Modulation of platelet surface adhesion receptors during cardiopulmonary bypass.


:Alterations in platelet receptors critical to adhesion may play a role in the pathogenesis of the qualitative platelet defect associated with cardiopulmonary bypass. Using flow cytometry, we measured changes in the following platelet surface adhesive proteins: the von Willebrand factor receptor, glycoprotein Ib; the fibrinogen receptor, glycoprotein IIb/IIIa; the thrombospondin receptor, glycoprotein IV; the adhesive glycoprotein granule membrane protein 140, whose expression also reflects platelet activation and alpha-granule release; and, as a control, the nonreceptor protein HLA, A,B,C. Glycoprotein Ib decreased during cardiopulmonary bypass (P less than 0.05) and reached a nadir at 72% (P less than 0.05) of its baseline value at 2-4 h after bypass. This decrease correlated (r = 0.76) with the magnitude of platelet activation (alpha-granule release) in any given patient, but even platelets that were not activated demonstrated a decrease in glycoprotein Ib expression. Glycoprotein IIb/IIIa also decreased in both the activated (47% of baseline, P less than 0.01) and unactivated (63% of baseline, P less than 0.01) subsets of platelets at the end of cardiopulmonary bypass. Glycoprotein IV and HLA A,B,C did not decrease, but instead increased 2-4 h after cardiopulmonary bypass (P less than 0.05). We conclude that cardiopulmonary bypass produces selective decreases in surface glycoproteins Ib and IIb/IIIa as well as in platelet activation; that these two alterations are temporally but not necessarily mechanistically linked; and that these changes have the potential to adversely affect platelet function.






Rinder CS,Mathew JP,Rinder HM,Bonan J,Ault KA,Smith BR




Has Abstract


1991-10-01 00:00:00












  • Retrograde light-guided laryngoscopy for tracheal intubation: clinical practice and comparison with conventional direct laryngoscopy.

    abstract:BACKGROUND:Tracheal intubation with conventional laryngoscopy requires many trials until beginners are sufficiently skilled in intubating patients safely. To facilitate intubation, the authors used retrograde light-guided laryngoscopy (RLGL) and compared its feasibility with conventional direct laryngoscopy (DL). METH...


    pub_type: 杂志文章,随机对照试验


    authors: Yang T,Hou J,Li J,Zhang X,Zhu X,Ni W,Mao Y,Deng X

    更新日期:2013-05-01 00:00:00

  • Comparative effects of propofol and halothane on outcome from temporary middle cerebral artery occlusion in the rat.

    abstract::Because propofol has cerebral effects similar to those observed for barbiturates, we postulated that it too might offer protection against a focal cerebral ischemic insult. Spontaneously hypertensive male rats were anesthetized with halothane (in 50% O2/balance N2), and their tracheas were intubated and their lungs me...


    pub_type: 杂志文章


    authors: Ridenour TR,Warner DS,Todd MM,Gionet TX

    更新日期:1992-05-01 00:00:00

  • Exaggerated anesthetic requirements in the preferentially anesthetized brain.

    abstract:BACKGROUND:The brain is assumed to be the site of anesthetic action, but anesthetics have effects elsewhere, such as the spinal cord. A preferentially anesthetized goat brain model was used to determine the importance of anesthetic action in the brain. METHODS:Six goats were anesthetized with isoflurane; after trachea...


    pub_type: 杂志文章


    authors: Antognini JF,Schwartz K

    更新日期:1993-12-01 00:00:00

  • Chronic pain management: American Society of Anesthesiologists Closed Claims Project.

    abstract:BACKGROUND:The practice of chronic pain management has grown steadily in recent years. The purpose of this study was to identify and describe issues and trends in liability related to chronic pain management by anesthesiologists. METHODS:Data from 5,475 claims in the American Society of Anesthesiologists Closed Claims...


    pub_type: 杂志文章


    authors: Fitzgibbon DR,Posner KL,Domino KB,Caplan RA,Lee LA,Cheney FW,American Society of Anesthesiologists.

    更新日期:2004-01-01 00:00:00

  • Isoflurane anesthesia and circadian temperature cycles in humans.

    abstract::Cognitive performance in postsurgical patients may be impaired by disturbances of normal circadian rhythm analogous to those produced by rapid transmeridian travel ("jet lag"). We therefore tested the hypothesis that isoflurane anesthesia alone produces a phase-delay in the human circadian temperature rhythm. We monit...


    pub_type: 杂志文章


    authors: Sessler DI,Lee KA,McGuire J

    更新日期:1991-12-01 00:00:00

  • No involvement of antidiuretic hormone in acute antidiuresis during PEEP ventilation in humans.

    abstract::Decreased urinary output (Vu ml/min) after institution of PEEP is attributed to a variety of mechanisms including decreased cardiac output and renal blood flow (RBF), activation of neurohormonal reflexes, increased catecholamines, plasma renin activity (PRA), and antidiuretic hormone (ADH) release. To evaluate these f...


    pub_type: 杂志文章


    authors: Payen DM,Farge D,Beloucif S,Leviel F,De La Coussaye JE,Carli P,Wirquin V

    更新日期:1987-01-01 00:00:00

  • Ventilatory response to CO2 following intravenous and epidural lidocaine.

    abstract::The authors determined the effects of intravenous infusion and epidural administration of lidocaine on the control of ventilation in two groups of eight healthy unpremedicated subjects. In the intravenous group, an injection of 1.5 mg/kg lidocaine was followed by an infusion at a rate of 60 micrograms X kg-1 X min-1 f...


    pub_type: 杂志文章


    authors: Labaille T,Clergue F,Samii K,Ecoffey C,Berdeaux A

    更新日期:1985-08-01 00:00:00

  • Cumulative duration of "triple low" state of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anesthesia is not associated with increased mortality.

    abstract:BACKGROUND:Mortality after noncardiac surgery has been associated with the "triple low state," a combination of low mean arterial blood pressure (<75 mmHg), low bispectral index (<45), and low minimum alveolar concentration of volatile anesthesia (<0.70). The authors set out to determine whether duration of a triple lo...


    pub_type: 杂志文章


    authors: Kertai MD,White WD,Gan TJ

    更新日期:2014-07-01 00:00:00

  • Halothane and isoflurane differentially affect the regulation of dopamine and gamma-aminobutyric acid release mediated by presynaptic acetylcholine receptors in the rat striatum.

    abstract:BACKGROUND:General anesthetics are thought to produce their hypnotic effects mainly by acting at ligand-gated ionic channels in the central nervous system (CNS). Although it is well established that volatile anesthetics significantly modify the activity of the acetylcholine nicotinic receptors of the neuromuscular junc...


    pub_type: 杂志文章


    authors: Salord F,Keita H,Lecharny JB,Henzel D,Desmonts JM,Mantz J

    更新日期:1997-03-01 00:00:00

  • Biotransformation of isoflurane: urinary and serum fluoride ion and organic fluorine.

    abstract::The serum and urinary concentrations of fluorinated metabolites of isoflurane after inhalation of three different concentrations of isoflurane were studied in 18 ASA physical status 1 or 2 patients, scheduled for orthopedic or otolaryngeal surgery. Isoflurane was administered for 60 min during fentanyl-nitrous oxide-o...


    pub_type: 杂志文章


    authors: Davidkova T,Kikuchi H,Fujii K,Mukaida K,Sato N,Kawachi S,Morio M

    更新日期:1988-08-01 00:00:00

  • Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels.

    abstract:BACKGROUND:Identifying functionally relevant anesthetic-binding sites in pentameric ligand-gated ion channels (pLGICs) is an important step toward understanding the molecular mechanisms underlying anesthetic action. The anesthetic propofol is known to inhibit cation-conducting pLGICs, including a prokaryotic pLGIC from...


    pub_type: 杂志文章


    authors: Kinde MN,Bu W,Chen Q,Xu Y,Eckenhoff RG,Tang P

    更新日期:2016-03-01 00:00:00

  • Anesthesia with Disuse Leads to Autophagy Up-regulation in the Skeletal Muscle.

    abstract:BACKGROUND:It has been known that skeletal muscles show atrophic changes after prolonged sedation or general anesthesia. Whether these effects are due to anesthesia itself or disuse during anesthesia has not been fully clarified. Autophagy dysregulation has been implicated in muscle-wasting conditions. This study teste...


    pub_type: 杂志文章


    authors: Kashiwagi A,Hosokawa S,Maeyama Y,Ueki R,Kaneki M,Martyn JA,Yasuhara S

    更新日期:2015-05-01 00:00:00

  • Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study.

    abstract:BACKGROUND:Sugammadex (Org 25969) forms a complex with steroidal neuromuscular blocking agents, thereby reversing neuromuscular block. This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block. METHODS:Twenty-seven male surgical patients aged 18-...


    pub_type: 杂志文章,随机对照试验


    authors: Sorgenfrei IF,Norrild K,Larsen PB,Stensballe J,Ostergaard D,Prins ME,Viby-Mogensen J

    更新日期:2006-04-01 00:00:00

  • Morphine inhibits spontaneous and cytokine-enhanced natural killer cell cytotoxicity in volunteers.

    abstract:BACKGROUND:Opioids are used by patients who have conditions ranging from the acute pain of surgery and chronic cancer pain to substance abuse. Despite their widespread use and considerable experimental data about them, little is known about how opioids may alter in vivo immunity in humans. This study was designed to ev...


    pub_type: 杂志文章


    authors: Yeager MP,Colacchio TA,Yu CT,Hildebrandt L,Howell AL,Weiss J,Guyre PM

    更新日期:1995-09-01 00:00:00

  • Effects of intrathecally administered lamotrigine, a glutamate release inhibitor, on short- and long-term models of hyperalgesia in rats.

    abstract:BACKGROUND:Lamotrigine is a sodium channel blocker that inhibits the neuronal release of glutamate. Systemic administration of lamotrigine induces analgesia in short- and long-term models of hyperalgesia in rats. Considering the key role of N-methyl-D-aspartate receptors in the sensitization of dorsal horn neurons that...


    pub_type: 杂志文章


    authors: Klamt JG

    更新日期:1998-02-01 00:00:00

  • Alfentanil pharmacokinetics and metabolism in humans.

    abstract::The metabolism of alfentanil was studied in three healthy subjects after a 1-h infusion of 2.5 mg alfentanil-3H. One of the subjects was a poor hydroxylator of debrisoquine. Pharmacokinetic parameters were similar in the three subjects and were in the same range as those reported for volunteers. The majority of the ad...


    pub_type: 杂志文章


    authors: Meuldermans W,Van Peer A,Hendrickx J,Woestenborghs R,Lauwers W,Heykants J,Vanden Bussche G,Van Craeyvelt H,Van der Aa P

    更新日期:1988-10-01 00:00:00

  • Factors associated with postoperative exacerbation of sleep-disordered breathing.

    abstract:INTRODUCTION:The knowledge on the mechanism of the postoperative exacerbation of sleep-disordered breathing may direct the perioperative management of patients with obstructive sleep apnea. The objective of this study is to investigate the factors associated with postoperative severity of sleep-disordered breathing. M...


    pub_type: 杂志文章


    authors: Chung F,Liao P,Elsaid H,Shapiro CM,Kang W

    更新日期:2014-02-01 00:00:00

  • Obesity decreases perioperative tissue oxygenation.

    abstract:BACKGROUND:Obesity is an important risk factor for surgical site infections. The incidence of surgical wound infections is directly related to tissue perfusion and oxygenation. Fat tissue mass expands without a concomitant increase in blood flow per cell, which might result in a relative hypoperfusion with decreased ti...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kabon B,Nagele A,Reddy D,Eagon C,Fleshman JW,Sessler DI,Kurz A

    更新日期:2004-02-01 00:00:00

  • Interaction of anesthesia, beta-receptor blockade, and blood loss in dogs with induced myocardial infarction.

    abstract::The cardiovascular effects of halothane-nitrous oxide anesthesia, and beta-receptor blockade with either propranolol or practolol, were studied in 15 dogs in which severe myocardial infarction had been induced ten days earlier. The hemodynamic responses to blood loss amounting to 25 per cent of estimated blood volume,...


    pub_type: 杂志文章


    authors: Prys-Roberts C,Roberts JG,Foëx P,Clarke TN,Bennett MJ,Ryder WA

    更新日期:1976-09-01 00:00:00

  • Days Alive and Out of Hospital: Validation of a Patient-centered Outcome for Perioperative Medicine.

    abstract:BACKGROUND:Days alive and out of hospital is a potentially useful patient-centered quality measure for perioperative care in adult surgical patients. However, there has been very limited prior validation of this endpoint with respect to its ability to capture differences in patient-level risk factor profiles and longer...


    pub_type: 杂志文章


    authors: Jerath A,Austin PC,Wijeysundera DN

    更新日期:2019-07-01 00:00:00

  • Bacterial reduction by cell salvage washing and leukocyte depletion filtration.

    abstract:BACKGROUND:Blood conservation techniques are being increasingly used because of the increased cost and lack of availability of allogeneic blood. Cell salvage offers great blood savings opportunities but is thought to be contraindicated in a number of areas (e.g., blood contaminated with bacteria). Several outcome studi...


    pub_type: 杂志文章


    authors: Waters JH,Tuohy MJ,Hobson DF,Procop G

    更新日期:2003-09-01 00:00:00

  • Efficacy of continuous insufflation of oxygen combined with active cardiac compression-decompression during out-of-hospital cardiorespiratory arrest.

    abstract:BACKGROUND:During experimental cardiac arrest, continuous insufflation of air or oxygen (CIO) through microcannulas inserted into the inner wall of a modified intubation tube and generating a permanent positive intrathoracic pressure, combined with external cardiac massage, has previously been shown to be as effective ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Saïssy JM,Boussignac G,Cheptel E,Rouvin B,Fontaine D,Bargues L,Levecque JP,Michel A,Brochard L

    更新日期:2000-06-01 00:00:00

  • Isoflurane activates intestinal sphingosine kinase to protect against renal ischemia-reperfusion-induced liver and intestine injury.

    abstract:BACKGROUND:Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and often leads to multiorgan dysfunction and systemic inflammation. Volatile anesthetics have potent antiinflammatory effects. We aimed to determine whether the representative volatile anesthetic isoflurane protects against acut...


    pub_type: 杂志文章


    authors: Kim M,Park SW,Kim M,D'Agati VD,Lee HT

    更新日期:2011-02-01 00:00:00

  • Sepsis is associated with a preferential diaphragmatic atrophy: a critically ill patient study using tridimensional computed tomography.

    abstract:BACKGROUND:Diaphragm and psoas are affected during sepsis in animal models. Whether diaphragm or limb muscle is preferentially affected during sepsis in the critically ill remains unclear. METHODS:Retrospective secondary analysis study including 40 patients, comparing control (n = 17) and critically ill patients, with...


    pub_type: 杂志文章


    authors: Jung B,Nougaret S,Conseil M,Coisel Y,Futier E,Chanques G,Molinari N,Lacampagne A,Matecki S,Jaber S

    更新日期:2014-05-01 00:00:00

  • Effect of pretreatment with intrathecal excitatory amino acid receptor antagonists on the development of pain behavior caused by plantar incision.

    abstract:BACKGROUND:Drugs that block spinal excitatory amino acid receptor activation may prevent pain after surgery. The authors previously studied the effect of excitatory amino acid receptor antagonists after incision. In the present study, we examined the role of N-methyl-d-aspartate (NMDA), non-NMDA, and metabotropic gluta...


    pub_type: 杂志文章


    authors: Pogatzki EM,Zahn PK,Brennan TJ

    更新日期:2000-08-01 00:00:00

  • Etomidate and thiopental inhibit the release of endothelium-derived hyperpolarizing factor in the human renal artery.

    abstract:BACKGROUND:Endothelium-derived hyperpolarizing factor is thought to be a cytochrome P450-derived arachidonic acid metabolite that hyperpolarizes vascular smooth muscle cells by opening Ca(2+)-activated K+ channels (K+Ca channels). In the rabbit carotid artery both volatile and intravenous anesthetics inhibit the acetyl...


    pub_type: 杂志文章


    authors: Kessler P,Lischke V,Hecker M

    更新日期:1996-06-01 00:00:00

  • Intracranial pressure during hypotension and subsequent vasopressor therapy in anesthetized cats.

    abstract::The effects of vasopressor therapy on intracranial pressure (ICP) during hypotension were evaluated in 45 adult cats anesthetized with pentobarbital and hyperventilated via an endotracheal tube with nitrous oxide, 70 per cent, and oxygen, 30 per cent, to maintain Paco2 25 plus or minus 5 torr. Hypotension was induced ...


    pub_type: 杂志文章


    authors: Stullken EH Jr,Sokoll MD

    更新日期:1975-04-01 00:00:00

  • Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients.

    abstract:BACKGROUND:Chronic pain remains a significant challenge for modern health care as its pathologic mechanisms are largely unknown and preclinical animal models suffer from limitations in assessing this complex subjective experience. However, human brain neuroimaging techniques enable the assessment of functional and neur...


    pub_type: 杂志文章,随机对照试验


    authors: Harris RE,Napadow V,Huggins JP,Pauer L,Kim J,Hampson J,Sundgren PC,Foerster B,Petrou M,Schmidt-Wilcke T,Clauw DJ

    更新日期:2013-12-01 00:00:00

  • Inhaled nitric oxide selectively decreases pulmonary vascular resistance without impairing oxygenation during one-lung ventilation in patients undergoing cardiac surgery.

    abstract:BACKGROUND:Inhaled nitric oxide (NO), an endothelium-derived relaxing factor, is a selective pulmonary vasodilator. The authors investigated whether inhaled NO decreases pulmonary vascular resistance (PVR) while preserving hypoxic pulmonary vasoconstriction and whether it maintains or improves oxygenation in patients d...


    pub_type: 杂志文章


    authors: Rich GF,Lowson SM,Johns RA,Daugherty MO,Uncles DR

    更新日期:1994-01-01 00:00:00

  • Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment.

    abstract:BACKGROUND:: Recent population studies have suggested that children with multiple exposures to anesthesia and surgery at an early age are at an increased risk of cognitive impairment. The authors therefore have established an animal model with single versus multiple exposures of anesthetic(s) in young versus adult mice...


    pub_type: 杂志文章


    authors: Shen X,Dong Y,Xu Z,Wang H,Miao C,Soriano SG,Sun D,Baxter MG,Zhang Y,Xie Z

    更新日期:2013-03-01 00:00:00