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A map of nuclear matrix attachment regions within the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1.

Abstract：

:There is abundant evidence that the DNA in eukaryotic cells is organized into loop domains that represent basic structural and functional units of chromatin packaging. To explore the DNA domain organization of the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1, we have identified a significant portion of the scaffold/matrix attachment regions (S/MARs) within this region. Forty independent putative S/MAR elements were assigned within the 16q22.1 locus. More than 90% of these S/MARs are AT rich, with GC contents as low as 27% in 2 cases. Thirty-nine (98%) of the S/MARs are located within genes and 36 (90%) in gene introns, of which 15 are in first introns of different genes. The clear tendency of S/MARs from this region to be located within the introns suggests their regulatory role. The S/MAR resource constructed may contribute to an understanding of how the genes in the region are regulated and of how the structural architecture and functional organization of the DNA are related.

journal_name

Genomics

journal_title

Genomics

authors

Shaposhnikov SA,Akopov SB,Chernov IP,Thomsen PD,Joergensen C,Collins AR,Frengen E,Nikolaev LG

doi

10.1016/j.ygeno.2006.11.003

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

354-61

issue

3

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(06)00321-1

journal_volume

89

pub_type

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