Influence of atrial natriuretic peptide on cyclic nucleotides and amylase release in rat parotid salivary gland in vitro.

Abstract:

:Atrial natriuretic peptide (ANP), sodium nitroprusside and hydroxylamine increased cGMP accumulation in rat parotid acinar cells both in the presence and absence of forskolin but in a different manner. On the other hand, ANP decreased forskolin-stimulated cAMP accumulation, although sodium nitroprusside and hydroxylamine had no effect on cAMP accumulation. Amylase release stimulated by forskolin, dibutyryl-cAMP or isoproterenol was depressed by ANP, whereas sodium nitroprusside and hydroxylamine did not evoke the inhibition of forskolin-stimulated amylase release. These results suggest that the inhibition of cAMP accumulation and of amylase release by ANP were not mediated via cGMP produced by guanylate cyclase-A.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Nashida T,Imai A,Shimomura H

doi

10.1016/0003-9969(94)90139-2

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

629-32

issue

7

eissn

0003-9969

issn

1879-1506

journal_volume

39

pub_type

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