Clinical pharmacokinetics of carbonated local anesthetics. II: Interscalene brachial block model.

Abstract:

:A double-blind comparison of 1.1% lidocaine carbonate and 1.0% lidocaine hydrochloride was carried out in 30 healthy adult patients undergoing upper-extremity surgery under interscalene brachial plexus block. Epinephrine (1:200,000) was added to both solutions just before injection. As compared to lidocaine hydrochloride, lidocaine carbonate produced, in addition to a 38% reduction in onset time, a remarkable increase in the extent of anesthesia: lidocaine carbonate produced surgical anesthesia of the entire upper extremity including the hand in 87% of the patients, whereas lidocaine hydrochloride produced similar anesthesia in only 53% of the patients. Thus, supplemental blocks were required in 66% of the patients who received lidocaine hydrochloride, whereas they were required in only 25% of those who received lidocaine carbonate.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Sukhani R,Winnie AP

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

1245-50

issue

12

eissn

0003-2999

issn

1526-7598

journal_volume

66

pub_type

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