Abstract：
CONTEXT:Case reports have described detection of candidemia by examination of peripheral blood smears. It is unclear whether this method has wider applicability for early detection of fungemia. OBJECTIVE:To determine the sensitivity of smear review for detecting candidemia. DESIGN:Normal and cytopenic blood was spiked with increasing concentrations of yeast. Smears were prepared and reviewed by a pathologist and by technical staff. Staff members blinded to the purpose of the study first performed a routine slide review and then a targeted review for yeast. RESULTS:The pathologist detected isolated yeast forms at a concentration of 1 to 5 x 10(5) colony-forming units (CFU)/mL. When blinded to the purpose of the study, technical staff could detect Candida in most samples when the yeast concentration was 1 to 5 x 10(7) CFU/mL, but found it in only a small fraction of samples with lower concentrations. When asked to examine the smears specifically for yeast, they could detect it in most samples containing 1 to 5 x 10(6) CFU/mL. CONCLUSIONS:Detection of candidemia by peripheral blood smear examination requires a yeast concentration of 1 to 5 x 10(5) CFU/mL or greater. This degree of fungemia is unusual; therefore, detection of candidemia by blood smear review will not be possible in most cases. Sensitivity of smear review for yeast detection is greatly increased if the microscopist is specifically directed to look for the presence of yeast.
journal_name
Arch Pathol Lab Medjournal_title
Archives of pathology & laboratory medicineauthors
Branda JA,Ferraro MJ,Kratz Adoi
10.1043/1543-2165(2007)131[97:SOPBSR]2.0.CO;2subject
Has Abstractpub_date
2007-01-01 00:00:00pages
97-101issue
1eissn
0003-9985issn
1543-2165pii
OA5-1174journal_volume
131pub_type
杂志文章abstract：:Microcystic transitional cell carcinoma is a rare variant of urothelial carcinoma; to date, it has been described only in the urinary bladder. We report 2 cases of microcystic transitional cell carcinoma arising in the renal pelvis. The first case occurred in a 73-year-old man with a history of superficially invasive ...
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journal_title：Archives of pathology & laboratory medicine
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journal_title：Archives of pathology & laboratory medicine
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