucleoprotein reverse transcriptase responsible for the maintenance of one strand of the telomere terminal repeats. The catalytic protein subunit of the telomerase complex, known as TERT, possesses a reverse transcriptase (RT) domain that mediates nucleotide addition. The RT domain of TERT is disti...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Lue NF,Lin YC,Mian IS

    更新日期:2003-12-01 00:00:00

  • Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.

    abstract::The forkhead transcription factor FoxM1 has been reported to regulate, variously, proliferation and/or spindle formation during the G2/M transition of the cell cycle. Here we define specific functions of FoxM1 during brain development by the investigation of FoxM1 loss-of-function mutations in the context of Sonic hed...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Schüller U,Zhao Q,Godinho SA,Heine VM,Medema RH,Pellman D,Rowitch DH

    更新日期:2007-12-01 00:00:00

  • Functional cooperation of lens-specific and nonspecific elements in the delta 1-crystallin enhancer.

    abstract::The expression of the chicken delta 1-crystallin gene is primarily regulated by the action of a lens-specific enhancer 1 kilobase long and located in the third intron of the gene (S. Hayashi, K. Goto, T. S. Okada, and H. Kondoh, Genes Dev. 1:818-828, 1987). The 120-base-long core segment is required for the activity o...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Goto K,Okada TS,Kondoh H

    更新日期:1990-03-01 00:00:00

  • Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

    abstract::Inactivating mutations within the von Hippel-Lindau (VHL) tumor suppressor gene predispose patients to develop a variety of highly vascularized tumors. pVHL targets alpha subunits of the heterodimeric transcription factor hypoxia-inducible factor (HIF), a critical regulator of energy metabolism, angiogenesis, hematopo...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Mack FA,Patel JH,Biju MP,Haase VH,Simon MC

    更新日期:2005-06-01 00:00:00

  • Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice.

    abstract::During mammalian dosage compensation, one of two X-chromosomes in female cells is inactivated. The choice of which X is silenced can be imprinted or stochastic. Although genetic loci influencing the choice decision have been identified, the primary marks for imprinting and random selection remain undefined. Here, we e...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Boumil RM,Ogawa Y,Sun BK,Huynh KD,Lee JT

    更新日期:2006-03-01 00:00:00

  • Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function.

    abstract::The human ERCC3 gene, which corrects specifically the nucleotide excision repair defect in human xeroderma pigmentosum group B and cross-complements the repair deficiency in rodent UV-sensitive mutants of group 3, encodes a presumed DNA helicase that is identical to the p89 subunit of the general transcription factor ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Ma L,Westbroek A,Jochemsen AG,Weeda G,Bosch A,Bootsma D,Hoeijmakers JH,van der Eb AJ

    更新日期:1994-06-01 00:00:00

  • Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant.

    abstract::mRNA in the yeast Saccharomyces cerevisiae is primarily degraded through a pathway that is stimulated by removal of the mRNA cap structure. Here we report that a mutation in the SPB8 (YJL124c) gene, initially identified as a suppressor mutation of a poly(A)-binding protein (PAB1) gene deletion, stabilizes the mRNA cap...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Boeck R,Lapeyre B,Brown CE,Sachs AB

    更新日期:1998-09-01 00:00:00

  • Methylation and rearrangement of mouse intracisternal a particle genes in development, aging, and myeloma.

    abstract::Sequences of DNA that hybridize on Southern blots with cloned intracisternal A-particle (IAP) sequences have been examined in genomic DNAs of neonatal mice, livers of adult mice (3, 6, 12, 18, 24, and 26 months old), and the solid myeloma tumor MOPC-315. The isoschizomers HpaII (CCGG or mCCGG) and MspI (CCGG or CmCGG)...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Mays-Hoopes LL,Brown A,Huang RC

    更新日期:1983-08-01 00:00:00

  • Receptor clustering is involved in Reelin signaling.

    abstract::The Reelin signaling cascade plays a crucial role in the correct positioning of neurons during embryonic brain development. Reelin binding to apolipoprotein E receptor 2 (ApoER2) and very-low-density-lipoprotein receptor (VLDLR) leads to phosphorylation of disabled 1 (Dab1), an adaptor protein which associates with th...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Strasser V,Fasching D,Hauser C,Mayer H,Bock HH,Hiesberger T,Herz J,Weeber EJ,Sweatt JD,Pramatarova A,Howell B,Schneider WJ,Nimpf J

    更新日期:2004-02-01 00:00:00

  • Transcriptional properties of BmX, a moderately repetitive silkworm gene that is an RNA polymerase III template.

    abstract::We analyzed the transcriptional properties of a repetitive sequence element, BmX, that belongs to a large gene family (approximately 2 x 10(4) copies) in the genome of the Bombyx mori silkworm. We discovered BmX elements because of their ability to direct transcription by polymerase III in vitro and used them to test ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Wilson ET,Condliffe DP,Sprague KU

    更新日期:1988-02-01 00:00:00

  • Highly conserved upstream regions of the alpha 1-antitrypsin gene in two mouse species govern liver-specific expression by different mechanisms.

    abstract::alpha 1-Antitrypsin (AT), the major elastase inhibitor in mammalian serum, is produced primarily in the liver. We have characterized AT gene structure and expression in the mouse species Mus caroli, which expresses high levels of AT in the kidneys as well as in the liver. Analysis of cDNA and genomic clones showed tha...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Latimer JJ,Berger FG,Baumann H

    更新日期:1990-02-01 00:00:00

  • Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.

    abstract::The transcription factor Nrf2 (NF-E2-related-factor 2) is essential for the oxidative and electrophilic stress responses. Keap1 (Kelch-like-ECH-associated-protein 1), an adaptor for a cullin-3 (Cul3)-based ubiquitin ligase, regulates Nrf2 activity through proteasomal degradation, and acts as a sensor for oxidative and...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Iso T,Suzuki T,Baird L,Yamamoto M

    更新日期:2016-11-28 00:00:00

  • Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals.

    abstract::In the early phase of bone damage, low concentrations of the cytokine tumor necrosis factor alpha (TNF-α) favor osteoblast differentiation. In contrast, chronic high doses of the same cytokine contribute to bone loss, demonstrating opposite effects depending on its concentration and on the time of exposure. In the bon...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Daniele S,Natali L,Giacomelli C,Campiglia P,Novellino E,Martini C,Trincavelli ML

    更新日期:2017-03-31 00:00:00

  • Repression by homeoprotein pitx1 of virus-induced interferon a promoters is mediated by physical interaction and trans repression of IRF3 and IRF7.

    abstract::Interferon A (IFN-A) genes are differentially expressed after virus induction. The differential expression of individual IFN-A genes is modulated by the specific transcription activators IFN regulatory factor 3 (IRF3) and IRF-7 and the homeoprotein transcription repressor Pitx1. We now show that repression by Pitx1 do...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Island ML,Mesplede T,Darracq N,Bandu MT,Christeff N,Djian P,Drouin J,Navarro S

    更新日期:2002-10-01 00:00:00

  • Caspase activity is required for engulfment of apoptotic cells.

    abstract::Clearance of apoptotic cells by phagocytic neighbors is crucial for normal development of multicellular organisms. However, how phagocytes discriminate between healthy and dying cells remains poorly understood. We focus on glial phagocytosis of apoptotic neurons during development of the Drosophila central nervous sys...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Shklyar B,Levy-Adam F,Mishnaevski K,Kurant E

    更新日期:2013-08-01 00:00:00

  • The Sgs1 helicase of Saccharomyces cerevisiae inhibits retrotransposition of Ty1 multimeric arrays.

    abstract::Ty1 retrotransposons in the yeast Saccharomyces cerevisiae are maintained in a genetically competent but transpositionally dormant state. When located in the ribosomal DNA (rDNA) locus, Ty1 elements are transcriptionally silenced by the specialized heterochromatin that inhibits rDNA repeat recombination. In addition, ...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Bryk M,Banerjee M,Conte D Jr,Curcio MJ

    更新日期:2001-08-01 00:00:00

  • Acetylation of Cavin-1 Promotes Lipolysis in White Adipose Tissue.

    abstract::White adipose tissue (WAT) serves as a reversible energy storage depot in the form of lipids in response to nutritional status. Cavin-1, an essential component in the biogenesis of caveolae, is a positive regulator of lipolysis in adipocytes. However, molecular mechanisms of cavin-1 in the modulation of lipolysis rema...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Zhou SR,Guo L,Wang X,Liu Y,Peng WQ,Liu Y,Wei XB,Dou X,Ding M,Lei QY,Qian SW,Li X,Tang QQ

    更新日期:2017-07-28 00:00:00

  • Densely methylated DNA islands in mammalian chromosomal replication origins.

    abstract::Densely methylated DNA sequence islands, designated DMIs, have been observed in two Chinese hamster cell chromosomal replication origins by using a PCR-based chemical method of detection. One of the origins, oriS14, is located within or adjacent to the coding sequence for ribosomal protein S14 on chromosome 2q, and th...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Tasheva ES,Roufa DJ

    更新日期:1994-09-01 00:00:00

  • Inheritance of extrachromosomal rDNA in Physarum polycephalum.

    abstract::In the acellular slime mold Physarum polycephalum, the several hundred genes coding for rRNA are located on linear extrachromosomal DNA molecules of a discrete size, 60 kilobases. Each molecule contains two genes that are arranged in a palindromic fashion and separated by a central spacer region. We investigated how r...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Ferris PJ,Vogt VM,Truitt CL

    更新日期:1983-04-01 00:00:00

  • Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development.

    abstract::Xenopus in vitro studies have implicated both transforming growth factor beta (TGF-beta) and fibroblast growth factor (FGF) families in mesoderm induction. Although members of both families are present during mouse mesoderm formation, there is little evidence for their functional role in mesoderm induction. We show th...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Johansson BM,Wiles MV

    更新日期:1995-01-01 00:00:00

  • Epstein-Barr virus suppresses a G(2)/M checkpoint activated by genotoxins.

    abstract::Several Epstein-Barr virus (EBV)-negative Burkitt lymphoma-derived cell lines (for example, BL41 and Ramos) are extremely sensitive to genotoxic drugs despite being functionally null for the tumor suppressor p53. They rapidly undergo apoptosis, largely from G(2)/M of the cell cycle. 5-bromo-2'-deoxyuridine labeling ex...

    journal_title:Molecular and cellular biology

    pub_type: 杂志文章


    authors: Wade M,Allday MJ

    更新日期:2000-02-01 00:00:00