Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.

abstract：:To delineate the functional importance of the highly conserved triplet amino acid sequence, Asp-Arg-Tyr (DRY) among G protein-coupled receptors in the second intracellular loop, these residues of rat angiotensin II (Ang II) receptor type 1A (AT(1A)) were changed by alanine or glycine by site-directed mutagenesis. Thes...

journal_title：Biochemical and biophysical research communications

authors： Ohyama K,Yamano Y,Sano T,Nakagomi Y,Wada M,Inagami T

更新日期：2002-03-29 00:00:00

abstract：:GH3/B6 pituitary cells release prolactin (PRL) in response to thyrotropin releasing hormone (TRH). Electrophysiological assays of individual GH3 cells with sharp high-resistance microelectrodes have revealed complex effects of TRH on membrane excitability consisting of a transient hyperpolarization (1), which is thoug...

journal_title：Biochemical and biophysical research communications

authors： Dufy B,MacDermott A,Barker JL

更新日期：1986-05-29 00:00:00

abstract：:N-Glycosylation has been shown to affect the rate of glycoprotein transport through the secretory pathway. In order to identify the critical components in the N-glycosylation pathway that directly influence protein secretion, we have studied the effects of downregulation of the first gene in the dolichol pathway, ALG7...

journal_title：Biochemical and biophysical research communications

authors： Kukuruzinska MA,Apekin V,Lamkin MS,Hiltz A,Rodriguez A,Lin CC,Paz MA,Oppenheim FG

更新日期：1994-02-15 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is the causal gene for autosomal dominant familial Parkinson's disease. We have previously reported a novel molecular feature characteristic to I2020T mutant LRRK2: higher susceptibility to post-translational degradation than the wild-type LRRK2. In the present study, we demonstrat...

journal_title：Biochemical and biophysical research communications

authors： Ohta E,Kubo M,Obata F

更新日期：2010-01-01 00:00:00

abstract：:Sheep thyroid cells cultured in serum-free medium were used to study the biologic activity, binding, and production of the insulin-like growth factors (IGFs). IGF-I, IGF-II, and insulin stimulated thyroid cell division. Abundant, specific IGF receptors on sheep thyroid cell membranes were identified by binding displac...

journal_title：Biochemical and biophysical research communications

authors： Bachrach LK,Eggo MC,Hintz RL,Burrow GN

更新日期：1988-08-15 00:00:00

abstract：:Unlike unsaturated fatty acids, which almost fully activated purified brain protein kinase C in a phosphatidylserine- and Ca2(+)-free reaction, related methyl esters were poorly active in vitro. In contrast, methyl arachidonate was revealed to be as potent as arachidonic acid in activating protein kinase C in intact p...

journal_title：Biochemical and biophysical research communications

authors： Fan XT,Huang XP,Da Silva C,Castagna M

更新日期：1990-06-29 00:00:00

abstract：:Aurora-C, a member of the Aurora kinase family, is implicated in the regulation of mitosis. In contrast to Aurora-A and Aurora-B its cellular localization and functions are poorly characterized. TACC1 protein belongs to the transforming acidic coiled-coil family shown to interact with the Aurora kinases. In the presen...

journal_title：Biochemical and biophysical research communications

authors： Gabillard JC,Ulisse S,Baldini E,Sorrenti S,Cremet JY,Coccaro C,Prigent C,D'Armiento M,Arlot-Bonnemains Y

更新日期：2011-05-20 00:00:00

abstract：:The interaction between isolated adrenal medullary plasma membranes and chromaffin granules has been proposed as a cell-free model for exocytosis. Phosphorylation experiments showed that isolated chromaffin granules as well as isolated plasma membranes contain protein kinases and phosphate accepting membranous protein...

journal_title：Biochemical and biophysical research communications

authors： Konings F,De Potter W

更新日期：1983-01-14 00:00:00

abstract：:alpha-Synuclein is the major component of the filamentous Lewy bodies and Lewy-related neurites, neuropathological hallmarks of Parkinson's disease. Although numerous studies on alpha-synuclein fibrillation have been reported, the molecular mechanisms of aggregation and fibrillation at the initial stage are still uncl...

journal_title：Biochemical and biophysical research communications

authors： Tashiro M,Kojima M,Kihara H,Kasai K,Kamiyoshihara T,Uéda K,Shimotakahara S

更新日期：2008-05-09 00:00:00

abstract：:Neuromedin K and neuromedin L are novel mammalian tachykinins isolated from porcine spinal cord. We have developed a highly sensitive radioimmunoassay for neuromedin K. Since the radioimmunoassay for neuromedin K has significant crossreactivity with neuromedin L and substance P, we can simultaneously determine the tis...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Masuda H,Kangawa K,Matsuo H

更新日期：1984-11-14 00:00:00

abstract：:The regulatory systems of endogenous endothelin-1 (ET-1) production from intact tissues and the effects of produced ET-1 on vascular tonus by a closed circuit perfusion system of rat mesenteric artery were investigated. It was demonstrated that ET-1 is released from intact mesenteric arterial beds from Wistar rats bot...

journal_title：Biochemical and biophysical research communications

authors： Tomobe Y,Yanagisawa M,Fujimori A,Masaki T,Goto K

更新日期：1993-03-15 00:00:00

abstract：:Sulforaphane, an aliphatic isothiocyanate derived from cruciferous vegetables, is known for its antidiabetic properties. The effects of sulforaphane on lipid metabolism in adipocytes are not clearly understood. Here, we investigated whether sulforaphane stimulates lipolysis. Mature adipocytes were incubated with sulfo...

journal_title：Biochemical and biophysical research communications

authors： Lee JH,Moon MH,Jeong JK,Park YG,Lee YJ,Seol JW,Park SY

更新日期：2012-10-05 00:00:00

abstract：:Cholestasis and hepatitis can cause continuous liver damage that may ultimately result in liver fibrosis. In a previous study, we demonstrated that microRNA-29a (miR-29a) protects against liver fibrosis. Toll-like receptor 2 (TLR2) and TLR4 are pattern recognition receptors of bacterial lipoprotein and lipopolysacchar...

journal_title：Biochemical and biophysical research communications

authors： Lin YC,Wang FS,Yang YL,Chuang YT,Huang YH

更新日期：2018-02-12 00:00:00

abstract：:Hepatitis C virus (HCV) infects its target cells in the form of cell-free viruses and through cell-cell contact. Here we report that HCV is associated with exosomes. Using highly purified exosomes and transmission electron microscopic imaging, we demonstrated that HCV occurred in both exosome-free and exosome-associat...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Zhang X,Yu Q,He JJ

更新日期：2014-12-12 00:00:00

abstract：:The binding site(s) in rabbit liver fructose-1,6-bisphosphatase for the active site binding ligand, fructose 6-phosphate, and the inhibitor, fructose 2,6-bisphosphate, have been investigated by using nuclear magnetic resonance spectroscopy. The distance from a nitroxide spin label to the bound ligands and the distance...

journal_title：Biochemical and biophysical research communications

authors： Liu F,Roy M,Fromm HJ

更新日期：1989-06-15 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is one of the major angiogenesis regulators. It binds to its tyrosine kinase receptors, KDR and Flt-1. However, little is known about their downstream signal transduction properties. We screened human brain cDNA library using the yeast two-hybrid system with the KDR cytoplasmi...

journal_title：Biochemical and biophysical research communications

authors： Igarashi K,Shigeta K,Isohara T,Yamano T,Uno I

更新日期：1998-10-09 00:00:00

abstract：:Multidrug transporters are of considerable importance because they present problems in the treatment of infectious disease and cancer. A central issue is the ability of efflux pumps to recognize an astounding array of structurally diverse compounds. The yeast Pdr5p efflux pump, which is a member of the ATP-binding cas...

journal_title：Biochemical and biophysical research communications

authors： Golin J,Ambudkar SV,May L

更新日期：2007-04-27 00:00:00

abstract：:Rabbit antibodies have been raised against rat liver nuclear envelopes. An enzyme-linked immunosorbent assay (ELISA) demonstrated high titer antiserum specific for the nuclear envelope preparation. Immunocytochemical studies showed that the antiserum stained the nuclear envelopes, but not intra-nuclear components of H...

journal_title：Biochemical and biophysical research communications

authors： Venkatraman JT,Gohill J,Fritzler MJ,Lefebvre YA

更新日期：1988-10-31 00:00:00

abstract：:When LHCII forms aggregates, the internal conformational changes will result in chlorophyll fluorescence quenching. Uncovering the molecular mechanism of this phenomenon will help us to understand how plants dissipate the excess excitation energy through non-photochemical quenching (NPQ) process. The crystal structure...

journal_title：Biochemical and biophysical research communications

authors： Yan H,Zhang P,Wang C,Liu Z,Chang W

更新日期：2007-04-06 00:00:00

abstract：:Ferroptosis is a form of regulated cell death resulting from iron accumulation and lipid peroxidation. While impaired ferroptosis is tightly linked to human diseases and conditions, the mechanism and regulation of ferroptosis remain largely unknown. Here, we demonstrate that STAT3 is a positive regulator of ferroptosi...

journal_title：Biochemical and biophysical research communications

authors： Gao H,Bai Y,Jia Y,Zhao Y,Kang R,Tang D,Dai E

更新日期：2018-09-10 00:00:00

abstract：:We have isolated and characterized the 5'-flanking region of the mouse RECK gene aiming to understand the mechanism of oncogene-mediated suppression of RECK gene expression. The upstream 52-base region was found to contain a promoter activity which is, to some extent, suppressed by the ras oncogene. This region contai...

journal_title：Biochemical and biophysical research communications

authors： Sasahara RM,Takahashi C,Noda M

更新日期：1999-11-02 00:00:00

abstract：:Our results show that in the intact normal animal cell mitochondrial ATP is directly connected to nuclear PARP-1 by way of a specific adenylate kinase enzymatic path. This mechanism is demonstrated in two models: (a) by its inhibition with a specific inhibitor of adenylate kinase, and (b) by disruption of ATP synthesi...

journal_title：Biochemical and biophysical research communications

authors： Kun E,Kirsten E,Hakam A,Bauer PI,Mendeleyev J

更新日期：2008-02-08 00:00:00

abstract：:The gene encoding rat cystatin S (Cys S), a salivary gland-specific secretory protein, has CAAT and TATA boxes upstream of the inititation codon (Cox and Shaw, 1992), and contains regions that resemble those of other hormonally responsive eukaryotic genes. The 5'-flanking sequence of the rat Cys S gene has a potential...

journal_title：Biochemical and biophysical research communications

authors： Shaw PA,Chaparro O

更新日期：1999-08-11 00:00:00

abstract：:The ΔpH-dependent/Tat pathway is unique for using only the proton motive force for driving proteins transport across the thylakoid membrane in chloroplasts. 9-aminoacridine fluorescence quenching is widely used to monitor the ΔpH developed across the thylakoid membrane in the light. However, this method suffers from l...

journal_title：Biochemical and biophysical research communications

authors： Yang H,Pu X,Wang L,Liu L,Theg SM

更新日期：2017-04-22 00:00:00

abstract：:The rSK3 gene encodes a small conductance Ca(2+)-activated K(+) channel that is transcriptionally regulated by estrogen. To examine determinants of rSK3 gene expression, the CAP site was defined and the promoter was identified. A 33 bp sequence adjacent to the promoter was shown to act as an enhancer in L6 cells that ...

journal_title：Biochemical and biophysical research communications

authors： Jacobson D,Pribnow D,Herson PS,Maylie J,Adelman JP

更新日期：2003-04-04 00:00:00

abstract：:Previously it was known that cytosolic Ca(2+) elevation was involved in regulating UV- or TNFalpha-induced apoptosis. Here, we reported new evidence that mitochondrial Ca(2+) signal is also involved in the apoptotic process. First, using living cell imaging techniques, we observed multiple mitochondrial Ca(2+) spikes ...

journal_title：Biochemical and biophysical research communications

authors： Lao Y,Chang DC

更新日期：2008-08-15 00:00:00

abstract：:Insulin receptor substrates (IRSs) are phosphorylated by activated insulin/insulin-like growth factor (IGF)-I receptor tyrosine kinases. Phosphotyrosyl IRSs are recognized by signaling molecules possessing src homology region 2 (SH2) domains, which mediate various insulin/IGF bioactivities. However, we have shown that...

journal_title：Biochemical and biophysical research communications

authors： Fukushima T,Arai T,Ariga-Nedachi M,Okajima H,Ooi Y,Iijima Y,Sone M,Cho Y,Ando Y,Kasahara K,Ozoe A,Yoshihara H,Chida K,Okada S,Kopchick JJ,Asano T,Hakuno F,Takahashi S

更新日期：2011-01-21 00:00:00

abstract：:Arylamine N-acetyltransferase 1 is a phase II metabolizing enzyme that has been associated with certain breast cancer subtypes. While it has been linked to breast cancer risk because of its role in the metabolic activation and detoxification of carcinogens, recent studies have suggested it may be important in cell gro...

journal_title：Biochemical and biophysical research communications

authors： Tiang JM,Butcher NJ,Minchin RF

更新日期：2010-02-26 00:00:00

abstract：:Human neuropeptide Y (NPY) analog ANA-NPY or [L17, Q19, A20, A23, L28, L31]NPY (13-36)-amide binds weakly to postjunctional receptors to raise blood pressure but binds tightly to prejunctional receptors to inhibit neurotransmitter release. ANA-NPY forms a well-conserved anti-parallel helical structure overlapping E23-...

journal_title：Biochemical and biophysical research communications

authors： Barden JA

更新日期：1995-10-04 00:00:00

abstract：:We evaluated the use of a combination of adipose tissue derived adult stem cells (ADSCs) obtained from liposuction and injectable poly(lactic-co-glycolic acid) (PLGA) spheres for adipose tissue engineering. Adipogenesis was examined in nude mice injected subcutaneously with ADSCs (group I), PLGA spheres (group II), or...

journal_title：Biochemical and biophysical research communications

authors： Choi YS,Cha SM,Lee YY,Kwon SW,Park CJ,Kim M

更新日期：2006-06-30 00:00:00