Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations.

Abstract:

CONTEXT:-Whole-slide imaging technology offers promise for rapid, Internet-based telepathology consultations between institutions. Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized. OBJECTIVE:-To determine whether interpretation of whole-slide images differed from glass-slide interpretation in difficult surgical pathology cases. DESIGN:-Diagnostically challenging pathology slides from a variety of anatomic sites from an outside laboratory were scanned into whole digital format. Digital and glass slides were independently diagnosed by 2 subspecialty pathologists. Reference, digital, and glass-slide interpretations were compared. Operator comments on technical issues were gathered. RESULTS:-Fifty-three case pairs were analyzed. There was agreement among digital, glass, and reference diagnoses in 45 cases (85%) and between digital and glass diagnoses in 48 (91%) cases. There were 5 digital cases (9%) discordant with both reference and glass diagnoses. Further review of each of these cases indicated an incorrect digital whole-slide interpretation. Neoplastic cases showed better correlation (93%) than did cases of nonneoplastic disease (88%). Comments on discordant cases related to digital whole technology focused on issues such as fine resolution and navigating ability at high magnification. CONCLUSIONS:-Overall concordance between digital whole-slide and standard glass-slide interpretations was good at 91%. Adjustments in technology, case selection, and technology familiarization should improve performance, making digital whole-slide review feasible for broader telepathology subspecialty consultation applications.

journal_name

Arch Pathol Lab Med

authors

Wilbur DC,Madi K,Colvin RB,Duncan LM,Faquin WC,Ferry JA,Frosch MP,Houser SL,Kradin RL,Lauwers GY,Louis DN,Mark EJ,Mino-Kenudson M,Misdraji J,Nielsen GP,Pitman MB,Rosenberg AE,Smith RN,Sohani AR,Stone JR,Tambouret

doi

10.1043/1543-2165-133.12.1949

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1949-53

issue

12

eissn

0003-9985

issn

1543-2165

pii

2008-0777-OAR

journal_volume

133

pub_type

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