Effects of ketamine on low intensity tactile sensory input are not dependent upon a spinal site of action.

Abstract:

:The development of a technique for studying spinal dorsal horn electrophysiology in intact, awake, drug-free cats enables the study of spinal sites and mechanisms of action of anesthetic and analgesic agents in a system that more closely reflects normal physiology. Using this technique, we reevaluated the effect of ketamine on spinal dorsal horn sensory transmission. The results of our study confirm previous work done in acute preparations. Ketamine (maximum dose 20 mg/kg) did not significantly reduce the response of low threshold (n = 11) dorsal horn neurons to low intensity sensory stimulation. However, that same dose of ketamine did suppress noxiously evoked activity of the two wide dynamic range neurons encountered in the study, while having a varied effect on neurons responsive to proprioceptive input (n = 7). These findings confirm that, in the intact animal with all modulatory systems intact, ketamine "dissociation" of low intensity tactile stimuli does not appear to involve a spinal mechanism of action. The results also support the importance of spinal sites of action for the analgesia produced by ketamine, as well as the importance of distinguishing between the anesthetic and analgesic effects of that drug.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Collins JG

subject

Has Abstract

pub_date

1986-11-01 00:00:00

pages

1123-9

issue

11

eissn

0003-2999

issn

1526-7598

journal_volume

65

pub_type

杂志文章
  • Little Black Boxes: Noncardiac Implantable Electronic Medical Devices and Their Anesthetic and Surgical Implications.

    abstract::Implanted electronic medical devices. or stimulators such as pacemakers and nerve stimulators have grown enormously in diversity and complexity over recent decades. The function and potential interaction of these devices with the perioperative environment is of increasing concern for anesthesiologists and surgeons. Be...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000001983

    authors: Srejic U,Larson P,Bickler PE

    更新日期:2017-07-01 00:00:00

  • A novel infraclavicular brachial plexus block: the lateral and sagittal technique, developed by magnetic resonance imaging studies.

    abstract:UNLABELLED:A new infraclavicular brachial plexus block method has the patient supine with an adducted arm. The target is any of the three cords behind the pectoralis minor muscle. The point of needle insertion is the intersection between the clavicle and the coracoid process. The needle is advanced 0 degrees -30 degree...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:10.1213/01.ane.0000094337.75996.ae

    authors: Klaastad Ø,Smith HJ,Smedby O,Winther-Larssen EH,Brodal P,Breivik H,Fosse ET

    更新日期:2004-01-01 00:00:00

  • Inhaled nitric oxide versus intravenous vasodilators in severe pulmonary hypertension after cardiac surgery.

    abstract:UNLABELLED:Inhaled nitric oxide (iNO) is superior to i.v. vasodilators for treatment of pulmonary hypertension (PH) after cardiac surgery, but iNO is a potentially toxic gas, and patient subsets who benefit from iNO are not yet clearly defined. We administered iNO 40 ppm, prostaglandin E1 (PGE1) 0.1 microg x kg(-1) min...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Schmid ER,Bürki C,Engel MH,Schmidlin D,Tornic M,Seifert B

    更新日期:1999-11-01 00:00:00

  • Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of phosphatidylinositol-3-kinase and opioid receptors in rabbits.

    abstract:UNLABELLED:Isoflurane reduces myocardial infarct size during early reperfusion by activating phosphatidylinositol-3-kinase (PI3K) signaling. We tested the hypothesis that this cardioprotection against reperfusion injury is enhanced by morphine and that a decrease in apoptosis plays a role in preservation of myocardial ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000171931.08371.a2

    authors: Weihrauch D,Krolikowski JG,Bienengraeber M,Kersten JR,Warltier DC,Pagel PS

    更新日期:2005-10-01 00:00:00

  • The effect of somatostatin on experimental inflammation in rats.

    abstract:UNLABELLED:The aim of the present study was to investigate the effect of somatostatin administration on experimentally induced inflammation in rats. Inflammation was induced by the intraplantar injection of carrageenan (50 microL) into the hind paw of the rat. Animals were treated intraplantarly with somatostatin in a ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199711000-00028

    authors: Corsi MM,Ticozzi C,Netti C,Fulgenzi A,Tiengo M,Gaja G,Guidobono F,Ferrero ME

    更新日期:1997-11-01 00:00:00

  • Hemodynamic effects of desflurane/nitrous oxide anesthesia in volunteers.

    abstract::We determined the cardiovascular effects of 0.91, 1.34, and 1.74 MAC of desflurane/nitrous oxide anesthesia (60% inspired nitrous oxide contributed 0.5 MAC at each level) in 12 healthy, normocapnic male volunteers. Desflurane/nitrous oxide anesthesia decreased systemic blood pressures, cardiac index, stroke volume ind...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199108000-00008

    authors: Cahalan MK,Weiskopf RB,Eger EI 2nd,Yasuda N,Ionescu P,Rampil IJ,Lockhart SH,Freire B,Peterson NA

    更新日期:1991-08-01 00:00:00

  • Evaluation of an on-demand, ex vivo bedside blood gas monitor on pulmonary artery blood gas determinations.

    abstract::Critically ill patients often have cardiopulmonary perturbations that require rapid and frequent assessment for optimal care, including cardiac output determinations, measurement of cardiac filling pressures, and arterial and mixed venous blood gas determinations. We evaluated the performance of a rapid, on-demand bed...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199609000-00010

    authors: Franklin ML,Peruzzi WT,Moen SG,Shapiro BA

    更新日期:1996-09-01 00:00:00

  • The division of the sciatic nerve in the popliteal fossa: anatomical implications for popliteal nerve blockade.

    abstract:UNLABELLED:The sciatic nerve (SN) originates from the L4-S3 roots in the form of two nerve trunks: the tibial nerve (TN) and the common peroneal nerve (CPN). The TN and CPN are encompassed by a single epineural sheath and eventually separate (divide) in the popliteal fossa. This division of the SN occurs at a variable ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200101000-00041

    authors: Vloka JD,Hadzić A,April E,Thys DM

    更新日期:2001-01-01 00:00:00

  • World Health Organization-World Federation of Societies of Anaesthesiologists (WHO-WFSA) International Standards for a Safe Practice of Anesthesia.

    abstract::The International Standards for a Safe Practice of Anesthesia were developed on behalf of the World Federation of Societies of Anaesthesiologists (WFSA), a nonprofit organization representing anesthesiologists in 150 countries, and the World Health Organization (WHO). The recommendations have been approved by WHO and ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0000000000002927

    authors: Gelb AW,Morriss WW,Johnson W,Merry AF,Abayadeera A,Belîi N,Brull SJ,Chibana A,Evans F,Goddia C,Haylock-Loor C,Khan F,Leal S,Lin N,Merchant R,Newton MW,Rowles JS,Sanusi A,Wilson I,Velazquez Berumen A,International

    更新日期:2018-06-01 00:00:00

  • S(+)-ketamine as an analgesic adjunct reduces opioid consumption after cardiac surgery.

    abstract::There are no studies evaluating S(+)-ketamine for pain management after sternotomy. In this prospective, randomized, double-blind, placebo-controlled clinical trial, we evaluated the efficacy and feasibility of S(+)-ketamine as an adjunctive analgesic after cardiac surgery. Ninety patients scheduled for elective coron...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ANE.0000133913.07342.B9

    authors: Lahtinen P,Kokki H,Hakala T,Hynynen M

    更新日期:2004-11-01 00:00:00

  • Clinical pharmacokinetics of carbonated local anesthetics. II: Interscalene brachial block model.

    abstract::A double-blind comparison of 1.1% lidocaine carbonate and 1.0% lidocaine hydrochloride was carried out in 30 healthy adult patients undergoing upper-extremity surgery under interscalene brachial plexus block. Epinephrine (1:200,000) was added to both solutions just before injection. As compared to lidocaine hydrochlor...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:

    authors: Sukhani R,Winnie AP

    更新日期:1987-12-01 00:00:00

  • Central administration of minocycline and riluzole prevents morphine-induced tolerance in rats.

    abstract:BACKGROUND:Long-term exposure to opiates induces tolerance to the analgesic effect. The neurobiological mechanism of this phenomenon is not completely clear. In this study, we evaluated the effects of central administration of minocycline (a tetracycline derivative) and riluzole (an antiglutamatergic drug) on morphine-...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181ae5f13

    authors: Habibi-Asl B,Hassanzadeh K,Charkhpour M

    更新日期:2009-09-01 00:00:00

  • Body temperature change during anesthesia for electroconvulsive therapy: implications for quality incentives in anesthesiology.

    abstract:BACKGROUND:The American Society of Anesthesiologists has announced that perioperative normothermia is a "Quality Incentive in Anesthesiology." We examined whether we could meet this quality incentive in a simple population: patients undergoing anesthesia for electroconvulsive therapy (ECT). METHODS:We compared infrare...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e31817b7c35

    authors: Modell JH,Gravenstein N,Morey TE

    更新日期:2008-11-01 00:00:00

  • The relationship between bispectral index and propofol during target-controlled infusion anesthesia: a comparative study between children and young adults.

    abstract:BACKGROUND:In this prospective study, we compared the relationship between propofol concentrations and bispectral index (BIS) in children versus young adults anesthetized with target-controlled infusion (TCI) of propofol. METHODS:Forty-five prepubertal subjects (children) and 45 postpubertal subjects (adults) were stu...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e318164f388

    authors: Rigouzzo A,Girault L,Louvet N,Servin F,De-Smet T,Piat V,Seeman R,Murat I,Constant I

    更新日期:2008-04-01 00:00:00

  • Density, specific gravity, and baricity of spinal anesthetic solutions at body temperature.

    abstract::One of the most important physical properties affecting the level of analgesia achieved after intrathecal administration of a local anesthetic is its density relative to the density of the cerebrospinal fluid (CSF) at 37 degrees C. In this study, density, specific gravity, and baricity of local anesthetic solutions at...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199305000-00018

    authors: Horlocker TT,Wedel DJ

    更新日期:1993-05-01 00:00:00

  • Hemodynamic effects of intravenous isoproterenol versus epinephrine in the chronic maternal-fetal sheep preparation.

    abstract::Isoproterenol 5 micrograms may be an effective marker of accidental intravascular injection in women in labor; however, before isoproterenol can be incorporated in routinely used epidural test doses, the safety and usefulness should be determined in an animal model. This study was designed to examine the hemodynamic e...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-199605000-00024

    authors: Marcus MA,Vertommen JD,Van Aken H,Wouters PF

    更新日期:1996-05-01 00:00:00

  • The impact of oral premedication with midazolam on respiratory function in children.

    abstract:BACKGROUND:Premedication with midazolam is commonly used in children to reduce anxiety and improve cooperation before anesthesia. However, it has the potential to alter respiratory function because of its muscle relaxant properties. We assessed functional residual capacity (FRC), ventilation homogeneity, using a lung c...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181a324c3

    authors: von Ungern-Sternberg BS,Erb TO,Habre W,Sly PD,Hantos Z

    更新日期:2009-06-01 00:00:00

  • Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting.

    abstract::In this prospective, randomized, double-blind study, we compared the efficacy and safety of ondansetron and metoclopramide in the treatment of postoperative nausea and vomiting (PONV). One hundred seventy-five patients with PONV during recovery from anesthesia for gynecological laparoscopy were treated intravenously w...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199708000-00027

    authors: Polati E,Verlato G,Finco G,Mosaner W,Grosso S,Gottin L,Pinaroli AM,Ischia S

    更新日期:1997-08-01 00:00:00

  • Thoracic epidural anesthesia for bilateral reduction mammoplasty in a patient with Klippel-Feil syndrome.

    abstract::General anesthesia is best avoided in cases of Klippel-Feil syndrome where tracheal intubation is potentially difficult. The syndrome features severe abnormalities of the neck and upper thoracic spine, which may also lead to difficulties with neuraxial blockade. We describe the use of epidural anesthesia for bilateral...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1097/00000539-200102000-00043

    authors: O'Connor PJ,Moysa GL,Finucane BT

    更新日期:2001-02-01 00:00:00

  • To do or not to do a preinduction check-up of the anesthesia machine.

    abstract::The anesthesia machine check is an integral part of the anesthesiologist's daily routine. It is standard operating procedure to check the high- and low-pressure systems of the machine as well as other integral parts that are accessible. Many new anesthesia machines offer a self-testing capability, but older ones with ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000175210.13435.82

    authors: Ianchulev SA,Comunale ME

    更新日期:2005-09-01 00:00:00

  • The effect of isoflurane or spinal anesthesia on indocyanine green disappearance rate in the elderly.

    abstract::This study was designed to measure the disappearance rate of indocyanine green (ICG) as an indicator of hepatic blood flow in elderly patients undergoing internal fixation of fractured neck of femur. All patients were aged 60-90 yr and were randomized to receive either spinal (n = 10) or isoflurane (n = 10) anesthesia...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199404000-00016

    authors: Darling JR,Murray JM,Hainsworth AM,Trinick TR

    更新日期:1994-04-01 00:00:00

  • Complications Associated With the Anesthesia Transport of Pediatric Patients: An Analysis of the Wake Up Safe Database.

    abstract:BACKGROUND:Transporting patients under anesthesia care incurs numerous potential risks, especially for those with critical illness. The purpose of this study is to identify and report all pediatric anesthesia transport-associated adverse events from a preexisting database of perioperative adverse events. METHODS:An ex...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000004433

    authors: Haydar B,Baetzel A,Stewart M,Voepel-Lewis T,Malviya S,Christensen R

    更新日期:2020-07-01 00:00:00

  • Safety of the LMA®Gastro™ for Endoscopic Retrograde Cholangiopancreatography.

    abstract:BACKGROUND:Endoscopic retrograde cholangiopancreatography (ERCP) patients typically receive either tubeless anesthesia or general endotracheal anesthesia (GETA). Patients receiving propofol-based total intravenous anesthesia (TIVA) are at higher risk of sedation-related adverse events (SRAEs) than patients receiving GE...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000005183

    authors: Hagan KB,Carlson R,Arnold B,Nguyen L,Lee J,Weston B,Hernandez M,Feng L,Syed T,Hagberg CA

    更新日期:2020-11-01 00:00:00

  • Generative Retrieval Improves Learning and Retention of Cardiac Anatomy Using Transesophageal Echocardiography.

    abstract:BACKGROUND:Transesophageal echocardiography (TEE) is a valuable monitor for patients undergoing cardiac and noncardiac surgery as it allows for evaluation of cardiovascular compromise in the perioperative period. It is challenging for anesthesiology residents and medical students to learn to use and interpret TEE in th...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000002004

    authors: Kleiman AM,Forkin KT,Bechtel AJ,Collins SR,Ma JZ,Nemergut EC,Huffmyer JL

    更新日期:2017-05-01 00:00:00

  • Preoperative "fentanyl challenge" as a tool to estimate postoperative opioid dosing in chronic opioid-consuming patients.

    abstract:UNLABELLED:When opioids are used for postoperative pain control, it is useful to define the dose-response relationship for analgesia and respiratory depression. We studied 20 chronically opioid-consuming patients having elective multilevel spine fusion. Preoperatively, each patient received a fentanyl infusion of 2 mic...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000156563.25878.19

    authors: Davis JJ,Swenson JD,Hall RH,Dillon JD,Johnson KB,Egan TD,Pace NL,Niu SY

    更新日期:2005-08-01 00:00:00

  • Progesterone-mediated potentiation of spinal sufentanil in rats.

    abstract::Pregnancy is associated with an increased sensitivity to both general and local anesthetics. The exact reason is uncertain, but increased concentrations of progesterone and endogenous opiates have been implicated. Therefore, we tested the ability of intrathecally administered progesterone to produce analgesia and to p...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199304000-00010

    authors: Jayaram A,Carp H

    更新日期:1993-04-01 00:00:00

  • Volume-independent elastance: a useful parameter for open-lung positive end-expiratory pressure adjustment.

    abstract:BACKGROUND:A decremental positive end-expiratory pressure (PEEP) trial after full lung recruitment allows for the adjustment of the lowest PEEP that prevents end-expiratory collapse (open-lung PEEP). For a tidal volume (Vt) approaching zero, the PEEP of minimum respiratory system elastance (PEEP(minErs)) is theoretical...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e31824a95ca

    authors: Carvalho AR,Bergamini BC,Carvalho NS,Cagido VR,Neto AC,Jandre FC,Zin WA,Giannella-Neto A

    更新日期:2013-03-01 00:00:00

  • Excessive postoperative bleeding and outcomes in neonates undergoing cardiopulmonary bypass.

    abstract:BACKGROUND:Neonates undergoing cardiac surgery are especially prone to the hemostatic alterations of cardiopulmonary bypass (CPB) and are at high risk for post-CPB bleeding. An immature coagulation system, significant hemodilution from the CPB prime, long CPB times at low temperatures, and extensive suture lines increa...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000000531

    authors: Guzzetta NA,Allen NN,Wilson EC,Foster GS,Ehrlich AC,Miller BE

    更新日期:2015-02-01 00:00:00

  • Small-dose ketamine reduces the pain of propofol injection.

    abstract:BACKGROUND:I.v. injection of propofol during anesthetic induction induces pain. Ketamine has been shown to reduce injection pain. In this study, we established the optimal dose of ketamine to prevent the pain of injection with propofol. METHODS:Two hundred forty patients presenting for elective surgery were randomly a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/01.ane.0000243334.83816.53

    authors: Koo SW,Cho SJ,Kim YK,Ham KD,Hwang JH

    更新日期:2006-12-01 00:00:00

  • Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats.

    abstract:BACKGROUND:Previous studies demonstrated that MAC for isoflurane directly correlates with the concentration of Na(+) in cerebrospinal fluid surrounding the spinal cord, the primary site for mediation of the immobility produced by inhaled anesthetics. If this correlation resulted from increased irritability of the cord,...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181815f2b

    authors: Shnayderman D,Laster MJ,Eger EI 2nd,Oh I,Zhang Y,Jinks SL,Antognini JF,Raines DE

    更新日期:2008-09-01 00:00:00