Responses of calcitonin gene-related peptide-immunopositive nerve fibres in the periodontal ligament of rat molars to experimental tooth movement.

Abstract:

:Nerve fibres showing CGRP-immunoreactivity were exclusively distributed around blood vessels in the periodontal ligament of normal teeth. The CGRP-positive nerves as well as the vessels were more dense during tooth movement and reached a maximum density and intensity of immunoreaction after 3 days. After that, the immunoreactive nerves gradually disappeared, and returned to the control level by the 7th day. Some of the CGRP-nerves were adjacent to bone resorptive lacunae at 3 days when active remodelling of alveolar bone was taking place. These findings suggest that the distribution of CGRP-positive nerves is dynamically changed around the blood vessels in the periodontal ligament during tooth movement, and that CGRP might affect the regulation of blood flow in the ligament. CGRP is possibly involved in the tissue remodelling, directly or indirectly, in addition to its function as a neurotransmitter.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Saito I,Ishii K,Hanada K,Sato O,Maeda T

doi

10.1016/0003-9969(91)90023-n

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

689-92

issue

9

eissn

0003-9969

issn

1879-1506

pii

0003-9969(91)90023-N

journal_volume

36

pub_type

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