Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2.

abstract：BACKGROUND:There is a considerable discrepancy between the reported incidences of awareness under anesthesia in children (0.2%-2.7%). In this prospective, observational, cohort study we evaluated 1) the incidence of awareness during general anesthesia in children across three settings, 2) factors contributing to awaren...

journal_title：Anesthesia and analgesia

authors： Malviya S,Galinkin JL,Bannister CF,Burke C,Zuk J,Popenhagen M,Brown S,Voepel-Lewis T

更新日期：2009-11-01 00:00:00

abstract：:Changes in cardiac output in response to augmenting cardiac contractility, preload, and heart rate during enflurane anesthesia were examined in 12 open-chested dogs. Cardiac contractility was assessed by the slope of the end-systolic pressure-volume relation (Emax). Dobutamine (3, 6, and 9 micrograms.kg-1.min-1) was a...

journal_title：Anesthesia and analgesia

authors： Sato M,Hoka S,Arimura H,Ono K,Yoshitake J

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:The increasing demand for anesthetic procedures in the gastrointestinal endoscopy area has not been followed by a similar increase in the methods to provide and control sedation and analgesia for these patients. In this study, we evaluated different combinations of propofol and remifentanil, administered thr...

journal_title：Anesthesia and analgesia

authors： Gambús PL,Jensen EW,Jospin M,Borrat X,Martínez Pallí G,Fernández-Candil J,Valencia JF,Barba X,Caminal P,Trocóniz IF

更新日期：2011-02-01 00:00:00

abstract：:We investigated the interaction between mivacurium and succinylcholine when mivacurium was administered during the early recovery from succinylcholine block. We studied 40 adult patients during propofol-alfentanil-N2O-O2 anesthesia. Neuromuscular function was monitored using an electromyographic method (Relaxograph, D...

journal_title：Anesthesia and analgesia

authors： Erkola O,Rautoma P,Meretoja OA

更新日期：1995-03-01 00:00:00

abstract：:Phenylephrine and methoxamine are direct-acting, predominantly α(1) adrenergic receptor (AR) agonists. To better understand their physiologic effects, we screened 463 articles on the basis of PubMed searches of "methoxamine" and "phenylephrine" (limited to human, randomized studies published in English), as well as ci...

journal_title：Anesthesia and analgesia

authors： Thiele RH,Nemergut EC,Lynch C 3rd

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Burnout is a psychological syndrome that results from chronic exposure to job stress. It is defined by a triad of emotional exhaustion, depersonalization, and reduced personal accomplishment. In research, mostly from high-income countries, burnout is common in health care professionals, especially in anesthe...

journal_title：Anesthesia and analgesia

authors： Mumbwe MC,McIsaac D,Jarman A,Bould MD

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Pediatric chronic pain is very common and results in significant health care costs. Pediatric chronic pain is both an individual and a public health concern. The primary objective of this study was to generate a descriptive clinical profile of the patients referred to an anesthesiology-based pediatric chroni...

journal_title：Anesthesia and analgesia

authors： Vetter TR

更新日期：2008-03-01 00:00:00

abstract：:To determine the pharmacokinetics of local anesthetics after lumbar sympathetic blocks, total and free (unbound) plasma concentrations of bupivacaine in venous blood samples were measured in 12 patients using a high-performance liquid chromatography (HPLC) technique. Administration of 30 mL of plain bupivacaine 0.175%...

journal_title：Anesthesia and analgesia

authors： Wulf H,Gleim M,Schele HA

更新日期：1994-11-01 00:00:00

abstract：UNLABELLED:In this randomized, double-blinded study we sought to assess the analgesic efficacy of ropivacaine and bupivacaine in combination with sufentanil and the efficacy of ropivacaine alone after major abdominal surgery. Sixty patients undergoing major abdominal surgery received standardized general anesthesia com...

journal_title：Anesthesia and analgesia

authors： Pouzeratte Y,Delay JM,Brunat G,Boccara G,Vergne C,Jaber S,Fabre JM,Colson P,Mann C

更新日期：2001-12-01 00:00:00

abstract：:Spontaneous ventilation may offer advantages over controlled mechanical ventilation (CMV), but increase in work of breathing may diminish its usefulness. During general anesthesia, respiratory depression and increased work of breathing often preclude spontaneous ventilation, and patients then receive CMV. We compared ...

journal_title：Anesthesia and analgesia

authors： Christie JM,Smith RA

更新日期：1992-08-01 00:00:00

abstract：:The advantages of laparoscopic over open surgery have been documented in nonblinded settings. Our prospective, double-blind setting evaluated pain scores 72 h after surgery by comparing patients who underwent laparoscopic myomectomy or with laparotomy. Forty women referred for conservative myomectomy were included in ...

journal_title：Anesthesia and analgesia

authors： Holzer A,Jirecek ST,Illievich UM,Huber J,Wenzl RJ

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:In this study we sought to determine and compare the minimum local anesthetic volumes (MLAV) and doses (MLAD) of two concentrations of bupivacaine for epidural pain relief in labor, and to quantify the effect on dose. METHODS:Eighty women were randomized in a double-blind manner to receive a first bolus of ...

journal_title：Anesthesia and analgesia

authors： Lyons GR,Kocarev MG,Wilson RC,Columb MO

更新日期：2007-02-01 00:00:00

abstract：UNLABELLED:Incorrect positioning of central venous catheters (CVC) in infants and children may lead to serious complications such as perforation of the heart or great vessels. CVC position is not usually assessed until the first postoperative chest radiograph, potentially leaving malposition undetected for several hour...

journal_title：Anesthesia and analgesia

authors： Andropoulos DB,Bent ST,Skjonsby B,Stayer SA

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Bilateral breast augmentation is an increasingly popular day-case procedure. Local infiltration with sedation is routinely used for its ease of application compared with the more complex and potentially riskier paravertebral blockade (PVB). We hypothesized that ropivacaine injected by experienced anesthesia ...

journal_title：Anesthesia and analgesia

authors： Gardiner S,Rudkin G,Cooter R,Field J,Bond M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Every facility that performs cases on holidays has in some way decided on its operating room (OR) and anesthesia staffing for holidays. Previous studies have not examined how best to calculate appropriate holiday staffing. METHODS:We analyzed weekend and holiday data from a university hospital. RESULTS:The...

journal_title：Anesthesia and analgesia

authors： Dexter F,Epstein RH

更新日期：2006-12-01 00:00:00

abstract：:Laser Doppler flowmetry was used to further investigate the role of nitric oxide (NO) in CO2-induced cerebrocortical hyperemia in rats. A second objective was to elucidate the source(s) of the NO involved in the response to hypercapnia. We used the L-arginine analogue N omega-nitro-L-arginine methyl ester (L-NAME) to ...

journal_title：Anesthesia and analgesia

authors： Smith JJ,Lee JG,Hudetz AG,Hillard CJ,Bosnjak ZJ,Kampine JP

更新日期：1997-02-01 00:00:00

abstract：:Colloids and crystalloids are usually administered as treatment for hypovolemia in severely injured patients. However, dilution of clotting factors and platelets together with impaired fibrinogen polymerization are associated with fluid therapy and may aggravate hemorrhage, thus worsening final outcome of these patien...

journal_title：Anesthesia and analgesia

authors： Fries D,Innerhofer P,Reif C,Streif W,Klingler A,Schobersberger W,Velik-Salchner C,Friesenecker B

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Recent randomized controlled trials have shown no benefit for transfusion to a hemoglobin >10 g/dL compared with lower hemoglobin thresholds in the perioperative period, even among older adults. Nevertheless, physicians may choose to transfuse older adults more liberally than younger adults. It is unclear wh...

journal_title：Anesthesia and analgesia

authors： Brown CH 4th,Savage WJ,Masear CG,Walston JD,Tian J,Colantuoni E,Hogue CW,Frank SM

更新日期：2014-06-01 00:00:00

abstract：:Aprotinin, a potent antifibrinolytic drug, reduces the proportion of adults who receive blood transfusions during cardiac surgery, although the effect in children remains unclear. We performed a systematic review of the literature to identify all English language, randomized controlled trials of aprotinin involving ch...

journal_title：Anesthesia and analgesia

authors： Arnold DM,Fergusson DA,Chan AK,Cook RJ,Fraser GA,Lim W,Blajchman MA,Cook DJ

更新日期：2006-03-01 00:00:00

abstract：UNLABELLED:Controversy surrounds the use of the antiemetic droperidol, because of the Food and Drug Administration-imposed "black box" warning alleging that even small doses of the drug can lead to serious (even fatal) arrhythmias when it is used for antiemetic prophylaxis during the perioperative period. We used mathe...

journal_title：Anesthesia and analgesia

authors： Zhang Y,Luo Z,White PF

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:It has been shown that the combination of electroencephalogram (EEG) and auditory evoked potentials (AEP) allows a good separation of consciousness from unconsciousness. In the present study, we sought a combined EEG/AEP indicator that allows both separation of consciousness from unconsciousness and discrimi...

journal_title：Anesthesia and analgesia

authors： Horn B,Pilge S,Kochs EF,Stockmanns G,Hock A,Schneider G

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Bupivacaine and ropivacaine are the preferred long-acting local anesthetics for peripheral nerve blocks as they provide prolonged analgesia in the postoperative period. No studies have directly compared the analgesic duration of these commonly used local anesthetics in the setting of low-volume ultrasound-gu...

journal_title：Anesthesia and analgesia

authors： Safa B,Flynn B,McHardy PG,Kiss A,Haslam L,Henry PD,Kaustov L,Choi S

更新日期：2021-01-15 00:00:00

abstract：UNLABELLED:Linking physiological pharmacokinetic models to models of the cardiovascular system requires knowledge of the sites in the body that mediate a drug's cardiovascular effects. We examined the role of the coronary concentrations of propofol. Nine sheep anesthetized with isoflurane (2%) were instrumented acutely...

journal_title：Anesthesia and analgesia

authors： Zheng D,Upton RN,Martinez AM

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Conventional concept suggests that infused crystalloid fluid is first distributed in the plasma volume and then, since the capillary permeability for fluid is very high, almost instantly equilibrates with the extracellular fluid space. We challenge whether this view is consistent with findings based on volum...

journal_title：Anesthesia and analgesia

authors： Svensen CH,Rodhe PM,Olsson J,Børsheim E,Aarsland A,Hahn RG

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:Prolongation of the Q-T interval may be associated with polymorphic ventricular tachycardia known as torsade de pointes, syncope and sudden death. Existing data show that isoflurane prolongs the Q-T interval, whereas halothane shortens it. The aim of this study was to determine whether sevoflurane or propofo...

journal_title：Anesthesia and analgesia

authors： Kleinsasser A,Kuenszberg E,Loeckinger A,Keller C,Hoermann C,Lindner KH,Puehringer F

更新日期：2000-01-01 00:00:00

abstract：:A case of possible malignant hyperthermia in a 6-month-old child is presented. Malignant hyperthermia was manifested in this patient by persistent metabolic acidosis in the intraoperative and postoperative periods, by a rapid rise in temperature with concomitant unresponsiveness in the postoperative period, and by a p...

journal_title：Anesthesia and analgesia

authors： Faust DK,Gergis SD,Sokoll MD

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:The extent to which insufflation of oxygen into the posterior pharynx during laryngoscopy prolongs adequate saturation in infants and small children remains unknown. Therefore, we compared oxygen saturation over time in preoxygenated small children with and without posterior pharynx oxygen insufflation. MET...

journal_title：Anesthesia and analgesia

authors： Windpassinger M,Plattner O,Gemeiner J,Röder G,Baumann A,Zimmerman NM,Sessler DI

更新日期：2016-04-01 00:00:00

abstract：:To quantify the effects of succinylcholine at the laryngeal adductor muscles and the adductor pollicis, 17 adult patients were studied during propofol-fentanyl anesthesia. Train-of-four stimulation was applied to the ulnar nerve at the wrist and the recurrent laryngeal nerve at the notch of the thyroid cartilage. Lary...

journal_title：Anesthesia and analgesia

authors： Meistelman C,Plaud B,Donati F

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Tissue damage associated with surgery often produces peripheral and central sensitization that may outlast the stimuli, leading to exaggerated postoperative pain. Paradoxically, the use of opioid analgesia, which is essential for surgical pain management may induce pain sensitization leading to enhanced post...

journal_title：Anesthesia and analgesia

authors： Laboureyras E,Chateauraynaud J,Richebé P,Simonnet G

更新日期：2009-08-01 00:00:00

abstract：:Clonidine in spinal and epidural blocks prolongs anesthesia, but can cause hypotension and bradycardia. The aim of our study was to compare hemodynamic and analgesic effects of spinal versus epidural clonidine alone and after repetitive dosing. In a prospective, randomized, double-blind study, we evaluated 40 patients...

journal_title：Anesthesia and analgesia

authors： Klimscha W,Chiari A,Krafft P,Plattner O,Taslimi R,Mayer N,Weinstabl C,Schneider B,Zimpfer M

更新日期：1995-02-01 00:00:00