Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes.

abstract：:The effect of physostigmine on the loss of consciousness and respiratory depression induced in rabbits by flunitrazepam, 1 mg/kg, was studied to demonstrate whether the restoration of consciousness and respiration rate results from an increase in central cholinergic activity or from an interference by physostigmine wi...

journal_title：Anesthesiology

authors： Vatashsky E,Beilin B,Razin M,Weinstock M

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Ketamine is often administered to patients in whom hemodynamic instability is suspected. This study was designed to investigate the effect and possible site of action of ketamine on baroreflex response in rats. The site focused upon was the N-methyl-D-aspartate (NMDA) receptor of the nucleus tractus solitari...

journal_title：Anesthesiology

authors： Ogawa A,Uemura M,Kataoka Y,Ol K,Inokuchi T

更新日期：1993-01-01 00:00:00

abstract：:Surgical conditions during conventional mechanical ventilation (CMV) and pulmonary gas exchange were compared with those during high-frequency ventilation (HFV) in 24 patients undergoing anesthesia for intrathoracic surgery. HFV at an oscillatory frequency of 3 Hz and a delivered gas volume of 1.3-1.9 ml/kg provided e...

journal_title：Anesthesiology

authors： Glenski JA,Crawford M,Rehder K

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Although inhalation anesthetic agents are thought to impair cerebral autoregulation more than intravenous agents, there are few controlled studies in humans. METHODS:In the first group (n = 24), dynamic autoregulation was assessed from the response of middle cerebral artery blood flow velocity (Vmca) to a t...

journal_title：Anesthesiology

authors： Strebel S,Lam AM,Matta B,Mayberg TS,Aaslid R,Newell DW

更新日期：1995-07-01 00:00:00

abstract：:The effects of halothane on uptake and phosphorylation of uridine, and on cellular ATP content were studied in Tetrahymena pyriformis, a ciliate protozoan. Exposure to halothane inhibited the accumulation of 14C-uridine into the following acid-soluble intracellular pools: UTP, UDP, UMP, and an unidentified compound. H...

journal_title：Anesthesiology

authors： Conklin KA,Lau SS

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:The distribution and elimination of 0.9% saline given by intravenous infusion has not been compared between the conscious state and during inhalational anesthesia. METHODS:Six adult sheep received an intravenous infusion of 25 ml/kg of 0.9% saline over 20 min in the conscious state and also during isofluran...

journal_title：Anesthesiology

authors： Brauer KI,Svensén C,Hahn RG,Traber LD,Prough DS

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Propofol has not been studied directly in animals subject to cerebral ischemia in the conscious state. Strokes are usually induced in animals while they are anesthetized, making it difficult to eliminate anesthetic interactions as a complicating factor. Therefore, to compare the neuroprotective effects of pr...

journal_title：Anesthesiology

authors： Gelb AW,Bayona NA,Wilson JX,Cechetto DF

更新日期：2002-05-01 00:00:00

abstract：:Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens oth...

journal_title：Anesthesiology

authors： Terrell RC

更新日期：2008-03-01 00:00:00

abstract：:Robert D. Dripps, M.D. (1911 to 1973), helped found academic anesthesiology. Newly reviewed teaching slides from the University of Pennsylvania (Philadelphia, Pennsylvania) contain six anesthesia records from 1965 to 1967 that involved Dripps. They illustrate the clinical philosophy he taught-to consider administratio...

journal_title：Anesthesiology

authors： Johnstone RE,Fleisher LA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Results from previous studies on the effect of nitrous oxide (N2O) on the cerebral circulation are conflicting. Early reports claim N2O to have no effect whereas recent findings demonstrate a cerebral cortical vasodilatation during N2O inhalation, but the regional cerebral blood flow (CBF) in the subcortical...

journal_title：Anesthesiology

authors： Reinstrup P,Ryding E,Algotsson L,Berntman L,Uski T

更新日期：1994-08-01 00:00:00

abstract：:Cardiac arrest causes a rapid loss of cerebral adenosine triphosphate [corrected] (ATP) and a decrease in cerebral intracellular pH (pHi). Depending on the efficacy of cardiopulmonary resuscitation (CPR), cerebral blood flow levels (CBF) ranging from near zero to near normal have been reported experimentally. Using 31...

journal_title：Anesthesiology

authors： Eleff SM,Schleien CL,Koehler RC,Shaffner DH,Tsitlik J,Halperin HR,Rogers MC,Traystman RJ

更新日期：1992-01-01 00:00:00

abstract：:Volatile anesthetics inhibit phagocytic cell function, yet little is known about their effects on target tissues or on the target tissue response to stimulated phagocytes. Experiments were performed to determine how exposure to halothane and isoflurane changes rat pulmonary artery endothelial cell (RPAEC) viability in...

journal_title：Anesthesiology

authors： Shayevitz JR,Varani J,Ward PA,Knight PR

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Drugs that block spinal excitatory amino acid receptor activation may prevent pain after surgery. The authors previously studied the effect of excitatory amino acid receptor antagonists after incision. In the present study, we examined the role of N-methyl-d-aspartate (NMDA), non-NMDA, and metabotropic gluta...

journal_title：Anesthesiology

authors： Pogatzki EM,Zahn PK,Brennan TJ

更新日期：2000-08-01 00:00:00

abstract：:Opioid receptors have been targeted for the treatment of pain and related disorders for thousands of years and remain the most widely used analgesics in the clinic. Mu (μ), kappa (κ), and delta (δ) opioid receptors represent the originally classified receptor subtypes, with opioid receptor like-1 (ORL1) being the leas...

journal_title：Anesthesiology

authors： Al-Hasani R,Bruchas MR

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The mechanism by which barbiturates protect neurons against ischemia is unclear, particularly when they are given after ischemia or reperfusion begins. Because an excess release of excitatory neurotransmitters causes postsynaptic membrane depolarization, which triggers neuronal damage in ischemia, the effect...

journal_title：Anesthesiology

authors： Amakawa K,Adachi N,Liu K,Ikemune K,Fujitani T,Arai T

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Acute lung injury (ALI) is a serious postoperative complication with limited treatment options. A preoperative risk-prediction model would assist clinicians and scientists interested in ALI. The objective of this investigation was to develop a surgical lung injury prediction (SLIP) model to predict risk of p...

journal_title：Anesthesiology

authors： Kor DJ,Warner DO,Alsara A,Fernández-Pérez ER,Malinchoc M,Kashyap R,Li G,Gajic O

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Management of cardiovascular implantable electronic devices (CIEDs), including pacemakers and implantable cardioverter defibrillators, for surgical procedures is challenging due to the increasing number of patients with CIEDs and limited availability of trained providers. At the authors' institution, a small...

journal_title：Anesthesiology

authors： Rooke GA,Lombaard SA,Van Norman GA,Dziersk J,Natrajan KM,Larson LW,Poole JE

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:An in vitro model of epidural catheter contamination was used to determine if disconnected catheters can be safely reconnected. METHODS:Epidural catheters were filled with brain-heart infusion (BHI) broth or preservative-free saline containing 5 micrograms/ml fentanyl. Escherichia coli, Pseudomonas aerugino...

journal_title：Anesthesiology

authors： Langevin PB,Gravenstein N,Langevin SO,Gulig PA

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:CW002 is a neuromuscular blocking drug that is inactivated by endogenous L-cysteine. This study determined the exogenous L-cysteine dose-response relationship for CW002 reversal along with acute cardiovascular effects and organ toxicity in dogs. METHODS:Six dogs were each studied four times during isofluran...

journal_title：Anesthesiology

authors： Sunaga H,Malhotra JK,Yoon E,Savarese JJ,Heerdt PM

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The minimum alveolar concentration (MAC) of volatile anesthetics is decreased during pregnancy, but MAC in the early postpartum period has not been reported. The aim of this study was to determine the MAC of isoflurane and to evaluate the relation between MAC and serum progesterone and beta-endorphin in pati...

journal_title：Anesthesiology

authors： Zhou HH,Norman P,DeLima LG,Mehta M,Bass D

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Volatile anesthetics depress left ventricular contractile function by altering voltage-dependent slow calcium (Ca2+) channel activity in the sarcolemmal membrane. This investigation examined the left ventricular systolic and diastolic mechanical effects of the dihydropyridine Ca2+ channel antagonist nifedipi...

journal_title：Anesthesiology

authors： Pagel PS,Hettrick DA,Warltier DC

更新日期：1994-07-01 00:00:00

abstract：:Because propofol has cerebral effects similar to those observed for barbiturates, we postulated that it too might offer protection against a focal cerebral ischemic insult. Spontaneously hypertensive male rats were anesthetized with halothane (in 50% O2/balance N2), and their tracheas were intubated and their lungs me...

journal_title：Anesthesiology

authors： Ridenour TR,Warner DS,Todd MM,Gionet TX

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:The decision to extubate brain-injured patients with residual impaired consciousness holds a high degree of uncertainty of success. The authors developed a pragmatic clinical score predictive of extubation failure in brain-injured patients. METHODS:One hundred and forty brain-injured patients were prospecti...

journal_title：Anesthesiology

authors： Godet T,Chabanne R,Marin J,Kauffmann S,Futier E,Pereira B,Constantin JM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The long-lasting high-affinity opioid buprenorphine has complex pharmacology, including ceiling effects with respect to analgesia and respiratory depression. Plasma concentrations of the major buprenorphine metabolites norbuprenorphine, buprenorphine-3-glucuronide, and norbuprenorphine-3-glucuronide approxim...

journal_title：Anesthesiology

authors： Brown SM,Holtzman M,Kim T,Kharasch ED

更新日期：2011-12-01 00:00:00

abstract：:The relationship between neuroleptic malignant syndrome (NMS) and malignant hyperthermia (MH) was investigated using the in vitro skeletal muscle contracture test to screen for MH-susceptibility in NMS patients. The maximum contracture tension which developed following exposure to halothane (1-3%), and incremental dos...

journal_title：Anesthesiology

authors： Caroff SN,Rosenberg H,Fletcher JE,Heiman-Patterson TD,Mann SC

更新日期：1987-07-01 00:00:00

abstract：:The tape recorded EEGs of 127 patients anesthetized with large doses of opioids were retrospectively analyzed for evidence of opioid-induced seizures, and in particular, correlated with movements that occurred during induction and could be clinically interpreted as seizures. Bilateral EEG leads in patients receiving f...

journal_title：Anesthesiology

authors： Smith NT,Benthuysen JL,Bickford RG,Sanford TJ,Blasco T,Duke PC,Head N,Dec-Silver H

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Exposure of rhesus macaque fetuses for 24 h or neonates for 9 h to ketamine anesthesia causes neuroapoptosis in the developing brain. The current study clarifies the minimum exposure required for and the extent and spatial distribution of ketamine-induced neuroapoptosis in rhesus fetuses and neonates. METHO...

journal_title：Anesthesiology

authors： Brambrink AM,Evers AS,Avidan MS,Farber NB,Smith DJ,Martin LD,Dissen GA,Creeley CE,Olney JW

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Increasing age appears to be associated with a slower onset of neuromuscular blockade, but such an effect has not been studied with the same doses of the same drugs across pediatric and adult age groups. METHODS:The authors measured the evoked compound action potential of the adductor pollicis muscle in res...

journal_title：Anesthesiology

authors： Koscielniak-Nielsen ZJ,Bevan JC,Popovic V,Baxter MR,Donati F,Bevan DR

更新日期：1993-08-01 00:00:00

abstract：:The effects of fentanyl or cardiovascular function, regional distribution of cardiac output, and the dose required for producing anesthesia were studied in ten previously catheterized, newborn lambs. In addition, the effects of fentanyl on cerebral blood flow and oxygen utilization were examined. Fentanyl in cumulativ...

journal_title：Anesthesiology

authors： Yaster M,Koehler RC,Traystman RJ

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:The lightwand may be useful as an alternative for tracheal intubation during a rapid-sequence induction of anesthesia in the presence of a full stomach. This study was undertaken to assess the effect of application of cricoid pressure on the success of lightwand intubation. METHODS:Sixty adult female patien...

journal_title：Anesthesiology

authors： Hodgson RE,Gopalan PD,Burrows RC,Zuma K

更新日期：2001-02-01 00:00:00