Abstract:
CONTEXT:Cervical cancer affects 12 000 women in the United States annually. However, despite its prevalence, there remains no good methodology to detect its recurrence. OBJECTIVE:To identify the role of cervicovaginal high-risk human papilloma virus (hr-HPV) testing in predicting cervical cancer recurrence. DESIGN:This is a retrospective study of patients who underwent hr-HPV testing as part of their routine surveillance for cervical cancer. Standard statistical analyses, including χ² test and multivariable logistic regression, were performed with IBM SPSS 19.0. RESULTS:A total of 133 patients were identified, of whom 107 (80%) had squamous cell carcinoma. Ninety patients (68%) had bulky disease and were treated primarily with chemoradiation and brachytherapy. Of patients whose disease recurred, 5 patients (42%) had tested positive for hr-HPV during their surveillance period, compared to 13 patients (11%) for whom disease did not recur (relative risk: 3.88, P = .002). On multivariate logistic regression, hr-HPV status remained significantly predictive of disease recurrence (odds ratio: 12.3, P = .02, 95% confidence interval: 1.5-99.6). Using 2 × 2 table analysis, we found that while cervicovaginal cytology has limited specificity (5.7%) in predicting recurrence, the combination of cytology with hr-HPV testing increases the specificity of testing to 89.3%. CONCLUSIONS:Persistence of hr-HPV is a risk factor for disease recurrence. High-risk-HPV testing is not routinely used during surveillance for cervical cancer, but this study suggests that large, prospective trials investigating the role of hr-HPV testing in cervical cancer surveillance are needed.
journal_name
Arch Pathol Lab Medjournal_title
Archives of pathology & laboratory medicineauthors
Yu MC,Austin RM,Lin J,Beck T,Beriwal S,Comerci JT,Edwards RP,Sukumvanich P,Kelley J,Olawaiye ABdoi
10.5858/arpa.2014-0534-OAsubject
Has Abstractpub_date
2015-11-01 00:00:00pages
1437-40issue
11eissn
0003-9985issn
1543-2165journal_volume
139pub_type
杂志文章abstract::Primary dural lymphoma is rare, and few of the small number of cases reported to date have been classified using immunohistochemical techniques. To our knowledge, we report the first case of T-cell-rich B-cell lymphoma (diffuse mixed small cell and large cell) presenting as a solitary intracranial dural mass. Cytologi...
journal_title:Archives of pathology & laboratory medicine
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abstract:CONTEXT:The endomyocardial biopsy is the mainstay for monitoring acute allograft rejection in heart transplantation. Objective and accurate assessment of cellular and humoral types of rejection is important to optimize immunosuppressive therapy, avoid therapeutic complications, and improve patient outcome. The grading ...
journal_title:Archives of pathology & laboratory medicine
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abstract::Amplification of the neu oncogene and overexpression of its product was found to be a potential marker for aggressive biological behavior in breast cancer. However, the expression of the neu oncoprotein in normal breast ducts and myoepithelial cells has also been demonstrated. Hence, we examined normal salivary gland ...
journal_title:Archives of pathology & laboratory medicine
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doi:
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abstract::We report the case of a primary breast rhabdomyosarcoma in a 51-year-old white woman. The tumor occupied the upper outer quadrant of the right breast. There was no association with the underlying pectoral muscle, and the patient was free of any other benign or malignant neoplastic processes outside the breast. Microsc...
journal_title:Archives of pathology & laboratory medicine
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abstract::The College of American Pathologists and the American Society of Human Genetics offer a proficiency testing program in clinical cytogenetics. Two hundred twenty-five laboratories now provide data for this survey, which was begun in 1986. Challenges have consisted of photographed metaphases, fixed lymphoblastoid cell s...
journal_title:Archives of pathology & laboratory medicine
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更新日期:1993-08-01 00:00:00
abstract::We report the clinical and postmortem findings in a newborn with Beckwith-Wiedemann syndrome and pulmonary hypoplasia. The infant was found to have a massively enlarged thymus gland that apparently caused pulmonary hypoplasia and respiratory insufficiency. Massive hyperplasia of the thymus gland should be considered i...
journal_title:Archives of pathology & laboratory medicine
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doi:
更新日期:1985-02-01 00:00:00
abstract::A case of primary fibrosarcoma of the urinary bladder showing extensive chondroid differentiation was studied by light microscopy and immunofluorescent microscopy using tissue-specific antibodies against intermediate filaments. The tumor cells were uniformly and positively labeled with vimentin antibodies and were neg...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1987-08-01 00:00:00
abstract::Histiocytes counted in smears made from the tracheobronchial washings of 208 patients with malignant melanomas were found to be 3.12 times more numerous than in a control group comparable in sex, age (decades), and smoking habit but without any type of prediagnosed malignant lesion. The discovery of this phenomenon ma...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Hemorrhagic endovasculitis (HEV) is a vasodisruptive alteration of fetal-placental blood vessels that has been associated with perinatal morbidity and mortality and abnormalities of growth and development. Clinicopathologic conditions that are often identified in pregnancies with HEV-affected p...
journal_title:Archives of pathology & laboratory medicine
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journal_title:Archives of pathology & laboratory medicine
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
abstract::A commercially available enzyme immunoassay (EIA) for the detection of Clostridium difficile toxin A (Premier Toxin A EIA, Meridian Diagnostics, Cincinnati, Ohio) was compared with tissue culture cytotoxicity assay, enterotoxigenic culture, and latex agglutination test for the laboratory diagnosis of C difficile-assoc...
journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1994-09-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
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doi:
更新日期:1998-12-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
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journal_title:Archives of pathology & laboratory medicine
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doi:
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journal_title:Archives of pathology & laboratory medicine
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journal_title:Archives of pathology & laboratory medicine
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doi:
更新日期:1978-11-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
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更新日期:1993-06-01 00:00:00
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journal_title:Archives of pathology & laboratory medicine
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更新日期:1979-11-01 00:00:00