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Nitric oxide stimulates insulin gene transcription in pancreatic beta-cells.

Abstract：

:Recent studies have identified a positive role for nitric oxide (NO) in the regulation of pancreatic beta-cell function. The aim of this study was to determine the effects of short-term exposure to NO on beta-cell gene expression and the activity of the transcription factor PDX-1. NO stimulated the activity of the insulin gene promoter in Min6 beta-cells and endogenous insulin mRNA levels in both Min6 and isolated islets of Langerhans. Addition of wortmannin prior to NO stimulation blocked the observed increases in insulin gene promoter activity. Although NO addition stimulated the phosphorylation of p38, inhibition by SB203580 did not block the effect of NO on the insulin gene promoter. NO addition also stimulated both the nuclear accumulation and the DNA binding activity of PDX-1. This study has shown that over 24h, NO stimulates insulin gene expression, PI-3-kinase activity and the activity of the critical beta-cell transcription factor PDX-1.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Campbell SC,Richardson H,Ferris WF,Butler CS,Macfarlane WM

doi

10.1016/j.bbrc.2006.12.127

subject

Has Abstract

pub_date

2007-02-23 00:00:00

pages

1011-6

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)02798-7

journal_volume

353

pub_type

杂志文章

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