An immunohistochemical study of the simultaneous expression of bcl-2 and p53 oncoproteins in epithelial tumors of the colon and rectum.

abstract：:We report here 2 separate cases in which patients with known low-grade B-cell lymphomas presented with transformed lesions that were CD30⁺, CD4⁺, Epstein-Barr virus negative, and negative or focally weak for a wide range of B-cell, T-cell, and histiocytic/dendritic cell markers. In each case the transformed lymphoma p...

journal_title：Archives of pathology & laboratory medicine

authors： Shaver AC,Ma L,Vnencak-Jones C,Schwarting RS,Fasig KJ,Kim AS

更新日期：2014-08-01 00:00:00

abstract：:Intravenously (IV) injected Evans blue dye consistently accumulates at particular areas in aortas of normal swine. Theses areas are also where IV injected tracer cholesterol accumulates. We studied the ultrastructural characteristics of blue vs nonblue areas in the abdominal aortas of both control and atherosclerotic ...

journal_title：Archives of pathology & laboratory medicine

authors： Imai H,Scott RF,Thomas WA

更新日期：1982-04-01 00:00:00

abstract：:The salivary glands, despite their relatively simple morphology, give rise to more than 30 histologically distinct benign and malignant tumors. Salivary gland neoplasms comprise less than 2% of all tumors in humans and 3% of all head and neck tumors. They arise in the parotid gland in 80% of cases, and approximately 8...

journal_title：Archives of pathology & laboratory medicine

authors： Schneider M,Rizzardi C

更新日期：2008-02-01 00:00:00

abstract：:Tumoral calcinosis is a rare ectopic calcification syndrome characterized by irregular soft tissue masses originally described as being found mainly in large joints. We report 3 cases of tumoral calcinosis that occurred in unusual locations, the metacarpophalageal and proximal interphalangeal joints of the hand. The p...

journal_title：Archives of pathology & laboratory medicine

authors： Kim HS,Suh JS,Kim YH,Park SH

更新日期：2006-04-01 00:00:00

abstract：CONTEXT:- Lobular carcinoma in situ (LCIS) refers to a neoplastic proliferation of cells that characteristically shows loss of E-cadherin expression and has long been regarded as a risk factor for invasive breast cancer. Long-term outcome studies and molecular data have also implicated LCIS as a nonobligate precursor t...

journal_title：Archives of pathology & laboratory medicine

authors： Ginter PS,D'Alfonso TM

更新日期：2017-12-01 00:00:00

abstract：:Histochemical staining of glyceraldehyde-3-phosphate dehydrogenase activity in fresh-frozen muscle tissue may be performed using a beta-nicotinamide adenine dinucleotide (beta-NAD) reduced-dehydrogenase tetrazolium-reductase linked reaction. The phosphate-buffered incubating medium contains glyceraldehyde-3-phosphate,...

journal_title：Archives of pathology & laboratory medicine

authors： Brumback RA,Susag ME,Gerst JW

更新日期：1981-08-01 00:00:00

abstract：CONTEXT:Methods to improve surgical pathology patient safety include measuring the frequency of error in specific steps of the surgical pathology testing process, root cause analysis of active and latent components, and implementation of quality improvement initiatives. OBJECTIVE:To determine the frequency and cause o...

journal_title：Archives of pathology & laboratory medicine

authors： Smith ML,Raab SS

更新日期：2011-11-01 00:00:00

abstract：CONTEXT:Tumors of the head and neck commonly arise from the squamous and respiratory mucosa that lines the nasal and oral cavity, sinuses, pharynx, and larynx. The rate of oropharyngeal cancers diagnosed among Americans younger than 50 years is increasing. Infection of the oropharynx and tonsils by the human papillomav...

journal_title：Archives of pathology & laboratory medicine

authors： Black CC,Bentley HA,Davis TH,Tsongalis GJ

更新日期：2010-12-01 00:00:00

abstract：:Two autopsy cases of sympodial monsters, sympus dipus, were studied. They are of interest not only because they show the characteristic malformations of the limbs and the viscera below the diaphragm, but because one case also shows Potter's face and an atrial septal defect of the heart. In addition, histologic determi...

journal_title：Archives of pathology & laboratory medicine

authors： Nakamura Y,Komatsu Y,Nagasue N,Fukagawa K,Hamaguchi H,Akashi M

更新日期：1981-10-01 00:00:00

abstract：CONTEXT:Although most primary cancers of the lung carry a heavy mutational load and will potentially present many "nonself" antigens to the immune system, there are a wide range of possible mechanisms for tumors to avoid so-called immune surveillance. One such mechanism is the adoption of immune checkpoints to inhibit ...

journal_title：Archives of pathology & laboratory medicine

authors： Kerr KM,Nicolson MC

更新日期：2016-03-01 00:00:00

abstract：:Sarcoidlike granulomas may occur in association with Hodgkin lymphoma and non-Hodgkin lymphoma. The granulomas may be concomitant and so extensive that they obscure the malignant process. In addition, a sarcoidosis-lymphoma syndrome has been described in which there appears to be a relationship between sarcoidosis and...

journal_title：Archives of pathology & laboratory medicine

authors： Dunphy CH,Panella MJ,Grosso LE

更新日期：2000-01-01 00:00:00

abstract：:We performed x-ray microanalysis of autopsy specimens using a scanning-transmission electron microscopy mode. Tissues were obtained at necropsy from a patient with history of angiography using thorium dioxide and from a patient with hemochromatosis. X-ray microanalysis confirmed the presence of thorium and iron in the...

journal_title：Archives of pathology & laboratory medicine

authors： Landas S,Turner JW,Moore KC,Mitros FA

更新日期：1984-03-01 00:00:00

abstract：CONTEXT:Recent advances in laboratory testing technology have resulted in a rapidly increasing number of test systems targeted for physician office, point-of-care, and home health care settings. With enhanced error detection mechanisms and unitized reagents, these new systems simplify the testing process and the assess...

journal_title：Archives of pathology & laboratory medicine

authors： LaBeau KM,Simon M,Steindel SJ

更新日期：2000-08-01 00:00:00

abstract：CONTEXT:Dysregulation of mediators of apoptosis is associated with carcinogenesis. For biliary duct cancers, p53 gene mutation is an important contributor to carcinogenesis. Mutations in the p53 gene affect transcription of the Fas gene, resulting in lack of Fas expression on cell membrane. It has been previously shown...

journal_title：Archives of pathology & laboratory medicine

authors： Jhala NC,Vickers SM,Argani P,McDonald JM

更新日期：2005-04-01 00:00:00

abstract：:Amplification of the human epidermal growth factor receptor 2/neu (HER2/neu) gene and overexpression of the HER2 protein (HER2) have been shown to occur in gastric and gastroesophageal junction adenocarcinoma in a number of studies. With a dismal survival rate, patients with these cancers stand to benefit from the ide...

journal_title：Archives of pathology & laboratory medicine

authors： Hechtman JF,Polydorides AD

更新日期：2012-06-01 00:00:00

abstract：CONTEXT:- Current 2013 World Health Organization classification of tumors of soft tissue arranges these tumors into 12 groups according to their histogenesis. Tumor behavior is classified as benign, intermediate (locally aggressive), intermediate (rarely metastasizing), and malignant. In our practice, a general approac...

journal_title：Archives of pathology & laboratory medicine

authors： Wei S,Henderson-Jackson E,Qian X,Bui MM

更新日期：2017-08-01 00:00:00

abstract：:Coronary ostial stenosis is a cause of angina pectoris and sudden death. It is due mainly to atherosclerosis, syphilis, and iatrogenic disease. The last is of growing importance because of the frequency of coronary arteriography and surgical procedures on the aortic valve. Since both may cause stenosis of the coronary...

journal_title：Archives of pathology & laboratory medicine

authors： Knutson EL,Smith JC

更新日期：1976-03-01 00:00:00

abstract：CONTEXT:Deletion of the short arm of chromosome 3 (3p deletion) is a cytogenetic abnormality generally associated with clear cell renal cell carcinoma, the most aggressive form of renal epithelial tumor. OBJECTIVE:To cytogenetically characterize 24 renal tumors in order to check the incidence and the type of 3p deleti...

journal_title：Archives of pathology & laboratory medicine

authors： Gayrard N,Cacheux V,Iborra F,Mourad G,Argilés A

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To review the current understanding of the pathophysiology of antithrombin deficiency and its role in congenital thrombophilia. Recommendations for diagnostic testing of antithrombin function and concentration, derived from the medical literature and consensus opinions of recognized experts in the field, are ...

journal_title：Archives of pathology & laboratory medicine

authors： Kottke-Marchant K,Duncan A

更新日期：2002-11-01 00:00:00

abstract：:To study the natural course of catheter-induced endocarditis secondarily infected with Staphylococcus epidermidis, 29 rabbits had catheters introduced surgically through the carotid artery to the aortic valve. Forty-eight hours later the catheters were removed from five rabbits. The rabbits were inoculated intravenous...

journal_title：Archives of pathology & laboratory medicine

authors： Shamsuddin D,Tuazon CU,Miller H,Shamsuddin AK,Friedman D

更新日期：1983-03-01 00:00:00

abstract：:Hepatoid carcinoma of the ovary (HCO) is a rare malignant tumor of uncertain histogenesis that was first described by Ishikura and Scully in the late 1980s. Unlike hepatoid yolk sac tumor (HYST), one of its main differential diagnoses, HCO usually presents in perimenopausal and postmenopausal women without gonadal dys...

journal_title：Archives of pathology & laboratory medicine

authors： Acosta AM,Pins MR

更新日期：2019-07-01 00:00:00

abstract：:While the level of marrow reticulin may be a factor that is used when the presence of a hematologic disorder is being considered, to our knowledge no study has graded the amount of reticulin present in normal iliac bone marrow. Grading reticulin stains of bone biopsy specimens from 100 hematologically normal patients ...

journal_title：Archives of pathology & laboratory medicine

authors： Beckman EN,Brown AW Jr

更新日期：1990-12-01 00:00:00

abstract：:During a surgical procedure, black vertebrae were observed in a 42-year-old white woman. An undecalcified iliac crest bone biopsy specimen revealed intense fluorescence compatible with tetracycline labeling and osteoporosis. A urinary screening test was negative for amino acids. The patient had been treated with minoc...

journal_title：Archives of pathology & laboratory medicine

authors： Rumbak MJ,Pitcock JA,Palmieri GM,Robertson JT

更新日期：1991-09-01 00:00:00

abstract：:Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well docume...

journal_title：Archives of pathology & laboratory medicine

authors： Ilario MJ,Ruiz JE,Axiotis CA

更新日期：2000-12-01 00:00:00

abstract：:A case of pronounced cystic dilatation of the intrahepatic bile ducts with biliary atresia is presented. Intrahepatic biliary cysts have been described in biliary atresia, although, as far as we are aware, none as extensive as in this case. The cysts represent end-stage obstruction with irreversible liver injury; thus...

journal_title：Archives of pathology & laboratory medicine

authors： Fain JS,Lewin KJ

更新日期：1989-12-01 00:00:00

abstract：:Histopathology is based on the interpretation of features of the microscopic image. In recent years, there has evolved interest in assessing quantifiable data from these images, with the intent of providing more precise diagnostic and prognostic information. Proliferation characteristics of tumors are among the most i...

journal_title：Archives of pathology & laboratory medicine

authors： Woosley JT

更新日期：1991-06-01 00:00:00

abstract：:Critical values in anatomic pathology are usually information sensitive, whereas most such values in laboratory medicine are time sensitive. However, there is an important time element in anatomic pathology as well. Pathologists should be aware that many medicolegal actions against radiologists are based on failure to...

journal_title：Archives of pathology & laboratory medicine

authors： LiVolsi VA,Leung S

更新日期：2006-05-01 00:00:00

abstract：CONTEXT:Assessment of BRAF p.V600E mutational status has become necessary for treatment of patients with metastatic melanoma. Detection of p.V600E mutation by immunohistochemistry was recently reported in several tumor types. OBJECTIVE:To evaluate the interobserver reproducibility of BRAF p.V600E detection by immunohi...

journal_title：Archives of pathology & laboratory medicine

authors： Marin C,Beauchet A,Capper D,Zimmermann U,Julié C,Ilie M,Saiag P,von Deimling A,Hofman P,Emile JF

更新日期：2014-01-01 00:00:00

abstract：:A 52-year-old man, suffering for years from malabsorption due to endemic sprue, developed progressive bowel dysfunction, ie, recurrent ileus and intestinal pseudo-obstruction. Because of partial volvulus formation, ileocecal resection was performed. Histopathologic examination of the resected specimen revealed signs o...

journal_title：Archives of pathology & laboratory medicine

authors： Ruchti C,Eisele S,Kaufmann M

更新日期：1990-01-01 00:00:00

abstract：:In this article, I review the submicroscopic organization of the human spermatozoon, the functional role of its individual organelles in motility, penetrating ability, and fusogenic and fertilizing competence, and its pathology as a cause of male infertility. ...

journal_title：Archives of pathology & laboratory medicine

authors： Zamboni L

更新日期：1992-04-01 00:00:00