Effect of pretreatment with intrathecal excitatory amino acid receptor antagonists on the development of pain behavior caused by plantar incision.

abstract：BACKGROUND:In children with a history of significant obstructive sleep apnea who undergo adenotonsillectomy, postsurgical administration of opiates has been alleged to be associated with an increased risk for respiratory complications, including respiratory depression. The authors hypothesize that this association is d...

journal_title：Anesthesiology

authors： Moss IR,Brown KA,Laferrière A

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:This study investigated the ability of the modified continual reassessment method (MCRM) to determine the maximum tolerated dose of the opioid antagonist nalmefene, which does not reverse analgesia in an acceptable number of postoperative patients receiving epidural fentanyl in 0.075% bupivacaine. METHODS:I...

journal_title：Anesthesiology

authors： Dougherty TB,Porche VH,Thall PF

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:The authors used the American Society of Anesthesiologists Closed Claims Project database to determine changes in the proportion of claims for death or permanent brain damage over a 26-yr period and to identify factors associated with the observed changes. METHODS:The Closed Claims Project is a structured e...

journal_title：Anesthesiology

authors： Cheney FW,Posner KL,Lee LA,Caplan RA,Domino KB

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:The authors developed a measure to determine whether maternal motivation to be present during induction (Motivation for Parental Presence during Induction of Anesthesia [MPPIA]) is related to children's anxiety during the induction process. METHODS:Mothers and children (aged 2-12 yr) undergoing outpatient, ...

journal_title：Anesthesiology

authors： Caldwell-Andrews AA,Kain ZN,Mayes LC,Kerns RD,Ng D

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:In pediatric patients, the Bispectral Index (BIS), derived from the electroencephalogram, and the composite A-Line autoregressive index (cAAI), derived from auditory evoked potentials and the electroencephalogram, have been used as measurements of depth of hypnosis during anesthesia. The performance and reli...

journal_title：Anesthesiology

authors： Blussé van Oud-Alblas HJ,Peters JW,de Leeuw TG,Tibboel D,Klein J,Weber F

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that volatile anesthetics cause not only vasodilation but also vasoconstriction, depending on the experimental conditions. However, the mechanism of the constrictive effect of volatile anesthetics has not been clarified. The aim of this study was to evaluate the vasoconstrictor effects...

journal_title：Anesthesiology

authors： Kakuyama M,Hatano Y,Nakamura K,Toda H,Terasako K,Nishiwada M,Mori K

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Anesthetics inhibit airway smooth muscle contraction in part by a direct effect on the smooth muscle cell. This study tested the hypothesis that the anesthetics halothane and hexanol, which both relax airway smooth muscle in vitro, inhibit acetylcholine-promoted nucleotide exchange at the alpha subunit of th...

journal_title：Anesthesiology

authors： Sakihara C,Perkins WJ,Warner DO,Jones KA

更新日期：2004-07-01 00:00:00

abstract：:The sensitivity of the masseter, one of the muscles of the upper airway, to pancuronium was measured in ten adults undergoing elective surgery and compared with that of the adductor pollicis. During thiopental-nitrous oxide-enflurane (end-tidal concentration less than 0.25%) anesthesia, supramaximal nerve stimulation ...

journal_title：Anesthesiology

authors： Smith CE,Donati F,Bevan DR

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:To interpret correctly the results from studies performed during surgery and anesthesia it is necessary to dissect the separate effect of the anesthetic technique itself. The purpose of this study was to investigate the metabolic effects of epidural blockade (T7-S1) with bupivacaine 0.25% after 12 h fasting ...

journal_title：Anesthesiology

authors： Schricker T,Klubien K,Wykes L,Carli F

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Studies have shown that long-term increase in the excitability of single wide dynamic range neurones in the spinal dorsal horn of rats may be induced after tetanic stimulation to the sciatic nerve. This sensory event is possibly an in vivo counterpart of long-term potentiation, described in the brain. This s...

journal_title：Anesthesiology

authors： Rygh LJ,Green M,Athauda N,Tjølsen A,Dickenson AH

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Pentobarbital decreases the gain of the baroreceptor reflex on the order of 50%, and this blunting is caused nearly entirely by decreasing cardioinhibitory parasympathetic activity. The most likely site of action of pentobarbital is the gamma-aminobutyric acid type A (GABA(A)) receptor. The authors tested wh...

journal_title：Anesthesiology

authors： Irnaten M,Walwyn WM,Wang J,Venkatesan P,Evans C,Chang KS,Andresen MC,Hales TG,Mendelowitz D

更新日期：2002-09-01 00:00:00

abstract：:Halothane-induced lipid peroxidation was studied in microsomes from phenobarbital-pretreated male rats at defined steady state oxygen partial pressures (PO2). At PO2 less than 10 mmHg on addition of halothane to NADPH-reduced microsomes, significant increases in malondialdehyde (MDA) formation, oxygen uptake, and conj...

journal_title：Anesthesiology

authors： de Groot H,Noll T

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Both pain and the pharmacologic management of pain can cause the undesirable effect of sleep disruption. One goal of basic and clinical neuroscience is to facilitate rational drug development by identifying the brain regions and neurochemical modulators of sleep and pain. Adenosine is thought to be an endoge...

journal_title：Anesthesiology

authors： Tanase D,Baghdoyan HA,Lydic R

更新日期：2002-12-01 00:00:00

abstract：:The effect of halothane on the pressor responses to hypoxia (3% O2, 5% CO2, balance N2) and to Angiotensin II (Ang II) (0.2 microgram) has been compared in an in vitro perfused and ventilated rat lung preparation in the presence and absence of agents known to block the lipoxygenase (BW755C) and/or the cyclooxygenase (...

journal_title：Anesthesiology

authors： Marshall C,Kim SD,Marshall BE

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:High-fidelity simulation is known to improve participant learning and behavioral performance. Simulation scenarios generate stress that affects memory retention and may impact future performance. The authors hypothesized that more participants would recall three or more critical key messages at three months ...

journal_title：Anesthesiology

authors： Lilot M,Evain JN,Bauer C,Cejka JC,Faure A,Balança B,Vassal O,Payet C,Bui Xuan B,Duclos A,Lehot JJ,Rimmelé T

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Protamine causes multiple adverse reactions. Heparinase I, a specific enzyme that inactivates heparin, is a possible alternative to protamine. In this study, the authors examined the efficacy of heparinase I to reverse heparin-induced anticoagulation in vitro and compared heparinase I to protamine as an anta...

journal_title：Anesthesiology

authors： Michelsen LG,Kikura M,Levy JH,Lee MK,Lee KC,Zimmermann JJ,Szlam F

更新日期：1996-08-01 00:00:00

abstract：:Ropivacaine is an amide local anesthetic structurally related to, but appearing less cardiotoxic, than bupivacaine. The authors' investigation was designed in a randomized, double-blind fashion to compare the clinical effectiveness of ropivacaine and bupivacaine in patients undergoing lower-extremity surgery. Forty-fi...

journal_title：Anesthesiology

authors： Brown DL,Carpenter RL,Thompson GE

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Anecdotal reports suggest that the second trimester is the safest time to conduct a laparoscopic procedure on a pregnant patient, but this supposition has not been tested empirically. METHODS:Previously instrumented preterm sheep (total n = 8) at gestational day 90 (term, 145 days) were anesthetized and the...

journal_title：Anesthesiology

authors： Uemura K,McClaine RJ,de la Fuente SG,Manson RJ,Campbell KA,McClaine DJ,White WD,Stamler JS,Eubanks WS,Reynolds JD

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C motif) receptor (CCR) 5 in neuropathic pain. METHODS:A spina...

journal_title：Anesthesiology

authors： Matsushita K,Tozaki-Saitoh H,Kojima C,Masuda T,Tsuda M,Inoue K,Hoka S

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The role of endothelial nitric oxide synthase (eNOS) in isoflurane postconditioning (IsoPC)-elicited cardioprotection is poorly understood. The authors addressed this issue using eNOS mice. METHODS:In vivo or Langendorff-perfused mouse hearts underwent 30 min of ischemia followed by 2 h of reperfusion in th...

journal_title：Anesthesiology

authors： Ge ZD,Pravdic D,Bienengraeber M,Pratt PF Jr,Auchampach JA,Gross GJ,Kersten JR,Warltier DC

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Clonidine, an alpha 2-adrenoceptor agonist, has been shown to be effective as a preanesthetic medication in adults. The current study was designed to investigate the efficacy of two doses of oral clonidine as a premedicant preceding oral atropine in children. METHODS:In a prospective, randomized, double-bli...

journal_title：Anesthesiology

authors： Mikawa K,Maekawa N,Nishina K,Takao Y,Yaku H,Obara H

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:This series investigated the quality of analgesia and the incidence and severity of side effects of intrathecal morphine for post-cesarean analgesia administered over a dose range of 0.0-0.5 mg. METHODS:ONE hundred eight term parturients undergoing cesarean delivery at term and given spinal anesthesia were ...

journal_title：Anesthesiology

authors： Palmer CM,Emerson S,Volgoropolous D,Alves D

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Effects of volatile anesthetic agents on N-methyl-D-aspartate (NMDA) receptor-mediated excitatory synaptic transmission have not been well characterized. The authors compared effects produced by halothane and isoflurane on electrophysiologic properties of NMDA and non-NMDA receptor-mediated synaptic response...

journal_title：Anesthesiology

authors： Nishikawa K,MacIver MB

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:The effects of triiodothyronine (T3) on systemic hemodynamics, myocardial contractility (preload recruitable stroke work slope; Mw), and left ventricular (LV) isovolumic relaxation (time constant; tau) were examined before and after the development of pacing-induced cardiomyopathy in conscious dogs. METHODS...

journal_title：Anesthesiology

authors： Jamall IN,Pagel PS,Hettrick DA,Lowe D,Kersten JR,Tessmer JP,Warltier DC

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:The authors compare three techniques for insertion of the ProSeal laryngeal mask airway. METHODS:Two hundred forty healthy patients aged 18-80 yr were randomly allocated for ProSeal laryngeal mask airway insertion using the digital, introducer tool (IT), or gum elastic bougie (GEB)-guided techniques. The di...

journal_title：Anesthesiology

authors： Brimacombe J,Keller C,Judd DV

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The authors previously reported that the pulmonary vasodilator response to the sympathetic beta-adrenoreceptor agonist isoproterenol is potentiated during isoflurane anesthesia compared with the conscious state. In the present in vivo study, the authors tested the hypothesis that halothane and enflurane anes...

journal_title：Anesthesiology

authors： Sato K,Seki S,Murray PA

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:The results of sevoflurane biotransformation (fluoromethyl-1,1,1,3,3,3,-hexafluoro-2-propyl ether) to inorganic fluoride have been examined. However, these investigations have lacked a simplified assay for determining the primary organic metabolite, hexafluoroisopropanol. Previous attempts have involved exte...

journal_title：Anesthesiology

authors： Morgan SE,Frink EJ,Gandolfi AJ

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Because oral erythromycin administration has been associated with reduced elimination of alfentanil, suspicion has been raised about related opioids with similar metabolic pathways. A controlled crossover study of sufentanil pharmacokinetics was undertaken to resolve this issue. METHODS:Six subjects had mea...

journal_title：Anesthesiology

authors： Bartkowski RR,Goldberg ME,Huffnagle S,Epstein RH

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Mechanical ventilation is delivered to sedated patients during anesthesia, but also to nonsedated patients (ventilator weaning, noninvasive ventilation). In these circumstances, patient-ventilator asynchrony may occur, provoking discomfort and unduly increasing work of breathing. In certain cases, it is asso...

journal_title：Anesthesiology

authors： Raux M,Ray P,Prella M,Duguet A,Demoule A,Similowski T

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:We aimed to assess the clinical effectiveness of intravenous exenatide compared to insulin in perioperative blood glucose control in coronary artery bypass grafting surgery patients. METHODS:Patients more than 18 yr old admitted for elective coronary artery bypass grafting were included in a phase II/III no...

journal_title：Anesthesiology

authors： Besch G,Perrotti A,Mauny F,Puyraveau M,Baltres M,Flicoteaux G,Salomon du Mont L,Barrucand B,Samain E,Chocron S,Pili-Floury S

更新日期：2017-11-01 00:00:00