Immunological characterization of plasminogen activators in human parotid saliva.

Abstract:

:These were characterized in stimulated saliva from 21 healthy volunteers using antibodies specific for human tissue-type plasminogen activator (t-PA) or urokinase. After pre-incubation with immunoglobulins, with and without specific antibodies, the fibrinolytic activity was assayed on fibrin plates containing plasminogen. Fibrinolytic activity was demonstrated in all salivas but one; it was completely quenched by antibodies against t-PA, but antibodies against urokinase-like plasminogen activator had no effect. The fibrinolytic activity was expressed in international units (IU) using a standard curve obtained by serial dilution of the international tissue-plasminogen standard. The normal range was 0.05-0.35 IU/ml, and the maximal value 2 IU/ml. There is thus considerable individual variation in fibrinolytic activity in parotid saliva, where it is regulated by t-PA under physiological conditions.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Kjaeldgaard M,Kjaeldgaard A

doi

10.1016/0003-9969(87)90097-5

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

855-7

issue

12

eissn

0003-9969

issn

1879-1506

journal_volume

32

pub_type

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