Plasma concentrations of bupivacaine after lumbar sympathetic block.

Abstract:

:To determine the pharmacokinetics of local anesthetics after lumbar sympathetic blocks, total and free (unbound) plasma concentrations of bupivacaine in venous blood samples were measured in 12 patients using a high-performance liquid chromatography (HPLC) technique. Administration of 30 mL of plain bupivacaine 0.175%, via two needles, resulted in a maximum total plasma concentration of 0.2-1.0 mg/L (mean 0.49 mg/L). These maximum concentrations were reached 10-45 min after the injection (mean 24 min). There were no clinical signs of central nervous system (CNS) toxicity attributable to local anesthetics. All patients showed hemodynamic stability after the blocks. We conclude that the absorption of local anesthetics after lumbar sympathetic blocks is slow compared to stellate ganglion or intercostal blocks, and does not result in toxic plasma concentrations. These blocks might well be performed in outpatients.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Wulf H,Gleim M,Schele HA

doi

10.1213/00000539-199411000-00017

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

918-20

issue

5

eissn

0003-2999

issn

1526-7598

journal_volume

79

pub_type

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