Comparisons of human, rat and mouse erythropoietins by isoelectric focusing: differences between serum and urinary erythropoietins.

abstract：:Although the beta thalassaemia trait affects millions of people worldwide, there have been no controlled studies to determine whether it is associated with any clinical disability or abnormal physical signs. To address this question, 402 individuals were studied: 217 with beta thalassaemia trait, of whom 154 were awar...

journal_title：British journal of haematology

authors： Premawardhena A,Arambepola M,Katugaha N,Weatherall DJ

更新日期：2008-05-01 00:00:00

abstract：:Primary familial and congenital polycythaemia (PFCP) is a disease characterized by increased red blood cell mass, and can be associated with mutations in the intracellular region of the erythropoietin (EPO) receptor (EPOR). Here we explore the mechanisms by which EPOR mutations induce PFCP, using an experimental syste...

journal_title：British journal of haematology

authors： Gross M,Ben-Califa N,McMullin MF,Percy MJ,Bento C,Cario H,Minkov M,Neumann D

更新日期：2014-05-01 00:00:00

abstract：:This phase 2 study (N = 116) evaluated single-agent vosaroxin, a first-in-class anticancer quinolone derivative, in patients ≥60 years of age with previously untreated unfavourable prognosis acute myeloid leukaemia. Dose regimen optimization was explored in sequential cohorts (A: 72 mg/m(2)  d 1, 8, 15; B: 72 mg/m(2) ...

journal_title：British journal of haematology

authors： Stuart RK,Cripe LD,Maris MB,Cooper MA,Stone RM,Dakhil SR,Turturro F,Stock W,Mason J,Shami PJ,Strickland SA,Costa LJ,Borthakur G,Michelson GC,Fox JA,Leavitt RD,Ravandi F

更新日期：2015-03-01 00:00:00

abstract：:Limited therapies exist for patients with refractory and relapsed (RR) higher-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukaemia with trilineage dysplasia (AML-TD). High dose (HD) lenalidomide (50 mg) has activity as frontline therapy in elderly AML but there is limited data in the RR setting. This ph...

journal_title：British journal of haematology

authors： Zeidan AM,Smith BD,Carraway HE,Gojo I,DeZern A,Gore SD

更新日期：2017-01-01 00:00:00

abstract：:Hepatitis E virus (HEV) is increasingly found to cause hepatitis in allogeneic haematopoietic stem cell transplantation (HSCT) patients. However, little is known about HEV infection in patients receiving haploidentical HSCT (haplo-HSCT). Here, we retrospectively evaluate the incidence and clinical course of HEV infect...

journal_title：British journal of haematology

authors： Tang FF,Mo XD,Wang Y,Yan CH,Chen YH,Chen H,Han W,Chang YJ,Zhang HY,Xie YD,Ma H,Wei L,Xu LP,Huang XJ,Zhang XH

更新日期：2019-03-01 00:00:00

abstract：:Dogs affected with cyclic haematopoiesis (CH) and experiencing recurrent 12-day cycles of neutropenia were supralethally irradiated and transplanted with marrow from their normal littermates. Following transplantation of the normal marrow, dogs with CH experienced no further cycles of neutropenia. Platelet and reticul...

journal_title：British journal of haematology

authors： Jones JB,Yang TJ,Dale JB,Lange RD

更新日期：1975-06-01 00:00:00

abstract：:A novel mutation of the N-RAS gene of T-ALL blast cells was detected by a direct sequencing of in vitro amplified exon-1 of the N-RAS gene. Threonine (ACA) was substituted for alanine (GCA) at codon 11. This mutation would have been overlooked by conventional probe hybridization techniques. A search for other mutation...

journal_title：British journal of haematology

authors： Bar-Eli M,Ahuja H,Foti A,Cline MJ

更新日期：1989-05-01 00:00:00

abstract：:We analysed the results of haematopoietic cell transplantation (HCT) in 30 patients aged 60-78 (median 65) years, with primary myelofibrosis or myelofibrosis evolving from antecedent polycythaemia vera or essential thrombocythaemia. Donors were human leucocyte antigen (HLA)-identical siblings (N = 15) or unrelated ind...

journal_title：British journal of haematology

authors： Samuelson S,Sandmaier BM,Heslop HE,Popat U,Carrum G,Champlin RE,Storb R,Prchal JT,Gooley TA,Deeg HJ

更新日期：2011-04-01 00:00:00

abstract：:The transforming growth factor-beta-related factor bone morphogenetic protein 4 (BMP4) is expressed in the human embryonic aorta-gonad-mesonephros (AGM) coincident with the emergence of haematopoietic cells and influences postnatal mammalian haematopoietic stem cells in vitro. To investigate the role of BMP4 in mammal...

journal_title：British journal of haematology

authors： Marshall CJ,Sinclair JC,Thrasher AJ,Kinnon C

更新日期：2007-10-01 00:00:00

abstract：:Expression of heat-shock proteins (hsp) was analysed in the leukaemic cells of 12 patients with acute myeloid leukaemia (AML) and nine patients with chronic myeloid leukaemia (CML). Using monoclonal antibodies to hsp70, hsp90 and hsp60 (ML30, a mycobacterial antigen with homology to human hsp60), we measured hsp level...

journal_title：British journal of haematology

authors： Chant ID,Rose PE,Morris AG

更新日期：1995-05-01 00:00:00

abstract：:In order to clarify the mechanism of the effect of erythropoietin (Epo) on the fetal haemoglobin (HbF) phenotype of peripheral erythrocytes, we studied the dose-response effect of Epo on HbF production by erythroid precursors derived from the peripheral blood of normal adult individuals and grown in a two-phase liquid...

journal_title：British journal of haematology

authors： Fibach E,Schechter AN,Noguchi CT,Rodgers GP

更新日期：1994-09-01 00:00:00

abstract：:The E4BP4 basic leucine zipper (bZIP) transcription factor is regulated by interleukin-3 (IL-3) in pro-B cells and has been reported to promote survival of the murine IL-3-dependent pro-B cell lines, FL5.12 and Baf-3. The E2A-HLF oncoprotein arises from a t(17;19) translocation in childhood pro-B cell acute lymphoblas...

journal_title：British journal of haematology

authors： Yeung J,O'Sullivan E,Hubank M,Brady HJ

更新日期：2004-06-01 00:00:00

abstract：:The economic impact of using prophylactic clodronate as an adjunct to chemotherapy in the management of multiple myeloma for the first 4 years following diagnosis was established from the perspective of the National Health Service (NHS). A state-transition model of the course of multiple myeloma was constructed using ...

journal_title：British journal of haematology

authors： Bruce NJ,McCloskey EV,Kanis JA,Guest JF

更新日期：1999-02-01 00:00:00

abstract：:Impaired switching from fetal haemoglobin (HbF) to adult globin gene expression leads to hereditary persistence of fetal haemoglobin (HPFH) in adult life. This is of prime interest because elevated HbF levels ameliorate β-thalassaemia and sickle cell anaemia. Fetal haemoglobin levels are regulated by complex mechanism...

journal_title：British journal of haematology

authors： Petruzzelli R,Gaudino S,Amendola G,Sessa R,Puzone S,Di Concilio R,d'Urzo G,Amendolara M,Izzo P,Grosso M

更新日期：2010-09-01 00:00:00

abstract：:High-dose chemotherapy (HDT) with autologous stem cell transplantation is the standard of care for relapsed/refractory (RR) Hodgkin lymphoma (HL). Given that HDT may cure a sizeable proportion of patients refractory to first salvage, development of newer conditioning regimens remains a priority. We present the results...

journal_title：British journal of haematology

authors： Musso M,Messina G,Di Renzo N,Di Carlo P,Vitolo U,Scalone R,Marcacci G,Scalzulli PR,Moscato T,Matera R,Crescimanno A,Santarone S,Orciuolo E,Merenda A,Pavone V,Pastore D,Donnarumma D,Carella AM,Ciochetto C,Cascavilla

更新日期：2016-01-01 00:00:00

abstract：:Prolyl hydroxylase (PH) is an important enzyme in collagen synthesis. It is required for the hydroxylation of prolyl residues in peptide chains in collagen synthesis. Serum PH activity was measured in patients with primary myelofibrosis (agnogenic myeloid metaplasia and myelofibrosis with prior history of polycythaemi...

journal_title：British journal of haematology

authors： Wang JC,Wong C,Kao WW

更新日期：1987-02-01 00:00:00

abstract：:The t(4;14) translocation is found in approximately 10% of myeloma patients and results in the deregulation of at least two genes, MMSET and fibroblast growth factor receptor 3 (FGFR3), with the formation of a fusion product between MMSET and the immunoglobulin heavy chain (IgH) locus and overexpression of FGFR3. We h...

journal_title：British journal of haematology

authors： Sibley K,Fenton JA,Dring AM,Ashcroft AJ,Rawstron AC,Morgan GJ

更新日期：2002-08-01 00:00:00

abstract：:The availability of a preparation of recombinant human erythropoietin (rEp) prompted us to investigate the role of Ep in the regulation of megakaryocytopoiesis in mice, using experimental procedures by which the effects on the mitotic and post-mitotic compartment of megakaryocytes could be evaluated separately. In aga...

journal_title：British journal of haematology

authors： Grossi A,Vannucchi AM,Rafanelli D,Rossi Ferrini P

更新日期：1989-04-01 00:00:00

abstract：:We studied the abnormal in vitro polyclonal B-cell activity observed in patients with multiple myeloma and Waldenström's macroglobulinaemia. Numbers of cells spontaneously secreting immunoglobulin (Ig) in freshly isolated suspensions of peripheral blood mononuclear cells and pokeweed mitogen (PWM) stimulated cultures ...

journal_title：British journal of haematology

authors： Levinson AI,Dziarski A,Blankenhorn E,Schreiber AD,Negendank WG

更新日期：1985-07-01 00:00:00

abstract：:MYD88 mutations are present in 95% of Waldenstrom Macroglobulinaemia (WM) patients, and support diagnostic discrimination from other IgM-secreting B-cell malignancies. Diagnostic discrimination can be difficult among suspected wild-type MYD88 (MYD88WT ) WM cases. We systematically reviewed the clinical, pathological a...

journal_title：British journal of haematology

authors： Treon SP,Gustine J,Xu L,Manning RJ,Tsakmaklis N,Demos M,Meid K,Guerrera ML,Munshi M,Chan G,Chen J,Kofides A,Patterson CJ,Yang G,Liu X,Severns P,Dubeau T,Hunter ZR,Castillo JJ

更新日期：2018-02-01 00:00:00

abstract：:Previous studies have established that protein kinase C-zeta (PKC-zeta) is critical for neuronal cell differentiation. However, the role of PKC-zeta in haematopoietic cell differentiation is less clear. In this study, we have investigated the influence of PKC-zeta overexpression on the phenotype of the human monocytic...

journal_title：British journal of haematology

authors： Mansat-De Mas V,de Thonel A,Gaulin V,Demur C,Laurent G,Quillet-Mary A

更新日期：2002-08-01 00:00:00

abstract：:Diamond Blackfan Anaemia (DBA) is a rare congenital pure red cell aplasia that may be associated with facio-skeletal developmental defects. The disease is caused by mutations in one of at least ten ribosomal proteins, which results in haploinsufficiency and an imbalance between the synthesis of rRNA and ribosomal prot...

journal_title：British journal of haematology

authors： Horos R,von Lindern M

更新日期：2012-12-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF)-induced alteration of phosphoprotein during differentiation of HL-60 cells was studied. From the two-dimensional gel electrophoresis analysis of phosphoproteins, a 45 kD phosphoprotein in the cytosolic fraction of DMSO-pretreated HL-60 cells was rapidly dephosphorylated by...

journal_title：British journal of haematology

authors： Yamaguchi T,Oshizawa T,Yamaguchi T,Suzuki K,Yamamoto Y,Hayakawa T

更新日期：1998-08-01 00:00:00

abstract：:Erythrocytes from elderly donors (> 70 years), but not young donors (18-35 years), are shown to undergo sequestration in an in vitro erythrophagocytosis assay. Comparable levels of sequestration are observed for high density erythrocytes from young individuals and both low density and high density erythrocytes from el...

journal_title：British journal of haematology

authors： Shapiro S,Kohn D,Gershon H

更新日期：1993-04-01 00:00:00

abstract：:An optimal antitumoral immune response requires the participation of both CD8 and CD4 T lymphocytes, which are activated by peptide antigen presentation via human leucocyte antigen (HLA) class I and class II molecules respectively. Loss of HLA molecules has been observed in different malignancies, and provides a mecha...

journal_title：British journal of haematology

authors： Drénou B,Le Friec G,Bernard M,Pangault C,Grosset JM,Lamy T,Fauchet R,Amiot L

更新日期：2002-11-01 00:00:00

abstract：:Positron emission tomography using fluorine-18 (FDG-PET) is increasingly used in the staging and follow-up of malignant lymphomas, although its precise role has not yet been determined. This review considers the results reported at the different stages in the disease history and separately considers the major histolog...

journal_title：British journal of haematology

authors： Burton C,Ell P,Linch D

更新日期：2004-09-01 00:00:00

abstract：:A woman with Ph-positive chronic myeloid leukaemia (CML) with an atypical e1a3 BCR-ABL hybrid gene is described. To our knowledge, this is the first report of this transcript type as a unique naturally occurring BCR-ABL fusion in a CML patient. This case was characterized by a low leucocyte count and a very indolent c...

journal_title：British journal of haematology

authors： Roman J,Jimenez A,Barrios M,Castillejo JA,Maldonado J,Torres A

更新日期：2001-09-01 00:00:00

abstract：:Up-regulation of Fas/APO-1 (CD95) on haematopoietic progenitors and Fas-mediated apoptosis have been suggested to occur in a possible pathological mechanism in some bone marrow failure syndromes. We examined the expression of Fas antigen and susceptibility to Fas-mediated suppression of donor-derived haematopoietic ce...

journal_title：British journal of haematology

authors： Saheki K,Fujimori Y,Takemoto Y,Kakishita E

更新日期：2000-05-01 00:00:00

abstract：:Platelet function was evaluated in eight patients with chronic granulocytic leukaemia (CGL), seven Ph1 positive and one Ph1 negative. Seven of the eight patients' platelets had an absence of the second wave of adrenaline induced aggregation on at least one occasion, while five had impaired collagen aggregation. The pl...

journal_title：British journal of haematology

authors： Gerrard JM,Stoddard SF,Shapiro RS,Coccia PF,Ramsay NK,Nesbit ME,Rao GH,Krivit W,White JG

更新日期：1978-12-01 00:00:00

abstract：:In the positron emission tomography (PET) era, traditional prognostic factors may not apply for patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) undergoing autologous stem cell transplantation (ASCT). Moreover, little is known about prognostic factors in patients transplanted for transform...

journal_title：British journal of haematology

authors： Armand P,Welch S,Kim HT,LaCasce AS,Jacobsen ED,Davids MS,Jacobson C,Fisher DC,Brown JR,Coughlin E,Freedman AS,Chen YB

更新日期：2013-03-01 00:00:00