Effect of topical anaesthesia in patients with persistent dentoalveolar pain disorders: A quantitative sensory testing evaluation.

Abstract:

OBJECTIVE:The aim of this study was to test the hypothesis that patients with persistent dentoalveolar pain disorder (PDAP) expresses somatosensory abnormalities through quantitative sensory testing (QST), when compared to healthy controls; and that individuals with PDAP do not have somatosensory alterations after application of a topical anaesthetic gel. DESIGN:QST was performed in 25 subjects with PDAP (19 women and 6 men), at baseline and after topical application of benzocaine 2% (Benzotop 200mg/g, DFL) and compared to 25 matched healthy controls. After "Z" score transformation, results were analyzed using the paired "t" test and "t" test with significance level of 5%. RESULTS:PDAP subjects have lower pain detection thresholds confirmed through mechanical tests; and higher pain intensity report through thermal stimuli tests (heat and cold) when compared to healthy subjects. Topical anaesthesia partially reduces in 60% pain intensity of PDAP patients; and anaesthetic gel increases mechanical detection thresholds and reduces pain intensity report in dynamical mechanical allodynia tests. CONCLUSIONS:PDAP patients had abnormal thermal sensory and mechanical allodynia, which is indicative of central sensitization. Moreover, topical anaesthetic incited a significant reduction in pain intensity, and an increase in mechanical and pain detection thresholds, which could be also suggestive of a peripheral disorder.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Porporatti AL,Costa YM,Stuginski-Barbosa J,Bonjardim LR,Conti PC

doi

10.1016/j.archoralbio.2015.02.027

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

973-81

issue

7

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(15)00087-4

journal_volume

60

pub_type

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